Lifestyle Interventions and Prevention of Suicide

Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle behaviors are amenable to change through the adoption of specific psychosocial interventions, and several approaches have been promoted. The current article provides a comprehensive review of the literature on lifestyle interventions, mental health, and suicide risk in the general population and in patients with psychiatric disorders. For this purpose, we investigated lifestyle behaviors and lifestyle interventions in three different age groups: adolescents, young adults, and the elderly. Several lifestyle behaviors including cigarette smoking, alcohol use, and sedentary lifestyle are associated with suicide risk in all age groups. In adolescents, growing attention has emerged on the association between suicide risk and internet addiction, cyberbullying and scholastic and family difficulties. In adults, psychiatric symptoms, substance and alcohol abuse, weight, and occupational difficulties seems to have a significant role in suicide risk. Finally, in the elderly, the presence of an organic disease and poor social support are associated with an increased risk of suicide attempt. Several factors may explain the association between lifestyle behaviors and suicide. First, many studies have reported that some lifestyle behaviors and its consequences (sedentary lifestyle, cigarette smoking underweight, obesity) are associated with cardiometabolic risk factors and with poor mental health. Second, several lifestyle behaviors may encourage social isolation, limiting the development of social networks, and remove individuals from social interactions; increasing their risk of mental health problems and suicide.


INTRODUCTION
Several well-established psychosocial factors and lifestyle behaviors including life satisfaction, economic adversities, family environment, major life and occupational stressor(s), substance and alcohol abuse, medical conditions, cigarette smoking, being sedentary, underweight or obese, and diet are considered prominent factors in the development of severe mental disorders and suicide risk. Psychiatric patients, including patients affected by schizophrenia, bipolar disorder, schizoaffective disorder and depressive disorder, have higher mortality rates and higher suicide risk compared to the general population (1,2). Increased mortality is probably also due, besides psychiatric impairment and psychotropic medication use, to unhealthy lifestyle behaviors including poor diet, excessive smoking, alcohol use, and lack of exercise. These unhealthy lifestyle behaviors can increase the development of many physical diseases including overweight, obesity, metabolic syndrome, diabetes, cardiovascular disease, cerebrovascular disease, hepatitis, amongst other medical conditions (3,4).
Suicide has been described as a multi-faceted construct in relation to psychiatric symptoms, medical conditions, and lifestyle risk factors (5)(6)(7). Moreover, lifestyle behaviors are involved in the pathogenesis of medical and severe psychiatric disorders such as depression and psychosis (8,9), increasing the risk of suicide (10).
Recently, considerable attention has been paid to the concept of life satisfaction and well-being as psychosocial indicators of mental health (11). It has been hypothesized (12,13) that life satisfaction and meaning in life can help people overcome adversity. Factors associated with optimal well-being and life satisfaction included prudent lifestyle behaviors such as healthy eating, adequate sleep, physical activity, avoiding tobacco, and limiting alcohol consumption (14). Few studies have revealed that suicide ideation is related to psychiatric symptomatology, lifestyle behavior, and lower life satisfaction (15,16). Koivumaa-Honkanen et al. (17) in a study of 29,067 Finnish adults found that unhappiness was associated with an increased risk of suicide. This group also reported that unhappiness was associated with older age, male gender, sickness, living alone, smoking, heavy alcohol consumption, physical inactivity, and belonging to intermediate social class.
In the past few decades, a lot of progress has been made to identify public health strategies for the prevention of mental health and suicide. Although the approach to suicide has always involved clinical aspects, especially the assessment and the treatment of depression (18), it seems necessary to consider also risk factors that can be identified and modified through specific lifestyle interventions.
Based on data demonstrating how lifestyle behaviors may be involved in both the genesis of severe psychiatric disorders and in increasing suicide risk (19), we aimed to provide a narrative review synthetizing existing published literature on lifestyle interventions and suicide prevention in psychiatric patients behavior. Additionally, we provide a review of the literature on lifestyle interventions promoting mental health reducing suicide risk in the general population and in patients with psychiatric disorders.

