The Severity of Depression, Anxiety, and Stress: Recommendations From Joint Work of Research Center and Psychology Clinics in COVID-19 Pandemic

The COVID-19 pandemic has significantly affected the psychological stability of general population of Pakistan. However, research on the severity of COVID-19 induced depression, anxiety, and stress (DAS) in Pakistan is scarce. This paper thereby investigates the severity of COVID-19 induced DAS based on demographic, socioeconomic, and personal feeling variables by modeling DAS. Snowball sampling strategy was adopted to conduct online survey from July 03, 2021 to July 09, 2021. Out of 2,442, 2,069 responses from Karachi were included. Descriptive and inferential statistics (binary and multinomial logistic regression analysis) were performed using SPSS V21 (IBM, 2013) to identify significant determinants and their association with DAS severity. The result of this study indicates 27.8, 21.7, and 18.3% respondents suffer from severe and extremely severe states of depression, anxiety, and stress, respectively. Binary logistic regression revealed that age is a significant determinant with odds of having 4.72 (95% CI = 1.86–11.97) and 5.86 (95% CI = 2.26–15.2) times greater depression, and stress for respondents aged 19–26 years. Moreover, gender-based difference is also observed with females 1.34 (95% CI = 1.08–1.68) and 1.75 (95% CI = 1.40–2.20) times more likely to exhibit anxiety and stress than males. Furthermore, marital status is a significant determinant of depression with odds of having depression is 0.67 (95% CI = 0.48–0.93) times greater for married population. Multinomial logistic regression revealed that those who believe COVID-19 pandemic has affected them mentally, fear new COVID-19 cases and deaths, depressed due to imposition of lockdown, believe they will not survive COVID-19 infection, and spend more time on social media gathering COVID-19 updates suffer from extremely severe state of depression (OR mental-effect-of-pandemic = 3.70, OR new-COVID-19-cases-and-deaths = 2.20, OR imposition-of-lockdown = 17.77, OR survival-probability = 8.17, OR time-on-social-media = 9.01), anxiety (OR mental-effect-of-pandemic = 4.78, OR new-COVID-19-cases-and-deaths = 3.52, OR imposition-of-lockdown = 5.06, OR survival-probability = 8.86, OR time-on-social-media = 5.12) and stress (OR mental-effect-of-pandemic = 6.07, OR imposition-of-lockdown = 11.38, OR survival-probability = 15.66, OR time-on-social-media = 4.39). Information regarding DAS severity will serve as a platform for research centers and psychological clinics, to work collectively and provide technology-based treatment to reduce the burden on the limited number of psychologist and psychotherapist.

The COVID-19 pandemic has significantly affected the psychological stability of general population of Pakistan. However, research on the severity of COVID-19 induced depression, anxiety, and stress (DAS) in Pakistan is scarce. This paper thereby investigates the severity of COVID-19 induced DAS based on demographic, socioeconomic, and personal feeling variables by modeling DAS. Snowball sampling strategy was adopted to conduct online survey from July 03, 2021 to July 09, 2021. Out of 2,442, 2,069 responses from Karachi were included. Descriptive and inferential statistics (binary and multinomial logistic regression analysis) were performed using SPSS V21 (IBM, 2013) to identify significant determinants and their association with DAS severity. The result of this study indicates 27.8, 21.7, and 18.3% respondents suffer from severe and extremely severe states of depression, anxiety, and stress, respectively. Binary logistic regression revealed that age is a significant determinant with odds of having 4.72 (95% CI = 1.86-11.97) and 5.86 (95% CI = 2. 26-15.2) times greater depression, and stress for respondents aged 19-26 years. Moreover, gender-based difference is also observed with females 1.34 (95% CI = 1.08-1.68) and 1.75 (95% CI = 1. 40-2.20) times more likely to exhibit anxiety and stress than males. Furthermore, marital status is a significant determinant of depression with odds of having depression is 0.67 (95% CI = 0.48-0.93) times greater for married population. Multinomial logistic regression revealed that those who believe COVID-19 pandemic has affected them mentally, fear new COVID-19 cases and deaths, depressed due to imposition of lockdown, believe they will not survive COVID-19 infection, and spend more time on social media gathering COVID-19 updates suffer from extremely severe state of depression (OR mental-effectof-pandemic = 3.70, OR new-COVID-19-cases-and-deaths = 2.20, OR imposition-oflockdown = 17.77, OR survival-probability = 8.17, OR time-on-social-media = 9.01), anxiety (OR mental-effect-of-pandemic = 4.78, OR new-COVID-19-cases-and-deaths

