AUTHOR=Shahid Muhammad Nabeel , Afzal Hassaan Shahzad , Farooq Bareerah , Yousaf Muhammad Rehan , Ijaz Muhammad Rauf , Shafqat Talha Ali , Khan Tahir Mehmood , Neoh Chin Fen , Lean Qi Ying , Bukhsh Allah , Karuppannan Mahmathi 

TITLE=A systematic review on the effectiveness of herbal interventions for the treatment of male infertility

JOURNAL=Frontiers in Physiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.930676

DOI=10.3389/fphys.2022.930676

ISSN=1664-042X

ABSTRACT=Background: Male infertility is an emerging health issue in the world today. Surgical interventions for the treatment of male infertility are available but are quite expensive. Herbal interventions pose a popular alternative for the treatment of infertility. However, much has to be learned regarding their safety and efficacy.
Objective: To investigate the efficacy of herbal interventions in male infertility and also assess the possibility of these interventions as complementary and alternative medicine (CAM) in the future.
Method: From inception till 16 December 2021 all articles emphasizing the efficacy of herbal interventions in the treatment of male infertility are included in this review. 7 databases are searched. The literature obtained is screened and extracted. Semen parameters, hormonal concentration and conception are the outcomes of interest. 
Results: 20 articles were included in this review. Herbal interventions might improve semen parameters in males with infertility. Among all the interventions, Hochu-ekki-to and W. somnifera have shown the most promising results and should be studied further in a larger sample size.
Conclusion: This systematic review has demonstrated the efficacy of herbal interventions especially Hochu-ekki-to & W. somnifera in treating male infertility.