AUTHOR=Zhang Sheng, Li Chiang-shan TITLE=Task-Related, Low-Frequency Task-Residual, and Resting State Activity in the Default Mode Network Brain Regions JOURNAL=Frontiers in Psychology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/articles/10.3389/fpsyg.2012.00172 DOI=10.3389/fpsyg.2012.00172 ISSN=1664-1078 ABSTRACT=The hypothesis of a default mode network (DMN) of brain function is based on observations of task-independent decreases of brain activity during effort as participants are engaged in tasks in contrast to resting. On the other hand, studies also showed that DMN regions activate rather than deactivate in response to task-related events. Thus, does DMN “deactivate” during effort as compared to resting? We hypothesized that, with high-frequency event-related signals removed, the task-residual activities of the DMN would decrease as compared to resting. We addressed this hypothesis with two approaches. First, we examined DMN activities during resting, task residuals, and task conditions in the stop signal task using independent component analysis (ICA). Second, we compared the fractional amplitude of low-frequency fluctuation (fALFF) signals of DMN in resting, task residuals, and task data. In the results of ICA of 76 subjects, the precuneus and posterior cingulate cortex (PCC) showed increased activation during task as compared to resting and task residuals, indicating DMN responses to task events. Precuneus but not the PCC showed decreased activity during task residual as compared to resting. The latter finding was mirrored by fALFF, which is decreased in the precuneus during task residuals, as compared to resting and task. These results suggested that the low-frequency blood oxygen level-dependent signals of the precuneus may represent a useful index of effort during cognitive performance.