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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychol.</journal-id>
<journal-title>Frontiers in Psychology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychol.</abbrev-journal-title>
<issn pub-type="epub">1664-1078</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyg.2014.00205</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychology</subject>
<subj-group>
<subject>Original Research Article</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Predictors of cognitive enhancement after training in preschoolers from diverse socioeconomic backgrounds</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Segretin</surname> <given-names>M. Soledad</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="author-notes" rid="fn001"><sup>&#x0002A;</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Lipina</surname> <given-names>Sebasti&#x000E1;n J.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Hermida</surname> <given-names>M. Julia</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Sheffield</surname> <given-names>Tiffany D.</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Nelson</surname> <given-names>Jennifer M.</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Espy</surname> <given-names>Kimberly A.</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Colombo</surname> <given-names>Jorge A.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Unidad de Neurobiolog&#x000ED;a Aplicada, Consejo Nacional de Investigaciones Cient&#x000ED;ficas y T&#x000E9;cnicas (CONICET), Centro de Educaci&#x000F3;n M&#x000E9;dica e Investigaciones Cl&#x000ED;nicas Norberto Quirno (CEMIC), Ciudad Autonoma de Buenos Aires</institution> <country>Buenos Aires, Argentina</country></aff>
<aff id="aff2"><sup>2</sup><institution>Office of Research, University of Nebraska</institution> <country>Lincoln, NE, USA</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Psychology, University of Nebraska</institution> <country>Lincoln, NE, USA</country></aff>
<aff id="aff4"><sup>4</sup><institution>Department of Psychology, University of Oregon</institution> <country>Eugene, OR, USA</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Philip D. Zelazo, University of Minnesota, USA</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Silvia A. Bunge, University of California Berkeley, USA; Frederick James Morrison, University of Michigan, USA</p></fn>
<fn fn-type="corresp" id="fn001"><p>&#x0002A;Correspondence: M. Soledad Segretin, Unidad de Neurobiolog&#x000ED;a Aplicada, Consejo Nacional de Investigaciones Cient&#x000ED;ficas y T&#x000E9;cnicas, Centro de Educaci&#x000F3;n M&#x000E9;dica e Investigaciones Cl&#x000ED;nicas, Unidad de Neurobiolog&#x000ED;a Aplicada, Avenida Galv&#x000E1;n 4102, Ciudad Aut&#x000F3;noma de Buenos Aires C1431FWO, Argentina e-mail: <email>soledadsegretin&#x00040;gmail.com</email></p></fn>
<fn fn-type="other" id="fn002"><p>This article was submitted to Developmental Psychology, a section of the journal Frontiers in Psychology.</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>13</day>
<month>03</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection">
<year>2014</year>
</pub-date>
<volume>5</volume>
<elocation-id>205</elocation-id>
<history>
<date date-type="received">
<day>12</day>
<month>09</month>
<year>2013</year>
</date>
<date date-type="accepted">
<day>23</day>
<month>02</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2014 Segretin, Lipina, Hermida, Sheffield, Nelson, Espy and Colombo.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract><p>The association between socioeconomic status and child cognitive development, and the positive impact of interventions aimed at optimizing cognitive performance, are well-documented. However, few studies have examined how specific socio-environmental factors may moderate the impact of cognitive interventions among poor children. In the present study, we examined how such factors predicted cognitive trajectories during the preschool years, in two samples of children from Argentina, who participated in two cognitive training programs (CTPs) between the years 2002 and 2005: the <italic>School Intervention Program</italic> (SIP; <italic>N</italic> &#x0003D; 745) and the <italic>Cognitive Training Program</italic> (CTP; <italic>N</italic> &#x0003D; 333). In both programs children were trained weekly for 16 weeks and tested before and after the intervention using a battery of tasks assessing several cognitive control processes (attention, inhibitory control, working memory, flexibility and planning). After applying mixed model analyses, we identified sets of socio-environmental predictors that were associated with higher levels of pre-intervention cognitive control performance and with increased improvement in cognitive control from pre- to post-intervention. Child age, housing conditions, social resources, parental occupation and family composition were associated with performance in specific cognitive domains at baseline. Housing conditions, social resources, parental occupation, family composition, maternal physical health, age, group (intervention/control) and the number of training sessions were related to improvements in specific cognitive skills from pre- to post-training.</p></abstract>
<kwd-group>
<kwd>cognitive development</kwd>
<kwd>intervention</kwd>
<kwd>SES</kwd>
<kwd>mixed models</kwd>
<kwd>socio-environmental predictors</kwd>
<kwd>preschool children</kwd>
</kwd-group>
<counts>
<fig-count count="3"/>
<table-count count="15"/>
<equation-count count="0"/>
<ref-count count="110"/>
<page-count count="21"/>
<word-count count="16523"/>
</counts>
</article-meta>
</front>
<body>
<sec sec-type="introduction" id="s1">
<title>Introduction</title>
<p>Broadly defined, executive functions (EF) refer to a complex set of cognitive abilities that underlie adaptive, goal-directed behaviors, and enable individuals to override more automatic or established thoughts and responses (Garon et al., <xref ref-type="bibr" rid="B38">2008</xref>; Diamond, <xref ref-type="bibr" rid="B26">2013</xref>). EF are critical when solving novel problems and thus essential for self-regulation, school learning, and social behavior (e.g., Hughes and Graham, <xref ref-type="bibr" rid="B50">2002</xref>; Anderson, <xref ref-type="bibr" rid="B1">2002</xref>; Isquith et al., <xref ref-type="bibr" rid="B54">2005</xref>; Diamond et al., <xref ref-type="bibr" rid="B27">2007</xref>; Garon et al., <xref ref-type="bibr" rid="B38">2008</xref>; Bull et al., <xref ref-type="bibr" rid="B17">2011</xref>; Espy et al., <xref ref-type="bibr" rid="B30">2011</xref>). At a more fine-grained level a set of cognitive control skills (e.g., attention, inhibitory control, self-monitoring, and flexibility) is defined as specific interrelated information-processing abilities that are involved in the control and coordination of information in the service of goal-directed actions, as studied in the cognitive development literature (Willoughby et al., <xref ref-type="bibr" rid="B112">2012</xref>). Focusing on these more narrowly defined abilities is particularly suitable when studying EF in early childhood, as many of the more complex aspects of EF (e.g., abstract thought; goal setting) have an extended developmental course and are not easily measured in very young children (Garon et al., <xref ref-type="bibr" rid="B38">2008</xref>; Willoughby et al., <xref ref-type="bibr" rid="B112">2012</xref>). The emergence and development of those cognitive processes depend on both biological maturation and environmental experiences (Fisher, <xref ref-type="bibr" rid="B35">2006</xref>; Berkman et al., <xref ref-type="bibr" rid="B10">2012</xref>), and follow different trajectories from the first year of life (Anderson, <xref ref-type="bibr" rid="B1">2002</xref>; Garon et al., <xref ref-type="bibr" rid="B38">2008</xref>; Marsh et al., <xref ref-type="bibr" rid="B73">2010</xref>; Howe et al., <xref ref-type="bibr" rid="B49">2012</xref>). In addition, these trajectories are sensitive to individual differences, and the quality of the micro- and mesosystemic developmental contexts (home and school) (Lipina and Colombo, <xref ref-type="bibr" rid="B64">2009</xref>; Cadima et al., <xref ref-type="bibr" rid="B21">2010</xref>; Sarsour et al., <xref ref-type="bibr" rid="B93">2011</xref>).</p>
<p>Several studies have suggested that associations between socioeconomic status and cognitive development during childhood are mediated by biological, psychological and environmental factors, which may be conceptualized at multiple levels of analysis (individual, family, and social contexts), and increase the likelihood of negative impacts later in life (Leinonen et al., <xref ref-type="bibr" rid="B63">2002</xref>; Raver et al., <xref ref-type="bibr" rid="B86">2007</xref>, <xref ref-type="bibr" rid="B85">2013</xref>; Santos et al., <xref ref-type="bibr" rid="B92">2008</xref>; Cadima et al., <xref ref-type="bibr" rid="B21">2010</xref>; Rhoades et al., <xref ref-type="bibr" rid="B88">2011</xref>; Sarsour et al., <xref ref-type="bibr" rid="B93">2011</xref>; Lipina et al., <xref ref-type="bibr" rid="B70">2013</xref>). Among the environmental factors that have been associated with these impacts, the following are the most cited in the scientific literature: family income, family composition, parental level of education and occupation, housing conditions, perinatal health factors, quality of home and school environments, attendance to early education programs, parental mental health, parenting styles, parent-child interactions, neighborhood characteristics, and social support (Burchinal et al., <xref ref-type="bibr" rid="B18">2000</xref>; Bradley and Corwyn, <xref ref-type="bibr" rid="B14">2002</xref>, <xref ref-type="bibr" rid="B15">2005</xref>; Evans, <xref ref-type="bibr" rid="B31">2004</xref>; Gassman-Pines and Yoshikawa, <xref ref-type="bibr" rid="B39">2006</xref>; Engle et al., <xref ref-type="bibr" rid="B28">2007</xref>; Grantham-McGregor et al., <xref ref-type="bibr" rid="B41">2007</xref>; Walker et al., <xref ref-type="bibr" rid="B110">2007</xref>; Rhoades et al., <xref ref-type="bibr" rid="B88">2011</xref>; Sarsour et al., <xref ref-type="bibr" rid="B93">2011</xref>). Additionally, the impact of these factors on different aspects of child development may vary according to the type, number and accumulation of risk factors to which children are exposed, the timing of exposure, and the individual susceptibility to each one (Najman et al., <xref ref-type="bibr" rid="B79">2004</xref>; Stanton-Chapman et al., <xref ref-type="bibr" rid="B102">2004</xref>; Belsky et al., <xref ref-type="bibr" rid="B8">2007</xref>; Walker et al., <xref ref-type="bibr" rid="B110">2007</xref>; Kiernan and Huerta, <xref ref-type="bibr" rid="B58">2008</xref>; Flouri et al., <xref ref-type="bibr" rid="B37">2009</xref>; Kiernan and Mensah, <xref ref-type="bibr" rid="B59">2009</xref>; Hall et al., <xref ref-type="bibr" rid="B45">2010</xref>; Rhoades et al., <xref ref-type="bibr" rid="B88">2011</xref>; Evans et al., <xref ref-type="bibr" rid="B32">2013</xref>). Thus, it is not only the mere presence or absence of specific risk factors that influence development, but also their accumulation in a context of individuality, with more risk leading to greater adjustment difficulties (Burchinal et al., <xref ref-type="bibr" rid="B18">2000</xref>; Stanton-Chapman et al., <xref ref-type="bibr" rid="B102">2004</xref>; Appleyard et al., <xref ref-type="bibr" rid="B2">2005</xref>; Gassman-Pines and Yoshikawa, <xref ref-type="bibr" rid="B39">2006</xref>; Cadima et al., <xref ref-type="bibr" rid="B21">2010</xref>; Evans et al., <xref ref-type="bibr" rid="B32">2013</xref>). Despite the significant advances in the field, more research is necessary to elucidate specific environmental experiences that contribute to individual differences in cognitive control development (Rhoades et al., <xref ref-type="bibr" rid="B88">2011</xref>), as well as their contribution to individual differences in the context of intervention trials.</p>
<p>Specifically, cognitive control performance of children living in poverty is limited in its potential due to the presence of multiple risk factors in these contexts, such as child health history (peri- and postnatal), maternal education, parental mental health, quality of stimulation at home, and social interactions in different contexts (e.g., home and school). Results from studies developed in Argentina assessing associations between poverty and impact on cognitive processing have verified the modulation of different cognitive processes (i.e., attentional, inhibitory control, working memory, flexibility, and planning) in infants and preschoolers as a result of socioeconomic status and income, as well as the influence of poverty on academic performance (i.e., language and mathematics) in elementary and high school children (Lipina et al., <xref ref-type="bibr" rid="B66">2004</xref>, <xref ref-type="bibr" rid="B65">2005</xref>, <xref ref-type="bibr" rid="B70">2013</xref>; Segretin et al., <xref ref-type="bibr" rid="B95">2009</xref>).</p>
<p>In Argentina, according to the latest data published by the National Institute of Statistics and Censuses (INDEC, <xref ref-type="bibr" rid="B51">2001</xref>), 14.3% of families live with Unsatisfied Basic Needs (UBN). Additionally, the Observatory on the Argentinean Social Debt reported that 29.6% of the population was poor during 2010 (Tu&#x000F1;&#x000F3;n, <xref ref-type="bibr" rid="B109">2011</xref>). With respect to child poverty, 40.5% of children under the age of 14 were living in poverty, and 14.2% in extreme poverty in 2006 (INDEC, <xref ref-type="bibr" rid="B52">2006</xref>). According to the report of the United Nations Fund for Children of 2010, 28.7% of children under the age of 18 in Argentina are in poverty (CEPAL-UNICEF, <xref ref-type="bibr" rid="B22">2010</xref>).</p>
<p>During the past decade, several interventions targeting cognitive control development have been designed and evaluated in the fields of developmental psychology and developmental cognitive neuroscience (Lipina and Colombo, <xref ref-type="bibr" rid="B64">2009</xref>; Burger, <xref ref-type="bibr" rid="B19">2010</xref>). The main goals of such interventions were the promotion of cognitive control development in early childhood, with the aim of influencing broader, long-term outcomes, such as academic and social adjustment (McCandliss et al., <xref ref-type="bibr" rid="B75">2003</xref>; Temple et al., <xref ref-type="bibr" rid="B105">2003</xref>; Colombo and Lipina, <xref ref-type="bibr" rid="B23">2005</xref>; Klingberg et al., <xref ref-type="bibr" rid="B61">2005</xref>; Rueda et al., <xref ref-type="bibr" rid="B90">2005</xref>; Wilson et al., <xref ref-type="bibr" rid="B113">2006</xref>; Diamond et al., <xref ref-type="bibr" rid="B27">2007</xref>; Stevens et al., <xref ref-type="bibr" rid="B104">2008</xref>; Beatty, <xref ref-type="bibr" rid="B7">2009</xref>; Thorell et al., <xref ref-type="bibr" rid="B108">2009</xref>; Barnett, <xref ref-type="bibr" rid="B5">2011</xref>; Espinet et al., <xref ref-type="bibr" rid="B29">2012</xref>). Most of the previous interventions were successful in promoting cognitive performance in the short- or medium-term, and evaluation of their success generally focused on pre- and post-training performance comparisons between groups. Only few studies have also included an analysis of the predictors of intervention impact, mostly based on variables, such as the initial cognitive performance, age, and/or program characteristics (e.g., Bierman et al., <xref ref-type="bibr" rid="B11">2008</xref>). The effectiveness of the intervention programs that include cognitive stimulation modules has been related to the following aspects of program design: (a) comprehensiveness of services (educational, nutritional, sanitation, and social services); (b) teacher and family participation; (c) direct and indirect interventions; (d) quality of services; (e) staff recruitment and training; and (f) cultural pertinence of interventions (Ramey and Ramey, <xref ref-type="bibr" rid="B83">1998</xref>, <xref ref-type="bibr" rid="B84">2003</xref>; Gray and McCormick, <xref ref-type="bibr" rid="B42">2005</xref>; Karoly et al., <xref ref-type="bibr" rid="B57">2005</xref>; Reynolds and Temple, <xref ref-type="bibr" rid="B87">2005</xref>; Perez-Johnson and Maynard, <xref ref-type="bibr" rid="B81">2007</xref>; Barnett, <xref ref-type="bibr" rid="B5">2011</xref>; Reynolds et al., <xref ref-type="bibr" rid="B106">2011</xref>). It is important, however, to consider that interventions are not equally effective for all participants. In this regard, different factors could moderate the impact of the intervention, and this information would be crucial to the design of new interventions, both experimental and applied.</p>
<p>In general, studies on the moderation of cognitive development by environmental factors have focused on the associations between child poverty and accumulation of risk factors (Gassman-Pines and Yoshikawa, <xref ref-type="bibr" rid="B39">2006</xref>; Weiland and Yoshikawa, <xref ref-type="bibr" rid="B111">2012</xref>; Flouri et al., <xref ref-type="bibr" rid="B36">2013</xref>; Meunier et al., <xref ref-type="bibr" rid="B77">2013</xref>). Less analytical efforts have been devoted to moderation based on risk factors in the area of intervention science. Thus, the implementation of risk-factor analysis, such as identifying different socio-environmental variables as predictors of intervention impact, is important in order to establish targets for improvement in the design of innovative interventions.</p>
<p>In this article, we propose the analysis of specific aspects of two intervention programs implemented in Argentina between 2002 and 2005, with the main goal of optimizing cognitive control performance in preschool children: the <italic>School Intervention Program</italic> (SIP), and the <italic>Cognitive Training Program</italic> (CTP) (Table <xref ref-type="table" rid="T1">1</xref>). We focus the analysis on the identification of different socio-environmental predictors of cognitive trajectories. Specifically, the main goals of the present study were: (1) to examine how environmental factors moderate cognitive performance; and (2) to identify factors that moderate the impact of two intervention programs aimed at optimizing cognitive performance in two samples of poor- and non-poor preschoolers. We examined children&#x00027;s performance in tasks demanding attention, inhibitory control, memory, flexibility, and planning, and considered the impact of environmental risk factors on each cognitive task at baseline and task trajectories (change in performance from pre- to post-assessment). Mixed model analyses were applied in order to identify socio-environmental predictors associated with higher levels of cognitive control performance in the pre-intervention phase, and with increased improvement in cognitive control between pre- and post-intervention phases. We expected that higher cognitive performance at baseline would be associated with better socio-environmental conditions (Feldman and Eidelman, <xref ref-type="bibr" rid="B33">2009</xref>; Kiernan and Mensah, <xref ref-type="bibr" rid="B59">2009</xref>). Additionally, we expected that children living in families with more resources (in terms of parental occupation and education, financial resources, type of housing and social support) would have higher improvements in their cognitive performance after training. This hypothesis was based on the idea that for children from worst socio-environmental conditions another type of intervention would be required (e.g., more specific for each cognitive skill, with more intervention intensity exposure-considering frequency, length, and age) (Ramey and Ramey, <xref ref-type="bibr" rid="B84">2003</xref>). We also expected to identify different predictors for each cognitive process and program, taking into account the differences in the cognitive developmental trajectories at these ages (Garon et al., <xref ref-type="bibr" rid="B38">2008</xref>), and the differences in the program characteristics (e.g., context of implementation, number and frequency of training sessions, and modalities of training) (Jolles and Crone, <xref ref-type="bibr" rid="B56">2012</xref>). Also, it is important to mention that results from different intervention programs for disadvantaged children have suggested that the frequency of intervention is a significant modulator of the impact (Ramey and Ramey, <xref ref-type="bibr" rid="B84">2003</xref>; Karoly et al., <xref ref-type="bibr" rid="B57">2005</xref>; Burger, <xref ref-type="bibr" rid="B19">2010</xref>). Based on this, we also expected that the number of training sessions (exposure to training) would be a significant predictor of cognitive trajectories, with higher cognitive performance improvements in children with more exposure to training.</p>
<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption><p><bold>Programs descriptions</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" colspan="2"><bold>Program</bold></th>
</tr>
<tr>
<th/>
<th align="left"><bold>SIP</bold></th>
<th align="left"><bold>CTP</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Design</td>
<td align="left" valign="top">Experimental, controlled, and random study.</td>
<td align="left" valign="top">Quasi-experimental and random study.</td>
</tr>
<tr>
<td align="left" valign="top">Participants</td>
<td align="left" valign="top">Children from 3 to 5 years from UBN<xref ref-type="table-fn" rid="TN1a"><sup>a</sup></xref> homes. City of Buenos Aires.</td>
<td align="left" valign="top">Children from 3 to 5 years from UBN and SBN<xref ref-type="table-fn" rid="TN1b"><sup>b</sup></xref> homes. City of Salta.</td>
</tr>
<tr>
<td align="left" valign="top">Study groups</td>
<td align="left" valign="top">Intervention/control.</td>
<td align="left" valign="top">Individual training modality/group training modality<xref ref-type="table-fn" rid="TN1s"><sup>&#x0002A;</sup></xref>.</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="3">Program phases</td>
<td align="left" valign="top">1. Cognitive assessment (Time 1)</td>
<td align="left" valign="top">1. Cognitive assessment (Time 1)</td>
</tr>
<tr>
<td align="left" valign="top">2. Intervention modules implementation</td>
<td align="left" valign="top">2. Intervention modules implementation</td>
</tr>
<tr>
<td align="left" valign="top">3. Cognitive assessment (Time 2)</td>
<td align="left" valign="top">3. Cognitive assessment (Time 2)</td>
</tr>
<tr>
<td align="left" valign="top">Intervention modules</td>
<td align="left" valign="top">Cognitive training; nutritional supplementation; counseling for parents; training; and counseling for teachers.</td>
<td align="left" valign="top">Cognitive training; nutritional supplementation (the government agency provided counseling for parents and adults working in the childcare centers).</td>
</tr>
<tr>
<td align="left" valign="top">Activities for the cognitive training module</td>
<td align="left" valign="top">Exercising activities (individual modality of training).</td>
<td align="left" valign="top">Activities with a pedagogical format (individual and group modalities of training).</td>
</tr>
<tr>
<td align="left" valign="top">Frequency of intervention</td>
<td align="left" valign="top">Once a week for 16 weeks in 1 year; twice a week during 16 weeks in 1 year.</td>
<td align="left" valign="top">Twice a week for 16 weeks in 1 year.</td>
</tr>
<tr>
<td align="left" valign="top">Total cognitive training sessions</td>
<td align="left" valign="top">16 or 32 sessions.</td>
<td align="left" valign="top">32 sessions.</td>
</tr>
<tr>
<td align="left" valign="top">Context of implementation</td>
<td align="left" valign="top">Kindergartens.</td>
<td align="left" valign="top">Childcare Centers.</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN1s"><label>&#x0002A;</label><p><italic>Only 4-year-old children were randomly assigned to individual or group training modalities. For that reason, analysis were run separately for this age group (with the aim to compare training modalities) (manuscript under revision), and in the present article only 3- to 5-year-old children assigned to the group training modality were considered for the prediction analysis.</italic></p></fn>
<fn id="TN1a"><label>a</label><p><italic>UBN (poverty criteria, see details in section Socioeconomic, Life, and Health Condition Measures).</italic></p></fn>
<fn id="TN1b"><label>b</label><p><italic>SBN: Satisfied Basic Needs.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec sec-type="methods" id="s2">
<title>Methods</title>
<sec>
<title>Study design, participants, and procedures</title>
<sec>
<title>SIP program</title>
<p>A sample of healthy Argentinean children aged 3&#x02013;5 years participated in the SIP, a longitudinal study implemented between years 2002 and 2004 in three kindergartens in the city of Buenos Aires, selected by applying the conglomerate sample method. The program was an experimental, randomized and controlled study with the main goal to train cognitive performance in preschool children from UBN homes (Colombo and Lipina, <xref ref-type="bibr" rid="B23">2005</xref>; Lipina et al., <xref ref-type="bibr" rid="B68">2012</xref>). Seven hundred and forty five preschool children were authorized to participate. We have verified an attrition rate around 15% per year. Each year new cohorts were enrolled, forming different study groups with 1 and 2 years of intervention. For the present article only data from children with 1 year of intervention between the years 2002 and 2004 were analyzed, because of the small sample size for 2 years of intervention, which did not allow executing the planned analytical procedures. Informed consents were obtained from parents/caregivers, and ethical approval was obtained from the Ethical Review Committee. The study was conducted according to APA&#x00027;s ethical standards, and international and national children rights laws.</p>
<p>Before the beginning of the program, we recruited and trained a group of college students (&#x0201C;trainers&#x0201D; from now on) from the school of psychology and education. During the same period, we informed the parents of children attending the selected institutions about the program activities and we asked them to sign written consents to include their children into the program. After that, from April to July in each year, we evaluated children&#x00027;s cognitive performance (Time 1, baseline) (see section Cognitive Measures), and parents attended individual interviews to give socioeconomic, sociodemographic and child health history information. Then, four intervention modules were implemented from July to November (see above). After the intervention, all children had a final cognitive assessment (Time 2, post-intervention) with the same battery of tasks used at Time 1. We provided trainers with an intervention procedure guide and supervised them daily. Trainers had to complete a form describing the implemented activities, which we revised daily to suggest adjustments. Trainers were blind to the hypotheses of the study. Activities for the control and intervention groups were organized in different days of the week and all trainers were reassigned to different schools for the final phase (post-intervention cognitive assessment).</p>
<p>The program included the following four modules:
<list list-type="simple">
<list-item><p>(1) The individual <italic>cognitive training module</italic> consisted of different exercises demanding cognitive control, with increasing complexity. Activities involved some of the tasks used for the pre- and post-assessment, using different trials (Figure <xref ref-type="fig" rid="F1">1</xref>). Exercises were implemented during the school day as an extracurricular activity. Two schemes were applied: once a week (a total of 16 sessions), or twice a week (a total of 32 sessions) during 16 weeks in 1 year. Activities followed a scheme previously designed considering the cognitive demand and the time available for the session (30/40 min), and were implemented by one trainer (adults/children ratio &#x0003D; 1 per 1), who was the same for each child.</p></list-item>
</list></p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption><p><bold>Description of training activities in the SIP</bold>.</p></caption>
<graphic xlink:href="fpsyg-05-00205-g0001.tif"/>
</fig>
<p>Each training session was structured in four consecutive steps: (1) assessment of children&#x00027;s motivational state with a Likert scale including the following constructs: willing/not willing to collaborate, extroversion/introversion, talkative/quiet, active/passive, impulsive/thoughtful, trustful/distrustful; (2) introduction of novel materials for the activity and task instructions; (3) evaluation of instruction comprehension with pretest exercises; and (4) activities: blocks of different exercises or trials. Only when children were adequately motivated and pretests were properly solved, trainers continued with the next step, otherwise, the activity was scheduled for a new day in the same week. With respect to the fourth step, for each activity children were asked to solve different exercises organized in blocks of 5&#x02013;10 trials (two blocks of exercises per session). After each block of exercises was completed, trainers evaluated children&#x00027;s performance, and determined the complexity level for the second block. When child efficiency in the first block of exercises reached at least 80%, the trainers increased the complexity level for the next block; otherwise, after trainers&#x00027; intervention (according to the child&#x00027;s difficulties, considering the problem solving scheme), the second block of exercises presented new trials with the same level of difficulty. Performance on the last block of exercises determined the initial level of difficulty in the next session (Figure <xref ref-type="fig" rid="F2">2</xref>).</p>
