AUTHOR=Collins Lucy M. , Williams-Gray Caroline H. TITLE=The Genetic Basis of Cognitive Impairment and Dementia in Parkinson’s Disease JOURNAL=Frontiers in Psychiatry VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2016.00089 DOI=10.3389/fpsyt.2016.00089 ISSN=1664-0640 ABSTRACT=
Cognitive dysfunction is a common feature of Parkinson’s disease (PD) with mild cognitive impairment affecting around a quarter of patients in the early stages of their disease, and approximately half developing dementia by 10 years from diagnosis. However, the pattern of cognitive impairments and their speed of evolution vary markedly between individuals. While some of this variability may relate to extrinsic factors and comorbidities, inherited genetic heterogeneity is also known to play an important role. A number of common genetic variants have been identified, which contribute to cognitive function in PD, including variants in catechol-