INTRODUCTION
The SARS-CoV-2 (COVID- 19) outbreak was first reported in Wuhan, China, at the end of December 2019 and has swiftly disseminated across the globe in early March 2020 (1)(2)(3)(4)(5). The novel COVID-19 virus was first reported in Karachi, Pakistan, in February 2020 as confirmed by the Pakistan Ministry of Health (6). Following which, community spread begins making Karachi the epicenter of COVID-19 virus (7). The COVID-19 confirmed cases have reached to 250 million by far with around 5 million deaths (8). In Pakistan alone, the count of individuals infected from COVID-19 is approaching 1.3 million with ∼30,000 deaths (9).
In an attempt to curb the spread of COVID-19 infection, extreme preventive measures such as lockdown, social distancing, social isolation, and quarantine were adopted which have induced fear in people at individual, societal, and international levels (1,10,11). The prevalence of this infectious diseases not only involves risks of lives but also threatens the psychological wellbeing of masses as documented in Asian Journal of Psychiatry (6,12). The psychological symptoms of depression, anxiety, and stress associated with such deadly infectious diseases are due to precarious situation of employment, social capital, and sociocultural factors such as economic burden, family and society support, and low quality education (1,8,9,(13)(14)(15)(16)(17)(18). Moreover, the increasing popularization and interaction with electronic and social media regarding COVID-19 updates have further exacerbated the mental wellbeing of general population as indicated in former studies (19,20).
The COVID-19 pandemic incurred massive mental health issues worldwide. It has an intense effect on mental health, reporting the prevalence of depression, anxiety, and stress at 47, 47, and 44%, respectively, in lower-middle-income countries (21). It is also observed that mental health problems are significantly associated with suicide (22,23). In addition, sleep problem has also been reported high in a nationwide sample of Bangladesh, i.e., 30.4, 13.1, and 2.8% of participants reported subthreshold, moderate, and severe forms of insomnia, respectively (24). During the pandemic time, fear of COVID-19 was also a significant factor of mental disorders in Bangladesh Students (25). Higher psychological distress (41.8%), poor sleep quality (57.1%), increased anxiety (37.19%), along with higher cutoff ratings for psychopathological symptomatology (31.38%) and PTSD (29.5%) have been reported in the Italian population (26)(27)(28). A deteriorated mental health status with increased prevalence of depression and anxiety by 19 and 14% in Hong Kong, 20 and 22.8% in Ireland, and 23.6 and 45.1% in Turkey has been found in former studies (29)(30)(31). Higher odds of anxiety and depression symptomatology were found in the American population as a consequence of the COVID-19 outburst (32). More than half of the respondents reported a profound psychological impact during COVID-19 outbreak in china (1). A previous study reported fear in general public for contacting virus during influenza outburst (33). Likewise, lower rate of quality education and awareness regarding infectious pandemic is also found associated with mental suffering as indicated in a prior study (18). Economic recession with a major cut in salaries and unemployment, and negative emotions experienced by people are intensified during isolation (13)(14)(15)(16). Socio-cultural factors such as economic burden, family support, and social support areas are also deemed essential to influence mental health (8). A strong influence of social capital has been reported in a study conducted in china during COVID-19 (8).
The psychological impacts of the COVID-19 in Pakistan could be catastrophic with only 0.48 psychologist and psychotherapist per 1,000 population (34). Prior to the pandemic, literature documenting pathological stress among working Pakistani adults also showed increased risk of anxiety and depressionrelated symptoms if stress was not appropriately addressed. Furthermore, the prevalence of extreme depression, anxiety, and stress is relatively high in those under 30 (35)(36)(37)(38)(39)(40). The COVID-19 pandemic has the potential to exacerbate a lot of these conditions, which can lead to worst mental health conditions.
Given the large span of COVID-19 outbreak along with the social and economic instabilities that accompanied it, the psychological problems associated with it will persist even after the outbreak is over. The prevalence of COVID-19 induced depression, anxiety, and stress is available for the general population of Pakistan (36)(37)(38)(39)(40)(41), but information related to its level of severity is not available. Keeping in view the limited number of psychologist and psychotherapist in Pakistani setting, the severity level of COVID-19 induced depression, anxiety, and stress demands serious attention. This study conducted in collaboration with clinical psychologist thereby aims to fill the research gap by investigating the prevalence of COVID-19 induced depression, anxiety, and stress along with the magnitude of severity based on demographic, socioeconomic, and personal feeling variable in Karachi, Pakistan, by modeling depression, anxiety, and stress. We hypothesized that the increase in the prevalence of depression, anxiety, and stress will result in an increased severity level of COVID-19 induced depression, anxiety, and stress. In addition to the clinical psychologist, this study also has academic institutes on board to focus on the distribution of the general population of Pakistan depending on the severity levels of depression, anxiety, and stress. The collaboration with academic institute will facilitate data collection from young population which constitutes large proportion of Pakistan's general population. Moreover, the collaboration with healthcare sector and research institutes will also allow appropriate management of each stage of DAS without burdening the limited number of psychologist and psychotherapist available in Pakistani setting by introducing technology in healthcare sectors for assessment and treatment of mental health issues.