<fig id="F2" position="float">
<label>Figure 2</label>
<caption><p><bold>Flowchart of the structure of each training session</bold>.</p></caption>
<graphic xlink:href="fpsyg-05-00205-g0002.tif"/>
</fig>
<p>The theoretical framework of the cognitive training module was based on the problem-solving framework proposed by Zelazo et al. (<xref ref-type="bibr" rid="B114">1997</xref>). It involves four temporally and functionally distinct steps and substeps: problem representation, planning, execution, and evaluation (detection and correction). To solve a problem, first it is necessary to create or restructure the problem representation, including its possible solutions. Another component considered in the cognitive training module was the dynamic testing approach proposed by Sternberg and Grigorenko (<xref ref-type="bibr" rid="B103">2002</xref>). This form of testing proposes giving the children some kind of feedback in order to help them improve their scores, which in turn is based on Vigotsky&#x00027;s conception of the proximal development zone. Finally, two other components of the cognitive training module were the inclusion of challenge activities or trials, and repeated practice (Diamond, <xref ref-type="bibr" rid="B25">2012</xref>).</p>
<list list-type="simple">
<list-item><p>(2) The <italic>nutritional supplementation module</italic> (implemented for both groups) consisted of the administration of one pill per week during the cognitive training period. Each pill contained 60 mg of elementary iron and 0.4 mg of folic acid, and was provided by UNICEF-Argentina.</p></list-item>
<list-item><p>(3) <italic>Parental Counseling</italic> was a module implemented for both groups, throughout the school year. Activities in this module included: (a) parent counseling; (b) child clinical exam; (c) child blood extraction to identify levels of hemoglobin; and (d) parent interviews.</p></list-item>
<list-item><p>(4) <italic>Teacher training and counseling</italic> (for both groups) was the fourth module, implemented throughout the school year, twice a month.</p></list-item>
</list>
</sec>
<sec>
<title>CTP program</title>
<p>Based on the results of the <italic>SIP</italic>, the same group of researchers designed a new CTP. In the year 2005, this program was implemented in the city of Salta in the context of a quasi-experimental prospective design (Segretin et al., <xref ref-type="bibr" rid="B94">2007a</xref>,<xref ref-type="bibr" rid="B97">b</xref>; Lipina et al., <xref ref-type="bibr" rid="B68">2012</xref>). Specifically, the aims of the program involved fostering cognitive development in preschoolers from UBN and Satisfied Basic Needs (SBN) homes with a reduction in the adult to child ratio (more children per adult) compared to the previous experience (SIP) (1/15 vs. 1/1, respectively). For this longitudinal study, a sample of 382 healthy Argentinean children aged 3&#x02013;5 years were recruited from official childcare centers in the city of Salta in Argentina (Secretary of Children and Family from the Government of the Province of Salta) applying a conglomerate sample method. The rate of attrition was 15%. Informed consents were obtained from parents/caregivers, and ethical approval was obtained from the Ethical Review Committee. The study was conducted according to APA&#x00027;s ethical standards, and international and national children rights laws.</p>
<p>In this program, we recruited and trained a group of trainers, and we informed parents of children attending the selected institutions about the program activities and asked them to sign written consents to include their children into the program. After that, from April to July, we evaluated children&#x00027;s cognitive performance (Time 1) (see section Cognitive Measures), and parents attended individual interviews to give socioeconomic, sociodemographic and child health history information. Then, 4-year-old children were randomly assigned to an individual or group modality of cognitive training. Three- and 5-year-old children were all assigned to the group modality. The reasons for such design were: (1) authorities did not allow the research team to generate a control group for ethical reasons (i.e., they considered that all children had to receive the same activities, and that the government was not a research agency aimed at supporting research practices); and (2) authorities required to reduce the number of human resources for the execution of the program (i.e., individual training modality requires more trainers). For the present study, only children assigned to the group modality of training were analyzed (<italic>n</italic> &#x0003D; 333). The rest of the children (49) were trained with the individual modality, which was similar to the one implemented in the SIP (Colombo and Lipina, <xref ref-type="bibr" rid="B23">2005</xref>; Lipina and Segretin, <xref ref-type="bibr" rid="B67">2006</xref>; Martelli et al., <xref ref-type="bibr" rid="B74">2007</xref>), to have a comparative training group (these children are not considered further in this paper) (Segretin et al., submitted for publication). Then, from July to November two intervention modules were implemented (see above), and after that, all children were administered a final cognitive assessment (Time 2) with the same battery of tasks used at Time 1. Like in the previous program, trainers&#x00027; work in each phase was supervised daily during the year, and they were provided a procedure guide. Also, trainers had to complete a form for each activity, which were reviewed daily by supervisors.</p>
<p>In the CTP two modules were implemented, and put together with other activities developed by the government agency:
<list list-type="simple">
<list-item><p>(1) The <italic>cognitive training module</italic> consisted of different activities demanding cognitive control, with increasing complexity. Activities for both training modalities were designed with a group of pedagogues (in this program activities differed from the basal and post-training cognitive assessment), and were implemented in weekly sessions (with two different activities within each session) during the school day, as an extracurricular classroom activity, for 16 weeks. As previously mentioned, for the present work only children in the group modality of training were considered in the analysis. Training groups were organized based on age and the maximum number of children necessary to form each group (from 10 to 25 children). Activities followed a scheme previously designed considering the cognitive demands and the time available for each session (30/40 min), and were implemented by two trainers (adults/children ratio &#x0003D; 1 per 10/15) (Figure <xref ref-type="fig" rid="F3">3</xref>).</p></list-item></list></p>
<fig id="F3" position="float">
<label>Figure 3</label>
<caption><p><bold>Description of training activities in the CTP</bold>.</p></caption>
<graphic xlink:href="fpsyg-05-00205-g0003.tif"/>
</fig>
<p>The theoretical framework for the cognitive training module was the same one that was used in the SIP program. Also, the CTP applied the same session structure as the previous program (see Figure <xref ref-type="fig" rid="F2">2</xref>), but adapted to the group modality of training. That is, activities were solved with the participation of all children in the group, and only when 80% of children successfully solved 80% of trials in one block of exercises was the complexity level increased.</p>
<list list-type="simple">
<list-item><p>(2) The nutritional supplementation module was implemented for all children in the program, with the same frequency and methodology applied in the SIP.</p></list-item>
</list>
<p>Additionally, the government agency provided counseling for parents and adults working in the childcare centers. Researchers had no access to the information regarding these interventions.</p>
</sec>
</sec>
<sec>
<title>Measures in both programs</title>
<sec>
<title>Socioeconomic, life, and health condition measures</title>
<p>In both programs data were collected during the school year (March to November) in a private interview with parents. A Socioeconomic Scale (NES) was used to evaluate parents&#x00027; education and occupation levels, overcrowding, housing and sanitation conditions, to identify indicators of UBN (Boltvinik, <xref ref-type="bibr" rid="B13">1995</xref>). Scores were assigned directly to mothers and fathers for educational and occupational backgrounds; however, only the higher score was considered for the total scores. For housing conditions, scores were assigned based on type of dwelling, floor, water, bathroom, ceiling, external walls, and home property. The Life Stressors and Social Resources Inventory (LISRES inventory) (Mikulic, <xref ref-type="bibr" rid="B78">1999</xref>) was used to identify life stressors and social resources in the family. Specifically, this inventory measures sets of stressors and resources by administering two scales: (1) <italic>stressors</italic> that includes physical health dimensions (29 items), housing/neighborhood (22 items), finance (9 items), work (15 items), family (13 items), children (15 items), extended family (15 items), friends and social activities, and negative life events (12 items); and (2) <italic>resources</italic> that includes: finance (9 items), work (15 items), family (13 items), children (15 items), extended family (15 items), friends and social activities (15 items), and positive life events (10 items). The total score for each scale was calculated by adding scores obtained in each set of items, which were then transformed into <italic>T</italic>-scores (mean &#x0003D; 50, standard deviation &#x0003D; 10). Additionally, a set of questions concerning child peri- and post-natal health conditions was included in the interviews. Finally, in the SIP the Hamilton Scale (Hamilton, <xref ref-type="bibr" rid="B46">1959</xref>, <xref ref-type="bibr" rid="B47">1960</xref>) was employed to consider important aspects of mothers&#x00027; mental health involved in self-regulation development (Buss et al., <xref ref-type="bibr" rid="B20">2011</xref>). The scale consists of 14 items related to signs and symptoms of anxiety (7 items) and depression (7 items), which measures the intensity and frequency of such behaviors. The sum of the specific items for each type of sign results in a total score for depression and another for anxiety. There are no cut-points to distinguish subjects with and without anxiety or depression, so the results should be interpreted as a quantification of the intensity.</p>
</sec>
<sec>
<title>Cognitive measures</title>
<p>We evaluated cognitive performance in the pre- and post-training phases (Time 1 and Time 2), with a set of tasks administered by trainers in two sessions of about 40 min. Children were tested individually at their schools, in a quiet testing room. Testing was scheduled at times reported by teachers not to interfere with regular meals and activities. Examiners were blind to the objectives of the study and the composition of the groups.</p>
<p>In both programs, the following four tasks were used:
<list list-type="alpha-lower">
<list-item><p>The <italic>Selective Attention</italic> task&#x02014;a manual adaptation of the computerized version of a subscale of the NEPSY battery (Korkman et al., <xref ref-type="bibr" rid="B62">1998</xref>)&#x02014;was used to evaluate attentional control. A set of sheets of paper with 25 pictures and one or more targets on each one was used. The child was required to identify and point to all the drawings that were identical to the target. Levels of difficulty (from 1 to 10) were determined according to the number of targets and the similarity between the target and the distractor drawings. Trials were administered until the child made more than 3 errors and/or omissions in three consecutive sheets. Scores represent the proportion of correct responses.</p></list-item>
<list-item><p>The <italic>Corsi Blocks</italic> task (Berch et al., <xref ref-type="bibr" rid="B9">1998</xref>) was used to assess visuo-spatial organization processes. In this task, a sequence of lights (from 2-to-8) was turned on (2 s each light, 1 s between lights). The child was required to remember and point to the boxes following the light sequences. Each level of difficulty comprised five trials with the same number of elements that children had to remember. Trials were administered until the child made three consecutive errors. A total score was computed as the sum of correct responses multiplied by level of difficulty (determined by the number of elements to remember on each trial).</p></list-item>
<list-item><p>The <italic>Tower of London</italic> task (Shallice, <xref ref-type="bibr" rid="B100">1982</xref>) was used to assess planning. In each trial the child was required to reach a goal configuration of three colored balls from a start configuration, moving one ball at a time, in a minimum number of movements. Any colored ball might be placed on top of any other ball, and children had to generate the appropriate action sequence. Levels of difficulty comprised exercises from 1 to 9 movements, and each one comprised five trials. Trials were administered until the child made three consecutive errors. A total score was computed as the sum of correct responses multiplied by level of difficulty (determined by the minimum number of movements necessary to reach the final model).</p></list-item>
<list-item><p>The <italic>Flexible Item Selection Task</italic> (Jacques and Zelazo, <xref ref-type="bibr" rid="B55">2001</xref>) was administered in the CPT, and in the second and third year of the SIP&#x02014;which explains the reduction of the sample size&#x02014;to assess abstract processing and cognitive flexibility. A set of cards was used conformed to items according to four dimensions: shape, color, size, and number. Tasks consisted of 12 trials in which the child was required to select two cards sharing the same dimension. The child was required to make two selections: first, select two cards equivalent in one way, and then select another two cards, equivalent in a different way. A total score was computed by adding correct responses in the first and second selection.</p></list-item>
</list></p>
<p>In addition, in the SIP, the <italic>Stroop-like Day-Night</italic> task was administered to assess inhibitory control processes (Gerstadt et al., <xref ref-type="bibr" rid="B40">1994</xref>). The task consisted of 16 trials in which children were asked to say the opposite of what they saw in a series of cards. When a picture of a <italic>sun</italic> was presented, they had to say &#x0201C;night,&#x0201D; and when the picture showed a <italic>moon</italic>, they had to say &#x0201C;day.&#x0201D; A total score was computed as the sum of correct responses divided by the total number of trials.</p>
</sec>
</sec>
</sec>
<sec sec-type="results" id="s3">
<title>Results</title>
<sec>
<title>SIP program</title>
<p>Based on the literature, a set of variables were pre-selected as potential predictors of cognitive performance at baseline and of the change in performance between pre- and post-intervention: <italic>housing conditions, overcrowding, parental education, parental occupation, mother&#x00027;s physical health, housing stressors, economic stressors, working stressors, couple stressors, child stressors, family stressors, friends, and social life stressors, negative life events, economic resources, working resources, couple resources, child resources, family resources</italic>, <italic>friends, and social life resources, positive life events, child health records, child age, child gender</italic>, and <italic>frequency of training sessions</italic> (Sameroff et al., <xref ref-type="bibr" rid="B91">1993</xref>; Brooks-Gunn and Duncan, <xref ref-type="bibr" rid="B16">1997</xref>; McLoyd, <xref ref-type="bibr" rid="B76">1998</xref>; Burchinal et al., <xref ref-type="bibr" rid="B18">2000</xref>; Bradley and Corwyn, <xref ref-type="bibr" rid="B14">2002</xref>; Gassman-Pines and Yoshikawa, <xref ref-type="bibr" rid="B39">2006</xref>). Descriptive statistics for each study group are presented in Tables <xref ref-type="table" rid="T2">2</xref>, <xref ref-type="table" rid="T3">3</xref>.</p>
<table-wrap position="float" id="T2">
<label>Table 2</label>
<caption><p><bold>Sociodemographic information of the SIP sample by group (continuous variables)</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left"><bold>Characteristic</bold></th>
<th align="center" colspan="3"><bold>Intervention</bold></th>
<th align="center" colspan="3"><bold>Control</bold></th>
<th/>
<th/>
</tr>
<tr>
<th/>
<th align="left"><bold><italic>n</italic></bold></th>
<th align="center"><bold>Mean</bold></th>
<th align="center"><bold><italic>SE</italic></bold></th>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>Mean</bold></th>
<th align="center"><bold><italic>SE</italic></bold></th>
<th align="center"><bold><italic>F</italic><xref ref-type="table-fn" rid="TN2s"><sup>&#x0002A;</sup></xref></bold></th>
<th align="center"><bold><italic>P</italic><xref ref-type="table-fn" rid="TN2s"><sup>&#x0002A;</sup></xref></bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Child age (at baseline)</td>
<td align="center" valign="top">161</td>
<td align="center" valign="top">4.50</td>
<td align="center" valign="top">0.07</td>
<td align="center" valign="top">161</td>
<td align="center" valign="top">4.53</td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">0.096</td>
<td align="center" valign="top">0.757</td>
</tr>
<tr>
<td align="left" colspan="9"><bold>SOCIOECONOMIC INFORMATION<xref ref-type="table-fn" rid="TN2a"><sup>a</sup></xref></bold></td>
</tr>
<tr>
<td align="left" valign="top">Parent education level<xref ref-type="table-fn" rid="TN2b"><sup>b</sup></xref></td>
<td align="center" valign="top">169</td>
<td align="center" valign="top">6.08<xref ref-type="table-fn" rid="TN2c"><sup>c</sup></xref></td>
<td align="center" valign="top">0.21</td>
<td align="center" valign="top">167</td>
<td align="center" valign="top">6.04<xref ref-type="table-fn" rid="TN2c"><sup>c</sup></xref></td>
<td align="center" valign="top">0.19</td>
<td align="center" valign="top">0.002</td>
<td align="center" valign="top">0.961</td>
</tr>
<tr>
<td align="left" valign="top">Parent occupation background<xref ref-type="table-fn" rid="TN2b"><sup>b</sup></xref></td>
<td align="center" valign="top">169</td>
<td align="center" valign="top">2.92<xref ref-type="table-fn" rid="TN2d"><sup>d</sup></xref></td>
<td align="center" valign="top">0.17</td>
<td align="center" valign="top">170</td>
<td align="center" valign="top">2.89<xref ref-type="table-fn" rid="TN2d"><sup>d</sup></xref></td>
<td align="center" valign="top">0.17</td>
<td align="center" valign="top">0.003</td>
<td align="center" valign="top">0.955</td>
</tr>
<tr>
<td align="left" valign="top">Housing<xref ref-type="table-fn" rid="TN2e"><sup>e</sup></xref></td>
<td align="center" valign="top">166</td>
<td align="center" valign="top">8.64</td>
<td align="center" valign="top">0.14</td>
<td align="center" valign="top">167</td>
<td align="center" valign="top">8.95</td>
<td align="center" valign="top">0.14</td>
<td align="center" valign="top">2.288</td>
<td align="center" valign="top">0.131</td>
</tr>
<tr>
<td align="left" valign="top">Overcrowding conditions<xref ref-type="table-fn" rid="TN2f"><sup>f</sup></xref></td>
<td align="center" valign="top">168</td>
<td align="center" valign="top">5.65</td>
<td align="center" valign="top">0.18</td>
<td align="center" valign="top">169</td>
<td align="center" valign="top">6.07</td>
<td align="center" valign="top">0.16</td>
<td align="center" valign="top">3.591</td>
<td align="center" valign="top">0.059</td>
</tr>
<tr>
<td align="left" colspan="9"><bold>LIFE STRESSORS AND SOCIAL RESOURCES<xref ref-type="table-fn" rid="TN2g"><sup>g</sup></xref></bold></td>
</tr>
<tr>
<td align="left" valign="top">Physical health</td>
<td align="center" valign="top">125</td>
<td align="center" valign="top">&#x02212;49.38</td>
<td align="center" valign="top">0.88</td>
<td align="center" valign="top">129</td>
<td align="center" valign="top">&#x02212;50.22</td>
<td align="center" valign="top">0.84</td>
<td align="center" valign="top">0.479</td>
<td align="center" valign="top">0.489</td>
</tr>
<tr>
<td align="left" valign="top">Housing stressors</td>
<td align="center" valign="top">127</td>
<td align="center" valign="top">&#x02212;60.14</td>
<td align="center" valign="top">1.13</td>
<td align="center" valign="top">131</td>
<td align="center" valign="top">&#x02212;58.79</td>
<td align="center" valign="top">1.12</td>
<td align="center" valign="top">0.728</td>
<td align="center" valign="top">0.394</td>
</tr>
<tr>
<td align="left" valign="top">Economic stressors</td>
<td align="center" valign="top">127</td>
<td align="center" valign="top">&#x02212;65.71</td>
<td align="center" valign="top">0.63</td>
<td align="center" valign="top">131</td>
<td align="center" valign="top">&#x02212;64.17</td>
<td align="center" valign="top">0.76</td>
<td align="center" valign="top">2.442</td>
<td align="center" valign="top">0.119</td>
</tr>
<tr>
<td align="left" valign="top">Working stressors</td>
<td align="center" valign="top">68</td>
<td align="center" valign="top">&#x02212;48.40</td>
<td align="center" valign="top">0.79</td>
<td align="center" valign="top">69</td>
<td align="center" valign="top">&#x02212;50.06</td>
<td align="center" valign="top">1.04</td>
<td align="center" valign="top">1.606</td>
<td align="center" valign="top">0.207</td>
</tr>
<tr>
<td align="left" valign="top">Couple stressors</td>
<td align="center" valign="top">103</td>
<td align="center" valign="top">&#x02212;55.77</td>
<td align="center" valign="top">0.90</td>
<td align="center" valign="top">108</td>
<td align="center" valign="top">&#x02212;56.35</td>
<td align="center" valign="top">0.84</td>
<td align="center" valign="top">0.227</td>
<td align="center" valign="top">0.634</td>
</tr>
<tr>
<td align="left" valign="top">Child stressors</td>
<td align="center" valign="top">125</td>
<td align="center" valign="top">&#x02212;67.89</td>
<td align="center" valign="top">0.92</td>
<td align="center" valign="top">131</td>
<td align="center" valign="top">&#x02212;66.96</td>
<td align="center" valign="top">0.85</td>
<td align="center" valign="top">0.548</td>
<td align="center" valign="top">0.460</td>
</tr>
<tr>
<td align="left" valign="top">Family stressors</td>
<td align="center" valign="top">112</td>
<td align="center" valign="top">&#x02212;46.99</td>
<td align="center" valign="top">0.84</td>
<td align="center" valign="top">116</td>
<td align="center" valign="top">&#x02212;47.68</td>
<td align="center" valign="top">1.00</td>
<td align="center" valign="top">0.276</td>
<td align="center" valign="top">0.600</td>
</tr>
<tr>
<td align="left" valign="top">Friends and social life stressors</td>
<td align="center" valign="top">107</td>
<td align="center" valign="top">&#x02212;46.55</td>
<td align="center" valign="top">0.94</td>
<td align="center" valign="top">108</td>
<td align="center" valign="top">&#x02212;45.52</td>
<td align="center" valign="top">0.83</td>
<td align="center" valign="top">0.682</td>
<td align="center" valign="top">0.410</td>
</tr>
<tr>
<td align="left" valign="top">Negative life events</td>
<td align="center" valign="top">127</td>
<td align="center" valign="top">&#x02212;55.36</td>
<td align="center" valign="top">1.08</td>
<td align="center" valign="top">130</td>
<td align="center" valign="top">&#x02212;54.49</td>
<td align="center" valign="top">1.05</td>
<td align="center" valign="top">0.331</td>
<td align="center" valign="top">0.565</td>
</tr>
<tr>
<td align="left" valign="top">Economic resources</td>
<td align="center" valign="top">126</td>
<td align="center" valign="top">38.36</td>
<td align="center" valign="top">0.07</td>
<td align="center" valign="top">130</td>
<td align="center" valign="top">38.50</td>
<td align="center" valign="top">0.09</td>
<td align="center" valign="top">1.484</td>
<td align="center" valign="top">0.224</td>
</tr>
<tr>
<td align="left" valign="top">Working resources</td>
<td align="center" valign="top">68</td>
<td align="center" valign="top">50.54</td>
<td align="center" valign="top">0.38</td>
<td align="center" valign="top">72</td>
<td align="center" valign="top">50.03</td>
<td align="center" valign="top">0.44</td>
<td align="center" valign="top">0.767</td>
<td align="center" valign="top">0.383</td>
</tr>
<tr>
<td align="left" valign="top">Couple resources</td>
<td align="center" valign="top">103</td>
<td align="center" valign="top">55.14</td>
<td align="center" valign="top">0.61</td>
<td align="center" valign="top">107</td>
<td align="center" valign="top">54.97</td>
<td align="center" valign="top">0.63</td>
<td align="center" valign="top">0.035</td>
<td align="center" valign="top">0.851</td>
</tr>
<tr>
<td align="left" valign="top">Child resources</td>
<td align="center" valign="top">125</td>
<td align="center" valign="top">65.95</td>
<td align="center" valign="top">0.47</td>
<td align="center" valign="top">130</td>
<td align="center" valign="top">65.94</td>
<td align="center" valign="top">0.52</td>
<td align="center" valign="top">0.000</td>
<td align="center" valign="top">0.985</td>
</tr>
<tr>
<td align="left" valign="top">Family resources</td>
<td align="center" valign="top">112</td>
<td align="center" valign="top">49.39</td>
<td align="center" valign="top">0.71</td>
<td align="center" valign="top">117</td>
<td align="center" valign="top">47.86</td>
<td align="center" valign="top">0.79</td>
<td align="center" valign="top">2.072</td>
<td align="center" valign="top">0.151</td>
</tr>
<tr>
<td align="left" valign="top">Friends and social life resources</td>
<td align="center" valign="top">105</td>
<td align="center" valign="top">49.96</td>
<td align="center" valign="top">0.98</td>
<td align="center" valign="top">107</td>
<td align="center" valign="top">47.28</td>
<td align="center" valign="top">1.23</td>
<td align="center" valign="top">2.879</td>
<td align="center" valign="top">0.091</td>
</tr>
<tr>
<td align="left" valign="top">Positive life events</td>
<td align="center" valign="top">127</td>
<td align="center" valign="top">48.77</td>
<td align="center" valign="top">0.77</td>
<td align="center" valign="top">130</td>
<td align="center" valign="top">50.74</td>
<td align="center" valign="top">0.77</td>
<td align="center" valign="top">3.274</td>
<td align="center" valign="top">0.072</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN2a"><label></label><p><italic>aSocioeconomic information was obtained for most cases (this is the reason for the higher sample sizes in those variables).</italic></p></fn>
<fn id="TN2b"><label>b</label><p><italic>Highest educational and occupational levels reached by parents.</italic></p></fn>
<fn id="TN2c"><label>c</label><p><italic>Incomplete secondary school level.</italic></p></fn>
<fn id="TN2d"><label>d</label><p><italic>Non-skilled worker.</italic></p></fn>
<fn id="TN2e"><label>e</label><p><italic>Scale range: 3&#x02013;12 points, with higher scores for better housing conditions.</italic></p></fn>
<fn id="TN2f"><label>f</label><p><italic>Scale range: 0&#x02013;9 points, with higher scores for better conditions.</italic></p></fn>
<fn id="TN2g"><label>g</label><p><italic>T-scores from each item evaluated in the Life Stressors and Social Resources Inventory (LISRES).</italic></p></fn>
<fn id="TN2s"><label>&#x0002A;</label><p><italic>Univariate ANOVA was performed for each variable.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="T3">
<label>Table 3</label>
<caption><p><bold>Sociodemographic information of the SIP sample by group (categorical variables)</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left"><bold>Characteristic</bold></th>
<th align="left" colspan="2"><bold>Intervention (<italic>n</italic> &#x0003D; 170)</bold></th>
<th align="left" colspan="2"><bold>Control (<italic>n</italic> &#x0003D; 173)</bold></th>
</tr>
<tr>
<th/>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>%</bold></th>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>%</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" colspan="5"><bold>CHILD GENDER</bold></td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">87</td>
<td align="center" valign="top">51.18</td>
<td align="center" valign="top">90</td>
<td align="center" valign="top">52.02</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">83</td>
<td align="center" valign="top">48.82</td>
<td align="center" valign="top">83</td>
<td align="center" valign="top">47.98</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>HEALTH HISTORY</bold></td>
</tr>
<tr>
<td align="left" valign="top">With history of medical illness<xref ref-type="table-fn" rid="TN3a"><sup>a</sup></xref></td>
<td align="center" valign="top">5</td>
<td align="center" valign="top">2.94</td>
<td align="center" valign="top">3</td>
<td align="center" valign="top">1.73</td>
</tr>
<tr>
<td align="left" valign="top">Without history of medical illness</td>
<td align="center" valign="top">165</td>
<td align="center" valign="top">97.06</td>
<td align="center" valign="top">170</td>
<td align="center" valign="top">98.27</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>FREQUENCY OF TRAINING SESSION</bold></td>
</tr>
<tr>
<td align="left" valign="top">Once a week</td>
<td align="center" valign="top">139</td>
<td align="center" valign="top">81.80</td>
<td align="center" valign="top">120</td>
<td align="center" valign="top">69.40</td>