MATERIALS AND METHODS
We searched the relevant databases including MEDLINE, ISI Web of Knowledge -Web of Science Index, Cochrane Reviews Library and PsychoINFO for papers published from January 2000 to March 2018.
The following keywords were used: "lifestyle intervention, " "life satisfaction", "diet, " "physical activity, " "nutrition, " "cholesterol, " "diabetes, " "lifestyle behaviors, " "cigarette smoke" matched with "suicide risk, " "healthy population, " "mental disorders, " "schizophrenia, " "psychotic disorders, " "bipolar disorder, " "depression, " "adolescents, " "adults, " and "elderly." Inclusion criteria were: studies adopting psychosocial interventions for promoting changes in lifestyle behaviors, studies aiming to improve patients' physical status (evaluated in terms of body mass index -BMI, level of physical activity, smoking status, etc.) and studies that assess the association between lifestyle behaviors and psychiatric disorders and suicide risk. Only papers written in English were included. Studies included in this narrative review were those that examined suicide and lifestyle interventions in adolescence, young adults or adults and the elderly. Studies in which the age group investigated was not clearly defined were excluded from this review.
Randomized controlled trials, clinical controlled trials, pilot studies, cohort studies and reviews were considered eligible for the review process. In addition, the reference lists of all included studies and of relevant existing systematic reviews were checked for possible studies. Papers were screened by an independent researcher (IB) and assessed for eligibility by a senior expert (MP).

LIFESTYLE BEHAVIOR AND SUICIDE IN ADOLESCENTS AND YOUNG PEOPLE
Suicidal ideation and suicide attempt are relatively common in this phase of life; with completed suicide being the second most common cause of death in adolescents (20).
It has been described that 10-20% of adolescents suffer from a mental disorder (21). Adolescence is often associated with elevated levels of anxiety, stress, and adverse life events, which may lead to maladaptive feelings of hopelessness, personal failure, and suicidal ideation (22). While positive coping strategies, efficacious problem-solving skills, and general life satisfaction are considered protective for suicide (23). Common severe psychiatric disorders in adolescents include depression, anxiety disorders, behavioral problems (e.g., oppositional defiant disorder or conduct disorder), early psychosis, eating disorders (e.g., anorexia nervosa and bulimia nervosa) and addictive disorders (24), all risk factors for suicidal behavior in adolescents (25,26).
Unhealthy lifestyle behaviors may impact mental health and suicidal behavior by influencing emotions and judgement. Studies have demonstrated that adolescents with first-episode psychosis have a high prevalence of tobacco, alcohol and cannabis use, selective dietary habits, lower physical activity, and lower level of activity during leisure time (27)(28)(29)(30). Other studies have demonstrated a close relationship between cannabis use, hypomania, mania, and suicide risk in adolescents (31,32). Furthermore, a relationship between weight, social relations, and depressive symptoms has been described (33); stressing the link between lifestyle behavior, mental health and suicide risk.
High symptom of any personality disorder in adolescence have negative repercussions on functioning over the subsequent 10 to 20 years. For instance, elevated Borderline Personality Disorder (BPD) symptoms in adolescence have been shown to be an independent risk factor for substance-use disorders during early adulthood, alcohol consumption, psychopathology, health risk behaviors, and suicide risk (34)(35)(36)(37). Prevention and early intervention for BPD are necessary not only for reduction on psychiatric symptoms but also for improving psychosocial functioning and decreasing substance abuse, which are known risk factors for suicide.
Im et al. (38) examined 370,568 students with the aim of recognizing risk factors for suicidal ideation in adolescents found that low sleep satisfaction, high stress, alcohol consumption, smoking, and sexual activity, were significant lifestyle factors associated with suicidal ideation. Lee et al. (39) in a sample of 860 adolescents confirmed the relationship between several lifestyle behaviors and suicide risk including sleep disturbance, internet game addiction, and interpersonal factors (e.g., family conflicts and peer problems). A recent systematic review of 17 studies recognized that, in adolescents, a diagnosis of binge eating disorder was predictive of suicidality, while a high body mass index (BMI) was not (40). Substance-use disorders, including alcohol use disorder, are considered one of the most important risk factors associated with suicide risk during adolescence (41,42). Moreover, it has been reported that the more the number of substances abused the higher the suicide risk (43). Borges et al. (44) in a recent trial on 1,071 young Mexicans reported that the use of cannabis before age 15, high frequency of cannabis use and another recent substance-use disorder increased the risk of suicide. Park et al. (45) collected data from 68,043 adolescents with the purpose of investigating the undesirable effects of frequent use of caffeinated energy drinks. Their results indicated that energy drink consumption was associated with sleep dissatisfaction, severe stress, depressive mood, suicidal ideation, suicide plan, and suicide attempt. Similarly, Kim et al. (46) in a study of 121,106 Korean adolescents confirmed that severe stress, inadequate sleep, and low school performance were associated with more energy drink consumption and suicide attempts.
Evidence suggests that sedentary lifestyle may impact emotional and mental health in adolescents (47). A systematic review on this topic found a strong relationship between sedentarism, depressive symptomatology, psychological distress, and suicide ideation in adolescents (48). In this regard, Lester et al. (49) demonstrated that participation in sports reduced the incidence of suicidal ideation.
Internet use has a mixed effect on children and young people's well-being. On one hand, internet users may develop a social support that may be artificial. On the other hand, it exposes adolescents to cyberbullying and meeting strangers online (50). In recent years, there has been an increased interest in the relationship between internet use, cyber-bullying, and suicide (51). A recent systematic review of 51 articles investigated the relationship between internet use and self-harm/suicidal behavior. This review demonstrated that internet addiction and elevated levels of internet use, were associated with a higher suicide risk (52). John et al. (53) highlighted that compared to non-victims of cyberbullying, victims of cyberbullying had a greater risk of both self-harm and suicidal behaviors. Rodelli et al. (54) evaluated the associations between physical activity, sport participation, healthy diet, higher sleep duration and lower levels of smoking and lower levels of alcohol use, and suicidal ideation when faced to cyberbullying. Results showed that cyberbullying victimization was associated with higher suicidal ideation while increased physical activity, sleeping longer, healthy diet and lower levels of smoking were associated with lower suicidal ideation. Moreover, a systematic review on the role of web technologies, mobile solutions, social networks, and machine learning in the prevention of suicide risk highlighted that many of these methods can help prevent suicide (55).
The potential role of family relationships (conflict, negative relationship with parents, other) as a risk factor for suicide was evaluated in 36,757 French adolescents (56). Results from this study demonstrated that negative relationships with parents and parental discord was significantly associated with suicide risk and/or depression in adolescents regardless of gender. The role of family interventions in the prevention of mental illness, substance abuse, and suicide ideation and attempts have been evaluated (57). The author suggested that family interventions could be useful in the prevention of suicidal ideation and behavior in both adolescents and parents.

