AUTHOR=Blom Jan Dirk, Coebergh Jan Adriaan F., Lauw René, Sommer Iris E. C. TITLE=Musical Hallucinations Treated with Acetylcholinesterase Inhibitors JOURNAL=Frontiers in Psychiatry VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/articles/10.3389/fpsyt.2015.00046 DOI=10.3389/fpsyt.2015.00046 ISSN=1664-0640 ABSTRACT=Musical hallucinations are relatively rare auditory percepts which, due to their intrusive nature and the accompanying fear of impending mental decline, tend to cause significant distress and impairment. Although their etiology and pathophysiology appear to be heterogeneous and no evidence-based treatment methods are available, case reports indicate that acetylcholinesterase inhibitors may yield positive results in patients with comorbid hearing loss. We present two female patients (aged 76 and 78 years) both of whom suffered from hearing impairment and practically incessant musical hallucinations. Both patients were successfully treated with the acetylcholinesterase inhibitor rivastigmine. Based on these two case descriptions and an overview of studies describing the use of acetylcholinesterase inhibitors in similar patients, we discuss possible mechanisms and propose further research on the use of acetylcholinesterase inhibitors for musical hallucinations experienced in concordance with hearing loss.