</tr>
<tr>
<td align="left" valign="top">Twice a week</td>
<td align="center" valign="top">31</td>
<td align="center" valign="top">18.20</td>
<td align="center" valign="top">53</td>
<td align="center" valign="top">30.60</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN3a"><label>a</label><p><italic>Low weight at birth, premature, neurological, and/or perinatal disorders.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<p>In order to identify basal differences between groups (intervention/control), univariate ANOVA models were applied with the pre-selected variables as dependent (separate analysis for each variable), <italic>group</italic> (intervention/control) as the fixed factor; and <italic>age</italic>, <italic>gender</italic> and <italic>socioeconomic group</italic> (UBN/SBN) as covariables. Results showed no significant differences between intervention and control groups, for all the socioenvironmental pre-selected variables (Table <xref ref-type="table" rid="T2">2</xref>).</p>
<p>We then evaluated the assumptions for mixed models procedures, including residual normality, homocedasticity and independence. For this purpose, descriptive and univariate analyses, histograms and plot graphics as well as Levene tests were executed for each variable. All dependent variables showed violations of at least one of the considered criteria, and therefore these variables were transformed for the analysis (using square root or arcsine transformations). Finally, for each dependent variable, scores were transformed to <italic>z</italic>-scores prior to their inclusion in the mixed model analyses. This was done to have a common metric to compare intervention outcome across the tasks. Means and standard deviations for each cognitive task are presented in Table <xref ref-type="table" rid="T5">5</xref>. Regarding basal cognitive performance, univariate ANOVA models were executed for each dependent variable in order to compare basal performance between the study groups. Analysis included <italic>group</italic> (intervention/control) as the fixed factor; baseline performance variables of each task were the dependent variables (separate analysis for each cognitive process); and <italic>age</italic>, <italic>gender</italic>, and <italic>socioeconomic group</italic> (UBN/SBN) were the covariables. Results indicated that both study groups were homogeneous with respect to their basal cognitive performance (Table <xref ref-type="table" rid="T4">4</xref>).</p>
<table-wrap position="float" id="T4">
<label>Table 4</label>
<caption><p><bold>Performance by task, time of assessment, and group in the SIP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left"><bold>Time</bold></th>
<th align="left"><bold>Task</bold></th>
<th align="center" colspan="3"><bold>Control</bold></th>
<th align="center" colspan="3"><bold>Intervention</bold></th>
<th/>
<th/>
</tr>
<tr>
<th/>
<th/>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>Mean</bold></th>
<th align="center"><bold><italic>SE</italic></bold></th>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>Mean</bold></th>
<th align="center"><bold><italic>SE</italic></bold></th>
<th align="center"><bold><italic>F</italic></bold></th>
<th align="center"><bold><italic>p</italic></bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">1 (pre-intervention)</td>
<td align="left" valign="top">Tower of London</td>
<td align="center" valign="top">144</td>
<td align="center" valign="top">18.59</td>
<td align="center" valign="top">1.58</td>
<td align="center" valign="top">141</td>
<td align="center" valign="top">16.52</td>
<td align="center" valign="top">1.42</td>
<td align="center" valign="top">1.09</td>
<td align="center" valign="top">0.298</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Corsi blocks</td>
<td align="center" valign="top">124</td>
<td align="center" valign="top">11.56</td>
<td align="center" valign="top">0.64</td>
<td align="center" valign="top">113</td>
<td align="center" valign="top">12.81</td>
<td align="center" valign="top">0.74</td>
<td align="center" valign="top">1.51</td>
<td align="center" valign="top">0.220</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">FIST<xref ref-type="table-fn" rid="TN4s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">96</td>
<td align="center" valign="top">4.66</td>
<td align="center" valign="top">0.33</td>
<td align="center" valign="top">73</td>
<td align="center" valign="top">3.89</td>
<td align="center" valign="top">0.33</td>
<td align="center" valign="top">2.02</td>
<td align="center" valign="top">0.157</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Selective attention</td>
<td align="center" valign="top">119</td>
<td align="center" valign="top">0.50</td>
<td align="center" valign="top">0.03</td>
<td align="center" valign="top">112</td>
<td align="center" valign="top">0.52</td>
<td align="center" valign="top">0.03</td>
<td align="center" valign="top">0.09</td>
<td align="center" valign="top">0.765</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Day/night</td>
<td align="center" valign="top">148</td>
<td align="center" valign="top">0.75</td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">147</td>
<td align="center" valign="top">0.76</td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">1.11</td>
<td align="center" valign="top">0.292</td>
</tr>
<tr>
<td align="left" valign="top">2 (post-intervention)</td>
<td align="left" valign="top">Tower of London</td>
<td align="center" valign="top">121</td>
<td align="center" valign="top">26.71</td>
<td align="center" valign="top">1.71</td>
<td align="center" valign="top">130</td>
<td align="center" valign="top">43.17</td>
<td align="center" valign="top">1.71</td>
<td align="center" valign="top">56.75</td>
<td align="center" valign="top">0.000</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Corsi blocks</td>
<td align="center" valign="top">93</td>
<td align="center" valign="top">15.40</td>
<td align="center" valign="top">0.92</td>
<td align="center" valign="top">82</td>
<td align="center" valign="top">23.20</td>
<td align="center" valign="top">1.39</td>
<td align="center" valign="top">27.40</td>
<td align="center" valign="top">0.000</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">FIST<xref ref-type="table-fn" rid="TN4s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">67</td>
<td align="center" valign="top">5.49</td>
<td align="center" valign="top">0.31</td>
<td align="center" valign="top">56</td>
<td align="center" valign="top">6.50</td>
<td align="center" valign="top">0.29</td>
<td align="center" valign="top">6.78</td>
<td align="center" valign="top">0.010</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Selective attention</td>
<td align="center" valign="top">95</td>
<td align="center" valign="top">0.63</td>
<td align="center" valign="top">0.03</td>
<td align="center" valign="top">83</td>
<td align="center" valign="top">0.77</td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">23.45</td>
<td align="center" valign="top">0.000</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Day/night</td>
<td align="center" valign="top">122</td>
<td align="center" valign="top">0.83</td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">121</td>
<td align="center" valign="top">0.88</td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">4.73</td>
<td align="center" valign="top">0.031</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>Time, moment of cognitive assessment;</italic></p>
<fn id="TN4s"><label>&#x0002A;</label><p><italic>this task was implemented in the second and third year of the program implementation (2003/2004).</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<p>Considering the sample sizes and the extensive number of pre-selected independent variables to enter as predictors, we decided to reduce them with different procedures including: principal component analysis (PCA) from a set of variables, and correlation analysis (see next section).</p>
<sec>
<title>Selection of potential predictors</title>
<p>A PCA was executed for variables selected from the Socioeconomic Status Scale and the LISRES inventory (see section Socioeconomic, Life, and Health Condition Measures) (PCA with a <italic>Promax</italic> rotation). The criteria used for the selection of the final PCA model were Eigenvalues over 1.00; Kaiser Coefficients over 0.6, total value of the commonalities over 10 and value of the commonalities for each variable over 0.4. The application of this procedure resulted in the identification of six factors (Table <xref ref-type="table" rid="T5">5</xref>): Factor 1 (Household economic status) involves <italic>economic</italic> and <italic>housing stressors</italic>, and <italic>economic resources</italic>; Factor 2 (Family context) concerns <italic>couple</italic> and <italic>child stressors</italic>, <italic>negative life events</italic>, and <italic>couple resources</italic>; Factor 3 (Socioeconomic status) comprises <italic>parental education</italic> and <italic>parental occupation level</italic>, <italic>housing conditions</italic>, and <italic>overcrowding</italic>; Factor 4 (Social resources) involves <italic>child</italic>, <italic>family</italic>, and <italic>social resources</italic>; Factor 5 (Ties support) concerns <italic>social</italic> and <italic>family stressors</italic>; and Factor 6 (Life events) involves <italic>positive life events</italic>. All these factors were incorporated into the data set, and for all of them, higher scores refer to better environmental conditions.</p>
<table-wrap position="float" id="T5">
<label>Table 5</label>
<caption><p><bold>PCA results depicting variables associated with socioeconomic status and level of stressors and resources in the SIP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center"><bold>Household economic status</bold></th>
<th align="center"><bold>Family context</bold></th>
<th align="center"><bold>Socio-economic status</bold></th>
<th align="center"><bold>Social resources</bold></th>
<th align="center"><bold>Ties support</bold></th>
<th align="center"><bold>Life events</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Economic stressors<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top"><bold>0.84</bold></td>
<td align="center" valign="top">0.00</td>
<td align="center" valign="top">0.03</td>
<td align="center" valign="top">&#x02212;0.12</td>
<td align="center" valign="top">&#x02212;0.06</td>
<td align="center" valign="top">0.24</td>
</tr>
<tr>
<td align="left" valign="top">Economic resources<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top"><bold>0.82</bold></td>
<td align="center" valign="top">&#x02212;0.11</td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top">0.08</td>
</tr>
<tr>
<td align="left" valign="top">Housing stressors<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top"><bold>0.60</bold></td>
<td align="center" valign="top">0.09</td>
<td align="center" valign="top">&#x02212;0.03</td>
<td align="center" valign="top">0.12</td>
<td align="center" valign="top">0.16</td>
<td align="center" valign="top">&#x02212;0.30</td>
</tr>
<tr>
<td align="left" valign="top">Couple stressors<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.02</td>
<td align="center" valign="top"><bold>0.79</bold></td>
<td align="center" valign="top">0.12</td>
<td align="center" valign="top">0.05</td>
<td align="center" valign="top">0.11</td>
<td align="center" valign="top">0.15</td>
</tr>
<tr>
<td align="left" valign="top">Couple resources<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.18</td>
<td align="center" valign="top"><bold>0.64</bold></td>
<td align="center" valign="top">&#x02212;0.05</td>
<td align="center" valign="top">0.24</td>
<td align="center" valign="top">&#x02212;0.21</td>
<td align="center" valign="top">0.06</td>
</tr>
<tr>
<td align="left" valign="top">Child stressors<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.27</td>
<td align="center" valign="top"><bold>0.58</bold></td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top">0.11</td>
<td align="center" valign="top">0.29</td>
<td align="center" valign="top">0.14</td>
</tr>
<tr>
<td align="left" valign="top">Negative life events<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.13</td>
<td align="center" valign="top"><bold>0.42</bold></td>
<td align="center" valign="top">0.22</td>
<td align="center" valign="top">&#x02212;0.20</td>
<td align="center" valign="top">0.24</td>
<td align="center" valign="top">&#x02212;<bold>0.41</bold></td>
</tr>
<tr>
<td align="left" valign="top">Overcrowding<xref ref-type="table-fn" rid="TN5b"><sup>b</sup></xref></td>
<td align="center" valign="top">&#x02212;0.19</td>
<td align="center" valign="top">0.15</td>
<td align="center" valign="top"><bold>0.79</bold></td>
<td align="center" valign="top">&#x02212;0.13</td>
<td align="center" valign="top">&#x02212;0.21</td>
<td align="center" valign="top">&#x02212;0.03</td>
</tr>
<tr>
<td align="left" valign="top">Housing conditions<xref ref-type="table-fn" rid="TN5b"><sup>b</sup></xref></td>
<td align="center" valign="top">0.12</td>
<td align="center" valign="top">&#x02212;0.10</td>
<td align="center" valign="top"><bold>0.67</bold></td>
<td align="center" valign="top">0.05</td>
<td align="center" valign="top">&#x02212;0.05</td>
<td align="center" valign="top">&#x02212;0.27</td>
</tr>
<tr>
<td align="left" valign="top">Parents occupation level<xref ref-type="table-fn" rid="TN5b"><sup>b</sup></xref></td>
<td align="center" valign="top">0.18</td>
<td align="center" valign="top">0.22</td>
<td align="center" valign="top"><bold>0.56</bold></td>
<td align="center" valign="top">0.05</td>
<td align="center" valign="top">&#x02212;0.05</td>
<td align="center" valign="top">0.09</td>
</tr>
<tr>
<td align="left" valign="top">Parents education level<xref ref-type="table-fn" rid="TN5b"><sup>b</sup></xref></td>
<td align="center" valign="top">0.11</td>
<td align="center" valign="top">&#x02212;0.37</td>
<td align="center" valign="top"><bold>0.47</bold></td>
<td align="center" valign="top">0.26</td>
<td align="center" valign="top">0.24</td>
<td align="center" valign="top">0.22</td>
</tr>
<tr>
<td align="left" valign="top">Child resources<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">0.10</td>
<td align="center" valign="top">0.03</td>
<td align="center" valign="top"><bold>0.72</bold></td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top">&#x02212;0.02</td>
</tr>
<tr>
<td align="left" valign="top">Social resources<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.17</td>
<td align="center" valign="top">0.00</td>
<td align="center" valign="top">0.11</td>
<td align="center" valign="top"><bold>0.70</bold></td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">0.04</td>
</tr>
<tr>
<td align="left" valign="top">Family resources<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.05</td>
<td align="center" valign="top">0.21</td>
<td align="center" valign="top">&#x02212;0.15</td>
<td align="center" valign="top"><bold>0.67</bold></td>
<td align="center" valign="top">&#x02212;0.09</td>
<td align="center" valign="top">&#x02212;0.15</td>
</tr>
<tr>
<td align="left" valign="top">Family stressors<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">0.04</td>
<td align="center" valign="top">&#x02212;0.14</td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top"><bold>0.75</bold></td>
<td align="center" valign="top">&#x02212;0.11</td>
</tr>
<tr>
<td align="left" valign="top">Social stressors<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top">0.08</td>
<td align="center" valign="top">&#x02212;0.07</td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top"><bold>0.68</bold></td>
<td align="center" valign="top">0.09</td>
</tr>
<tr>
<td align="left" valign="top">Positive life events<xref ref-type="table-fn" rid="TN5a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.17</td>
<td align="center" valign="top">0.24</td>
<td align="center" valign="top">&#x02212;0.05</td>
<td align="center" valign="top">&#x02212;0.10</td>
<td align="center" valign="top">0.04</td>
<td align="center" valign="top"><bold>0.87</bold></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>n &#x0003D; 221.</italic></p>
<fn id="TN5a"><label>a</label><p><italic>Variables from the LISRES inventory.</italic></p></fn>
<fn id="TN5b"><label>b</label><p><italic>Variables from the Socioeconomic Status Scale.</italic></p></fn>
<p><italic>Bold text indicates variables loading on each factor. These six factors were the only ones with eigenvalues larger than 1 in the correlation matrix, and the Scree plot also suggested the six-factor solution.</italic></p>
</table-wrap-foot>
</table-wrap>
<p>We performed a Pearson Correlation analysis including all potential predictors (socio-environmental factors derived from the PCA, and other variables not included in the PCA: demographic information, child health records and training exposure information) to identify variables with significant and high associations (Pearson coefficient over 0.5, <italic>p</italic> &#x0003C; 0.05). In those cases, only one of the correlated variables was selected for the subsequent steps&#x02014;the selection was made based on the reliability of measures. The degree of association among independent and dependent variables was separately analyzed. For both, dependent and independent variables results showed no significant associations between variables (Tables <xref ref-type="table" rid="T6">6</xref>, <xref ref-type="table" rid="T7">7</xref>).</p>
<table-wrap position="float" id="T6">
<label>Table 6</label>
<caption><p><bold>Correlations for independent variables in the SIP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center"><bold>1</bold></th>
<th align="center"><bold>2</bold></th>
<th align="center"><bold>3</bold></th>
<th align="center"><bold>4</bold></th>
<th align="center"><bold>5</bold></th>
<th align="center"><bold>6</bold></th>
<th align="center"><bold>7</bold></th>
<th align="center"><bold>8</bold></th>
<th align="center"><bold>9</bold></th>
<th align="center"><bold>10</bold></th>
<th align="center"><bold>11</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">1. Factor 1 (Household economic status)</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">2. Factor 2 (Family context)</td>
<td align="center" valign="top">0.265<xref ref-type="table-fn" rid="TN6ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">3. Factor 3 (Socioeconomic status)</td>
<td align="center" valign="top">0.272<xref ref-type="table-fn" rid="TN6ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.002</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">4. Factor 4 (Social resources)</td>
<td align="center" valign="top">0.156<xref ref-type="table-fn" rid="TN6s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.106</td>
<td align="center" valign="top">0.093</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">5. Factor 5 (Ties support)</td>
<td align="center" valign="top">0.047</td>
<td align="center" valign="top">0.072</td>
<td align="center" valign="top">0.023</td>
<td align="center" valign="top">0.046</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">6. Factor 6 (Life events)</td>
<td align="center" valign="top">&#x02212;0.05</td>
<td align="center" valign="top">&#x02212;0.138<xref ref-type="table-fn" rid="TN6s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.103</td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">&#x02212;0.102</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">7. Maternal stress for physical health problems</td>
<td align="center" valign="top">&#x02212;0.038</td>
<td align="center" valign="top">0.055</td>
<td align="center" valign="top">&#x02212;0.055</td>
<td align="center" valign="top">&#x02212;0.038</td>
<td align="center" valign="top">0.133</td>
<td align="center" valign="top">0.057</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">8. Child sex</td>
<td align="center" valign="top">&#x02212;0.059</td>
<td align="center" valign="top">&#x02212;0.109</td>
<td align="center" valign="top">&#x02212;0.045</td>
<td align="center" valign="top">&#x02212;0.048</td>
<td align="center" valign="top">0.022</td>
<td align="center" valign="top">&#x02212;0.043</td>
<td align="center" valign="top">0.000</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">9. Health records</td>
<td align="center" valign="top">0.075</td>
<td align="center" valign="top">0.046</td>
<td align="center" valign="top">0.165<xref ref-type="table-fn" rid="TN6s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.024</td>
<td align="center" valign="top">0.281<xref ref-type="table-fn" rid="TN6ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02212;0.075</td>
<td align="center" valign="top">0.119<xref ref-type="table-fn" rid="TN6s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02212;0.018</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">10. Child age</td>
<td align="center" valign="top">&#x02212;0.15</td>
<td align="center" valign="top">0.013</td>
<td align="center" valign="top">&#x02212;0.142</td>
<td align="center" valign="top">0.161</td>
<td align="center" valign="top">&#x02212;0.073</td>
<td align="center" valign="top">&#x02212;0.073</td>
<td align="center" valign="top">0.014</td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">&#x02212;0.081</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">11. Frequency of sessions</td>
<td align="center" valign="top">0.046</td>
<td align="center" valign="top">0.121</td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top">0.046</td>
<td align="center" valign="top">0.118</td>
<td align="center" valign="top">0.054</td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">0.067</td>
<td align="center" valign="top">0.06</td>
<td align="center" valign="top">0.045</td>
<td align="center" valign="top">&#x02013;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN6s"><label>&#x0002A;</label><p><italic>p &#x0003C; 0.05;</italic></p></fn>
<fn id="TN6ss"><label>&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.01.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="T7">
<label>Table 7</label>
<caption><p><bold>Correlations for dependent variables in the SIP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center"><bold>1</bold></th>
<th align="center"><bold>2</bold></th>
<th align="center"><bold>3</bold></th>
<th align="center"><bold>4</bold></th>
<th align="center"><bold>5</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">1. Planning</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">2. Visuo-spatial organization</td>
<td align="center" valign="top">0.380<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">3. Cognitive flexibility</td>
<td align="center" valign="top">0.335<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.338<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">4. Attentional control</td>
<td align="center" valign="top">0.425<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.307<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.375<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">5. Inhibitory control</td>
<td align="center" valign="top">0.155<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.195<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.208<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.189<xref ref-type="table-fn" rid="TN7ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN7ss"><label>&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.01.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec>
<title>Final models for the prediction analysis</title>
<p>Regarding the methodological approaches to analyze how ecological factors (i.e., micro- and mesosystemic) affect development, one of the traditional methods is the analysis of variance for repeated measures. During the past decade, a number of analytical models that overcome some disadvantages of the previous models (e.g., the ability to handle missing data) have been implemented for this type of analysis. These models are known as general linear mixed models (GLMM) (Long and Pellegrini, <xref ref-type="bibr" rid="B71">2003</xref>; Singer and Willett, <xref ref-type="bibr" rid="B101">2003</xref>; Arnau and Balluerka, <xref ref-type="bibr" rid="B3">2004</xref>; Ferrer et al., <xref ref-type="bibr" rid="B34">2004</xref>; Arnau and Bono, <xref ref-type="bibr" rid="B4">2008</xref>; Seltman, <xref ref-type="bibr" rid="B98">2009</xref>). Based on that, we conducted a sequence of mixed model analyses to identify significant predictors associated with higher levels of cognitive performance pre-intervention and with more improvement in cognitive performance from pre- to post-intervention.</p>
<p>We first conducted mixed model analyses with a basal predictor (<italic>time</italic>) and the interaction between <italic>time</italic> and <italic>group</italic> (intervention and control), in order to identify differences at baseline performance and trajectories (training impact) between both groups. Results showed a significant effect of <italic>time</italic> (<italic>Attention</italic>: <italic>B</italic> &#x0003D; 0.916, <italic>p</italic> &#x0003C; 0.0001; <italic>Working memory</italic>: <italic>B</italic> &#x0003D; 1.076, <italic>p</italic> &#x0003C; 0.0001; <italic>Inhibitory control</italic>: <italic>B</italic> &#x0003D; 0.396, <italic>p</italic> &#x0003D; 0.0004; <italic>Flexibility</italic>: <italic>B</italic> &#x0003D; 0.899, <italic>p</italic> &#x0003C; 0.0001; and <italic>Planning</italic>: <italic>B</italic> &#x0003D; 1.219, <italic>p</italic> &#x0003C; 0.0001), which means that all children (intervention and control) increased their baseline performance on all tasks. Additionally, results evidenced significant effects of <italic>group</italic> for most of the dependent variables (<italic>Attention</italic>: <italic>B</italic> &#x0003D; &#x02212;0.493, <italic>p</italic> &#x0003D; 0.00004; <italic>Working memory</italic>: <italic>B</italic> &#x0003D; &#x02212;0.590, <italic>p</italic> &#x0003C; 0.0001; <italic>Flexibility:</italic> <italic>B</italic> &#x0003D; &#x02212;0.569, <italic>p</italic> &#x0003D; 0.0069; and <italic>Planning:</italic> <italic>B</italic> &#x0003D; &#x02212;0.750, <italic>p</italic> &#x0003C; 0.0001), which means that children in the intervention group demonstrated improved performance after training compared to children in the control group. In addition, no significant differences at baseline were identified between groups.</p>
<p>Second, independent variables were grouped into four blocks of information: (1) <italic>living conditions at home, life stressors, and social resources</italic> (including the six factors derived from the PCA analysis); (2) <italic>demographic information</italic> (<italic>child age</italic> and <italic>gender</italic>, and <italic>maternal stress for physical health problems</italic>); (3) <italic>child health</italic> (<italic>health records</italic>); and (4) <italic>training exposure</italic> (<italic>frequency of sessions</italic> and <italic>group</italic>). Analyses were executed separately for each block. The interactions between independent variables with <italic>time</italic> and <italic>group</italic> (intervention or control) were included in the models, in order to identify differences between both groups at baseline performance and cognitive trajectories after training.</p>
<p>Before the next step, we tested the missing completely at random (MARC) assumption for the independent variables included in the blocks, and the cognitive performance variables. The assumption was verified for the independent variables (<italic>X</italic><sup>2</sup> &#x0003D; 22.85, <italic>p</italic> &#x0003D; 0.196), but not for the dependent cognitive variables. However, we did not input cognitive data based on the notion that doing this could alter the slope of the trajectories.</p>
<p>For each block, mixed model analyses were executed several times, removing the non-significant variables each time. This procedure was repeated until only significant variables were included for each block for each given cognitive outcome (dependent variable). The purpose of this was to reduce the number of independent variables to generate a final model of prediction to detect significant variables associated with cognitive performance. In general, results from this step showed significant socio-environmental predictors for each dependent variable, and overall, they evidenced a similar pattern, and yet also some differences, between the cognitive control processes and programs. A summary of results from these analyses is available from the authors upon request.</p>
<p>We combined the significant variables detected from each block in the previous step and included them in a final model of predictors. Similarly to what we explained above, we executed mixed model analyses several times, removing every time the non-significant predictors. At the end of this procedure, we identified a set of significant predictors (final model). This step was also executed for each dependent variable.</p>
<p>Each step was performed to ensure that the final model adequately reflected predictors associated with levels of pre-intervention cognitive performance and with improvement in cognitive performance from pre- to post-intervention. For the number of comparisons (<italic>attention</italic> &#x0003D; 4, <italic>workingmemory</italic> &#x0003D; 5, <italic>inhibitorycontrol</italic> &#x0003D; 2, <italic>flexibility</italic> &#x0003D; 6, <italic>planning</italic> &#x0003D; 4), the Bonferroni correction was used for a 0.05 level of significance (the final values of <italic>p</italic> were: attention &#x0003D; 0.0125, <italic>workingmemory</italic> &#x0003D; 0.01, <italic>inhibitorycontrol</italic> &#x0003D; 0.025, <italic>flexibility</italic> &#x0003D; 0.0083, <italic>planning</italic> &#x0003D; 0.0125).</p>
</sec>
<sec>
