TY - JOUR AU - Preuss, Ulrich W. AU - Huestis, Marilyn A. AU - Schneider, Miriam AU - Hermann, Derik AU - Lutz, Beat AU - Hasan, Alkomiet AU - Kambeitz, Joseph AU - Wong, Jessica W. M. AU - Hoch, Eva PY - 2021 M3 - Systematic Review TI - Cannabis Use and Car Crashes: A Review JO - Frontiers in Psychiatry UR - https://www.frontiersin.org/articles/10.3389/fpsyt.2021.643315 VL - 12 SN - 1664-0640 N2 - In this review, state-of-the-art evidence on the relationship between cannabis use, traffic crash risks, and driving safety were analyzed. Systematic reviews, meta-analyses, and other relevant papers published within the last decade were systematically searched and synthesized. Findings show that meta-analyses and culpability studies consistently indicate a slightly but significantly increased risk of crashes after acute cannabis use. These risks vary across included study type, crash severity, and method of substance application and measurement. Some studies show a significant correlation between high THC blood concentrations and car crash risk. Most studies do not support this relationship at lower THC concentrations. However, no scientifically supported clear cut-off concentration can be derived from these results. Further research is needed to determine dose-response effects on driving skills combined with measures of neuropsychological functioning related to driving skills and crash risk. ER -