%A Kim,Sungkean %A Kim,Yong-Wook %A Shim,Miseon %A Jin,Min Jin %A Im,Chang-Hwan %A Lee,Seung-Hwan %D 2020 %J Frontiers in Psychiatry %C %F %G English %K Bipolar Disorder,Cortical functional networks,graph theory,Resting-state EEG,Schizophrenia %Q %R 10.3389/fpsyt.2020.00661 %W %L %M %P %7 %8 2020-July-17 %9 Original Research %+ Seung-Hwan Lee,Clinical Emotion and Cognition Research Laboratory, Inje University,Republic of Korea,lshpss@paik.ac.kr %+ Seung-Hwan Lee,Department of Psychiatry, Inje University Ilsan Paik Hospital,Republic of Korea,lshpss@paik.ac.kr %# %! Altered networks in SZ and BP %* %< %T Altered Cortical Functional Networks in Patients With Schizophrenia and Bipolar Disorder: A Resting-State Electroencephalographic Study %U https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00661 %V 11 %0 JOURNAL ARTICLE %@ 1664-0640 %X BackgroundPathologies of schizophrenia and bipolar disorder have been poorly understood. Brain network analysis could help understand brain mechanisms of schizophrenia and bipolar disorder. This study investigates the source-level brain cortical networks using resting-state electroencephalography (EEG) in patients with schizophrenia and bipolar disorder.MethodsResting-state EEG was measured in 38 patients with schizophrenia, 34 patients with bipolar disorder type I, and 30 healthy controls. Graph theory based source-level weighted functional networks were evaluated: strength, clustering coefficient (CC), path length (PL), and efficiency in six frequency bands.ResultsAt the global level, patients with schizophrenia or bipolar disorder showed higher strength, CC, and efficiency, and lower PL in the theta band, compared to healthy controls. At the nodal level, patients with schizophrenia or bipolar disorder showed higher CCs, mostly in the frontal lobe for the theta band. Particularly, patients with schizophrenia showed higher nodal CCs in the left inferior frontal cortex and the left ascending ramus of the lateral sulcus compared to patients with bipolar disorder. In addition, the nodal-level theta band CC of the superior frontal gyrus and sulcus (cognition-related region) correlated with positive symptoms and social and occupational functioning scale (SOFAS) scores in the schizophrenia group, while that of the middle frontal gyrus (emotion-related region) correlated with SOFAS scores in the bipolar disorder group.ConclusionsAltered cortical networks were revealed and these alterations were significantly correlated with core pathological symptoms of schizophrenia and bipolar disorder. These source-level cortical network indices could be promising biomarkers to evaluate patients with schizophrenia and bipolar disorder.