<title>Variables associated to cognitive performance and trajectories (final models)</title>
<p>We selected predictors for a final model for each program based on the results from previous steps. Table <xref ref-type="table" rid="T8">8</xref> includes the final parameter estimates for each cognitive process, and show significant predictors of cognitive performance at Time 1 (baseline) and of intervention trajectories (difference between Time 2 and Time 1). It is important to point out that for the final models there was a reduction in the number of participants due to the lack of information for all the predictors for some children.</p>
<table-wrap position="float" id="T8">
<label>Table 8</label>
<caption><p><bold>Results for the final model for each cognitive process in the SIP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left"><bold>Dependent variable<xref ref-type="table-fn" rid="TN8a"><sup>a</sup></xref></bold></th>
<th align="left"><bold>Parameters</bold></th>
<th align="center"><bold>Estimate (<italic>SE</italic>)</bold></th>
<th align="center"><bold>&#x003B7;<sup>2</sup></bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Attention (<italic>n</italic> &#x0003D; 329)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;1.578 (0.157)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Time</td>
<td align="center" valign="top">0.930 (0.098)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.349</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.564 (0.058)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.295</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Group (control)<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">&#x02212;0.477 (0.135)<xref ref-type="table-fn" rid="TN8ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.060</td>
</tr>
<tr>
<td align="left" valign="top">Working memory (<italic>n</italic> &#x0003D; 138)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;1.348 (0.226)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Time</td>
<td align="center" valign="top">0.810 (0.102)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.404</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Group (control)</td>
<td align="center" valign="top">&#x02212;0.398 (0.136)<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.078</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.540 (0.087)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.278</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Social resources<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">0.202 (0.092)<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.050</td>
</tr>
<tr>
<td align="left" valign="top">Inhibitory control (<italic>n</italic> &#x0003D; 382)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;0.141 (0.141)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Time</td>
<td align="center" valign="top">0.334 (0.075)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.064</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.348 (0.051)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.131</td>
</tr>
<tr>
<td align="left" valign="top">Flexibility (<italic>n</italic> &#x0003D; 329)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;1.284 (0.223)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Time</td>
<td align="center" valign="top">1.920 (0.294)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.185</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.516 (0.075)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.138</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Frequency (once a week)</td>
<td align="center" valign="top">&#x02212;0.577 (0.103)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.163</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Group (control)<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">&#x02212;0.550 (0.191)<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.050</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">&#x02212;0.423 (0.109)<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref><xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.085</td>
</tr>
<tr>
<td align="left" valign="top">Planning (<italic>n</italic> &#x0003D; 329)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;2.133 (0.116)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Time</td>
<td align="center" valign="top">1.192 (0.078)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.444</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.667 (0.039)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.501</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Group (control)<xref ref-type="table-fn" rid="TN8s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">&#x02212;0.720 (0.111)<xref ref-type="table-fn" rid="TN8sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.130</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>Estimates from Proc Mixed using the Restricted Maximum Likelihood estimator.</italic></p>
<fn id="TN8a"><label>a</label><p><italic>Dependent Variables &#x0003D; Z-scores; parameter estimate standard errors (SE) listed in parentheses.</italic></p></fn>
<fn id="TN8s"><label>&#x0002A;</label><p><italic>p &#x0003C; 0.05;</italic></p></fn>
<fn id="TN8ss"><label>&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.001;</italic></p></fn>
<fn id="TN8sss"><label>&#x0002A;&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.0001.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<p>In the final model for <italic>Attention</italic> (Model &#x0003D; <italic>time, group, age, time<sup>&#x0002A;</sup>group</italic>; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.0522; <italic>n</italic> &#x0003D; 329), the main effect of <italic>time</italic> shows that children from both groups, on average, significantly increased their basal performance around one standard deviation after training (<italic>B</italic> &#x0003D; 0.930; <italic>p</italic> &#x0003C; 0.0001). In addition, results show that children in the intervention group had higher performance after training than children in the control group (<italic>B</italic> &#x0003D; &#x02212;0.477, <italic>p</italic> &#x0003D; 0.0005). Results also show effects of child <italic>age</italic> on Time 1 (<italic>B</italic> &#x0003D; 0.564; <italic>p</italic> &#x0003C; 0.0001). This result indicates that performance at baseline was higher for older children.</p>
<p>In the final model for <italic>Working memory</italic> [Model &#x0003D; <italic>time, group, age, social resources (factor 4), time<sup>&#x0002A;</sup>social resources (factor 4)</italic>; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.2055; <italic>n</italic> &#x0003D; 138], the main effect of <italic>time</italic> shows that children from both groups increased their basal performance around one standard deviation (<italic>B</italic> &#x0003D; 0.810; <italic>p</italic> &#x0003C; 0.0001). In this final model the interaction between <italic>time</italic> and <italic>group</italic> was not included (due to dropping out of the model as non-significant; thus, differences between groups in the cognitive trajectory were not evaluated). Despite that, it is important to consider that results from previous analytical steps (prior to the inclusion of the predictors) show significant differences in cognitive trajectories between groups (i.e., more improvement in the intervention group).</p>
<p>With respect to the prediction of trajectories, results show that for each point on the <italic>social resources</italic> score (which means the perception of more resources associated with family, children and friends) children increased 0.202 points between pre and post-intervention performance in this task (<italic>p</italic> &#x0003D; 0.0303). Results also show effects of child <italic>age</italic> (<italic>B</italic> &#x0003D; 0.540; <italic>p</italic> &#x0003C; 0.0001) and <italic>group</italic> (<italic>B</italic> &#x0003D; &#x02212;0.398; <italic>p</italic> &#x0003D; 0.0042) at Time 1. This pattern of results suggests that performance on Time 1 was higher for older children, and that children in the control group had, on average, lower baseline performance than children assigned to the intervention group.</p>
<p>For the <italic>Inhibitory control</italic> variable, results from the final model (Model &#x0003D; <italic>time</italic>, <italic>age</italic>, Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.0203; <italic>n</italic> &#x0003D; 382) show main effects of the two variables included in the model. With respect to the effect of <italic>time</italic>, results suggest that children in both groups, on average, increased their initial performance after the intervention (<italic>B</italic> &#x0003D; 0.334; <italic>p</italic> &#x0003C; 0.0001). As in the previous case, in this model the variable <italic>group</italic> was not included. Also, results from previous steps showed non-significant differences in cognitive trajectories between groups for this task (i.e., both groups had similar change in performance from pre- to post-test).</p>
<p>Regarding the effect of <italic>age</italic> (<italic>B</italic> &#x0003D; 0.348; <italic>p</italic> &#x0003C; 0.0001), results suggest that older children had higher scores on this task. Moreover, our results show that none of the socio-environmental variables were related to the change in inhibitory control from pre- to post-intervention assessment.</p>
<p>In the final model for <italic>Flexibility</italic> (Model &#x0003D; <italic>time, group, age, frequency of sessions, time<sup>&#x0002A;</sup>group, time<sup>&#x0002A;</sup>age</italic>; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.1728; <italic>n</italic> &#x0003D; 329), the main effect of <italic>time</italic> shows that children in both groups increased their initial performance around two standard deviations (<italic>B</italic> &#x0003D; &#x02212;1.920; <italic>p</italic> &#x0003C; 0.0001). In addition, results show that children in the intervention group had a higher increase in their performance after training than the control group (<italic>B</italic> &#x0003D; &#x02212;0.550; <italic>p</italic> &#x0003D; 0.0046). Likewise, change in flexibility after training was also associated with child <italic>age</italic> (<italic>B</italic> &#x0003D; &#x02212;0.423; <italic>p</italic> &#x0003D; 0.0002), which suggests that older children had smaller increases in their performance after training. Results also show that older children had higher scores at baseline (<italic>B</italic> &#x0003D; 0.516; <italic>p</italic> &#x0003C; 0.0001), and children who were involved in the intervention with a frequency of one session per week had 0.577 lower scores than children who were involved in the intervention with a frequency of two times per week (<italic>p</italic> &#x0003C; 0.0001).</p>
<p>Finally, in the model for <italic>Planning</italic> (Model &#x0003D; <italic>time, group, age, time<sup>&#x0002A;</sup>group</italic>; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.1355; <italic>n</italic> &#x0003D; 329), the main effect of <italic>time</italic> shows that children from both groups increased their initial performance around one standard deviation (<italic>B</italic> &#x0003D; 1.192; <italic>p</italic> &#x0003C; 0.0001). Results also suggest significant effects of <italic>group</italic> on cognitive trajectories after training, such that children in the intervention group had higher scores after the intervention than children in the control group (<italic>B</italic> &#x0003D; 0.720; <italic>p</italic> &#x0003C; 0.0001). Also, our results indicate effects of child <italic>age</italic> (<italic>B</italic> &#x0003D; 0.667; <italic>p</italic> &#x0003C; 0.0001) on Time 1 performance, which suggest that scores tended to be higher for older children.</p>
</sec>
</sec>
<sec>
<title>CTP program</title>
<p>In this program we implemented the same procedures as in the SIP. First, a set of variables was pre-selected as potential predictors of cognitive performance at baseline and of the cognitive performance change after intervention: <italic>housing conditions, overcrowding, parental education, parental occupation, mother&#x00027;s physical health, housing stressors, economic stressors, working stressors, couple stressors, child stressors, family stressors, friends and social life stressors, negative life events, economic resources, working resources, couple resources, child resources, family resources, friends and social life resources, positive life events, child health records, child age, child gender, family composition, reception of social benefits (subsidies), mother age, low weight at birth, premature, neurological disorders, perinatal disorders</italic>, and the <italic>number of training sessions</italic>. Descriptive statistics are presented in Tables <xref ref-type="table" rid="T9">9</xref>, <xref ref-type="table" rid="T10">10</xref>.</p>
<table-wrap position="float" id="T9">
<label>Table 9</label>
<caption><p><bold>Socio-demographic information of the CTP sample (continuous variables)</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left"><bold>Characteristic</bold></th>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>Mean (<italic>SD</italic>)</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Child age (at baseline)</td>
<td align="center" valign="top">333</td>
<td align="center" valign="top">3.97 (0.73)</td>
</tr>
<tr>
<td align="left" valign="top">Mother age</td>
<td align="center" valign="top">318</td>
<td align="center" valign="top">29.05 (5.76)</td>
</tr>
<tr>
<td align="left" colspan="3"><bold>SOCIOECONOMIC INFORMATION<xref ref-type="table-fn" rid="TN9a"><sup>a</sup></xref></bold></td>
</tr>
<tr>
<td align="left" valign="top">Parent education level<xref ref-type="table-fn" rid="TN9b"><sup>b</sup></xref></td>
<td align="center" valign="top">320</td>
<td align="center" valign="top">7.07<xref ref-type="table-fn" rid="TN9c"><sup>c</sup></xref> (2.68)</td>
</tr>
<tr>
<td align="left" valign="top">Parent occupation background<xref ref-type="table-fn" rid="TN9b"><sup>b</sup></xref></td>
<td align="center" valign="top">321</td>
<td align="center" valign="top">3.78<xref ref-type="table-fn" rid="TN9d"><sup>d</sup></xref> (2.92)</td>
</tr>
<tr>
<td align="left" valign="top">Housing<xref ref-type="table-fn" rid="TN9e"><sup>e</sup></xref></td>
<td align="center" valign="top">321</td>
<td align="center" valign="top">9.91 (2.16)</td>
</tr>
<tr>
<td align="left" valign="top">Overcrowding conditions<xref ref-type="table-fn" rid="TN9f"><sup>f</sup></xref></td>
<td align="center" valign="top">321</td>
<td align="center" valign="top">6.26 (2.30)</td>
</tr>
<tr>
<td align="left" colspan="3"><bold>LIFE STRESSORS AND SOCIAL RESOURCES<xref ref-type="table-fn" rid="TN9g"><sup>g</sup></xref></bold></td>
</tr>
<tr>
<td align="left" valign="top">Physical health</td>
<td align="center" valign="top">268</td>
<td align="center" valign="top">&#x02212;48.97 (10.71)</td>
</tr>
<tr>
<td align="left" valign="top">Housing stressors</td>
<td align="center" valign="top">268</td>
<td align="center" valign="top">&#x02212;55.49 (10.99)</td>
</tr>
<tr>
<td align="left" valign="top">Economic stressors</td>
<td align="center" valign="top">268</td>
<td align="center" valign="top">&#x02212;61.87 (8.08)</td>
</tr>
<tr>
<td align="left" valign="top">Working stressors</td>
<td align="center" valign="top">190</td>
<td align="center" valign="top">&#x02212;49.67 (7.64)</td>
</tr>
<tr>
<td align="left" valign="top">Couple stressors</td>
<td align="center" valign="top">188</td>
<td align="center" valign="top">&#x02212;54.82 (8.88)</td>
</tr>
<tr>
<td align="left" valign="top">Child stressors</td>
<td align="center" valign="top">257</td>
<td align="center" valign="top">&#x02212;64.83 (8.79)</td>
</tr>
<tr>
<td align="left" valign="top">Family stressors</td>
<td align="center" valign="top">258</td>
<td align="center" valign="top">&#x02212;46.37 (8.49)</td>
</tr>
<tr>
<td align="left" valign="top">Friends and social life stressors</td>
<td align="center" valign="top">236</td>
<td align="center" valign="top">&#x02212;45.82 (8.17)</td>
</tr>
<tr>
<td align="left" valign="top">Negative life events</td>
<td align="center" valign="top">268</td>
<td align="center" valign="top">&#x02212;59.57 (12.96)</td>
</tr>
<tr>
<td align="left" valign="top">Economic resources</td>
<td align="center" valign="top">266</td>
<td align="center" valign="top">38.42 (0.84)</td>
</tr>
<tr>
<td align="left" valign="top">Working resources</td>
<td align="center" valign="top">189</td>
<td align="center" valign="top">51.01 (2.57)</td>
</tr>
<tr>
<td align="left" valign="top">Couple resources</td>
<td align="center" valign="top">189</td>
<td align="center" valign="top">54.34 (6.37)</td>
</tr>
<tr>
<td align="left" valign="top">Child resources</td>
<td align="center" valign="top">256</td>
<td align="center" valign="top">66.39 (5.34)</td>
</tr>
<tr>
<td align="left" valign="top">Family resources</td>
<td align="center" valign="top">258</td>
<td align="center" valign="top">48.98 (7.43)</td>
</tr>
<tr>
<td align="left" valign="top">Friends and social life resources</td>
<td align="center" valign="top">232</td>
<td align="center" valign="top">46.91 (11.12)</td>
</tr>
<tr>
<td align="left" valign="top">Positive life events</td>
<td align="center" valign="top">268</td>
<td align="center" valign="top">55.38 (10.59)</td>
</tr>
<tr>
<td align="left" valign="top">Number of training sessions<xref ref-type="table-fn" rid="TN9h"><sup>h</sup></xref></td>
<td align="center" valign="top">292</td>
<td align="center" valign="top">19.34 (5.96)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN9a"><label>a</label><p><italic>Socioeconomic information was obtained in most cases (this is the reason for the higher sample sizes in those variables).</italic></p></fn>
<fn id="TN9b"><label>b</label><p><italic>Highest educational and occupational levels reached by parents.</italic></p></fn>
<fn id="TN9c"><label>c</label><p><italic>Incomplete secondary school level.</italic></p></fn>
<fn id="TN9d"><label>d</label><p><italic>Non-skilled worker.</italic></p></fn>
<fn id="TN9e"><label>e</label><p><italic>Scale range: 3&#x02013;12 points, with higher scores for better housing conditions.</italic></p></fn>
<fn id="TN9f"><label>f</label><p><italic>Scale range: 0&#x02013;9 points, with higher scores for better conditions.</italic></p></fn>
<fn id="TN9g"><label>g</label><p><italic>T scores from each item evaluated in the Life Stressors and Social Resources Inventory (LISRES).</italic></p></fn>
<fn id="TN9h"><label>h</label><p><italic>The total number of sessions vary between children due to their absence to the institutions.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="T10">
<label>Table 10</label>
<caption><p><bold>Socio-demographic information of the CTP sample (categorical variables)</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left"><bold>Characteristic</bold></th>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>%</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" colspan="3"><bold>CHILD SEX</bold></td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">175</td>
<td align="center" valign="top">52.55</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">158</td>
<td align="center" valign="top">47.45</td>
</tr>
<tr>
<td align="left" colspan="3"><bold>HEALTH HISTORY</bold></td>
</tr>
<tr>
<td align="left" valign="top">With history of medical illness<xref ref-type="table-fn" rid="TN10a"><sup>a</sup></xref></td>
<td align="center" valign="top">160</td>
<td align="center" valign="top">49.54</td>
</tr>
<tr>
<td align="left" valign="top">Without history of medical illness</td>
<td align="center" valign="top">163</td>
<td align="center" valign="top">50.46</td>
</tr>
<tr>
<td align="left" colspan="3"><bold>SINGLE PARENT HOUSEHOLD</bold></td>
</tr>
<tr>
<td align="left" valign="top">Yes</td>
<td align="center" valign="top">123</td>
<td align="center" valign="top">38.44</td>
</tr>
<tr>
<td align="left" valign="top">No</td>
<td align="center" valign="top">197</td>
<td align="center" valign="top">61.56</td>
</tr>
<tr>
<td align="left" colspan="3"><bold>FAMILY WITH SOCIAL BENEFIT SUPPORT (SUBSIDIES)</bold></td>
</tr>
<tr>
<td align="left" valign="top">Yes</td>
<td align="center" valign="top">169</td>
<td align="center" valign="top">52.65</td>
</tr>
<tr>
<td align="left" valign="top">No</td>
<td align="center" valign="top">152</td>
<td align="center" valign="top">47.35</td>
</tr>
<tr>
<td align="left" colspan="3"><bold>SOCIOECONOMIC GROUP</bold></td>
</tr>
<tr>
<td align="left" valign="top">Unsatisfied basic need home</td>
<td align="center" valign="top">161</td>
<td align="center" valign="top">49.80</td>
</tr>
<tr>
<td align="left" valign="top">Satisfied basic need home</td>
<td align="center" valign="top">160</td>
<td align="center" valign="top">50.20</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN10a"><label>a</label><p><italic>Low weight at birth, premature, neurological, and/or perinatal disorders.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<p>We adapted some of these variables for the analysis. Specifically, <italic>age of mother</italic> and <italic>number of sessions</italic> were re-categorized into categorical predictors for the analyses in order to have comparative groups within each predictor, and be able to distinguish between very young, young or older mothers as well as low, middle or high training exposure. In both cases, based on descriptive statistics, we created three groups [1 &#x0003D; values below 1 standard deviation (SD) of the mean; 2 &#x0003D; values between 1 <italic>SD</italic> above and below the mean, 3 &#x0003D; values above 1 <italic>SD</italic> of the mean]. Specifically, for <italic>age of mother</italic> groups were: less than 24 years, between 24 and 34.4 years, more than 34.4 years. For training exposure groups were: low training exposure (less than 13 sessions), middle training exposure (13&#x02013;24 sessions), and high training exposure (more than 24 sessions).</p>
<p>Regarding the dependent variables, we evaluated the assumptions for mixed models procedures, and, like in the SIP, all dependent variables showed violations of at least one of the criteria considered. Therefore, these variables were transformed for the analysis (using square root or arcsine transformations). Finally, for each dependent variable, scores were transformed to z to have a common metric to be able to compare intervention outcome across the tasks. Means and standard deviations for each cognitive task are presented in Table <xref ref-type="table" rid="T11">11</xref>.</p>
<table-wrap position="float" id="T11">
<label>Table 11</label>
<caption><p><bold>Performance by task and time of assessment in the CTP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" colspan="3"><bold>Time 1</bold></th>
<th align="center" colspan="3"><bold>Time 2</bold></th>
</tr>
<tr>
<th align="left"><bold>Task</bold></th>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>Mean</bold></th>
<th align="center"><bold><italic>SD</italic></bold></th>
<th align="center"><bold><italic>n</italic></bold></th>
<th align="center"><bold>Mean</bold></th>
<th align="center"><bold><italic>SD</italic></bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Tower of London</td>
<td align="center" valign="top">284</td>
<td align="center" valign="top">11.61</td>
<td align="center" valign="top">15.53</td>
<td align="center" valign="top">271</td>
<td align="center" valign="top">21.79</td>
<td align="center" valign="top">21.52</td>
</tr>
<tr>
<td align="left" valign="top">Corsi blocks</td>
<td align="center" valign="top">280</td>
<td align="center" valign="top">8.71</td>
<td align="center" valign="top">6.85</td>
<td align="center" valign="top">270</td>
<td align="center" valign="top">10.83</td>
<td align="center" valign="top">6.77</td>
</tr>
<tr>
<td align="left" valign="top">FIST</td>
<td align="center" valign="top">280</td>
<td align="center" valign="top">15.80</td>
<td align="center" valign="top">8.87</td>
<td align="center" valign="top">271</td>
<td align="center" valign="top">18.42</td>
<td align="center" valign="top">7.63</td>
</tr>
<tr>
<td align="left" valign="top">Selective attention</td>
<td align="center" valign="top">273</td>
<td align="center" valign="top">0.31</td>
<td align="center" valign="top">0.24</td>
<td align="center" valign="top">271</td>
<td align="center" valign="top">0.42</td>
<td align="center" valign="top">0.25</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>Time 1, cognitive assessment pre-intervention (baseline); Time 2, cognitive assessment post-intervention.</italic></p>
</table-wrap-foot>
</table-wrap>
<p>In this program it was also necessary to reduce the number of pre-selected variables to enter them into the analyses, and the same procedures executed in the previous program were implemented (see next section).</p>
<sec>
<title>Selection of potential predictors</title>
<p>First, a PCA was executed for variables from the Socioeconomic Status Scale and the LISRES inventory. Same criteria used for the SIP were considered for this program, and seven components were identified (see Table <xref ref-type="table" rid="T12">12</xref>): Factor 1 (Housing conditions) involves <italic>housing conditions</italic>, <italic>overcrowding</italic>, and <italic>housing stressors</italic>; Factor 2 (Economic status) contains <italic>economic stressors</italic> and <italic>economic resources</italic> variables; Factor 3 (Ties support) comprises <italic>family stressors</italic>, <italic>negative life events</italic> and <italic>child stressors</italic>; Factor 4 (Social aspects of health) concerns <italic>social stressors</italic>, <italic>physical health</italic>, and <italic>social benefit reception</italic>; Factor 5 (Social resources) involves <italic>family, child</italic> and <italic>social resources</italic> variables; Factor 6 (Family composition) comprises <italic>family composition</italic> and <italic>parental occupation level</italic>; and Factor 7 (Positive events) concerns the variable <italic>positive life events</italic>. All these factors were incorporated into the data set, and for all of them, higher scores refer to better environmental conditions.</p>
<table-wrap position="float" id="T12">
<label>Table 12</label>
<caption><p><bold>PCA results depicting variables associated with socioeconomic status and level of stressors and resources in the CTP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center"><bold>Housing conditions</bold></th>
<th align="center"><bold>Economic status</bold></th>
<th align="center"><bold>Ties support</bold></th>
<th align="center"><bold>Social aspects of health</bold></th>
<th align="center"><bold>Social resources</bold></th>
<th align="center"><bold>Family composition</bold></th>
<th align="center"><bold>Positive events</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Housing stressors<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top"><bold>0.83</bold></td>
<td align="center" valign="top">&#x02212;0.06</td>
<td align="center" valign="top">0.26</td>
<td align="center" valign="top">0.03</td>
<td align="center" valign="top">&#x02212;0.09</td>
<td align="center" valign="top">0.03</td>
<td align="center" valign="top">0.18</td>
</tr>
<tr>
<td align="left" valign="top">Housing conditions<xref ref-type="table-fn" rid="TN12b"><sup>b</sup></xref></td>
<td align="center" valign="top"><bold>0.79</bold></td>
<td align="center" valign="top">&#x02212;0.05</td>
<td align="center" valign="top">&#x02212;0.20</td>
<td align="center" valign="top">0.10</td>
<td align="center" valign="top">&#x02212;0.02</td>
<td align="center" valign="top">0.04</td>
<td align="center" valign="top">&#x02212;0.16</td>
</tr>
<tr>
<td align="left" valign="top">Overcrowding<xref ref-type="table-fn" rid="TN12b"><sup>b</sup></xref></td>
<td align="center" valign="top"><bold>0.72</bold></td>
<td align="center" valign="top">0.11</td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">&#x02212;0.29</td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top">&#x02212;0.10</td>
<td align="center" valign="top">0.03</td>
</tr>
<tr>
<td align="left" valign="top">Economic stressors<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.02</td>
<td align="center" valign="top"><bold>0.75</bold></td>
<td align="center" valign="top">&#x02212;0.03</td>
<td align="center" valign="top">0.18</td>
<td align="center" valign="top">&#x02212;0.03</td>
<td align="center" valign="top">0.24</td>
<td align="center" valign="top">0.20</td>
</tr>
<tr>
<td align="left" valign="top">Economic resources<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top"><bold>0.71</bold></td>
<td align="center" valign="top">&#x02212;0.09</td>
<td align="center" valign="top">0.05</td>
<td align="center" valign="top">0.11</td>
<td align="center" valign="top">0.01</td>
<td align="center" valign="top">&#x02212;0.12</td>
</tr>
<tr>
<td align="left" valign="top">Family stressors<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top">0.01</td>
<td align="center" valign="top"><bold>0.79</bold></td>
<td align="center" valign="top">0.19</td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top">&#x02212;0.12</td>
<td align="center" valign="top">0.05</td>
</tr>
<tr>
<td align="left" valign="top">Negative life events<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.06</td>
<td align="center" valign="top">0.60</td>
<td align="center" valign="top"><bold>0.59</bold></td>
<td align="center" valign="top">&#x02212;0.14</td>
<td align="center" valign="top">&#x02212;0.13</td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top">&#x02212;0.23</td>
</tr>
<tr>
<td align="left" valign="top">Child stressors<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.10</td>
<td align="center" valign="top">&#x02212;0.25</td>