LIFESTYLE BEHAVIOR AND SUICIDE IN YOUNG ADULTS AND ADULTS
In adults, the relationship between lifestyle behavior, severe psychiatric symptoms, and suicide risk is well documented (58,59). Recent literature has demonstrated that behavioral lifestyle interventions help patients with serious mental illnesses lose weight and reduce cigarette smoking. Behavioral lifestyle interventions also helped patients achieve changes in fasting glucose levels in patients taking antipsychotic medications (60); simultaneously reducing the possibility of developing medical conditions; indirectly reducing the risk of suicide.
Studies have demonstrated that adult psychiatric inpatients who had attempted suicide presented higher levels of sedentarism and higher tobacco use compared to psychiatric patients who did not attempt suicide (61,62).
Research reporting on the relationship between suicide, obesity, total serum cholesterol, and dietary patterns is controversial (63). Research examining the relationship between lipid profile and suicide attempts have shown that compared to non-attempters, suicide attempters had lower cholesterol levels (64,65). More recently, a case control study of a Mexican population found a positive association between lower cholesterol levels and suicide attempt (66). Although the mechanism behind hypocholesterolemia and suicide has not been elucidated, it has been hypothesized that altered cholesterol at synaptic lipid rafts cause a decrease in serotonin transmission, neurotransmitter implicated in the pathophysiology of suicide (67,68). A recent systematic review and meta-analysis of 11 studies evaluating lipid profile in suicide attempters and nonattempters in people with bipolar disorder failed to clarify the relationship between LDL-cholesterol, triglycerides and suicide in these patients. Shrivastava et al. (69) in a naturalistic crosssectional cohort study of 60 patients with early psychosis, found that low levels of cholesterol were present only in the group of patients with severe suicidality. Similarly, Messaoud et al. (70) found a positive association between low plasma cholesterol level and suicidal behavior in patients with major depressive disorder.
Studies on the associations between depression, suicidal behavior, glucose levels or insulin resistance are scarce. Higher glucose levels have been associated with dysthymia (71) and higher HbA1c concentrations have been associated with psychotic depression (72). Koponen et al. (73) in 448 patients aged 35 years old found that patients with depression and suicidal behavior had higher blood glucose concentrations at baseline and at 2 h in the oral glucose tolerance test (OGTT).
Although dietary habits have been linked to depression, only few studies have examined the association between dietary patterns and suicide risk (74,75). Li et al. (75) found that a dietary pattern comprise of vegetables, fruits, potatoes, soy products, mushrooms, seaweed and fish was associated with a decreased risk of suicide. Mukamal et al. (74) reviewed retrospectively the dietary information of 6,803 adults describing the differences in eating habits between suicide attempters and non-attempters. Results indicated that male attempters presented low consumption of vegetables and female attempters presented insufficient fruit consumption. It was further observed that female attempters ate significantly less fish and sea food compared to female non-attempters. Finally, results showed that fruits, vegetables, and meat were significantly under-consumed in those individuals with a history of suicide attempt.
The relationship between body mass index (BMI) and suicide risk in adult seems controversial. A study by Perera et al. (63) supported the hypothesis of an inverse association between BMI and completed suicide, where underweight was associated with an increased risk of completed suicide while obesity and overweight were associated with a decreased risk of suicide in comparison to people of normal weight. Contrarily, Branco et al. (76) stressed that obesity was associated with a higher prevalence of suicide risk, especially in women. Kim et al. (77) on 6,022 nationally representative sample of Korean adults aged 18 to 74 found that being underweight was associated with higher suicide risk and obesity was associated only with risk of suicide ideation but not with suicide attempt. In the same study, underweight individuals were more likely to report severe level of perceived stress (OR, 1.7; 95% Cl, 1.26-2.17) and life dissatisfaction (OR, 1.3; 95% Cl, 1.07-1.68) compared to obese individuals.
