AUTHOR=Hale T. Sigi TITLE=A Distributed Effects Perspective of Dimensionally Defined Psychiatric Disorders: And Convergent Versus Core Deficit Effects in ADHD JOURNAL=Frontiers in Psychiatry VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/articles/10.3389/fpsyt.2014.00062 DOI=10.3389/fpsyt.2014.00062 ISSN=1664-0640 ABSTRACT=The focus of psychiatric and psychological research has arguably shifted from brain damage and psychosis to more common forms of psychopathology that reflect extremes variants of otherwise normal cognitive and behavioral characteristics. Now, in addition to trying to understand overtly damaged brain-function (flat tire effects), we are also seeking to understand liabilities associated with non-optimized, but otherwise intact, cognitive and behavioral abilities (poor tuning effects). This shift has pushed us to evolve our investigational strategies to more broadly consider whole-brain integrated brain systems, as well as seek to develop more specific quantifiable indicators of impoverished brain function and behavior. This paper discusses such challenges in relation to dimensionally defined psychiatric disorders and presents a novel whole-brain integrated perspective of ADHD brain function pathology.