Population and Sample Size
A total of 2,442 respondents participated in the study from all over Pakistan. Out of these, 373 responses from provinces and states other than Karachi were excluded as these were from nonurban areas. This small number of responses was excluded to avoid biasness and ensures homogeneous sample population. Eventually, we included 2,069 respondents who had completed and submitted the questionnaires from Karachi-a city with then reported 203,716 COVID-19 cases (42).

Ethical Considerations
Consent was obtained from Nadirshaw Eduljee Dinshaw (NED) University of Engineering and Technology's ethical review committee in Karachi, Pakistan. This questionnaire was developed using Google forms. The survey comprises of a contextual overview, inclusion criteria, directions on answering questions, informed consent, and details of mental healthcare providers as well as principal investigator for reference. There was no anticipated psychological risk associated with participation in the study. All of the participants voluntarily agreed and provided their informed consent to participate in the study by clicking on the "I agree to participate" option provided in the online form. No electronic signature of the participants was obtained to avoid misuse and ensure participant comfort. To ensure privacy, anonymity, and confidentiality, no personal information about the participants was obtained. Demographic information of state and area was required and appeared prior to the questionnaire. Since children under 18 lack intellectual capacity as identified from previous research (43), participants below 18 years of age were asked to fill questionnaires in presence of their parent or guardian to avoid misinterpretation of the questions. This was made certain with a checkbox for under 18 respondents only.

Inclusion/Exclusion Criteria and Data Collection Procedures
Our participants came predominately from Karachi, the most populous metropolitan city of Pakistan and the country's financial hub with highest COVID-19 cases (more than 250 thousand) (44)(45)(46). The nationals of Pakistan living in different countries were excluded from this study to analyze the severity and intensity of psychological distress during COVID-19 outbreak. Moreover, authors who have designed the survey were also excluded from the study to control biasing. Furthermore, a screening question regarding whether the respondent has consulted a psychologist in the past 2 years has enabled exclusion of the respondents having a history of psychiatric disorders. This was done to maintain homogeneity in the sample and to control the potential impact of prior history of psychological problems on current psychological problems.