<td align="center" valign="top"><bold>0.58</bold></td>
<td align="center" valign="top">0.26</td>
<td align="center" valign="top">0.10</td>
<td align="center" valign="top">0.09</td>
<td align="center" valign="top">&#x02212;0.04</td>
</tr>
<tr>
<td align="left" valign="top">Social stressors<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.11</td>
<td align="center" valign="top">&#x02212;0.03</td>
<td align="center" valign="top">0.18</td>
<td align="center" valign="top"><bold>0.72</bold></td>
<td align="center" valign="top">&#x02212;0.08</td>
<td align="center" valign="top">0.05</td>
<td align="center" valign="top">&#x02212;0.04</td>
</tr>
<tr>
<td align="left" valign="top">Physical health<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.00</td>
<td align="center" valign="top">0.24</td>
<td align="center" valign="top">0.16</td>
<td align="center" valign="top"><bold>0.68</bold></td>
<td align="center" valign="top">&#x02212;0.05</td>
<td align="center" valign="top">&#x02212;0.02</td>
<td align="center" valign="top">0.14</td>
</tr>
<tr>
<td align="left" valign="top">Social benefits reception<xref ref-type="table-fn" rid="TN12b"><sup>b</sup></xref></td>
<td align="center" valign="top">0.20</td>
<td align="center" valign="top">0.29</td>
<td align="center" valign="top">&#x02212;0.08</td>
<td align="center" valign="top"><bold>0.41</bold></td>
<td align="center" valign="top">0.19</td>
<td align="center" valign="top">&#x02212;0.13</td>
<td align="center" valign="top">&#x02212;0.35</td>
</tr>
<tr>
<td align="left" valign="top">Social resources<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.11</td>
<td align="center" valign="top">0.14</td>
<td align="center" valign="top">&#x02212;0.19</td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top"><bold>0.76</bold></td>
<td align="center" valign="top">&#x02212;0.16</td>
<td align="center" valign="top">0.15</td>
</tr>
<tr>
<td align="left" valign="top">Child resources<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top">&#x02212;0.22</td>
<td align="center" valign="top">0.19</td>
<td align="center" valign="top">&#x02212;0.07</td>
<td align="center" valign="top"><bold>0.66</bold></td>
<td align="center" valign="top">0.30</td>
<td align="center" valign="top">&#x02212;0.16</td>
</tr>
<tr>
<td align="left" valign="top">Family resources<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.02</td>
<td align="center" valign="top">0.12</td>
<td align="center" valign="top">0.54</td>
<td align="center" valign="top">&#x02212;0.03</td>
<td align="center" valign="top"><bold>0.62</bold></td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top">0.09</td>
</tr>
<tr>
<td align="left" valign="top">Family composition <xref ref-type="table-fn" rid="TN12b"><sup>b</sup></xref></td>
<td align="center" valign="top">&#x02212;0.09</td>
<td align="center" valign="top">0.08</td>
<td align="center" valign="top">&#x02212;0.04</td>
<td align="center" valign="top">0.10</td>
<td align="center" valign="top">&#x02212;0.09</td>
<td align="center" valign="top"><bold>0.88</bold></td>
<td align="center" valign="top">&#x02212;0.01</td>
</tr>
<tr>
<td align="left" valign="top">Parents occupation level<xref ref-type="table-fn" rid="TN12b"><sup>b</sup></xref></td>
<td align="center" valign="top">0.20</td>
<td align="center" valign="top">0.29</td>
<td align="center" valign="top">&#x02212;0.11</td>
<td align="center" valign="top">&#x02212;0.16</td>
<td align="center" valign="top">0.15</td>
<td align="center" valign="top"><bold>0.63</bold></td>
<td align="center" valign="top">0.02</td>
</tr>
<tr>
<td align="left" valign="top">Positive life events<xref ref-type="table-fn" rid="TN12a"><sup>a</sup></xref></td>
<td align="center" valign="top">0.05</td>
<td align="center" valign="top">&#x02212;0.01</td>
<td align="center" valign="top">&#x02212;0.03</td>
<td align="center" valign="top">0.07</td>
<td align="center" valign="top">0.09</td>
<td align="center" valign="top">&#x02212;0.02</td>
<td align="center" valign="top"><bold>0.93</bold></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>n &#x0003D; 256.</italic></p>
<fn id="TN12a"><label>a</label><p><italic>Variables from the LISRES inventory.</italic></p></fn>
<fn id="TN12b"><label>b</label><p><italic>Variables from the Socioeconomic Status Scale.</italic></p></fn>
<p><italic>Bold text indicates variables loading on each factor. These seven factors were the only ones with eigenvalues larger than 1 in the correlation matrix, and the Scree plot also suggested the seven-factor solution.</italic></p>
</table-wrap-foot>
</table-wrap>
<p>We performed a Pearson Correlation analysis including socio-environmental factors derived from the PCA and other variables (demographic information, child health records, and training exposure information). For the independent variables, results show a pair of variables with a moderately high degree of association: <italic>Low weight at birth</italic> and <italic>Premature</italic> (<italic>r</italic> &#x0003D; 0.53, <italic>p</italic> &#x0003C; 0.0001) (Table <xref ref-type="table" rid="T13">13</xref>). Based on these results, low weight at birth was selected for the block analysis, as it can result from preterm birth or intrauterine growth restriction, or a combination of both (Shah and Ohlsson, <xref ref-type="bibr" rid="B99">2002</xref>). Results show no significant correlations for the dependent variables (Table <xref ref-type="table" rid="T14">14</xref>).</p>
<table-wrap position="float" id="T13">
<label>Table 13</label>
<caption><p><bold>Correlations for independent variables in the CTP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th/>
<th align="center"><bold>1</bold></th>
<th align="center"><bold>2</bold></th>
<th align="center"><bold>3</bold></th>
<th align="center"><bold>4</bold></th>
<th align="center"><bold>5</bold></th>
<th align="center"><bold>6</bold></th>
<th align="center"><bold>7</bold></th>
<th align="center"><bold>8</bold></th>
<th align="center"><bold>9</bold></th>
<th align="center"><bold>10</bold></th>
<th align="center"><bold>11</bold></th>
<th align="center"><bold>12</bold></th>
<th align="center"><bold>13</bold></th>
<th align="center"><bold>14</bold></th>
<th align="center"><bold>15</bold></th>
<th align="center"><bold>16</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">1.</td>
<td align="left" valign="top">Factor 1</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">2.</td>
<td align="left" valign="top">Factor 2</td>
<td align="center" valign="top">0.359<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">3.</td>
<td align="left" valign="top">Factor 3</td>
<td align="center" valign="top">&#x02212;0.120</td>
<td align="center" valign="top">&#x02212;0.043</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">4.</td>
<td align="left" valign="top">Factor 4</td>
<td align="center" valign="top">0.043</td>
<td align="center" valign="top">0.043</td>
<td align="center" valign="top">0.083</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">5.</td>
<td align="left" valign="top">Factor 5</td>
<td align="center" valign="top">0.270<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.108</td>
<td align="center" valign="top">&#x02212;0.099</td>
<td align="center" valign="top">0.012</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">6.</td>
<td align="left" valign="top">Factor 6</td>
<td align="center" valign="top">0.150<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.036</td>
<td align="center" valign="top">0.164<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.012</td>
<td align="center" valign="top">0.156<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">7.</td>
<td align="left" valign="top">Factor 7</td>
<td align="center" valign="top">&#x02212;0.092</td>
<td align="center" valign="top">&#x02212;0.112</td>
<td align="center" valign="top">0.075</td>
<td align="center" valign="top">0.039</td>
<td align="center" valign="top">&#x02212;0.131</td>
<td align="center" valign="top">&#x02212;0.030</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">8.</td>
<td align="left" valign="top">Child sex</td>
<td align="center" valign="top">&#x02212;0.015</td>
<td align="center" valign="top">&#x02212;0.023</td>
<td align="center" valign="top">&#x02212;0.094</td>
<td align="center" valign="top">0.035</td>
<td align="center" valign="top">&#x02212;0.040</td>
<td align="center" valign="top">&#x02212;0.051</td>
<td align="center" valign="top">&#x02212;0.029</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">9.</td>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">&#x02212;0.056</td>
<td align="center" valign="top">0.006</td>
<td align="center" valign="top">&#x02212;0.001</td>
<td align="center" valign="top">0.058</td>
<td align="center" valign="top">&#x02212;0.048</td>
<td align="center" valign="top">0.034</td>
<td align="center" valign="top">0.000</td>
<td align="center" valign="top">&#x02212;0.067</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">10.</td>
<td align="left" valign="top">Parental education</td>
<td align="center" valign="top">0.373<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.310<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02212;0.209<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02212;0.105</td>
<td align="center" valign="top">0.145<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.129</td>
<td align="center" valign="top">&#x02212;0.037</td>
<td align="center" valign="top">0.038</td>
<td align="center" valign="top">&#x02212;0.070</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">11.</td>
<td align="left" valign="top">Low weight at birth</td>
<td align="center" valign="top">0.042</td>
<td align="center" valign="top">&#x02212;0.081</td>
<td align="center" valign="top">&#x02212;0.168<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02212;0.103</td>
<td align="center" valign="top">0.069</td>
<td align="center" valign="top">0.011</td>
<td align="center" valign="top">&#x02212;0.044</td>
<td align="center" valign="top">&#x02212;0.029</td>
<td align="center" valign="top">&#x02212;0.031</td>
<td align="center" valign="top">0.059</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">12.</td>
<td align="left" valign="top">Neurological disorders</td>
<td align="center" valign="top">&#x02212;0.006</td>
<td align="center" valign="top">&#x02212;0.120</td>
<td align="center" valign="top">&#x02212;0.079</td>
<td align="center" valign="top">&#x02212;0.031</td>
<td align="center" valign="top">0.121</td>
<td align="center" valign="top">&#x02212;0.008</td>
<td align="center" valign="top">0.035</td>
<td align="center" valign="top">0.030</td>
<td align="center" valign="top">0.073</td>
<td align="center" valign="top">&#x02212;0.003</td>
<td align="center" valign="top">0.240<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">13.</td>
<td align="left" valign="top">Perinatal disorders</td>
<td align="center" valign="top">&#x02212;0.054</td>
<td align="center" valign="top">&#x02212;0.181<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02212;0.026</td>
<td align="center" valign="top">&#x02212;0.171<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.035</td>
<td align="center" valign="top">0.122</td>
<td align="center" valign="top">&#x02212;0.145<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.028</td>
<td align="center" valign="top">&#x02212;0.034</td>
<td align="center" valign="top">0.000</td>
<td align="center" valign="top">0.075</td>
<td align="center" valign="top">0.206<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">14.</td>
<td align="left" valign="top">Premature</td>
<td align="center" valign="top">&#x02212;0.023</td>
<td align="center" valign="top">&#x02212;0.090</td>
<td align="center" valign="top">&#x02212;0.155<xref ref-type="table-fn" rid="TN13s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02212;0.076</td>
<td align="center" valign="top">0.015</td>
<td align="center" valign="top">0.104</td>
<td align="center" valign="top">&#x02212;0.034</td>
<td align="center" valign="top">0.045</td>
<td align="center" valign="top">&#x02212;0.023</td>
<td align="center" valign="top">0.037</td>
<td align="center" valign="top">0.529<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.230<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.189<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">15.</td>
<td align="left" valign="top">Training exposure</td>
<td align="center" valign="top">&#x02212;0.009</td>
<td align="center" valign="top">0.125</td>
<td align="center" valign="top">0.023</td>
<td align="center" valign="top">&#x02212;0.105</td>
<td align="center" valign="top">&#x02212;0.030</td>
<td align="center" valign="top">0.015</td>
<td align="center" valign="top">&#x02212;0.051</td>
<td align="center" valign="top">0.006</td>
<td align="center" valign="top">0.047</td>
<td align="center" valign="top">0.030</td>
<td align="center" valign="top">0.025</td>
<td align="center" valign="top">&#x02212;0.081</td>
<td align="center" valign="top">&#x02212;0.054</td>
<td align="center" valign="top">0.037</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">16.</td>
<td align="left" valign="top">Mother age</td>
<td align="center" valign="top">0.076</td>
<td align="center" valign="top">0.050</td>
<td align="center" valign="top">0.082</td>
<td align="center" valign="top">&#x02212;0.087</td>
<td align="center" valign="top">0.023</td>
<td align="center" valign="top">0.021</td>
<td align="center" valign="top">&#x02212;0.030</td>
<td align="center" valign="top">&#x02212;0.044</td>
<td align="center" valign="top">0.102</td>
<td align="center" valign="top">0.007</td>
<td align="center" valign="top">0.029</td>
<td align="center" valign="top">0.026</td>
<td align="center" valign="top">0.054</td>
<td align="center" valign="top">0.053</td>
<td align="center" valign="top">0.175<xref ref-type="table-fn" rid="TN13ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN13s"><label>&#x0002A;</label><p><italic>p &#x0003C; 0.05;</italic></p></fn>
<fn id="TN13ss"><label>&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.01.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="T14">
<label>Table 14</label>
<caption><p><bold>Correlations for dependent variables in the CTP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center"><bold>1</bold></th>
<th align="center"><bold>2</bold></th>
<th align="center"><bold>3</bold></th>
<th align="center"><bold>4</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">1. Planning</td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">2. Visuo-spatial organization</td>
<td align="center" valign="top">0.244<xref ref-type="table-fn" rid="TN14ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">3. Cognitive flexibility</td>
<td align="center" valign="top">0.408<xref ref-type="table-fn" rid="TN14ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.208<xref ref-type="table-fn" rid="TN14ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">4. Attentional control</td>
<td align="center" valign="top">0.476<xref ref-type="table-fn" rid="TN14ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.289<xref ref-type="table-fn" rid="TN14ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.486<xref ref-type="table-fn" rid="TN14ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TN14ss"><label>&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.01.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec>
<title>Creation of the final models for the prediction analysis</title>
<p>With the purpose of identifying significant predictors for both, basal cognitive performance and cognitive performance change between pre- to post-intervention, we conducted a sequence of mixed model analyses. We first ran a model with a basal predictor (<italic>time</italic>). Results showed significant estimates for all variables (<italic>Attention</italic>: <italic>B</italic> &#x0003D; 0.4596, <italic>p</italic> &#x0003C; 0.0001; <italic>Working memory</italic>: <italic>B</italic> &#x0003D; 0.3816, <italic>p</italic> &#x0003C; 0.0001; <italic>Flexibility</italic>: <italic>B</italic> &#x0003D; 0.3458, <italic>p</italic> &#x0003C; 0.0001; <italic>Planning</italic>: <italic>B</italic> &#x0003D; 0.5745, <italic>p</italic> &#x0003C; 0.0001), which means that children improved their performance on all these tasks following the group modality of cognitive training.</p>
<p>Second, independent variables were grouped into four blocks of information: (1) <italic>Living conditions at home, life stressors and social resources</italic> (including the seven factors derived from the PCA analysis); (2) <italic>demographic information</italic> (<italic>child age</italic> and <italic>gender</italic>, <italic>parental education</italic> and <italic>mother age group</italic>); (3) <italic>child health</italic> (<italic>low weight at birth</italic>, <italic>neurological disorders</italic>, <italic>perinatal disorders</italic>); and (4) <italic>training exposure</italic> (<italic>training exposure group</italic>). Analyses were executed separately for each block. The model included the interaction between each variable with <italic>time</italic> (see section Study Design, Participants, and Procedures).</p>
<p>Before the next step, the MARC assumption was tested for the independent variables included in the blocks, and the cognitive performance variables. The assumption was verified for all variables (independent variables: <italic>X</italic><sup>2</sup> &#x0003D; 4.46, <italic>p</italic> &#x0003D; 0.216; basal cognitive performance variables: <italic>X</italic><sup>2</sup> &#x0003D; 0.931, <italic>p</italic> &#x0003D; 0.818; post-intervention cognitive performance variables: <italic>X</italic><sup>2</sup> &#x0003D; 0.513, <italic>p</italic> &#x0003D; 0.916).</p>
<p>For each block, we executed mixed model analyses several times, removing the non-significant variables each time. In general, results from this step showed significant socio-environmental predictors for each dependent variable, and overall, they evidenced a similar pattern, and yet also some differences between cognitive processes. As was mentioned for the SIP, the summary of results of these analyses is available upon request.</p>
<p>Significant variables from the previous step were combined and included in a final model of prediction (also for this step, analyses were executed several times removing every time the non-significant predictors). At the end of this procedure we identified a set of significant predictors (final model). For the number of comparisons (<italic>attention</italic> &#x0003D; 7, <italic>workingmemory</italic> &#x0003D; 3, <italic>flexibility</italic> &#x0003D; 5, <italic>planning</italic> &#x0003D; 6), the Bonferroni correction was used for a 0.05 level of significance (the final values of <italic>p</italic> were: <italic>attention</italic> &#x0003D; 0.00714, <italic>workingmemory</italic> &#x0003D; 0.01667, <italic>flexibility</italic> &#x0003D; 0.01, <italic>planning</italic> &#x0003D; 0.0083).</p>
</sec>
<sec>
<title>variables associated to cognitive performance and trajectories (final models)</title>
<p>Table <xref ref-type="table" rid="T15">15</xref> includes the final parameter estimates for each cognitive process, and shows significant predictors of cognitive performance at Time 1 (baseline) and of intervention trajectories (difference between Time 2 and Time 1).</p>
<table-wrap position="float" id="T15">
<label>Table 15</label>
<caption><p><bold>Results for the final model for each cognitive process in the CTP</bold>.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left"><bold>Dependent variable<xref ref-type="table-fn" rid="TN15a"><sup>a</sup></xref></bold></th>
<th align="left"><bold>Parameters</bold></th>
<th align="center"><bold>Estimate (<italic>SE</italic>)</bold></th>
<th align="center"><bold>&#x003B7;<sup>2</sup></bold></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Attention (<italic>N</italic> &#x0003D; 188)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;1.621 (0.199)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Family composition</td>
<td align="center" valign="top">0.179 (0.051)<xref ref-type="table-fn" rid="TN15ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.063</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.607 (0.070)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.294</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Housing conditions<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">0.191 (0.063)<xref ref-type="table-fn" rid="TN15ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.050</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Middle training exposure<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">0.495 (0.214)<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.036</td>
</tr>
<tr>
<td align="left" valign="top">Working memory (<italic>N</italic> &#x0003D; 215)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;1.429 (0.138)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Time</td>
<td align="center" valign="top">0.403 (0.083)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.105</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Ties support</td>
<td align="center" valign="top">0.120 (0.047)<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.032</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.600 (0.064)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.307</td>
</tr>
<tr>
<td align="left" valign="top">Flexibility (<italic>N</italic> &#x0003D; 188)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;1.655 (0.197)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Time</td>
<td align="center" valign="top">0.364 (0.076)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.115</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Housing conditions</td>
<td align="center" valign="top">0.139 (0.054)<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.037</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Family composition</td>
<td align="center" valign="top">0.172 (0.054)<xref ref-type="table-fn" rid="TN15ss"><sup>&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.055</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.579 (0.073)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.266</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Middle training exposure</td>
<td align="center" valign="top">0.333 (0.161)<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.030</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">High training exposure</td>
<td align="center" valign="top">0.430 (0.185)<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.030</td>
</tr>
<tr>
<td align="left" valign="top">Planning (<italic>N</italic> &#x0003D; 188)</td>
<td align="left" valign="top">Intercept</td>
<td align="center" valign="top">&#x02212;1.771 (0.197)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">&#x02013;</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Child age</td>
<td align="center" valign="top">0.765 (0.071)<xref ref-type="table-fn" rid="TN15sss"><sup>&#x0002A;&#x0002A;&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.395</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">Family composition<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">0.150 (0.060)<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.035</td>
</tr>
<tr>
<td/>
<td align="left" valign="top">High training exposure<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref>time</td>
<td align="center" valign="top">0.564 (0.225)<xref ref-type="table-fn" rid="TN15s"><sup>&#x0002A;</sup></xref></td>
<td align="center" valign="top">0.033</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>Estimates from Proc Mixed using the Restricted Maximum Likelihood estimator.</italic></p>
<fn id="TN15a"><label>a</label><p><italic>Dependent variables &#x0003D; Z-scores; parameter estimate standard errors (SE) listed in parentheses.</italic></p></fn>
<fn id="TN15s"><label>&#x0002A;</label><p><italic>p &#x0003C; 0.05;</italic></p></fn>
<fn id="TN15ss"><label>&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.01;</italic></p></fn>
<fn id="TN15sss"><label>&#x0002A;&#x0002A;&#x0002A;</label><p><italic>p &#x0003C; 0.0001.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<p>In the final model for Attention (Model &#x0003D; time, housing conditions, family composition, child age, training exposure, housing conditions<sup>&#x0002A;</sup>time, training exposure<sup>&#x0002A;</sup>time; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.0953, <italic>n</italic> &#x0003D; 188), the main effect of time (after controlling for the other variables in the model) became non-significant (<italic>B</italic> &#x0003D; 0.064; <italic>p</italic> &#x0003D; 0.7463). However, results suggest significant effects of housing conditions (<italic>B</italic> &#x0003D; 0.191; <italic>p</italic> &#x0003D; 0.003) and marginally significant effects of training exposure (middle exposure: <italic>B</italic> &#x0003D; 0.4952; <italic>p</italic> &#x0003D; 0.0217) on cognitive trajectories. This also suggests that changes in performance from pre- to post-assessment enhanced with increasing scores on housing conditions (higher scores in this factor indicate better housing conditions, less perception of stress associated with housing, and less overcrowding conditions), and with a middle exposure to training in comparison to a low exposure. Results also show main effects of family composition (<italic>B</italic> &#x0003D; 0.1791; <italic>p</italic> &#x0003D; 0.0006) and child age (<italic>B</italic> &#x0003D; 0.6067; <italic>p</italic> &#x0003C; 0.0001) at Time 1. This pattern of results suggests that performance on the attention task was enhanced with increasing scores on family composition (higher scores for this factor indicate better parental occupation backgrounds and the presence of two parents in the home), and for older children.</p>
<p>In the final model for <italic>Working memory</italic> (Model &#x0003D; <italic>time, ties support</italic> and <italic>child age</italic>; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.0817, <italic>n</italic> &#x0003D; 215), the main effect of <italic>time</italic> shows that children, on average, significantly increased their basal working memory performance 0.40 of a standard deviation from pre- to post-test performance (<italic>p</italic> &#x0003C; 0.0001). None of the socio-environmental variables were related to performance change in working memory between assessments. Results also show effects of <italic>ties support</italic> (<italic>B</italic> &#x0003D; 0.1199; <italic>p</italic> &#x0003D; 0.0113) and <italic>child age</italic> (<italic>B</italic> &#x0003D; 0.5992; <italic>p</italic> &#x0003C; 0.0001) on Time 1 performance. This pattern of results indicates that performance in working memory at Time 1 was higher in older children and with increasing scores on the <italic>ties support</italic> factor (higher scores for this factor are associated with the perception of less stress associated with the family and the children, and with less negative life events).</p>
<p>In the final model for <italic>Flexibility</italic> (Model &#x0003D; <italic>time, housing conditions, family composition, child age</italic>, and <italic>training exposure</italic>; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; &#x02212;0.0098, <italic>n</italic> &#x0003D; 188), the main effect of <italic>time</italic> shows that children, on average, significantly increased their basal performance by 0.3641 points after training (<italic>p</italic> &#x0003C; 0.0001). None of the socio-environmental variables were related to the performance change in flexibility from pre- to post-assessment. Results also suggest significant effects of <italic>family composition</italic> (<italic>B</italic> &#x0003D; 0.1717; <italic>p</italic> &#x0003D; 0.0016), <italic>child age</italic> (<italic>B</italic> &#x0003D; 0.5790; <italic>p</italic> &#x0003C; 0.0001), and marginally significant effects of <italic>housing conditions</italic> (<italic>B</italic> &#x0003D; 0.1386; <italic>p</italic> &#x0003D; 0.0113) and <italic>training exposure</italic> (middle exposure: <italic>B</italic> &#x0003D; 0.3329, <italic>p</italic> &#x0003D; 0.0402; high exposure: <italic>B</italic> &#x0003D; 0.4304, <italic>p</italic> &#x0003D; 0.0209) at Time 1. This pattern of results indicates that performance at Time 1 was higher for older children; with increasing scores on <italic>housing conditions</italic> (higher scores on this factor indicate better housing conditions, less perception of stress associated with housing, and less overcrowding conditions) and <italic>family composition</italic> (higher scores for this factor indicate better parental occupation backgrounds and the presence of two parents at home); and with high or middle exposure to training activities.</p>
<p>In the final model for <italic>Planning</italic> (Model &#x0003D; <italic>time, family composition, child age, training exposure, family composition<sup>&#x0002A;</sup>time, training exposure<sup>&#x0002A;</sup>time</italic>; Pseudo <italic>R</italic><sup>2</sup> &#x0003D; 0.0105, <italic>n</italic> &#x0003D; 188), the main effect of <italic>time</italic> (after controlling for the other variables in the model) became non-significant (<italic>B</italic> &#x0003D; 0.2634; <italic>p</italic> &#x0003D; 0.1613). However, results suggest significant effects of <italic>family composition</italic> (<italic>B</italic> &#x0003D; 0.1495; <italic>p</italic> &#x0003D; 0.0130) and marginally significant effects of <italic>training exposure</italic> (high exposure: <italic>B</italic> &#x0003D; 0.5643; <italic>p</italic> &#x0003D; 0.0131) on cognitive trajectories. These results suggest that change between pre- and post-training performances increases with increasing scores on <italic>family composition</italic> (higher scores for this factor indicate better parental occupation backgrounds and the presence of two parents at home); and with high exposure to training activities. Results also show main effects of <italic>child age</italic> (<italic>B</italic> &#x0003D; 0.7653; <italic>p</italic> &#x0003C; 0.0001) on Time 1, which suggests that baseline performance in the planning task was higher in older children.</p>