A strong relationship exists between well-being and physical activity, sports activities and level of fitness (78,79). Physical activity and sports activities are considered protective lifestyle behaviuors against stress, depression and other unhealthy behaviors linked to medical illness. In particular, sport activities improve coronary functioning and reduce obesity prevalence (61,80). Physical activity could be effective in reducing mental health disorders and suicidal behaviors through biological and psychosocial mechanisms; for example, releasing endorphins, increasing serotonin and norepinephrine synthesis, increasing the sense of mastery, self-esteem and social interaction (81). Vancampfort et al. (82) in a recent metanalysis showed that in adults, low physical activity was associated with higher suicide risk. Adams et al. (83) demonstrated that vigorous/moderate physical activity was associated with a positive perceived health and modestly associated with psychiatric symptoms and suicidal ideation reduction; confirming the link between physical activity and well-being.
In patients with schizophrenia, the evidence suggests that increasing physical exercise promotes wellbeing, and improves mental health in these patients (84). Dietary habits and levels of physical activity were evaluated in 428 people with schizophrenia spectrum disorders and increased waist circumference demonstrating that in these patients the intake of fiber, vegetables, fruit, and fish were insufficient and these patients also had low levels of physical activity. Furthermore, negative symptoms were associated with poor diet and less physical activity (85).
The positive relationship between smoking and suicide risk in adult patients with psychotic disorders has been evaluated in a systematic-review and a meta-analysis of observational studies on this topic (86). The same authors, in a randomized study, investigated the effect of smoking reduction on suicidality on 255 patients with a psychotic disorder. This author found that smoking reduction, besides the positive effects on physical health, had a protective effect on suicidal ideation in people with psychosis (87). Bhatt et al. (88) characterized and identified risk factors for suicide attempt in patients with psychiatric disorders. Findings from this study indicated no significant differences on demographic characteristics between psychiatric inpatients who attempted suicide and psychiatric inpatients who did not attempt suicide. The only risk factors for suicide in psychiatric patients found in this study were the presence of impulsivity and borderline personality symptoms. Howard et al. (89) in a recent population-based cohort study on 12,888 subjects (6,456 men, 6,432 women) investigated the relationship between chronic disease conditions, smoking habits, alcohol consumption, depressive symptoms, personality type, and other psychological parameters and suicide found that male sex, obesity, smoking, and living alone were associated with depression and with risk of suicide.
Several studies have focused on the role of occupation and work stressors on suicide risk. Research on this topic has shown that work characteristics and personal resources are linked to depression and suicide attempts (90). A study on 2,855 employees demonstrated that job autonomy, task variety, work-family conflict, family-work conflict, and job dissatisfaction contributed to suicide attempts (89). Furthermore, Kerr et al. (91) showed that poor interpersonal relationships, unemployment, debt and financial difficulties contribute to an increased risk of suicide in the general population. A recent study of 2,027 employed patients in primary care setting examined the association between workplace and suicidal ideation (92). Suicidality was significantly associated with work intensity in men and with work-related emotional demands in women.
Alcohol and substance abuse can worsen psychological wellbeing and contribute to suicide risk (93). Consumption of alcohol immediately prior to suicide is common (94,95), with an estimated 37% of deaths from suicide having positive blood alcohol concentrations on toxicology screening indicating acute alcohol consumption before death (96). Bowden et al. (97) in a large cohort study of 2,803,457 residents of Wales, UK, highlighted the relationship between emergency alcoholrelated hospital admission and the increased risk of suicide. A recent systematic review of 108 studies explored the associations between substance use and suicide risk in low-and middleincome countries (98) demonstrated an association between alcohol use, intoxication and pathological use of alcohol, tobacco, cannabis, illicit drugs and non-medical use of prescription drugs and suicide risk. Furthermore, Choi et al. (99) examined blood alcohol concentration (BAC) among suicide decedents aged 50 years or older. This study showed that alcohol problems prior to suicide, relationship problems and death/suicide of family/friends were associated with greater odds of having a positive BAC. This study also found that alcohol intoxication was linked to more violent means of suicide.