Recruitment Strategy
A cross-sectional survey design with a snowball sampling strategy was employed to recruit general public of Pakistan. Data were collected from July 03, 2021 to July 09, 2021. In adherence to social distancing practices as recommended by the Government of Pakistan, potential respondents were electronically invited by the investigators. A multilingual survey was designed that comprises of standard English language accompanied with its local Urdu translation in order to overcome the language barrier and facilitate the residents of Pakistan having limited English proficiency (47). The purpose to develop a multilingual survey was to eliminate the likelihood of misinterpretation of the survey questions which is quite frequent when the respondents have a limited English proficiency (48). The general public from all the provinces of Pakistan were invited to take this short assessment of up to 8 mins to help in identification of the factors that are primary contributors of stress, anxiety, and depression during the pandemic. This assessment could only be taken once. The response for each participant was restricted to a single response. The confidential assessment involves minimum risk and does not promise any reward of your participation and neither guarantee any benefit from this study. The survey was disseminated via WhatsApp Inc., Facebook Inc., and other social media platforms that includes LinkedIn and Twitter. The participants were also encouraged to circulate the survey to their contacts.
Demographic variable of generalized questionnaire collected data regarding gender, age, education, and marital status. In the demographic variable, the factor of gender includes male and female. The factor of age is divided into 15-18 years, 19-26 years, 27-40 years, 41-60 years, and above 60 years of age. The factor of education includes bachelor/diploma, F.Sc./intermediate, illiterate, master, matric, and PhD. The factor of marital status is categorized into single, married, divorced, and widow.
Socioeconomic variable of generalized questionnaire included information of the respondents for variation in earning during COVID-19, household size, profession, and engagement in indoor activities during COVID-19 pandemic. The factor of variation in earning during COVID-19, in socioeconomic variable, includes decrease in earning, increase in earning, no change in earning, loss of job, and not applicable (mostly for students). The factor of household size collects information regarding the number of dependents that includes 0-4 dependents, 5-7 dependents, 8-10 dependents, and more than 10 dependents. The profession factor is categorized into corporate owner, government employee, housewife, private sector employee, retired, self-employed, shopkeeper, student, and those who are unemployed. The factor of engagement in indoor activities gathers information of participant involvement in indoor activities, participants not involved in indoor activities, and those who are somewhat involved in indoor activities.
Variable of personal feeling explicitly describes the thoughts of the responders regarding the pandemic and is not standardized. The parameters of personal feelings in the generalized questionnaire included the survival chances if infected with COVID-19 virus, psychological impact during exposure to a public health crisis, time spent on TV and social media collecting COVID-19 updates, the trend of new cases and death, and effect on mood of the respondents during lockdown. The factor of survival chances if infected with COVID-19 virus is categorized into those who believe that they will get well soon, those who believe that they will not survive COVID-19 infection, and those who are not sure. The factor of psychological impact during exposure to a public health crisis collects information regarding those who believe that COVID-19 pandemic has affected them mentally, those who believe that pandemic have not affected them mentally, and those who are not sure of the effect of pandemic on their mental health. The factor of time spent on TV and social media collecting COVID-19 updates is categorized into <1 h spent on social media, 1-3 h spent on social media, 4-6 h spent on social media, and more than 6 h spent on social media. Anxious, depressed, fear, upset, worried, and no effect are the subcategories for the factors of effect of lockdown as well as new cases and death.