</sec>
</sec>
<sec>
<title>Basal performance comparisons between SIP and CTP</title>
<p>We executed univariate ANOVA models for common variables between both programs (variables for the Socioeconomic Status Scale, the Lisres inventory and performance in attentional control, visuo spatial organization and planning), in order to compare basal cognitive performance and socio-environmental factors. The model included <italic>program</italic> (SIP/CTP) as the fixed factor; baseline cognitive performance and socio-demographic variables were the dependent variables (analyses were run separately for each variable); and <italic>age</italic>, <italic>gender</italic>, and <italic>socioeconomic group</italic> (UBN/SBN) were the covariables. Comparisons between the two programs regarding socioeconomic status and life conditions evidence significant differences between programs in some variables: overcrowding conditions [<italic>F</italic><sub>(1&#x02212;658)</sub> &#x0003D; 17.83; <italic>p</italic> &#x0003C; 0.0001], economic resources [<italic>F</italic><sub>(1&#x02212;522)</sub> &#x0003D; 5.14; <italic>p</italic> &#x0003D; 0.024], couple resources [<italic>F</italic><sub>(1&#x02212;399)</sub> &#x0003D; 4.19; <italic>p</italic> &#x0003D; 0.041], friends and social life resources [<italic>F</italic><sub>(1&#x02212;444)</sub> &#x0003D; 5.55; <italic>p</italic> &#x0003D; 0.019], positive life events [<italic>F</italic><sub>(1&#x02212;525)</sub> &#x0003D; 41.85; <italic>p</italic> &#x0003C; 0.0001], child stressors [<italic>F</italic><sub>(1&#x02212;513)</sub> &#x0003D; 12.58; <italic>p</italic> &#x0003C; 0.0001], family stressors [<italic>F</italic><sub>(1&#x02212;486)</sub> &#x0003D; 5.50; <italic>p</italic> &#x0003D; 0.019], and negative life events [<italic>F</italic><sub>(1&#x02212;525)</sub> &#x0003D; 13.67; <italic>p</italic> &#x0003C; 0.0001]. In the other variables (housing conditions, parent education and occupation levels, mother physical health, housing stressors, economic stressors, working stressors and resources, couple stressors, friends and social life stressors, working resources, child resources, and family resources) no significant differences were found between programs. With respect to cognitive performance at Time 1, results show significant differences in attentional control [<italic>F</italic><sub>(1&#x02212;500)</sub> &#x0003D; 20.68; <italic>p</italic> &#x0003C; 0.0001] and visuo-spatial organization [<italic>F</italic><sub>(1&#x02212;513)</sub> &#x0003D; 4.45; <italic>p</italic> &#x0003D; 0.035]. Also, results show marginally significant differences between programs in planning basal performance [<italic>F</italic><sub>(1&#x02212;565)</sub> &#x0003D; 3.17; <italic>p</italic> &#x0003D; 0.076].</p>
</sec>
</sec>
<sec sec-type="discussion" id="s4">
<title>Discussion</title>
<p>The main goals of the present study were to investigate: (1) how socio-environmental factors influence baseline cognitive performance; and (2) the influence of environmental factors on cognitive trajectories (based on pre- and post-intervention assessments of attention, memory, inhibitory control, flexibility and planning). We analyzed data from two intervention programs implemented in Argentina for such objectives. Both programs have their strengths and weaknesses: the SIP included a control group, and the cognitive training module consisted of an exercising approach&#x02014;same materials, different trials&#x02014;, whereas the CTP did not include a control group, but the cognitive training module included pedagogic activities. Despite these advantages and limitations, results allow identifying significant predictors of both basal cognitive performance and performance changes between cognitive assessments.</p>
<p>Although most of the socio-environmental factors considered in the present study have often been found to be related to cognitive functioning (e.g., Brooks-Gunn and Duncan, <xref ref-type="bibr" rid="B16">1997</xref>; Burchinal et al., <xref ref-type="bibr" rid="B18">2000</xref>; Bradley and Corwyn, <xref ref-type="bibr" rid="B14">2002</xref>; Evans, <xref ref-type="bibr" rid="B31">2004</xref>; Gassman-Pines and Yoshikawa, <xref ref-type="bibr" rid="B39">2006</xref>; Rhoades et al., <xref ref-type="bibr" rid="B88">2011</xref>; Sarsour et al., <xref ref-type="bibr" rid="B93">2011</xref>), they have rarely been simultaneously considered in training studies, so their effect on training outcome has been unclear.</p>
<p>Results across both intervention studies show that baseline performance of healthy preschoolers on a set of basic cognitive processes (attention, working memory, inhibitory control, flexibility, and planning), and their trajectories after training and exercising (based on pre- and post-intervention assessments) can be modulated by specific socio-environmental and individual factors. Specifically, for all cognitive processes in both programs, older children had higher baseline performance. Additionally, different variables were identified as influencing performance at baseline on attention, working memory, flexibility, and planning. Specifically, in the CTP, for attention, results show that children from dual-parent households and parents with better occupational backgrounds had higher performance at baseline. The same was verified for flexibility, where in addition, performance was higher at baseline among children with better housing conditions, as well as those who had more training sessions. Finally, in the case of working memory, our results show that baseline performance was higher for children living in homes with more ties support.</p>
<p>This pattern of results is in agreement with the literature on the impact of poverty on cognitive performance, suggesting that worse environmental conditions (i.e., <italic>housing conditions, parental occupation level, family composition, social resources</italic>) predict lower cognitive performance (e.g., Conger and Brent-Donnellan, <xref ref-type="bibr" rid="B24">2007</xref>; Hackman and Farah, <xref ref-type="bibr" rid="B43">2009</xref>; Lipina and Colombo, <xref ref-type="bibr" rid="B64">2009</xref>; Hackman et al., <xref ref-type="bibr" rid="B44">2010</xref>; Rhoades et al., <xref ref-type="bibr" rid="B88">2011</xref>). In addition, results could indicate a differential sensitivity of each cognitive process to different socio-environmental factors. To investigate and examine this differential sensitivity to context, similar studies with other tasks for the same processes, as well as with samples of a wider age range (from infancy through adolescence), should be implemented. In general, the literature about poverty and cognitive development is based on a broad definition of poverty. In that sense, the identification of differential sensitivity of cognitive control processes to some environmental factors would be important to the design of interventions aimed at improving cognitive performance (Lipina et al., <xref ref-type="bibr" rid="B69">2011</xref>).</p>
<p>With respect to cognitive trajectories from pre- to post-training, different profiles were also identified for each cognitive process and intervention program. In the SIP, for attention, working memory, flexibility, and planning, training impacts were verified (children in the intervention group had more improvement than children in the control group). Additionally, trajectories for the same tasks were predicted by some environmental factors and program characteristics. Specifically, in the case of flexibility, child <italic>age</italic> predicted the trajectory (older children had lower change in performance from pre- to post-test). A different pattern was verified for working memory trajectories, in which the variable <italic>social resources</italic> was a marginally significant predictor of change (performance change increased for children from homes with more social resources).</p>
<p>Results in the CTP show that <italic>housing conditions</italic> scores predicted the attention trajectory, indicating that change in performance from pre- to post assessment was higher for children with better home conditions, less overcrowding and fewer housing stressors. A different pattern was verified for planning trajectories, where <italic>family composition</italic> was the significant predictor of change. That is, change in planning performance from pre- to post-test was higher for children living in homes with two parents and with better parental occupation levels. Additionally, for both tasks (i.e., attention and planning), <italic>training exposure</italic> was also a marginally significant predictor of change in performance, indicating that children with more training sessions tended to have higher performances after training.</p>
<p>It is important to note that in the CTP, the design did not include a control group because governmental agencies did not allow researchers to do that. Nevertheless, taking into account results obtained in the SIP, designed as a randomized control program, results for the CTP show similar trends regarding the associations between better socio-environmental and individual factors (e.g., age, housing conditions, and family composition) and higher cognitive performance. Specifically, in both programs children improved their basal performance in attention, working memory, flexibility and planning. Results also suggest, for the same dependent variables that older children present larger performance increments. Additionally, for working memory, children with more family and child resources tended to perform better at baseline (CTP) or had higher post-training improvements (SIP).</p>
<p>Again, results for the trajectories were not homogeneous across dependent variables and programs. These variations are consistent with other studies that indicate that not all aspects of deprivation or intervention impacts affect the relation between cognitive performance and socioeconomic status (e.g., Hoff, <xref ref-type="bibr" rid="B48">2006</xref>). These differences, both between cognitive performances and between programs, could suggest differential susceptibilities of each cognitive process, as well as different patterns of cognitive integration throughout development (Garon et al., <xref ref-type="bibr" rid="B38">2008</xref>).</p>
<p>In the present study, it is important to consider that children attending both programs had different socio-demographic characteristics, and also had different cognitive performance in the same tasks at baseline stages. Furthermore, considering the absence of significant socio-environmental predictors in both programs for some baseline performances (e.g., planning in the SIP and CTP) and for cognitive trajectories (e.g., working memory, and flexibility in the CTP; and inhibitory control in the SIP), it is necessary to consider in future analyses other socio-environmental variables that could be related to those particular cognitive processes. Additionally, it would be important to consider the administration of other cognitive measures for the same processes (Lyons and Zelazo, <xref ref-type="bibr" rid="B72">2011</xref>; Bauer and Zelazo, <xref ref-type="bibr" rid="B6">2013</xref>). In spite of that, it is possible to conceive that not all cognitive skills are equally susceptible to training (Jolles and Crone, <xref ref-type="bibr" rid="B56">2012</xref>; Rueda et al., <xref ref-type="bibr" rid="B89">2012</xref>). Therefore, although we did not verify significant predictors for some baseline performances and for some cognitive trajectories in both programs, based on the present analyses we cannot conclude that socio-environmental conditions would not predict them.</p>
<p>Likewise, it is important to consider differences between sample characteristics when interpreting differences in results between programs and cognitive processes [e.g., intervention programs contexts of application (prekindergarten or child cares), staff instruction, supervision and curriculum design among childcare centers in CPT; districts of implementation; and PCA results] (Ramey and Ramey, <xref ref-type="bibr" rid="B84">2003</xref>; Barnett, <xref ref-type="bibr" rid="B5">2011</xref>; Reynolds et al., <xref ref-type="bibr" rid="B106">2011</xref>; Weiland and Yoshikawa, <xref ref-type="bibr" rid="B111">2012</xref>).</p>
<p>Besides the need to deepen the analysis of different sensitivity to the context of cognitive processes (both, baseline performances and the effects of interventions), studies with different cognitive measures, socio-environmental variables, different levels of analysis-such as individual susceptibility or sensitive periods (Thomas and Johnson, <xref ref-type="bibr" rid="B107">2008</xref>; Obradovi&#x00107; et al., <xref ref-type="bibr" rid="B80">2010</xref>), would contribute in such a sense.</p>
<p>Finally, it is important to mention that results must be tempered by some study limitations. First, each of the cognitive processes was measured using a single task. Future studies should consider using a variety of tasks that target the same cognitive process. Second, the analysis of change of performance over time by training is based on two time points of measurement. Although short time effects can be evaluated, future studies should include the analysis of long-term effects of training for a better understanding of the links between family and child background and training impact. Third, it is possible that the analyses in this study were underpowered, perhaps partially due to the number of evaluated subjects. Despite that, results tend to be similar to those of other studies that have used socio-environmental factors as well as training exposure to predict cognitive development (e.g., Ramey and Ramey, <xref ref-type="bibr" rid="B84">2003</xref>; Rhoades et al., <xref ref-type="bibr" rid="B88">2011</xref>). Finally, with respect to the program design, the CTP did not include a control group as the aim was to compare two training modalities (individual/group). Although results showed similar profiles in both programs, studies should include control designs.</p>
<p>Overall, this work contributes to elucidating the complex relationships between socio-environmental factors, cognitive development and intervention strategies, suggesting that environmental factors could be associated in particular ways with performance in tasks demanding attention, working memory, inhibitory control, cognitive flexibility and planning.</p>
</sec>
<sec sec-type="conclusions" id="s5">
<title>Conclusions</title>
<p>Analysis suggests that environmental factors moderated cognitive performance at baseline and through the course of the interventions in some, but not all, cognitive processes.</p>
<p>In sum, the contribution of the present study consists in the identification of factors that contribute to performance changes after cognitive interventions. The methodology implemented gives additional information about the impact of training, traditionally evaluated by comparing pre and post mean scores. It also contributes to the current literature about the emergence and development of cognitive processes, and their modulation by interventions in longitudinal analyses. The implemented approach and results are important for informing future intervention designs for both children and their families in Argentina.</p>
</sec>
<sec>
<title>Author contributions</title>
<p>M. Soledad Segretin participation as operator and supervisor in both training programs; tabulation and preparation of datasets; statistical analysis design and execution; manuscript writing. Sebasti&#x000E1;n J. Lipina participation as designer and coordinator in both intervention programs; statistical analysis design and supervision; manuscript writing. M. Julia Hermida collaboration in preparation of datasets; manuscript review. Tiffany D. Sheffield statistical analysis execution and supervision; manuscript review. Jennifer M. Nelson statistical analysis design and supervision; manuscript review. Kimberly A. Espy statistical analysis design and supervision; manuscript review. Jorge A. Colombo participation as designer in both intervention programs; manuscript review.</p>
<sec>
<title>Conflict of interest statement</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec>
</sec>
</body>
<back>
<ack>
<p>Research was supported by UNICEF-Argentina, Fundaci&#x000F3;n Bunge y Born, CONICET, Secretar&#x000ED;a de la Ni&#x000F1;ez y de la Familia (Gobierno de Salta), Fundaci&#x000F3;n Conectar, OMHSA, SAMSA, Unidad de Neurobiolog&#x000ED;a Aplicada (UNA, CEMIC-CONICET); and NIH Grant 2 R01 MH065668 (Kimberly Espy). The authors thank the following people for their contribution to the programs implementations: Mar&#x000ED;a In&#x000E9;s Martelli, Beatriz Vuelta, Ver&#x000F3;nica Cristiani, Marisol Blanco, Irene Injoque-Ricle, and Beatriz Stuto.</p>
</ack>
<ref-list>
<title>References</title>
<ref id="B1">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Anderson</surname> <given-names>P.</given-names></name></person-group> (<year>2002</year>). <article-title>Assessment and development of executive function (EF) during childhood</article-title>. <source>Child Neuropsychol</source>. <volume>8</volume>, <fpage>71</fpage>&#x02013;<lpage>82</lpage>. <pub-id pub-id-type="doi">10.1076/chin.8.2.71.8724</pub-id><pub-id pub-id-type="pmid">12638061</pub-id></citation>
</ref>
<ref id="B2">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Appleyard</surname> <given-names>K.</given-names></name> <name><surname>Egeland</surname> <given-names>B.</given-names></name> <name><surname>van Dulmen</surname> <given-names>M. H. M.</given-names></name> <name><surname>Sroufe</surname> <given-names>L. A.</given-names></name></person-group> (<year>2005</year>). <article-title>When more is not better: the role of cumulative risk in child behavior outcomes</article-title>. <source>J. Child Psychol. Psychiatry</source> <volume>46</volume>, <fpage>235</fpage>&#x02013;<lpage>245</lpage>. <pub-id pub-id-type="doi">10.1111/j.1469-7610.2004.00351.x</pub-id><pub-id pub-id-type="pmid">15755300</pub-id></citation>
</ref>
<ref id="B3">
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Arnau</surname> <given-names>J.</given-names></name> <name><surname>Balluerka</surname> <given-names>N.</given-names></name></person-group> (<year>2004</year>). <article-title>An&#x000E1;lisis de datos longitudinales y de curvas de crecimiento. Enfoque cl&#x000E1;sico y propuestas actuales. [longitudinal and growth trajectory data analysis. traditional approach and current proposals.]</article-title> <source>Psicothema</source> <volume>6</volume>, <fpage>156</fpage>&#x02013;<lpage>162</lpage>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.psicothema.com/psicothema.asp?ID=1175">http://www.psicothema.com/psicothema.asp?ID&#x0003D;1175</ext-link></citation>
</ref>
<ref id="B4">
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Arnau</surname> <given-names>J.</given-names></name> <name><surname>Bono</surname> <given-names>R.</given-names></name></person-group> (<year>2008</year>). <article-title>Estudios longitudinales. modelos de dise&#x000F1;o y an&#x000E1;lisis. [longitudinal studies. desing and analysis models.]</article-title> <source>Escritos de Psicolog&#x000ED;a</source> <volume>2</volume>, <fpage>32</fpage>&#x02013;<lpage>41</lpage>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.redalyc.org/articulo.oa?id=271020194005">http://www.redalyc.org/articulo.oa?id&#x0003D;271020194005</ext-link></citation>
</ref>
<ref id="B5">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Barnett</surname> <given-names>W. S.</given-names></name></person-group> (<year>2011</year>). <article-title>Effectiveness of early educational intervention</article-title>. <source>Science</source> <volume>333</volume>, <fpage>975</fpage>&#x02013;<lpage>978</lpage>. <pub-id pub-id-type="doi">10.1126/science.1204534</pub-id><pub-id pub-id-type="pmid">21852490</pub-id></citation>
</ref>
<ref id="B6">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bauer</surname> <given-names>P. J.</given-names></name> <name><surname>Zelazo</surname> <given-names>P. D.</given-names></name></person-group> (<year>2013</year>). <article-title>Ix. Nih toolbox cognition battery (cb): summary, conclusions, and implications for cognitive development</article-title>. <source>Monogr. Soc. Res. Child Dev</source>. <volume>78</volume>, <fpage>133</fpage>&#x02013;<lpage>46</lpage>. <pub-id pub-id-type="doi">10.1111/mono.12039</pub-id><pub-id pub-id-type="pmid">23952207</pub-id></citation>
</ref>
<ref id="B7">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Beatty</surname> <given-names>A.</given-names></name></person-group> (<year>2009</year>). <source>Benefit-Cost Analysis for Early Childhood Interventions</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>National Academies Press</publisher-name>.</citation>
</ref>
<ref id="B8">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Belsky</surname> <given-names>J.</given-names></name> <name><surname>Bakermans-Kranenburg</surname> <given-names>M. J.</given-names></name> <name><surname>van IJzendoorn</surname> <given-names>M. H.</given-names></name></person-group> (<year>2007</year>). <article-title>For better and for worse. differential susceptibility to environmental influences</article-title>. <source>Curr. Dir. Psychol. Sci</source>. <volume>16</volume>, <fpage>300</fpage>&#x02013;<lpage>304</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-8721.2007.00525.x</pub-id></citation>
</ref>
<ref id="B9">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Berch</surname> <given-names>D. B.</given-names></name> <name><surname>Krikorian</surname> <given-names>R.</given-names></name> <name><surname>Huha</surname> <given-names>E. M.</given-names></name></person-group> (<year>1998</year>). <article-title>The corsi block-tapping task: methodological and theoretical considerations</article-title>. <source>Brain Cogn</source>. <volume>38</volume>, <fpage>317</fpage>&#x02013;<lpage>338</lpage>. <pub-id pub-id-type="doi">10.1006/brcg.1998.1039</pub-id><pub-id pub-id-type="pmid">9841789</pub-id></citation>
</ref>
<ref id="B10">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Berkman</surname> <given-names>E. T.</given-names></name> <name><surname>Graham</surname> <given-names>A. M.</given-names></name> <name><surname>Fisher</surname> <given-names>P. A.</given-names></name></person-group> (<year>2012</year>). <article-title>Training self-control: a domain-general translational neuroscience approach</article-title>. <source>Child Dev. Perspect</source>. <volume>6</volume>, <fpage>374</fpage>&#x02013;<lpage>384</lpage>. <pub-id pub-id-type="doi">10.1111/j.1750-8606.2012.00248.x</pub-id><pub-id pub-id-type="pmid">23894251</pub-id></citation>
</ref>
<ref id="B11">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bierman</surname> <given-names>K. L.</given-names></name> <name><surname>Nic</surname> <given-names>R. L.</given-names></name> <name><surname>Greenberg</surname> <given-names>M. T.</given-names></name> <name><surname>Blair</surname> <given-names>C.</given-names></name> <name><surname>Domitrovich</surname> <given-names>C. E.</given-names></name></person-group> (<year>2008</year>). <article-title>Executive function and school readiness intervention: impact, moderation, and mediation in the head start REDI program</article-title>. <source>Dev. Psychopathol</source>. <volume>20</volume>, <fpage>821</fpage>&#x02013;<lpage>843</lpage>. <pub-id pub-id-type="doi">10.1017/S0954579408000394</pub-id><pub-id pub-id-type="pmid">18606033</pub-id></citation>
</ref>
<ref id="B12">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Bodrova</surname> <given-names>E.</given-names></name> <name><surname>Leong</surname> <given-names>D. J.</given-names></name></person-group> (<year>1996</year>). <source>Tools of the Mind. The Vygotskian Approach to Early Childhood Education</source>. <publisher-loc>New Jersey, NJ</publisher-loc>: <publisher-name>Prentice Hall</publisher-name>.</citation>
</ref>
<ref id="B13">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Boltvinik</surname> <given-names>J.</given-names></name></person-group> (<year>1995</year>). <source>Poverty Measurement Methods: An Overview</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>PNUD</publisher-name>.</citation>
</ref>
<ref id="B14">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bradley</surname> <given-names>R. H.</given-names></name> <name><surname>Corwyn</surname> <given-names>R. F.</given-names></name></person-group> (<year>2002</year>). <article-title>Socioeconomic status and child development</article-title>. <source>Annu. Rev. Psychol</source>. <volume>53</volume>, <fpage>371</fpage>&#x02013;<lpage>399</lpage>. <pub-id pub-id-type="doi">10.1146/annurev.psych.53.100901.135233</pub-id><pub-id pub-id-type="pmid">11752490</pub-id></citation>
</ref>
<ref id="B15">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bradley</surname> <given-names>R. H.</given-names></name> <name><surname>Corwyn</surname> <given-names>R. F.</given-names></name></person-group> (<year>2005</year>). <article-title>Caring for children around the world: a view from HOME</article-title>. <source>Int. J. Behav. Dev</source>. <volume>29</volume>, <fpage>468</fpage>&#x02013;<lpage>478</lpage>. <pub-id pub-id-type="doi">10.1177/01650250500146925</pub-id></citation>
</ref>
<ref id="B16">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Brooks-Gunn</surname> <given-names>J.</given-names></name> <name><surname>Duncan</surname> <given-names>G. J.</given-names></name></person-group> (<year>1997</year>). <article-title>The effects of poverty on children</article-title>. <source>Future Child</source>. <volume>7</volume>, <fpage>55</fpage>&#x02013;<lpage>71</lpage>. <pub-id pub-id-type="doi">10.2307/1602387</pub-id><pub-id pub-id-type="pmid">9299837</pub-id></citation>
</ref>
<ref id="B17">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bull</surname> <given-names>R.</given-names></name> <name><surname>Espy</surname> <given-names>K. A.</given-names></name> <name><surname>Wiebe</surname> <given-names>S. A.</given-names></name> <name><surname>Sheffield</surname> <given-names>T. D.</given-names></name> <name><surname>Nelson</surname> <given-names>J. M.</given-names></name></person-group> (<year>2011</year>). <article-title>Using confirmatory factor analysis to understand executive control in preschool children: sources of variation in emergent mathematic achievement</article-title>. <source>Dev. Sci</source>. <volume>14.</volume> <fpage>679</fpage>&#x02013;<lpage>692</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-7687.2010.01012.x</pub-id><pub-id pub-id-type="pmid">21676089</pub-id></citation>
</ref>
<ref id="B18">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Burchinal</surname> <given-names>M. R.</given-names></name> <name><surname>Roberts</surname> <given-names>J.</given-names></name> <name><surname>Hooper</surname> <given-names>S.</given-names></name> <name><surname>Zeisel</surname> <given-names>S. A.</given-names></name></person-group> (<year>2000</year>). <article-title>Cumulative risk and early cognitive development. a comparison of statistical risk models</article-title>. <source>Dev. Psychol</source>. <volume>36</volume>, <fpage>793</fpage>&#x02013;<lpage>807</lpage>. <pub-id pub-id-type="doi">10.1037/0012-1649.36.6.793</pub-id><pub-id pub-id-type="pmid">11081702</pub-id></citation>
</ref>
<ref id="B19">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Burger</surname> <given-names>K.</given-names></name></person-group> (<year>2010</year>). <article-title>How does early childhood care and education affect cognitive development? an international review of the effects of early interventions for children from different social backgrounds</article-title>. <source>Early Child. Res. Q</source>. <volume>25</volume>, <fpage>140</fpage>&#x02013;<lpage>165</lpage>. <pub-id pub-id-type="doi">10.1016/j.ecresq.2009.11.001</pub-id></citation>
</ref>
<ref id="B20">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Buss</surname> <given-names>C.</given-names></name> <name><surname>Davis</surname> <given-names>E. P.</given-names></name> <name><surname>Hobel</surname> <given-names>C. J.</given-names></name> <name><surname>Sandman</surname> <given-names>C. A.</given-names></name></person-group> (<year>2011</year>). <article-title>Maternal pregnancy-specific anxiety is associated with child executive function at 6&#x02013;9 years age</article-title>. <source>Stress</source> <volume>14</volume>, <fpage>665</fpage>&#x02013;<lpage>676</lpage>. <pub-id pub-id-type="doi">10.3109/10253890.2011.623250</pub-id><pub-id pub-id-type="pmid">21995526</pub-id></citation>
</ref>
<ref id="B21">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cadima</surname> <given-names>J.</given-names></name> <name><surname>McWilliam</surname> <given-names>R. A.</given-names></name> <name><surname>Leal</surname> <given-names>T.</given-names></name></person-group> (<year>2010</year>). <article-title>Environmental risk factors and children&#x00027;s literacy skills during the transition to elementary school</article-title>. <source>Int. J. Behav. Dev</source>. <volume>34</volume>, <fpage>24</fpage>&#x02013;<lpage>33</lpage>. <pub-id pub-id-type="doi">10.1177/0165025409345045</pub-id></citation>
</ref>
<ref id="B22">