LIFESTYLE BEHAVIOR AND SUICIDE IN OLDER ADULTS
Over 20% of adults aged 60 and over suffer from a psychiatric or neurological disorder. In the elderly, severe mental disorders present differently than in younger adults. The most common mental and neurological disorders in this age group are  depression and dementia. However, anxiety disorders, schizophrenia and psychotic disorders, and substance use problems are also prevalent (100). A body of literature supports the association between late-life suicide ideation and various risk factors including depression and hopelessness (101,102), while subjective well-being and meaning in life have been identified as protective factors for suicide in older adults (101). Innamorati et al. (103) in a study using psychological autopsy interviews studied 117 old-old adults who died by suicide and compared them to 97 young-old adults (6,574 years), 98 middle aged (50-64 years) suicide victims, and 117 psychiatric outpatients 75 years and older without a history of suicidal behaviors. They found that, in the elderly, unlike others stages of life, loneliness and lack of social support, were associated with risk of suicide. Physical illness, chronic severe pain, debilitating disease, and diagnosis of a terminal illness are common antecedents to suicide in older adults (104). Lee et al. (39) after analyzing age and sex-related features and suicide risk in the elderly stressed that the only stable risk factor for suicide in this age group was the negative perception of one's own health status. Difficulties in interpersonal relations, social interactions, and social participation have been also linked to suicidal ideation and suicidal intent in the elderly (105). Mogensen et al. (106) reported that in the elderly, suicide risk appeared highest during the 6 months following the loss of a close relative and McLaren et al. (107) observed that widowhood was associated with suicidal ideation both in men and women. A longitudinal study on the importance of social support while adjusting to loneliness in bereaving elderly persons (108) and other studies examining on the importance of social supports reported that primary prevention programs designed specifically to increase social relations could decrease suicide risk (109). Older people are at risk for health decline and loss of independence that can affect social interactions negatively.