Statistical Analysis
Investigators stored data in a Microsoft Excel template (Microsoft, 2019) and exported the results to SPSS V21 (IBM, 2013) for statistical analysis. We used frequencies and percentages along with means and standard deviations to analyze the distribution of respondents among normal, mild, moderate, severe, and extremely severe state of DASS subscale.
We used binary logistic regression model to identify the strong determinants of depression, anxiety, and stress. The model used depression, anxiety, and stress as dependent variables and demographic, socioeconomic, and personal feeling factors as independent variables. For this purpose, DASS subscale results were transformed into "dummy variables, " represented with non-symptomatic and symptomatic. Respondents who were normal on DASS scale were referred to as non-symptomatic. Symptomatic, in this instance, referred to anyone who scored "mild, " "moderate, " "severe, " and "extremely severe" on the DASS. We then created three binary logistic regression models for each subscale. Wald coefficient was obtained to determine strength of significant determinants. p < 0.05 was set as significance level. Beta and confidence interval were obtained. A Homer-Lemeshow test was conducted to determine the goodness of fit. The 2 log likelihood ratio was used to determine the significance of the logistic models, while a Cox-Snell R2 and a Nagelkerke 2 were used to determine the value of each of the determinant to the outcome of interest.
We also performed multinomial logistic regression analysis and created three distinct models each for depression, anxiety, and stress to determine the association of level of severity of DASS subscales with the personal feeling variable identified significant from binary logistic regression. For each of the three models, only psychological determinants identified as significant with the binary regression model were used as independent variables. Only the dependent variable differs between the three models with depression being dependent variable in model 1, anxiety in model 2, and stress in model 3. p < 0.05 was set as significance level. Crude odds ratio and confidence interval were obtained. The goodness of fit was determined via Pearson's chi-square, and extreme variables were determined through deviance residuals. The Cox-Snell R2 and a Nagelkerke 2 were used to determine the value of each of the predictors to the outcome of interest, while Mc Fadden was used to determine the effect size. Table 1 presents the distribution of the respondents in demographic, socioeconomic, and psychological variables. The distribution of the demographic variable reveals that the majority of the respondents were male (56.1%), aged 19-26 (49.3%), single (59.8%), and well-educated with or enrolled in bachelor's degree (50.5%). The socioeconomic distribution reflects that a large amount of the study population was private sector employee (32.9%), 0-4 dependents (66.6%), no change   were identified to be symptomatic (mild, moderate, severe, and extremely severe) with 29.8%, 21.7%, and 18.3% severe and extremely severe cases for depression, anxiety, and stress. Table 3 presents binary logistic regression to identify the strong determinants from generalized variables for depression, anxiety, and stress. The demographic variable "marital status" (Wald = 6.66) is found to be a strong determinant of depression with the odds of 0.67 for married respondents as opposed  to unmarried respondents. Furthermore, factor "gender" is found to be a strong determinant of anxiety (Wald = 7.03) and stress (Wald = 24.20) with females being 1.34 and 1.75 times more likely to exhibit anxiety and stress, respectively, than males. Moreover, "age, " another demographic variable, is found to be a strong determinant of depression (Wald = 12.46) and stress (Wald = 16.52). Decreasing age was associated with an increased likelihood of exhibiting depression and stress. The respondents aged 19-26 years are most likely to suffer from depression (Wald = 10.69, OR = 4.72) and stress (Wald = 13.27, OR = 5.86) than those aged above 60 years.