<citation citation-type="book"><person-group person-group-type="author"><collab>CEPAL-UNICEF.</collab></person-group> (<year>2010</year>). <source>Pobreza infantil en Am&#x000E9;rica Latina y el Caribe (Childhood poverty in Latin America and the Caribbean)</source>. <publisher-loc>Washington DC</publisher-loc>: <publisher-name>Naciones Unidas</publisher-name>.</citation>
</ref>
<ref id="B23">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Colombo</surname> <given-names>J. A.</given-names></name> <name><surname>Lipina</surname> <given-names>S. J.</given-names></name></person-group> (<year>2005</year>) <source>Hacia un Programa P&#x000FA;blico de Estimulaci&#x000F3;n Cognitiva Infantil. Fundamentos, M&#x000E9;todos y Resultados de una Experiencia de Intervenci&#x000F3;n Preescolar Controlada. [Towards a Cognitive Stimulation Public Program. Foundations, Methods and Results from a Controlled Intervention in Preschoolers]</source>. <publisher-loc>Buenos Aires</publisher-loc>: <publisher-name>Editorial Paid&#x000F3;s</publisher-name>.</citation>
</ref>
<ref id="B24">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Conger</surname> <given-names>R. D.</given-names></name> <name><surname>Brent-Donnellan</surname> <given-names>M.</given-names></name></person-group> (<year>2007</year>). <article-title>An interactionist perspective on the socioeconomic context of human development</article-title>. <source>Annu. Rev. Psychol</source>. <volume>58</volume>, <fpage>175</fpage>&#x02013;<lpage>199</lpage>. <pub-id pub-id-type="doi">10.1146/annurev.psych.58.110405.085551</pub-id><pub-id pub-id-type="pmid">16903807</pub-id></citation>
</ref>
<ref id="B25">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Diamond</surname> <given-names>A.</given-names></name></person-group> (<year>2012</year>). <article-title>Activities and programs that improve children&#x00027;s executive functions</article-title>. <source>Curr. Dir. Psychol. Sci</source>. <volume>21</volume>, <fpage>335</fpage>&#x02013;<lpage>341</lpage>. <pub-id pub-id-type="doi">10.1177/0963721412453722</pub-id></citation>
</ref>
<ref id="B26">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Diamond</surname> <given-names>A.</given-names></name></person-group> (<year>2013</year>). <article-title>Executive functions</article-title>. <source>Annu. Rev. Psychol</source>. <volume>64</volume>, <fpage>135</fpage>&#x02013;<lpage>168</lpage>. <pub-id pub-id-type="doi">10.1146/annurev-psych-113011-143750</pub-id><pub-id pub-id-type="pmid">23020641</pub-id></citation>
</ref>
<ref id="B27">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Diamond</surname> <given-names>A.</given-names></name> <name><surname>Barnett</surname> <given-names>W. S.</given-names></name> <name><surname>Thomas</surname> <given-names>J.</given-names></name> <name><surname>Munro</surname> <given-names>S.</given-names></name></person-group> (<year>2007</year>). <article-title>Preschool program improves cognitive control</article-title>. <source>Science</source> <volume>318</volume>, <fpage>1387</fpage>&#x02013;<lpage>1388</lpage>. <pub-id pub-id-type="doi">10.1126/science.1151148</pub-id><pub-id pub-id-type="pmid">18048670</pub-id></citation>
</ref>
<ref id="B28">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Engle</surname> <given-names>P. L.</given-names></name> <name><surname>Black</surname> <given-names>M. M.</given-names></name> <name><surname>Behrman</surname> <given-names>J. R.</given-names></name> <name><surname>Cabral de Mello</surname> <given-names>M.</given-names></name> <name><surname>Gertler</surname> <given-names>P. J.</given-names></name> <name><surname>Kapiriri</surname> <given-names>L.</given-names></name> <etal/></person-group>. (<year>2007</year>). <article-title>Strategies to avoid the loss of developmental potential in more than 200 million children in the developing world</article-title>. <source>Lancet</source> <volume>369</volume>, <fpage>229</fpage>&#x02013;<lpage>242</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(07)60112-3</pub-id><pub-id pub-id-type="pmid">17240290</pub-id></citation>
</ref>
<ref id="B29">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Espinet</surname> <given-names>S. D.</given-names></name> <name><surname>Anderson</surname> <given-names>J. E.</given-names></name> <name><surname>Zelazo</surname> <given-names>P. D.</given-names></name></person-group> (<year>2012</year>). <article-title>Reflection training improves executive function in preschool-age children: behavioral and neural effects</article-title>. <source>Dev. Cogn. Neurosci</source>. <volume>4</volume>, <fpage>3</fpage>&#x02013;<lpage>15</lpage>. <pub-id pub-id-type="doi">10.1016/j.dcn.2012.11.009</pub-id><pub-id pub-id-type="pmid">23280362</pub-id></citation>
</ref>
<ref id="B30">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Espy</surname> <given-names>K. A.</given-names></name> <name><surname>Sheffield</surname> <given-names>T. D.</given-names></name> <name><surname>Wiebe</surname> <given-names>S. A.</given-names></name> <name><surname>Clark</surname> <given-names>C. A. C.</given-names></name> <name><surname>Moehr</surname> <given-names>M. J.</given-names></name></person-group> (<year>2011</year>). <article-title>Executive control and dimensions of problem behaviors in preschool children</article-title>. <source>J. Child Psychol. Psychiatry</source> <volume>52</volume>, <fpage>33</fpage>&#x02013;<lpage>46</lpage>. <pub-id pub-id-type="doi">10.1111/j.1469-7610.2010.02265.x</pub-id><pub-id pub-id-type="pmid">20500238</pub-id></citation>
</ref>
<ref id="B31">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Evans</surname> <given-names>G. W.</given-names></name></person-group> (<year>2004</year>). <article-title>The environment of childhood poverty</article-title>. <source>Am. Psychol</source>. <volume>59</volume>, <fpage>77</fpage>&#x02013;<lpage>92</lpage>. <pub-id pub-id-type="doi">10.1037/0003-066X.59.2.77</pub-id><pub-id pub-id-type="pmid">14992634</pub-id></citation>
</ref>
<ref id="B32">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Evans</surname> <given-names>G. W.</given-names></name> <name><surname>Li</surname> <given-names>D.</given-names></name> <name><surname>Sepanski Whipple</surname> <given-names>S.</given-names></name></person-group> (<year>2013</year>). <article-title>Cumulative risk and child development</article-title>. <source>Psychol. Bull</source>. <volume>16</volume>, <fpage>688</fpage>&#x02013;<lpage>696</lpage>. <pub-id pub-id-type="doi">10.1037/a0031808</pub-id><pub-id pub-id-type="pmid">23566018</pub-id></citation>
</ref>
<ref id="B33">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Feldman</surname> <given-names>R.</given-names></name> <name><surname>Eidelman</surname> <given-names>A. I.</given-names></name></person-group> (<year>2009</year>). <article-title>Biological and environmental initial conditions shape the trajectories of cognitive and social-emotional development across the first years of life</article-title>. <source>Dev. Sci</source>. <volume>12</volume>, <fpage>194</fpage>&#x02013;<lpage>200</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-7687.2008.00761.x</pub-id><pub-id pub-id-type="pmid">19120428</pub-id></citation>
</ref>
<ref id="B34">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ferrer</surname> <given-names>E.</given-names></name> <name><surname>Salthouse</surname> <given-names>T. A.</given-names></name> <name><surname>Stewart</surname> <given-names>W. F.</given-names></name> <name><surname>Schwartz</surname> <given-names>B. S.</given-names></name></person-group> (<year>2004</year>). <article-title>Modeling age and retest processes in longitudinal studies of cognitive abilities</article-title>. <source>Psychol. Aging</source> <volume>19</volume>, <fpage>243</fpage>&#x02013;<lpage>259</lpage>. <pub-id pub-id-type="doi">10.1037/0882-7974.19.2.243</pub-id><pub-id pub-id-type="pmid">15222818</pub-id></citation>
</ref>
<ref id="B35">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fisher</surname> <given-names>S. E.</given-names></name></person-group> (<year>2006</year>). <article-title>Tangled webs: tracing the connections between genes and cognition</article-title>. <source>Cognition</source> <volume>101</volume>, <fpage>270</fpage>&#x02013;<lpage>297</lpage>. <pub-id pub-id-type="doi">10.1016/j.cognition.2006.04.004</pub-id><pub-id pub-id-type="pmid">16764847</pub-id></citation>
</ref>
<ref id="B36">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Flouri</surname> <given-names>E.</given-names></name> <name><surname>Mavroveli</surname> <given-names>S.</given-names></name> <name><surname>Panourgia</surname> <given-names>C.</given-names></name></person-group> (<year>2013</year>). <article-title>The role of general cognitive ability in moderating the relation of adverse life events to emotional and behavioural problems</article-title>. <source>Br. J. Psychol</source>. <volume>104</volume>, <fpage>130</fpage>&#x02013;<lpage>139</lpage>. <pub-id pub-id-type="doi">10.1111/j.2044-8295.2012.02106.x</pub-id><pub-id pub-id-type="pmid">23320447</pub-id></citation>
</ref>
<ref id="B37">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Flouri</surname> <given-names>E.</given-names></name> <name><surname>Tzavidis</surname> <given-names>N.</given-names></name> <name><surname>Kallis</surname> <given-names>C.</given-names></name></person-group> (<year>2009</year>) <article-title>Adverse life events, area socio-economic disadvantage, and psychopathology and resilience in young children: The importance of risk factors&#x00027; accumulation and protective factors&#x00027; specificity</article-title>. <source>Eur. Child Adolesc. Psychiatry</source> <volume>19</volume>, <fpage>535</fpage>&#x02013;<lpage>546</lpage>. <pub-id pub-id-type="doi">10.1007/s00787-009-0068-x</pub-id><pub-id pub-id-type="pmid">19820985</pub-id></citation>
</ref>
<ref id="B38">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Garon</surname> <given-names>N.</given-names></name> <name><surname>Bryson</surname> <given-names>S. E.</given-names></name> <name><surname>Smith</surname> <given-names>I. M.</given-names></name></person-group> (<year>2008</year>). <article-title>Executive function in preschoolers: a review using an integrative framework</article-title>. <source>Psychol. Bull</source>. <volume>134</volume>, <fpage>31</fpage>&#x02013;<lpage>60</lpage>. <pub-id pub-id-type="doi">10.1037/0033-2909.134.1.31</pub-id><pub-id pub-id-type="pmid">18193994</pub-id></citation>
</ref>
<ref id="B39">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gassman-Pines</surname> <given-names>A.</given-names></name> <name><surname>Yoshikawa</surname> <given-names>H.</given-names></name></person-group> (<year>2006</year>). <article-title>The effects of antipoverty programs on children&#x00027;s cumulative level of poverty-related risk</article-title>. <source>Dev. Psychol</source>. <volume>42</volume>, <fpage>981</fpage>&#x02013;<lpage>999</lpage>. <pub-id pub-id-type="doi">10.1037/0012-1649.42.6.981</pub-id><pub-id pub-id-type="pmid">17087535</pub-id></citation>
</ref>
<ref id="B40">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gerstadt</surname> <given-names>C. L.</given-names></name> <name><surname>Hong</surname> <given-names>J. Y.</given-names></name> <name><surname>Diamond</surname> <given-names>A.</given-names></name></person-group> (<year>1994</year>). <article-title>The relationship between cognition and action: performance of children 3&#x000BD;-7 years old on a Stroop-like day-night test</article-title>. <source>Cognition</source> <volume>53</volume>, <fpage>129</fpage>&#x02013;<lpage>153</lpage>. <pub-id pub-id-type="doi">10.1016/0010-0277(94)90068-X</pub-id><pub-id pub-id-type="pmid">7805351</pub-id></citation>
</ref>
<ref id="B41">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Grantham-McGregor</surname> <given-names>S.</given-names></name> <name><surname>Cheung</surname> <given-names>Y. B.</given-names></name> <name><surname>Cueto</surname> <given-names>S.</given-names></name> <name><surname>Glewwe</surname> <given-names>P.</given-names></name> <name><surname>Richter</surname> <given-names>L.</given-names></name> <name><surname>Strupp</surname> <given-names>B.</given-names></name> <etal/></person-group>. (<year>2007</year>). <article-title>Developmental potential in the first 5 years for children in developing countries</article-title>. <source>Lancet</source> <volume>369</volume>, <fpage>60</fpage>&#x02013;<lpage>70</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(07)60032-4</pub-id><pub-id pub-id-type="pmid">17208643</pub-id></citation>
</ref>
<ref id="B42">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gray</surname> <given-names>R.</given-names></name> <name><surname>McCormick</surname> <given-names>M. C.</given-names></name></person-group> (<year>2005</year>). <article-title>Early childhood intervention programs in the US: recent advances and future recommendations</article-title>. <source>J. Prim. Prev</source>. <volume>26</volume>, <fpage>259</fpage>&#x02013;<lpage>275</lpage>. <pub-id pub-id-type="doi">10.1007/s10935-005-3600-x</pub-id><pub-id pub-id-type="pmid">15977054</pub-id></citation>
</ref>
<ref id="B43">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hackman</surname> <given-names>D. A.</given-names></name> <name><surname>Farah</surname> <given-names>M. J.</given-names></name></person-group> (<year>2009</year>). <article-title>Socioeconomic status and the developing brain</article-title>. <source>Trends Cogn. Sci</source>. <volume>30</volume>, <fpage>1</fpage>&#x02013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1016/j.tics.2008.11.003</pub-id></citation>
</ref>
<ref id="B44">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hackman</surname> <given-names>D.</given-names></name> <name><surname>Farah</surname> <given-names>M. J.</given-names></name> <name><surname>Meany</surname> <given-names>M. J.</given-names></name></person-group> (<year>2010</year>). <article-title>Socioeconomic status and the brain: mechanistic insights from human and animal research</article-title>. <source>Nat. Rev. Neurosci</source>. <volume>11</volume>, <fpage>651</fpage>&#x02013;<lpage>659</lpage>. <pub-id pub-id-type="doi">10.1038/nrn2897</pub-id><pub-id pub-id-type="pmid">20725096</pub-id></citation>
</ref>
<ref id="B45">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hall</surname> <given-names>J. E.</given-names></name> <name><surname>Sammons</surname> <given-names>P.</given-names></name> <name><surname>Sylva</surname> <given-names>K.</given-names></name> <name><surname>Melhuish</surname> <given-names>E.</given-names></name> <name><surname>Taggart</surname> <given-names>B.</given-names></name> <name><surname>Siraj-Blatchford</surname> <given-names>I.</given-names></name> <etal/></person-group>. (<year>2010</year>). <article-title>Measuring the combined risk to young children&#x00027;s cognitive development: An alternative to cumulative indices</article-title>. <source>Br. J. Dev. Psychol</source>. <volume>28</volume>, <fpage>219</fpage>&#x02013;<lpage>238</lpage>. <pub-id pub-id-type="doi">10.1348/026151008X399925</pub-id><pub-id pub-id-type="pmid">20481385</pub-id></citation>
</ref>
<ref id="B46">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hamilton</surname> <given-names>M.</given-names></name></person-group> (<year>1959</year>). <article-title>The assessment of anxiety states by rating</article-title>. <source>Br. J. Med. Psychol</source>. <volume>32</volume>, <fpage>50</fpage>&#x02013;<lpage>55</lpage>. <pub-id pub-id-type="doi">10.1111/j.2044-8341.1959.tb00467.x</pub-id><pub-id pub-id-type="pmid">13638508</pub-id></citation>
</ref>
<ref id="B47">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hamilton</surname> <given-names>M.</given-names></name></person-group> (<year>1960</year>). <article-title>A rating scale for depression</article-title>. <source>J. Neurol. Neurosurg. Psychiatry</source> <volume>23</volume>, <fpage>56</fpage>&#x02013;<lpage>62</lpage>. <pub-id pub-id-type="doi">10.1136/jnnp.23.1.56</pub-id><pub-id pub-id-type="pmid">14399272</pub-id></citation>
</ref>
<ref id="B48">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hoff</surname> <given-names>E.</given-names></name></person-group> (<year>2006</year>). <article-title>How social contexts support and shape language development</article-title>. <source>Dev. Rev</source>. <volume>26</volume>, <fpage>55</fpage>&#x02013;<lpage>88</lpage>. <pub-id pub-id-type="doi">10.1016/j.dr.2005.11.002</pub-id><pub-id pub-id-type="pmid">24383661</pub-id></citation>
</ref>
<ref id="B49">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Howe</surname> <given-names>L. D.</given-names></name> <name><surname>Tilling</surname> <given-names>K.</given-names></name> <name><surname>Galobardes</surname> <given-names>B.</given-names></name> <name><surname>Smith</surname> <given-names>G. D.</given-names></name> <name><surname>Gunnell</surname> <given-names>D.</given-names></name> <name><surname>Lawlor</surname> <given-names>D. A.</given-names></name></person-group> (<year>2012</year>). <article-title>Socioeconomic differences in childhood growth trajectories: at what age do height inequalities emerge?</article-title> <source>J. Epidemiol. Comm. Health</source> <volume>66</volume>, <fpage>143</fpage>&#x02013;<lpage>148</lpage>. <pub-id pub-id-type="doi">10.1136/jech.2010.113068</pub-id><pub-id pub-id-type="pmid">20724285</pub-id></citation>
</ref>
<ref id="B50">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hughes</surname> <given-names>C.</given-names></name> <name><surname>Graham</surname> <given-names>A.</given-names></name></person-group> (<year>2002</year>). <article-title>Measuring executive functions in childhood: problems and solutions?</article-title> <source>Child Adolesc. Ment. Health</source> <volume>7</volume>, <fpage>131</fpage>&#x02013;<lpage>142</lpage>. <pub-id pub-id-type="doi">10.1111/1475-3588.00024</pub-id></citation>
</ref>
<ref id="B51">
<citation citation-type="book"><person-group person-group-type="author"><collab>INDEC.</collab></person-group> (<year>2001</year>). <source>Censo Nacional. Ministerio de Econom&#x000ED;a (National Census. Ministery of Economy)</source>. <publisher-loc>Buenos Aires</publisher-loc>: <publisher-name>National Institute for Statistics and Census (INDEC)</publisher-name>.</citation>
</ref>
<ref id="B52">
<citation citation-type="book"><person-group person-group-type="author"><collab>INDEC.</collab></person-group> (<year>2006</year>). <source>Incidencia de la Pobreza y de la Indigencia en Menores de 14 A&#x000F1;os de 28 Aglomerados Urbanos (Incidence of Poverty and Indigence in Children Under 14 Years of 28 Urban Areas)</source>. <publisher-loc>Buenos Aires</publisher-loc>: <publisher-name>National Institute for Statistics and Census (INDEC)</publisher-name>.</citation>
</ref>
<ref id="B54">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Isquith</surname> <given-names>P.</given-names></name> <name><surname>Crawford</surname> <given-names>J. S.</given-names></name> <name><surname>Espy</surname> <given-names>K. A.</given-names></name> <name><surname>Gioia</surname> <given-names>G. A.</given-names></name></person-group> (<year>2005</year>). <article-title>Assessment of executive function in preschool-aged children</article-title>. <source>Ment. Retard. Dev. Disabil</source>. <volume>11</volume>, <fpage>209</fpage>&#x02013;<lpage>215</lpage>. <pub-id pub-id-type="doi">10.1002/mrdd.20075</pub-id><pub-id pub-id-type="pmid">16161093</pub-id></citation>
</ref>
<ref id="B55">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jacques</surname> <given-names>S.</given-names></name> <name><surname>Zelazo</surname> <given-names>P. D.</given-names></name></person-group> (<year>2001</year>). <article-title>The Flexible Item Selection Task (FIST): a measure of executive function in preschoolers</article-title>. <source>Dev. Neuropsychol</source>. <volume>20</volume>, <fpage>573</fpage>&#x02013;<lpage>591</lpage>. <pub-id pub-id-type="doi">10.1207/S15326942DN2003_2</pub-id><pub-id pub-id-type="pmid">12002094</pub-id></citation>
</ref>
<ref id="B56">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jolles</surname> <given-names>D. D.</given-names></name> <name><surname>Crone</surname> <given-names>E. A.</given-names></name></person-group> (<year>2012</year>). <article-title>Training the developing brain: a neurocognitive perspective</article-title>. <source>Front. Hum. Neurosci</source>. <volume>6</volume>:<issue>76</issue>. <pub-id pub-id-type="doi">10.3389/fnhum.2012.00076</pub-id><pub-id pub-id-type="pmid">22509161</pub-id></citation>
</ref>
<ref id="B57">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Karoly</surname> <given-names>L. A.</given-names></name> <name><surname>Kilburn</surname> <given-names>M. R.</given-names></name> <name><surname>Cannon</surname> <given-names>J. S.</given-names></name></person-group> (<year>2005</year>). <source>Early childhood interventions. Proven Results, Future Promise</source>. <publisher-loc>Pennsylvania, PA</publisher-loc>: <publisher-name>RAND Labor and Population</publisher-name>.</citation>
</ref>
<ref id="B58">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kiernan</surname> <given-names>K. E.</given-names></name> <name><surname>Huerta</surname> <given-names>M. C.</given-names></name></person-group> (<year>2008</year>). <article-title>Economic deprivation, maternal depression, parenting and children&#x00027;s cognitive and emotional development in early childhood</article-title>. <source>Br. J. Sociol</source>. <volume>59</volume>, <fpage>783</fpage>&#x02013;<lpage>806</lpage>. <pub-id pub-id-type="doi">10.1111/j.1468-4446.2008.00219.x</pub-id><pub-id pub-id-type="pmid">19035922</pub-id></citation>
</ref>
<ref id="B59">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kiernan</surname> <given-names>K. E.</given-names></name> <name><surname>Mensah</surname> <given-names>F. K.</given-names></name></person-group> (<year>2009</year>). <article-title>Poverty, maternal depression, family status and children&#x00027;s cognitive and behavioural development in early childhood: a longitudinal study</article-title>. <source>J. Soc. Policy</source> <volume>38</volume>, <fpage>569</fpage>&#x02013;<lpage>588</lpage>. <pub-id pub-id-type="doi">10.1017/S0047279409003250</pub-id></citation>
</ref>
<ref id="B61">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Klingberg</surname> <given-names>T.</given-names></name> <name><surname>Fernell</surname> <given-names>E.</given-names></name> <name><surname>Olesen</surname> <given-names>P. J.</given-names></name> <name><surname>Johnson</surname> <given-names>M.</given-names></name> <name><surname>Gustafsson</surname> <given-names>P.</given-names></name> <name><surname>Dahlstrom</surname> <given-names>K.</given-names></name> <etal/></person-group>. (<year>2005</year>). <article-title>Computerized training of working memory in children with ADHD- a randomized controlled trial</article-title>. <source>J. Acad. Child Adolesc. Psychiatry</source> <volume>44</volume>, <fpage>177</fpage>&#x02013;<lpage>186</lpage>. <pub-id pub-id-type="doi">10.1097/00004583-200502000-00010</pub-id><pub-id pub-id-type="pmid">15689731</pub-id></citation>
</ref>
<ref id="B62">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Korkman</surname> <given-names>M.</given-names></name> <name><surname>Kirk</surname> <given-names>U.</given-names></name> <name><surname>Kemp</surname> <given-names>S.</given-names></name></person-group> (<year>1998</year>). <source>NEPSY: A Developmental Neuropsychological Assessment</source>, <publisher-loc>San Antonio, TX</publisher-loc>: <publisher-name>Psychological Corporation</publisher-name>.</citation>
</ref>
<ref id="B63">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Leinonen</surname> <given-names>J. A.</given-names></name> <name><surname>Solantaus</surname> <given-names>T. S.</given-names></name> <name><surname>Punam&#x000E4;ki</surname> <given-names>R. L.</given-names></name></person-group> (<year>2002</year>). <article-title>The specific mediating paths between economic hardship and the quality of parenting</article-title>. <source>Int. J. Behav. Dev</source>. <volume>26</volume>, <fpage>423</fpage>&#x02013;<lpage>435</lpage>. <pub-id pub-id-type="doi">10.1080/01650250143000364</pub-id></citation>
</ref>
<ref id="B64">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Colombo</surname> <given-names>J. A.</given-names></name></person-group> (<year>2009</year>). <source>Poverty and Brain Development During Childhood: An Approach From Cognitive Psychology and Neuroscience</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>American Psychological Association</publisher-name>. <pub-id pub-id-type="doi">10.1037/11879-000</pub-id></citation>
</ref>
<ref id="B65">
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Martelli</surname> <given-names>M. I.</given-names></name> <name><surname>Vuelta</surname> <given-names>B. L.</given-names></name> <name><surname>Colombo</surname> <given-names>J. A.</given-names></name></person-group> (<year>2005</year>). <article-title>Performance on the AnoB task of argentinean infants from unsatisfied basic needs homes</article-title>. <source>Int. J. Psychol</source>. <volume>39</volume>, <fpage>49</fpage>&#x02013;<lpage>60</lpage>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.psicorip.org/Resumos/PerP/RIP/RIP036a0/RIP03906.pdf">http://www.psicorip.org/Resumos/PerP/RIP/RIP036a0/RIP03906.pdf</ext-link></citation>
</ref>
<ref id="B66">
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Martelli</surname> <given-names>M. I.</given-names></name> <name><surname>Vuelta</surname> <given-names>B. L.</given-names></name> <name><surname>Injoque Ricle</surname> <given-names>I.</given-names></name> <name><surname>Colombo</surname> <given-names>J. A.</given-names></name></person-group> (<year>2004</year>). <article-title>Pobreza y desempe&#x000F1;o ejecutivo en alumnos preescolares de la ciudad de buenos aires (Argentina)</article-title>. <source>Interdisciplinaria</source> <volume>21</volume>, <fpage>153</fpage>&#x02013;<lpage>193</lpage>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.scielo.org.ar/pdf/interd/v21n2/v21n2a02">http://www.scielo.org.ar/pdf/interd/v21n2/v21n2a02</ext-link></citation>
</ref>
<ref id="B67">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Segretin</surname> <given-names>M. S.</given-names></name></person-group> (<year>2006</year>). <article-title>Pobreza y salud mental infantil: aportes de la neurociencia cognitiva</article-title>, en <source>Psicolog&#x000ED;a de la Salud Infantil, Cap&#x000ED;tulo 11</source>, eds <person-group person-group-type="editor"><name><surname>Osorio</surname> <given-names>M.</given-names></name> <name><surname>Oblitas</surname> <given-names>L. A.</given-names></name></person-group> [&#x0201C;Poverty and mental health in children: contribution from the cognitive neuroscience,&#x0201D; in <italic>Child Health Psychology, Chapter 11</italic>] (<publisher-loc>Bogot&#x000E1;</publisher-loc>: <publisher-name>Psicom Editores</publisher-name>), <fpage>1</fpage>&#x02013;<lpage>24</lpage>.</citation>
</ref>
<ref id="B68">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Segretin</surname> <given-names>M. S.</given-names></name> <name><surname>Hermida</surname> <given-names>M. J.</given-names></name> <name><surname>Colombo</surname> <given-names>J. A.</given-names></name></person-group> (<year>2012</year>). <article-title>Research on child poverty and development from a cognitive neuroscience perspective: examples of studies in argentina</article-title>, in <source>Child and Adolescent Mental Health, Chapter 17</source> ed <person-group person-group-type="editor"><name><surname>Nayar</surname> <given-names>U. S.</given-names></name></person-group> (<publisher-loc>Mumbai</publisher-loc>: <publisher-name>SAGE</publisher-name>), <fpage>256</fpage>&#x02013;<lpage>274</lpage>.</citation>
</ref>
<ref id="B69">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Simonds</surname> <given-names>J.</given-names></name> <name><surname>Segretin</surname> <given-names>M. S.</given-names></name></person-group> (<year>2011</year>). <article-title>Recognizing the child in child poverty</article-title>. <source>Vulnerable Child. Youth Stud</source>. <volume>6</volume>, <fpage>8</fpage>&#x02013;<lpage>17</lpage>. <pub-id pub-id-type="doi">10.1080/17450128.2010.521598</pub-id></citation>
</ref>
<ref id="B70">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lipina</surname> <given-names>S.</given-names></name> <name><surname>Segretin</surname> <given-names>S.</given-names></name> <name><surname>Hermida</surname> <given-names>J.</given-names></name> <name><surname>Prats</surname> <given-names>L.</given-names></name> <name><surname>Fracchia</surname> <given-names>C.</given-names></name> <name><surname>L&#x000F3;pez Camelo</surname> <given-names>J.</given-names></name> <etal/></person-group>. (<year>2013</year>). <article-title>Linking childhood poverty and cognition: environmental mediators of non-verbal executive control in an argentine sample</article-title>. <source>Dev. Sci</source>. <volume>16</volume>, <fpage>697</fpage>&#x02013;<lpage>707</lpage>. <pub-id pub-id-type="doi">10.1111/desc.12080</pub-id><pub-id pub-id-type="pmid">24033575</pub-id></citation>
</ref>
<ref id="B71">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Long</surname> <given-names>J. D.</given-names></name> <name><surname>Pellegrini</surname> <given-names>A. D.</given-names></name></person-group> (<year>2003</year>). <article-title>Studying change in dominance and bulling with linear mixed models</article-title>. <source>School Psych. Rev</source>. <volume>32</volume>, <fpage>401</fpage>&#x02013;<lpage>417</lpage>.</citation>
</ref>
<ref id="B72">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lyons</surname> <given-names>K. E.</given-names></name> <name><surname>Zelazo</surname> <given-names>P.D.</given-names></name></person-group> (<year>2011</year>). <article-title>Monitoring, metacognition, and executive function: elucidating the role of self-reflection in the development of self-regulation</article-title>. <source>Adv. Child Dev. Behav</source>. <volume>40</volume>, <fpage>379</fpage>&#x02013;<lpage>412</lpage>. <pub-id pub-id-type="doi">10.1016/B978-0-12-386491-8.00010-4</pub-id><pub-id pub-id-type="pmid">21887967</pub-id></citation>
</ref>
<ref id="B73">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Marsh</surname> <given-names>H. L.</given-names></name> <name><surname>Stavropoulos</surname> <given-names>J.</given-names></name> <name><surname>Nienhuis</surname> <given-names>T.</given-names></name> <name><surname>Legerstee</surname> <given-names>M.</given-names></name></person-group> (<year>2010</year>). <article-title>Six- and 9-month-old infants discriminate between goals despite similar action patterns</article-title>. <source>Infancy</source> <volume>15</volume>, <fpage>94</fpage>&#x02013;<lpage>106</lpage>. <pub-id pub-id-type="doi">10.1111/j.1532-7078.2009.00002.x</pub-id></citation>
</ref>
<ref id="B74">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Martelli</surname> <given-names>M. I.</given-names></name> <name><surname>Vuelta</surname> <given-names>B. L.</given-names></name> <name><surname>Blanco</surname> <given-names>M.</given-names></name> <name><surname>Cristiani</surname> <given-names>V.</given-names></name> <name><surname>Segretin</surname> <given-names>M. S.</given-names></name> <name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <etal/></person-group>. (<year>2007</year>). <article-title>Programas de intervenci&#x000F3;n temprana en nuestro pa&#x000ED;s. Experiencia de una aplicaci&#x000F3;n individual de estimulaci&#x000F3;n cognitiva</article-title>, en <source>Pobreza y desarrollo infantil. Una contribuci&#x000F3;n multidisciplinaria, Cap&#x000ED;tulo 10</source>, ed <person-group person-group-type="editor"><name><surname>Colombo</surname> <given-names>J. A.</given-names></name></person-group> [&#x0201C;Early intervention programs in our country. Experience of an individual application of cognitive stimulation,&#x0201D; in <italic>Poverty and child development. A multidisciplinary contribution, Chapter 10</italic>] (<publisher-loc>Buenos Aires</publisher-loc>: <publisher-name>Editorial Paid&#x000F3;s</publisher-name>), <fpage>229</fpage>&#x02013;<lpage>250</lpage>.</citation>
</ref>
<ref id="B75">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>McCandliss</surname> <given-names>B. D.</given-names></name> <name><surname>Beck</surname> <given-names>I. L.</given-names></name> <name><surname>Sandak</surname> <given-names>R.</given-names></name> <name><surname>Perfetti</surname> <given-names>C.</given-names></name></person-group> (<year>2003</year>). <article-title>Focusing attention on decoding for children with poor reading skills: design and preliminary tests of the word building intervention</article-title>. <source>Sci. Stud. Read</source>. <volume>7</volume>, <fpage>75</fpage>&#x02013;<lpage>104</lpage>. <pub-id pub-id-type="doi">10.1207/S1532799XSSR0701_05</pub-id></citation>
</ref>
<ref id="B76">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>McLoyd</surname> <given-names>V. C.</given-names></name></person-group> (<year>1998</year>). <article-title>Socioeconomic disadvantage and child development</article-title>. <source>Am. Psychol</source>. <volume>53</volume>, <fpage>185</fpage>&#x02013;<lpage>204</lpage>. <pub-id pub-id-type="doi">10.1037/0003-066X.53.2.185</pub-id><pub-id pub-id-type="pmid">9491747</pub-id></citation>
</ref>
<ref id="B77">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Meunier</surname> <given-names>J. C.</given-names></name> <name><surname>Boyle</surname> <given-names>M.</given-names></name> <name><surname>O&#x00027;Connor</surname> <given-names>T. G.</given-names></name> <name><surname>Jenkins</surname> <given-names>J. M.</given-names></name></person-group> (<year>2013</year>). <article-title>Multilevel mediation: Cumulative contextual risk, maternal differential treatment, and children&#x00027;s behavior within families</article-title>. <source>Child Dev</source>. <volume>84</volume>, <fpage>1594</fpage>&#x02013;<lpage>1615</lpage>. <pub-id pub-id-type="doi">10.1111/cdev.12066</pub-id><pub-id pub-id-type="pmid">23397960</pub-id></citation>
</ref>
<ref id="B78">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Mikulic</surname> <given-names>I. M.</given-names></name></person-group> (<year>1999</year>). <source>La evaluaci&#x000F3;n Psicol&#x000F3;gica de los Recursos Sociales y los Estresores de vida. Aportes del Inventario LISRES. [Psychological Assessment of Social Resources and Life Stressors. Contributions from the LISRES Inventory]</source>. <publisher-loc>Buenos Aires</publisher-loc>: <publisher-name>Saint Claire Editora</publisher-name>.</citation>
</ref>
<ref id="B79">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Najman</surname> <given-names>J. M.</given-names></name> <name><surname>Aird</surname> <given-names>R.</given-names></name> <name><surname>Bor</surname> <given-names>W.</given-names></name> <name><surname>O&#x00027;Callaghan</surname> <given-names>M.</given-names></name> <name><surname>Williams</surname> <given-names>G. M.</given-names></name> <name><surname>Shuttlewood</surname> <given-names>G. J.</given-names></name></person-group> (<year>2004</year>). <article-title>The generational transmission of socioeconomic inequalities in child cognitive development and emotional health</article-title>. <source>Soc. Sci. Med</source>. <volume>58</volume>, <fpage>1147</fpage>&#x02013;<lpage>1158</lpage>. <pub-id pub-id-type="doi">10.1016/S0277-9536(03)00286-7</pub-id><pub-id pub-id-type="pmid">14723909</pub-id></citation>
</ref>
<ref id="B80">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Obradovi&#x00107;</surname> <given-names>J.</given-names></name> <name><surname>Bush</surname> <given-names>N. R.</given-names></name> <name><surname>Stamperdahl</surname> <given-names>J.</given-names></name> <name><surname>Adler</surname> <given-names>N. E.</given-names></name> <name><surname>Boyce</surname> <given-names>W. T.</given-names></name></person-group> (<year>2010</year>). <article-title>Biological sensitivity to context: the interactive effects of stress reactivity and family adversity on socioemotional behavior and school readiness</article-title>. <source>Child Dev</source>. <volume>81</volume>, <fpage>270</fpage>&#x02013;<lpage>289</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-8624.2009.01394.x</pub-id><pub-id pub-id-type="pmid">20331667</pub-id></citation>
</ref>
<ref id="B81">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Perez-Johnson</surname> <given-names>I.</given-names></name> <name><surname>Maynard</surname> <given-names>R.</given-names></name></person-group> (<year>2007</year>). <article-title>The case for early, targeted interventions to prevent academic failure</article-title>. <source>Peabody J. Educ</source>. <volume>82</volume>, <fpage>587</fpage>&#x02013;<lpage>616</lpage>. <pub-id pub-id-type="doi">10.1080/01619560701602983</pub-id></citation>
</ref>
<ref id="B83">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ramey</surname> <given-names>C. T.</given-names></name> <name><surname>Ramey</surname> <given-names>S. L.</given-names></name></person-group> (<year>1998</year>). <article-title>Early intervention and early experience</article-title>. <source>Am. Psychol</source>. <volume>53</volume>, <fpage>109</fpage>&#x02013;<lpage>120</lpage>. <pub-id pub-id-type="doi">10.1037/0003-066X.53.2.109</pub-id><pub-id pub-id-type="pmid">9491742</pub-id></citation>
</ref>
<ref id="B84">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Ramey</surname> <given-names>S.</given-names></name> <name><surname>Ramey</surname> <given-names>C. T.</given-names></name></person-group> (<year>2003</year>). <article-title>Understanding efficacy of early educational programs: critical design, practice, and policy issues</article-title>, in <source>Early Childhood Programs for a New Century</source>, eds <person-group person-group-type="editor"><name><surname>Reynolds</surname> <given-names>A. J.</given-names></name> <name><surname>Wang</surname> <given-names>M. C.</given-names></name> <name><surname>Walberg</surname> <given-names>H. J.</given-names></name></person-group> (<publisher-loc>Washington, DC</publisher-loc>: <publisher-name>Child Welfare League of America Press</publisher-name>), <fpage>35</fpage>&#x02013;<lpage>65</lpage>.</citation>
</ref>
<ref id="B85">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Raver</surname> <given-names>C. C.</given-names></name> <name><surname>Blair</surname> <given-names>C.</given-names></name> <name><surname>Willoughby</surname> <given-names>M.</given-names></name></person-group> (<year>2013</year>). <article-title>Poverty as a predictor of 4-year-olds&#x00027; executive function: new perspectives on models of differential susceptibility</article-title>. <source>Dev. Psychol</source>. <volume>49</volume>, <fpage>292</fpage>&#x02013;<lpage>304</lpage>. <pub-id pub-id-type="doi">10.1037/a0028343</pub-id><pub-id pub-id-type="pmid">22563675</pub-id></citation>
</ref>
<ref id="B86">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Raver</surname> <given-names>C. C.</given-names></name> <name><surname>Gershoff</surname> <given-names>E. T.</given-names></name> <name><surname>Aber</surname> <given-names>J. L.</given-names></name></person-group> (<year>2007</year>). <article-title>Testing equivalence of mediating models of income, parenting, and school readiness for white, black, and hispanic children in a national sample</article-title>. <source>Child Dev</source>. <volume>78</volume>, <fpage>96</fpage>&#x02013;<lpage>115</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-8624.2007.00987.x</pub-id><pub-id pub-id-type="pmid">17328695</pub-id></citation>
</ref>
<ref id="B87">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Reynolds</surname> <given-names>A. J.</given-names></name> <name><surname>Temple</surname> <given-names>J. A.</given-names></name></person-group> (<year>2005</year>). <article-title>Priorities for a new century of early childhood programs</article-title>. <source>Infants Young Child</source>. <volume>18</volume>, <fpage>104</fpage>&#x02013;<lpage>118</lpage>. <pub-id pub-id-type="doi">10.1097/00001163-200504000-00004</pub-id></citation>
</ref>
<ref id="B88">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Rhoades</surname> <given-names>B. L.</given-names></name> <name><surname>Greenberg</surname> <given-names>M. T.</given-names></name> <name><surname>Lanza</surname> <given-names>S. T.</given-names></name> <name><surname>Blair</surname> <given-names>C.</given-names></name></person-group> (<year>2011</year>). <article-title>Demographic and familial predictors of early executive function development: contribution of a person-centered perspective</article-title>. <source>J. Exp. Child Psychol</source>. <volume>38</volume>, <fpage>638</fpage>&#x02013;<lpage>662</lpage>. <pub-id pub-id-type="doi">10.1016/j.jecp.2010.08.004</pub-id><pub-id pub-id-type="pmid">20828709</pub-id></citation>
</ref>
<ref id="B89">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Rueda</surname> <given-names>M. R.</given-names></name> <name><surname>C&#x000F3;mbita</surname> <given-names>L. M.</given-names></name> <name><surname>Paz-Alonso</surname> <given-names>P. M.</given-names></name> <name><surname>Pozuelos</surname> <given-names>J. P.</given-names></name> <name><surname>Abundis</surname> <given-names>A.</given-names></name></person-group> (<year>2012</year>). <article-title>Genetic variation modulates the effect of executive attention training in preschool children</article-title>. <source>Cogn. Neurosci. Soc. Abstr</source>. <volume>D25</volume>, <fpage>109</fpage>. <pub-id pub-id-type="doi">10.1016/j.dcn.2011.09.004</pub-id></citation>
</ref>
<ref id="B90">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Rueda</surname> <given-names>M. R.</given-names></name> <name><surname>Rothbart</surname> <given-names>M. K.</given-names></name> <name><surname>McCandliss</surname> <given-names>B. D.</given-names></name> <name><surname>Saccomanno</surname> <given-names>L.</given-names></name> <name><surname>Posner</surname> <given-names>M. I.</given-names></name></person-group> (<year>2005</year>). <article-title>Training, maturation, and genetic influences on the development of executive attention</article-title>. <source>Proc. Nati. Acad. Sci. U.S.A</source>. <volume>102</volume>, <fpage>14931</fpage>&#x02013;<lpage>14936</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.0506897102</pub-id><pub-id pub-id-type="pmid">16192352</pub-id></citation>
</ref>
<ref id="B91">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sameroff</surname> <given-names>A. J.</given-names></name> <name><surname>Seifer</surname> <given-names>R.</given-names></name> <name><surname>Baldwin</surname> <given-names>A.</given-names></name> <name><surname>Baldwin</surname> <given-names>C.</given-names></name></person-group> (<year>1993</year>). <article-title>Stability of intelligence from preschool to adolescence: the influence of social and family risk factor</article-title>. <source>Child Dev</source>. <volume>64</volume>, <fpage>80</fpage>&#x02013;<lpage>97</lpage>. <pub-id pub-id-type="doi">10.2307/1131438</pub-id><pub-id pub-id-type="pmid">8436039</pub-id></citation>
</ref>
<ref id="B92">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Santos</surname> <given-names>D. N., O.</given-names></name> <name><surname>Assis</surname> <given-names>A. M.</given-names></name> <name><surname>Bastos</surname> <given-names>A. C. S.</given-names></name> <name><surname>Santos</surname> <given-names>L. M.</given-names></name> <name><surname>Santos</surname> <given-names>C. A. S. T.</given-names></name> <name><surname>Strina</surname> <given-names>A.</given-names></name> <etal/></person-group>. (<year>2008</year>). <article-title>Determinants of cognitive function in childhood: A cohort study in a middle income context</article-title>. <source>BMC Public Health</source> <volume>8</volume>:<fpage>202</fpage>. <pub-id pub-id-type="doi">10.1186/1471-2458-8-202</pub-id><pub-id pub-id-type="pmid">18534035</pub-id></citation>
</ref>
<ref id="B93">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sarsour</surname> <given-names>K.</given-names></name> <name><surname>Sheridan</surname> <given-names>M.</given-names></name> <name><surname>Jutte</surname> <given-names>D.</given-names></name> <name><surname>Nuru-Jeter</surname> <given-names>A.</given-names></name> <name><surname>Hinshaw</surname> <given-names>S.</given-names></name> <name><surname>Boyce</surname> <given-names>W. T.</given-names></name></person-group> (<year>2011</year>). <article-title>Family socioeconomic status and child executive functions: the roles of language, home environment, and single parenthood</article-title>. <source>J. Int. Neuropsychol. Soc</source>. <volume>17</volume>, <fpage>120</fpage>&#x02013;<lpage>132</lpage>. <pub-id pub-id-type="doi">10.1017/S1355617710001335</pub-id><pub-id pub-id-type="pmid">21073770</pub-id></citation>
</ref>
<ref id="B94">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Segretin</surname> <given-names>M. S.</given-names></name> <name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Colombo</surname> <given-names>J. A.</given-names></name></person-group> (<year>2007a</year>). <article-title>Intervenciones para ni&#x000F1;os en riesgo social: an&#x000E1;lisis de predicci&#x000F3;n de mejora cognitiva</article-title>, en <source>Avances en Investigaci&#x000F3;n en ciencias del comportamiento en Argentina, Cap&#x000ED;tulo 13</source>, ed <person-group person-group-type="editor"><collab>Asociaci&#x000F3;n Argentina de Ciencias del Comportamiento</collab></person-group> [&#x0201C;Interventions for children at social risk: predicting cognitive imporvement,&#x0201D; in <italic>Progress in behavioral science research in Argentina, Chapter 13</italic>] (<publisher-loc>Mendoza</publisher-loc>: <publisher-name>Editorial de la Universidad Aconcagua</publisher-name>).</citation>
</ref>
<ref id="B95">
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Segretin</surname> <given-names>M. S.</given-names></name> <name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <name><surname>Petetta</surname> <given-names>D. R.</given-names></name></person-group> (<year>2009</year>). <article-title>Methodological and conceptual considerations for the analysis of school performance predictions, based on home and school context indexes</article-title>. <source>Revista Iberoamericana de Evaluaci&#x000F3;n Educativa</source> <volume>2</volume>, <fpage>104</fpage>&#x02013;<lpage>123</lpage>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://rinace.net/riee/numeros/vol2-num2/art6.pdf">http://rinace.net/riee/numeros/vol2-num2/art6.pdf</ext-link></citation>
</ref>
<ref id="B97">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Segretin</surname> <given-names>M. S.</given-names></name> <name><surname>Martelli</surname> <given-names>M. I.</given-names></name> <name><surname>Cristiani</surname> <given-names>V. A.</given-names></name> <name><surname>Blanco</surname> <given-names>M.</given-names></name> <name><surname>Vuelta</surname> <given-names>B.</given-names></name> <name><surname>Lipina</surname> <given-names>S. J.</given-names></name> <etal/></person-group>. (<year>2007b</year>). <article-title>Programas de intervenci&#x000F3;n temprana en nuestro pa&#x000ED;s. Experiencia de aplicaciones grupales de estimulaci&#x000F3;n cognitiva</article-title>, en <source>Pobreza y Desarrollo Infantil. Una Contribuci&#x000F3;n Multidisciplinaria Cap&#x000ED;tulo 11</source>, ed <person-group person-group-type="editor"><name><surname>Colombo</surname> <given-names>J. A.</given-names></name></person-group> [&#x0201C;Early intervention programs in our country. Experience of group application of cognitive stimulation,&#x0201D; in <italic>Poverty and Child Development. A Multidisciplinary Contribution, Chapter 11</italic>] (<publisher-loc>Buenos Aires</publisher-loc>: <publisher-name>Editorial Paid&#x000F3;s</publisher-name>), <fpage>251</fpage>&#x02013;<lpage>269</lpage>.</citation>
</ref>
<ref id="B98">
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Seltman</surname> <given-names>H. J.</given-names></name></person-group> (<year>2009</year>). <article-title>Mixed models. A flexible approach to correlated data</article-title>, in <source>Experimental Design and Analysis, Chapter 15</source>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.stat.cmu.edu/_hseltman/309/Book/Book.pdf">http://www.stat.cmu.edu/_hseltman/309/Book/Book.pdf</ext-link></citation>
</ref>
<ref id="B99">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Shah</surname> <given-names>P.</given-names></name> <name><surname>Ohlsson</surname> <given-names>A.</given-names></name></person-group> (<year>2002</year>). <source>Literature Review of Low Birth Weight, Including Small for Gestational Age and Preterm Birth</source>. <publisher-loc>Ontario, CA</publisher-loc>: <publisher-name>Toronto Public Health, Toronto</publisher-name>.</citation>
</ref>
<ref id="B100">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Shallice</surname> <given-names>T.</given-names></name></person-group> (<year>1982</year>). <article-title>Specific impairments of planning</article-title>. <source>Philos. Trans. R. Soc. Lond. B Biol. Sci</source>. <volume>298</volume>, <fpage>199</fpage>&#x02013;<lpage>209</lpage>. <pub-id pub-id-type="doi">10.1098/rstb.1982.0082</pub-id><pub-id pub-id-type="pmid">6125971</pub-id></citation>
</ref>
<ref id="B101">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Singer</surname> <given-names>J. D.</given-names></name> <name><surname>Willett</surname> <given-names>J. B.</given-names></name></person-group> (<year>2003</year>). <source>Applied Longitudinal Data analysis. Modeling Change and Event Occurrence</source>. <publisher-loc>New York, NY</publisher-loc>: <publisher-name>Oxford Uneversity Press</publisher-name>. <pub-id pub-id-type="doi">10.1093/acprof:oso/9780195152968.001.0001</pub-id></citation>
</ref>
<ref id="B102">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Stanton-Chapman</surname> <given-names>T. L.</given-names></name> <name><surname>Chapman</surname> <given-names>D. A.</given-names></name> <name><surname>Kaiser</surname> <given-names>A. P.</given-names></name> <name><surname>Hancock</surname> <given-names>T. B.</given-names></name></person-group> (<year>2004</year>). <article-title>Cumulative risk and low-income children&#x00027;s language development</article-title>. <source>Topics Early Child. Spec. Educ</source>. <volume>24</volume>, <fpage>227</fpage>&#x02013;<lpage>237</lpage>. <pub-id pub-id-type="doi">10.1177/02711214040240040401</pub-id><pub-id pub-id-type="pmid">24147448</pub-id></citation>
</ref>
<ref id="B103">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Sternberg</surname> <given-names>R. J.</given-names></name> <name><surname>Grigorenko</surname> <given-names>E. L.</given-names></name></person-group> (<year>2002</year>). <source>Dynamic Testing</source>. <publisher-loc>Cambridge</publisher-loc>: <publisher-name>Cambridge University Press</publisher-name>.</citation>
</ref>
<ref id="B104">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Stevens</surname> <given-names>C.</given-names></name> <name><surname>Fanning</surname> <given-names>J.</given-names></name> <name><surname>Coch</surname> <given-names>D.</given-names></name> <name><surname>Sanders</surname> <given-names>L.</given-names></name> <name><surname>Neville</surname> <given-names>H. J.</given-names></name></person-group> (<year>2008</year>). <article-title>Neural mechanisms of selective auditory attention are enhanced by computerized training: Electrophysiological evidence from language-impaired and typically developing children</article-title>. <source>Brain Res</source>. <volume>1205</volume>, <fpage>55</fpage>&#x02013;<lpage>69</lpage>. <pub-id pub-id-type="doi">10.1016/j.brainres.2007.10.108</pub-id><pub-id pub-id-type="pmid">18353284</pub-id></citation>
</ref>
<ref id="B105">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Temple</surname> <given-names>E.</given-names></name> <name><surname>Gayle</surname> <given-names>K.</given-names></name> <name><surname>Deutsch</surname> <given-names>G. K.</given-names></name> <name><surname>Poldrack</surname> <given-names>R. A.</given-names></name> <name><surname>Miller</surname> <given-names>S. L.</given-names></name> <name><surname>Tallal</surname> <given-names>P.</given-names></name> <etal/></person-group>. (<year>2003</year>). <article-title>Neural deficits in children with dyslexia ameliorated by behavioral remediation: evidence from functional MRI</article-title>. <source>PNAS</source> <volume>100</volume>, <fpage>2860</fpage>&#x02013;<lpage>2865</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.0030098100</pub-id><pub-id pub-id-type="pmid">12604786</pub-id></citation>
</ref>
<ref id="B106">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Reynolds</surname> <given-names>A. J.</given-names></name> <name><surname>Temple</surname> <given-names>J. A.</given-names></name> <name><surname>White</surname> <given-names>B.A.</given-names></name> <name><surname>Ou</surname> <given-names>S. R.</given-names></name> <name><surname>Robertson</surname> <given-names>D. L.</given-names></name></person-group> (<year>2011</year>). <article-title>Age 26 cost-benefit analysis of the child-parent center early education program</article-title>. <source>Child Dev</source>. <volume>82</volume>, <fpage>379</fpage>&#x02013;<lpage>404</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-8624.2010.01563.x</pub-id><pub-id pub-id-type="pmid">21291448</pub-id></citation>
</ref>
<ref id="B107">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Thomas</surname> <given-names>M. S.</given-names></name> <name><surname>Johnson</surname> <given-names>M. H.</given-names></name></person-group> (<year>2008</year>). <article-title>New advances in understanding sensitive periods in brain development</article-title>. <source>Curr. Dir. Psychol. Sci</source>. <volume>17</volume>, <fpage>1</fpage>&#x02013;<lpage>5</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-8721.2008.00537.x</pub-id></citation>
</ref>
<ref id="B108">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Thorell</surname> <given-names>L. B.</given-names></name> <name><surname>Lindqvist</surname> <given-names>S.</given-names></name> <name><surname>Nutley</surname> <given-names>S. B.</given-names></name> <name><surname>Bohlin</surname> <given-names>G.</given-names></name> <name><surname>Klingberg</surname> <given-names>T.</given-names></name></person-group> (<year>2009</year>). <article-title>Training and transfer effects of executive functions in preschool children</article-title>. <source>Dev. Sci</source>. <volume>12</volume>, <fpage>106</fpage>&#x02013;<lpage>113</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-7687.2008.00745.x</pub-id><pub-id pub-id-type="pmid">19120418</pub-id></citation>
</ref>
<ref id="B109">
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Tu&#x000F1;&#x000F3;n</surname> <given-names>I.</given-names></name></person-group> (<year>2011</year>). <source>Infancias en Observaci&#x000F3;n: Progresos, Ausencias y Desigualdades. Evoluci&#x000F3;n de Indicadores de Derechos y Desarrollo Humano (Childhood Observation: Progress, Absences and Inequalities. Rights and Human Development Indicator&#x00027;s Evolution)</source>. <publisher-loc>Buenos Aires</publisher-loc>: <publisher-name>Pontificia Universidad Cat&#x000F3;lica Argentina, Bar&#x000F3;metro de la deuda social de la infancia</publisher-name>.</citation>
</ref>
<ref id="B110">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Walker</surname> <given-names>S. P.</given-names></name> <name><surname>Wachs</surname> <given-names>T. D.</given-names></name> <name><surname>Meeks Gardner</surname> <given-names>J.</given-names></name> <name><surname>Lozoff</surname> <given-names>B.</given-names></name> <name><surname>Wasserman</surname> <given-names>G. A.</given-names></name> <name><surname>Pollitt</surname> <given-names>E.</given-names></name> <etal/> <collab>The International Child Development Steering Group.</collab></person-group> (<year>2007</year>). <article-title>Child development: risk factors for adverse outcomes in developing countries</article-title>. <source>Lancet</source>, <volume>369</volume>, <fpage>145</fpage>&#x02013;<lpage>157</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(07)60076-2</pub-id><pub-id pub-id-type="pmid">17223478</pub-id></citation>
</ref>
<ref id="B111">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Weiland</surname> <given-names>C.</given-names></name> <name><surname>Yoshikawa</surname> <given-names>H.</given-names></name></person-group> (<year>2012</year>). <article-title>The effects of large-scale economic change and policies on children&#x00027;s developmental contexts and developmental outcomes</article-title>. <source>Child Dev. Perspect</source>. <volume>6</volume>, <fpage>342</fpage>&#x02013;<lpage>350</lpage>. <pub-id pub-id-type="doi">10.1111/j.1750-8606.2011.00222.x</pub-id></citation>
</ref>
<ref id="B112">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Willoughby</surname> <given-names>M. T.</given-names></name> <name><surname>Wirth</surname> <given-names>R. J.</given-names></name> <name><surname>Blair</surname> <given-names>C. B.</given-names></name> <collab>The Family Life Project Investigators.</collab></person-group> (<year>2012</year>). <article-title>Executive function in early childhood: longitudinal measurement invariance and developmental change</article-title>. <source>Psychol. Assess</source>. <volume>24</volume>, <fpage>418</fpage>&#x02013;<lpage>431</lpage> <pub-id pub-id-type="doi">10.1037/a0025779</pub-id><pub-id pub-id-type="pmid">22023561</pub-id></citation>
</ref>
<ref id="B113">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wilson</surname> <given-names>A. J.</given-names></name> <name><surname>Dehaene</surname> <given-names>S.</given-names></name> <name><surname>Pinel</surname> <given-names>P.</given-names></name> <name><surname>Revkin</surname> <given-names>S. K.</given-names></name> <name><surname>Coehn</surname> <given-names>L.</given-names></name> <name><surname>Cohen</surname> <given-names>D.</given-names></name></person-group> (<year>2006</year>). <article-title>Principles underlying the design of the number race, an adaptive computer game for remediation of dyscalculia</article-title>. <source>Behav. Brain Funct</source>. <volume>2</volume>, <fpage>1</fpage>&#x02013;<lpage>14</lpage>. <pub-id pub-id-type="doi">10.1186/1744-9081-2-1</pub-id><pub-id pub-id-type="pmid">16734905</pub-id></citation>
</ref>
<ref id="B114">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zelazo</surname> <given-names>P. D.</given-names></name> <name><surname>Carter</surname> <given-names>A.</given-names></name> <name><surname>Reznick</surname> <given-names>J. S.</given-names></name> <name><surname>Frye</surname> <given-names>D.</given-names></name></person-group> (<year>1997</year>). <article-title>Early development of executive function: a problem-solving framework</article-title>. <source>Rev. Gen. Psychol</source>. <volume>1</volume>, <fpage>198</fpage>&#x02013;<lpage>226</lpage>. <pub-id pub-id-type="doi">10.1037/1089-2680.1.2.198</pub-id><pub-id pub-id-type="pmid">12754681</pub-id></citation>
</ref>
</ref-list>
</back>
</article>