Psychiatric disorders
Lifestyle behavior and suicide risk

Psychotic disorders
Substance and alcohol abuse, difficulties in interpersonal relations, tobacco's smoke.

Depressive disorders
Substance and alcohol abuse, occupation and work stressor.
Frontiers in Psychiatry | www.frontiersin.org flexibility (115), social skills (116), self-esteem (117), sense of belonging (118), reasons for living (119), hope (120), meaning in life (101,121), religion or spirituality (122) could became promising directions to prevent suicide in older adults. Several studies have demonstrated the importance of a balanced diet to prevent depression (123,124) and of sleepbased interventions to prevent suicide (125). Considering that hypnotics use in the elderly has been associated with an increased risk of suicide (126), behavioral treatment of insomnia represents an efficacious alternative to pharmacotherapy in this age group (127). O' Rourke et al. (128) studied specific predictors of suicide in a sample of 220 older adults affected by Bipolar Disorder (BD). Alcohol misuse, medication non-adherence, and cognitive impairment were found to be direct predictors of suicide in these patients, while sleep disturbances acts as a risk factor on suicide ideation via depressive symptoms. Contrary to what happens in other age groups, a link between smoking prevalence and suicide rates in the elderly has not been observed (129).

DISCUSSION
In this article, we reviewed a growing body of literature demonstrating a relationship between lifestyle behaviors, mental health, and suicide risk (Table 1) in differing stages of life ( Table 2) and in severe psychiatric disorders ( Table 3). Our review suggests that enhancing protective factors and reducing risk factors known to increase suicidal behaviors (75,(130)(131)(132) could help prevent suicide in some individuals. Given the high comorbidity between psychiatric disorders and medical illnesses that result from unhealthy lifestyle behaviors, lifestyle interventions to reduce medical diseases, and increase patient's well-being are urgently needed.
The relationship between lifestyle behavior and suicide is complex and multifactorial. Unhealthy lifestyle behaviors can directly increase the risk of suicide; at the same time increasing the risk for many medical diseases. It is well known that medical illnesses are associated with disability, social isolation and associated with an increased risk of suicide. Sedentary behaviors, underweight, obesity, cigarette smoking, and alcohol abuse are associated with cardiometabolic risk factors, poor mental health, and severe psychiatric disorders. These factors contribute to an increased risk of suicide. Sedentary behaviors, weight issues and fewer social supports contribute to social isolation, limiting the development of social relationships, which increase the risk of developing mental health problems and suicide. Adopting healthy lifestyle behaviors are indispensable for both, improving health and for the prevention of suicide at any stage in life.
Studies included in this article showed different lifestyle behaviors in different lifestages. In adolescent and young adults there are multiple important risk factors for suicide including psychosis, depression, low sleep satisfaction, high stress, substance abuse, alcohol consumption, smoking, sexual activity, internet addiction, interpersonal factors, personality disorders, anxiety or conduct disorders, eating disorders, and aggressive, irritable and antisocial tendencies (38,39).
Though it has been demonstrated that school-based suicide prevention programs increase knowledge on suicide without really preventing suicidal behaviors (133), it seems necessary to consider prevention programs that identify substance abuse, educational competencies (literacy, study skills, time management), educational environment, school programs, social interactions, academic attainment, cognitive progress, emotional control, behavioral expectations, physical and moral development, and encouragement of active engagement in sports.
In adults, lifestyle interventions on smoking, heavy alcohol consumption, physical inactivity, BMI, sedentarism, and eating habits should play a significant role in suicide prevention (17,65). Effective lifestyle prevention programs in adults can be developed through screening programs identifying and assessing at-risk groups. These programs should include lifestyle training, psychoeducation, support/skills training and crisis response and referral resources (134). In patients with severe psychiatric disease, strategies that promote exercise and sport activities, that reduce caffeine consumption and other healthadverse behaviors are particularly important for the reduction of psychotic symptoms, depression, anxiety, low self-esteem, and life dissatisfaction, factors that increase suicide risk. Gallego et al. (135) suggested that in patients with either schizophrenia spectrum disorders or affective disorders, physicians should be alert for the presence of a previous suicidal attempts and financial or relationship losses, factors that can increase suicidal risk. Furthermore, psychiatric hospitalization, a close psychiatric follow up, collaboration with family would be important strategies in reducing the risk of suicidal behavior in patients affected by severe psychiatric disorders.
Finally, in the elderly, difficulties in interpersonal relations, social isolation and the consequences of physical disability can represent targeted and specific points for intervention. The concomitant presence of depressive symptoms and stressing life events including loneliness and physical illness should be considered warning signs for suicidal risk (136). In the elderly, innovative strategies should promote positive aging, involve family and community gatekeepers, and use telecommunications to identify older adult at risk of suicide (112). Psychosocial interventions influence depressive symptoms and considering that mental illness is one of the most significant factors in suicide; psychosocial interventions should be part of suicide prevention programs in the elderly. Further trials are warranted, especially for the most promising type of interventions for preventing suicide, that is, social activities (137,138).

LIMITATIONS
When interpreting the results of this review, several limitations should be considered. First, this is a narrative review, therefore, studies were subjectively selected, which could have led to selection bias. Second, we only selected articles in English leaving relevant articles in other languages out of our review. Finally, we did not draw a distinction between gender and risk factors for suicide.

CONCLUSIONS
Lifestyle behavior is of paramount importance for suicide prevention as maladaptive maneuvers (such as drinking or drug abuse) as to face increased psychological pain and distress consistently reduce cognitive skill to solve source of suffering.
Furthermore, reduced quality of life as observed by impairment of some psychiatric disorders can be worsened by low exercise, excessive smoking, poor diet, and determinants associated with pharmacological treatment. Community mental health with proper programs such as assertive community treatment, psychoeducational family treatment, social skills training, and psychosocial therapies are important interventions that can incorporate education on lifestyle and ultimately reduce suicide risk.

AUTHOR CONTRIBUTIONS
IB and VC searched the literature and provided first draft. MH, AC, and DE independently reviewed the paper and added relevant information. MP provided the intellectual impetuous and supervised the entire process of development of the paper.