RESULTS
In the socioeconomic variable, the factors of "variation in earning" (Wald = 20.92) and "number of dependents" (Wald = 7.82) are found to be a strong determinants of depression only.
All the factors of personal feelings are found to be a strong determinant of depression, anxiety, and stress. The "mental effect of pandemic" is a significant factor for depression (Wald = 57.60), anxiety (Wald = 71.59), and stress (Wald = 49.53). The respondents who believe that the pandemic has not affected them mentally have reduced odds of having depression (OR = 0.36), anxiety (OR = 0.33), and stress (OR = 0.42). Moreover, the "effect of lockdown" is a significant factor for depression (Wald . The respondents who fear new COVID-19 cases and deaths and those who spend more than 6 h on social media are 2.74 and 3.10 times more likely to suffer from depression, 2.61 and 2.76 times more likely to suffer from anxiety, and 2.18 and 2.70 times more likely to suffer from stress. Also, respondents who believe to have a greater survival chance are 0.74, 0.73, and 0.65 times less likely to suffer from depression, anxiety, and stress Tables 4A-C presents multinomial logistic regression analysis for severity of depression, anxiety, and stress, respectively, as opposed to the respondents having normal DAS scores. For Table 4A, the factor "mental effect of pandemic" increases the likelihood of depression for the respondents who believe that the pandemic has affected them mentally and those who remains neutral regarding the mental effect of pandemic with mild (OR affected = 1. 74 The increase in "time spent on social media" to gather COVID-19 updates increases the likelihood of severe (OR = 4.56) and extremely severe (OR = 9.01) state of depression. When compared with those who believe that they will "survive the COVID-19 infection, " the respondents who believe that they will have less or no survival probability are at higher likelihood of severe (OR not survive = 5.05) and extremely severe (OR not survive = 8.17, OR not sure = 1.76) state depression.
As per Table 4B (Anxiety), the factor "mental effect of pandemic" increases the likelihood of anxiety for the respondents who believe that the pandemic has affected them mentally and those who remains neutral regarding the mental effect of pandemic with mild (OR affected = 2.67, OR neutral = 1.98), moderate (OR affected = 2.11, OR neutral = 1.68), severe (OR affected = 4.00), and extremely severe states (OR affected = 4.78) of anxiety. In contrast to those who does not report any effect of "new COVID-19 cases and deaths, " an increased likelihood of having anxiety is observed for the respondents who fear, depressed, worried, and anxious with moderate (OR fear = 3.60, OR depressed = 3.06, OR worried= 2.41, OR anxious = 2.32) and extremely severe (OR fear = 2.58, OR depressed = 3.52) states of anxiety. It is also observed that the likelihood of anxiety increases for the respondents who fear, depressed, worried, anxious, and upset from the "implication of lockdown" evident with mild (OR fear = 3.34), moderate (OR fear = 5.33, OR depressed = 2.82, OR worried = 1.71, OR anxious = 2.40, OR upset = 1.78), severe (OR fear = 4.75, OR anxious = 2.28), and extremely severe (OR fear = 9.24, OR depressed = 5.06, OR worried = 2.13, OR anxious = 3.57, OR upset = 2.55) states of anxiety, as opposed to those with no affect. The increase in "time spent on social media" to gather COVID-19 updates increases the likelihood of extremely severe (OR = 5.12) state of anxiety. When compared with those who believe that they will "survive the COVID-19 infection, " the respondents who believe that they will have less or no survival probability are at higher likelihood of moderate (OR not survive = 3.74, OR not sure = 1.31), severe (OR not survive = 6.71, OR not sure = 1.63), and extremely severe (OR not survive = 8.86, OR not sure = 1.57) state anxiety.
As per Table 4C (Stress), the factor "mental effect of pandemic" increases the likelihood of stress for the respondents who believe that the pandemic has affected them mentally with mild (OR affected = 1.59), moderate (OR affected = 2.52), severe (OR affected = 4.35), and extremely severe states (OR affected = 6.07) of stress. In contrast to those who does not report any effect of "new COVID-19 cases and deaths, " an increased likelihood of having stress is observed for the respondents who fear and depressed, with mild (OR fear = 2.32) and moderate (OR fear = 2.85, OR depressed = 2.33) states of stress. It is also observed that the likelihood of stress increases for the respondents who fear, depressed, worried, anxious, and upset from the "implication of lockdown" evident with mild (OR depressed = 3.06, OR anxious = 1.80), moderate (OR fear = 2.56, OR depressed = 3.52, OR worried = 1.68, OR anxious = 2.95, OR upset = 1.87), severe (OR fear = 6.99, OR depressed = 6.30, OR worried = 2.76, OR anxious = 4.39, OR upset = 2.65), and extremely severe (OR fear = 10.31, OR depressed = 11.33, OR worried = 3.75, OR anxious = 6.48) state of stress, as opposed to those with no affect. The increase in "time spent on social media" to gather COVID-19 updates increases the likelihood of mild (OR = 2.25), moderate (OR = 3.57), severe (OR = 3.28), and extremely severe (OR = 4.39) state of stress. When compared with those who believe that they will "survive the COVID-19 infection, " the respondents who believe that they will have less or no survival probability are at higher likelihood of mild (OR not survive = 4.42, OR not sure = 1.40), moderate (OR not sure = 1.47), severe (OR not sure = 1.56), and extremely severe (OR not survive = 15.66, OR not sure = 2.02) state stress.

DISCUSSION
The aim of this study is to investigate the mental health status of general public of Pakistan and the level of severity of emotional states of depression, anxiety, and stress in the   These increased levels of psychological distress evident from this study could therefore be perceived as the impact of COVID-19 pandemic. The findings from our demographic data revealed gender, age, and marital status to be a strong predictor of DASS subscales. A greater psychological distress was observed for females and unmarried population under the age of 30 and is coherent with the previous studies (1,(59)(60)(61)(62)(63). Increased depression, anxiety, and stress levels in unmarried population could be explained with the fact that Pakistan is a country with a dominant population of young adults, most of which are unmarried or single for up to 30 years of age (35,64,65). These findings recommend the government to take serious attention to conduct awareness sessions and to take initiatives for the assessment of the mental health of young individuals under the age of 30 which are identified to be more prone to increasing level of severity of depression, anxiety, and stress and provide psychological interventions to the identified high-risk group, thereby targeting majority of Pakistani population.
The government of Pakistan took initiative to support smallscale business and for providing financial aid in order to ensure food supplies for those having large household size and for those whose earnings are reduced during this pandemic. These programs include Ehsaas Koye Bhooka Na Soye (EKBNS) and Kamyab Pakistan Program (KPP) (66,67). This study reported that earnings and household size are strong predictor of depression, which is in accordance with other studies conducted in pandemic (62,68,69). Hence, it is recommended that government should not only continue but expand those programs because controlling mental health issues due to socioeconomic predictors requires financial assistance from state. These initiatives would have an impact even after pandemic.
The most notable finding of this study is that the outbreak of COVID-19 pandemic induces fear in general public of Pakistan primarily in the target population that spend more time on social media to obtain updated information related to rise in COVID-19 infected cases, misconception of lower survival possibility upon acquiring COVID-19 infection and escalated mortality rate and complies with the existing literature (70)(71)(72). This adverse psychological impact due to electronic and social media could be explained with 77% population using smartphones and 63% of the 76 million people who have Internet access (18,73,74). It is further supported from the existing literature which indicated that the excessive Internet use was significantly associated with depression and anxiety (75) and social media use was a significant factor in higher problematic smartphone use (76). The academic institutes in particular universities majorly comprise of young population together with the support of research centers will allow the clinicians to offer digitize assessment and up-to-date technology-based treatment to the majority of the most vulnerable group of Pakistani population. The engineers and researchers at research centers can develop and implement the state-of-the-art technology that could transform the traditional clinical practices and enable the psychologist and psychotherapist to conduct multiple treatment sessions simultaneously thereby reducing their load. To support the limited number of psychologist and psychiatrist (i.e., 0.48 per 100,000 population), the neurocomputation research group is working in close collaboration with clinical psychologist to deliver effective technological solutions such as transcranial direct current stimulation, neurofeedback, and binaural beat necessary to reduce the psychological sufferings of the general population of Pakistan without burdening the healthcare practitioners. A total of 40 respondents were provided with the technology-based treatment by the neurocomputation research group at the request of clinical practitioners, out of 120 respondents who visited the mental healthcare professionals via this survey. The preliminary findings of technologybased treatment are promising, and clinicians showed comfort for practicing in clinic. The availability of technology-based treatment will reduce the treatment load of mental healthcare providers so that they could concentrate more on assessment of the mental wellbeing of the respondents thereby managing the assessment load. As indicated in this study, where COVID-19 induced depression, anxiety, and stress is at its peak, it is highly needed that similar model with interdisciplinary field should work collectively and also ensure its practical implementation for better management of mental health issues in a country where mental health is considered a social stigma and have limited number of psychologist and psychotherapist to provide medical attention to the affected individuals. Hence, this study will serve as a model for other clinics and research centers to revolutionize the conventional clinical practices.
This study has several limitations. It includes online responses since population-based survey was not possible during the COVID-19 outbreak. The online response has limited the accessibility of the survey to the respondents having an Internet facility which is largely available in the urban centers of Pakistan. The non-urban areas of Pakistan have limited Internet accessibility because of which a relatively small number of responses were gathered. This reduces the generalizability and increases the selection bias, of our model. However, the usability of Internet has enabled collection of large data. Moreover, the population of Karachi have diversified origins and cover people from both rural and urban regions (77)(78)(79) thereby ensuring generalizability of the study to the general population of Pakistan and in particular to the urban center of Pakistan. Most of the respondents were educated, thus skewing results of an entire population to solely college-educated civilians and not those with other forms of education or work. Oversampling of young participants may also cause bias and limits its applicability to the entire population. However, the distribution of Pakistan population is skewed toward young age under 30 as indicated by the Pakistan Bureau of Statistics (35). As this is an online research study, the responses obtained from the respondents under 18 years of age could be argued. Moreover, with online survey, a Hawthorne effect, that is the feeling that someone is analyzing these results, may skew the results to be more favorable one way or another. Future research is needed to include people from rural areas, those with a less than college education, as well as to further increase the generalizability of the data collected.

CONCLUSION
This study suggests that variable of personal feeling has significantly impacted the mental wellbeing and has largely induced increasing severity levels of COVID-19 related depression, anxiety, and stress. Hence, it is required to conduct awareness seminars, assessment, and treatment sessions on large scale. This indicates the need of collaborative initiatives of technology-based treatment so that the limited number of mental health practitioners could cope up with the increasing number of patients with COVID-19 induced depression, anxiety, and stress.

DATA AVAILABILITY STATEMENT
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

ETHICS STATEMENT
The studies involving human participants were reviewed and approved by Nadirshaw Eduljee Dinshaw (NED) University of Engineering and Technology's Ethical Review Committee in Karachi, Pakistan. Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin.