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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2022.930059</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Problematic substance use and its associated factors among street youth in Bahir Dar city, Ethiopia</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Shegaw</surname> <given-names>Maregu</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1786196/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Fekadu</surname> <given-names>Wubalem</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/588241/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Beka</surname> <given-names>Michael</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Menberu</surname> <given-names>Melake</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Yohannes</surname> <given-names>Kalkidan</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/683487/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Yimer</surname> <given-names>Solomon</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/738663/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Seid</surname> <given-names>Mohammed</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Necho</surname> <given-names>Mogesie</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1458462/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Moges</surname> <given-names>Solomon</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Anbesaw</surname> <given-names>Tamrat</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1490240/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Department of Psychiatry, College of Medicine and Health Science, Wollo University</institution>, <addr-line>Dessie</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff2"><sup>2</sup><institution>Department of Psychiatry, College of Medicine and Health Science, Bahir Dar University</institution>, <addr-line>Bahir Dar</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Psychiatry, College of Medicine and Health Science, Dilla University</institution>, <addr-line>Dilla</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff4"><sup>4</sup><institution>Department of Psychiatry, College of Medicine and Health Science, Woldia University</institution>, <addr-line>Woldia</addr-line>, <country>Ethiopia</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Julian Schwarz, Brandenburg Medical School Theodor Fontane, Germany</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Getasew Legas, Debre Tabor University, Ethiopia; Dinaol Urgessa Gita, Jimma University College of Education and Behavioral Sciences, Ethiopia</p></fn>
<corresp id="c001">&#x002A;Correspondence: Maregu Shegaw, <email>maregu386@gmail.com</email></corresp>
<fn fn-type="other" id="fn004"><p>This article was submitted to Public Mental Health, a section of the journal Frontiers in Psychiatry</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>28</day>
<month>07</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="collection">
<year>2022</year>
</pub-date>
<volume>13</volume>
<elocation-id>930059</elocation-id>
<history>
<date date-type="received">
<day>27</day>
<month>04</month>
<year>2022</year>
</date>
<date date-type="accepted">
<day>05</day>
<month>07</month>
<year>2022</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2022 Shegaw, Fekadu, Beka, Menberu, Yohannes, Yimer, Seid, Necho, Moges and Anbesaw.</copyright-statement>
<copyright-year>2022</copyright-year>
<copyright-holder>Shegaw, Fekadu, Beka, Menberu, Yohannes, Yimer, Seid, Necho, Moges and Anbesaw</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>Problematic substance use is becoming a common problem in marginalized groups such as street youths. However, there is a dearth of studies on the prevalence and factors associated with problematic substance use among street youth in Ethiopia.</p>
</sec>
<sec>
<title>Objective</title>
<p>The objective of this study was to determine the prevalence of problematic substance use and identify its associated factors among street youth.</p>
</sec>
<sec>
<title>Methods</title>
<p>This community-based cross-sectional study was conducted between June and July 2020. A total of 252 participants were included in this study. Systematic random sampling was used to recruit participants. Cut down, annoyed, guilty feeling, and eye opening-adapted to include drugs (CAGE-AIDs) were used to assess problematic substance use. The data were entered into epidata and exported to SPSS version 25 for analysis. Logistic regression with a 95% confidence interval (CI) was used to show the strength of association. A <italic>p</italic>-value &#x003C; 0.5 was statistically significant.</p>
</sec>
<sec>
<title>Results</title>
<p>The prevalence of problematic substance use was 55.8%, 95% CI (49&#x2013;63%). Peer pressure [adjusted odds ratio (AOR) = 3.01, 95% CI: 1.38, 6.59], family conflict [AOR = 5.05, 95% CI: 1.67, 15.25], physical abuse [AOR = 2.56, 95% CI: 1.11, 5.84], and substance use in the family [AOR = 2.85, 95% CI: 1.29, 6.27] were the factors significantly associated with problematic substance use.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>The prevalence of problematic substance use was high. It was also found that peer pressure, family conflict, substance use in the family, and physical abuse were the factors associated with problematic substance use. Therefore, proper screening and intervention for individuals with problematic substance use are needed, and further research should be conducted for marginalized groups.</p>
</sec>
</abstract>
<kwd-group>
<kwd>problematic substance use</kwd>
<kwd>street youth</kwd>
<kwd>associated factors</kwd>
<kwd>Bahir Dar city</kwd>
<kwd>Ethiopia</kwd>
</kwd-group>
<counts>
<fig-count count="0"/>
<table-count count="4"/>
<equation-count count="0"/>
<ref-count count="40"/>
<page-count count="9"/>
<word-count count="6196"/>
</counts>
</article-meta>
</front>
<body>
<sec id="S1" sec-type="intro">
<title>Introduction</title>
<p>Problematic substance use is a complex condition in which patterns of use may interfere with a person&#x2019;s life and lead to physical and/or psychological dependence and withdrawal symptoms (<xref ref-type="bibr" rid="B1">1</xref>). It is also becoming a serious, ongoing public health problem; it affects almost every community and family in some way, and youths are the most at-risk population for abusing different psychoactive substances (<xref ref-type="bibr" rid="B2">2</xref>). It is believed that the adverse effects of problematic substance use are more serious among young individuals as over 90% of substance users experience their first use during adolescence and later face substance use disorder and its serious adverse effects, including depression, suicide, problems in interpersonal relationships, and traffic-related injuries or deaths (<xref ref-type="bibr" rid="B3">3</xref>). The living conditions of street children are rough; therefore, the threats hanging over them endanger their survival all the time. Being a street child means not taking one&#x2019;s fill, sleeping in unsanitary places, facing up to violence, and sometimes becoming a sacrificial victim, as well as growing up without a bear, love, or safeguard, having no access to education or health services, losing all dignity, and becoming an adult before knowing what it is to be a child. In such circumstances, drugs, HIV/AIDS, sexually transmitted diseases (STDs), and unwanted pregnancy don&#x2019;t represent a danger. In this case, drugs help deal with everyday life (<xref ref-type="bibr" rid="B4">4</xref>).</p>
<p>Their health and the welfare of people are also endangered because of the use of illicit drugs throughout the world (<xref ref-type="bibr" rid="B5">5</xref>). The mortality rates among street youth are 10 times those of the general adolescent population, and drug overdose is one of the leading causes of death (<xref ref-type="bibr" rid="B6">6</xref>). In addition, youth experiencing homelessness, in general, are more likely to be substance users (<xref ref-type="bibr" rid="B7">7</xref>).</p>
<p>In contrast, street youth come from tense and distressed families, characterized, in most cases, by poverty and parental mental health and/or substance use concerns (<xref ref-type="bibr" rid="B8">8</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>). They also experience various forms of abuse, neglect, chronic stress, and trauma. These unpleasant conditions generally begin in their early lives, while young people live with their families of origin (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B11">11</xref>). Approximately 23% of homeless youth reported that a loved one was the first person to supply or promote their use of alcohol, marijuana, or a particular drug and thus was liable for their initiation into substance use (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B13">13</xref>). There is also evidence that family plays a key role in prevention and intervention, both by inducing risk or encouraging and promoting protection and resilience (<xref ref-type="bibr" rid="B14">14</xref>). Their nature of continuous exposure to the street and its associated lifestyles make street youth susceptible to the use of psychoactive substances. In addition, intentional inhalation of volatile solvents and other inhalants is also an increasing problem, particularly in marginalized groups. Besides this, the use of cannabis or marijuana is becoming increasingly widespread worldwide (<xref ref-type="bibr" rid="B15">15</xref>). According to the World Health Organization (WHO) report, sexual abuse, police violence, and drug use are major problems for street children and youth in Africa, Latin America, and North America (<xref ref-type="bibr" rid="B16">16</xref>).</p>
<p>Various studies have shown that the overall prevalence rate of problematic substance use among street youth is high. A study done in Texas among homeless youth showed the lifetime use of alcohol and marijuana was 66%. The current prevalence of alcohol and marijuana was found to be 38 and 36%, respectively, 29% had ever used stimulants, and 12% had used them in the past month (<xref ref-type="bibr" rid="B17">17</xref>). A related study in the United States city of Los Angeles on cigarette and alternative tobacco product use indicated that nearly 90% of participants reported smoking regular cigarettes, and 78% reported using at least one tobacco product other than regular cigarettes (<xref ref-type="bibr" rid="B18">18</xref>). In Canada, hazardous alcohol use among street-involved youth was 55% (<xref ref-type="bibr" rid="B19">19</xref>). Other studies in Accra, Ghana, revealed that substance use was relatively high, as 12 and 16.2% reported daily use of alcohol and marijuana, respectively (<xref ref-type="bibr" rid="B3">3</xref>). In Ethiopia, the prevalence of substance use among street children was 30.8% (<xref ref-type="bibr" rid="B20">20</xref>).</p>
<p>A systematic review and meta-analysis conducted in resource-constrained settings showed that the main reason for drug use was found to be the duration of time a child was street-involved. Staying at night, having family contact, being older age, male sex, and sexual activities were associated with substance use in all studies. They also further identified that peers and peer pressure are the most commonly reported reasons for substance use behavior (<xref ref-type="bibr" rid="B21">21</xref>).</p>
<p>Substance abuse is common among street youth and young adults, with more than 75% having used alcohol (<xref ref-type="bibr" rid="B22">22</xref>) and/or marijuana (<xref ref-type="bibr" rid="B23">23</xref>) in their lifetime. It is associated with psychological distress, functional impairment, physical ill-health, and risk-taking behavior. Khat and alcohol are among the substances widely consumed by youths in Ethiopia (<xref ref-type="bibr" rid="B24">24</xref>).</p>
<p>There are also various factors associated with the high rate of alcohol use among street youth, including individual-level variables such as using alcohol or drugs for coping or for fun, followed by family level factors (<xref ref-type="bibr" rid="B25">25</xref>). Furthermore, increasing age was linked to an increase in the likelihood of using alcohol and marijuana (<xref ref-type="bibr" rid="B26">26</xref>). Those aged &#x003E; 14 years, those in grades 1&#x2013;4, those in grades 5th and above, children whose mother used substances, children who did not know their maternal substance use status, children whose siblings used substances, best friend&#x2019;s substance use, staying 12&#x2013;60 months on the street, and staying &#x003E; 5 years on the street were all significantly associated with substance use (<xref ref-type="bibr" rid="B20">20</xref>).</p>
<p>Even though substance abuse has become a widespread problem in Ethiopia, most previous studies have focused on school, college, and university students, with less or no research on street youths and their substance abuse habits in Ethiopia, particularly in Bahir Dar.</p>
<p>Problematic substance use, as previously mentioned, seriously affects youths, who are the major labor force of the country. In addition, the street youth who are unemployed, homeless, and drug users are a burden on the country. Unfortunately, studies focusing on this plague are very limited. However, the nature of the problem was underestimated and wasn&#x2019;t realized by the concerned bodies. Therefore, this study aimed to investigate the prevalence of problematic substance use and its associated factors among street youth in Bahir Dar, Ethiopia.</p>
</sec>
<sec id="S2" sec-type="materials|methods">
<title>Materials and methods</title>
<sec id="S2.SS1">
<title>Study design and setting</title>
<p>A community-based cross-sectional study was conducted between June and July 2020 in the city of Bahr Dar, which is located in the Amhara region, 565-km northwest of Addis Ababa. Previously, Bahr Dar was registered as a municipality, but now it is the capital city of Amhara National Regional State. The nearby rural kebeles and other satellite towns of Meshenti, Zeghe, and Tis Abay are currently administered by the Bahir Dar city administration. The town now serves as a center for various social, economic, and political activities.</p>
</sec>
<sec id="S2.SS2">
<title>Population</title>
<p>All street youths in Bahir Dar during the study period were included in the study population. All street youths between the ages of 12 and 24 years were included in the study, although those who were extremely ill at the time of the data collection or had communication difficulties were not.</p>
</sec>
<sec id="S2.SS3">
<title>Sample size determination</title>
<p>The sample size was calculated based on a single population proportion formula by considering the following assumptions: (1) with a margin of error of 5, (2) a 95% CI; (3) the prevalence of problematic substance use from the study done in Kenya (78%) was taken (<xref ref-type="bibr" rid="B26">26</xref>); (4) a non-response rate of 10%; and (5) finally, we used a correction formula since the total source population was less than 10,000 (2,000) according to Bahir Dar City Labor and Social Affairs 2019 statistics. Using the abovementioned assumptions, the final sample size after adding the 10% non-response rate was 257.</p>
</sec>
<sec id="S2.SS4">
<title>Sampling procedure</title>
<p>Various measures were implemented during the COVID-19 pandemic, but the lockdown was the only one to stop the virus from spreading. Street children and youths were placed under lockdown by the Bahir Dar municipal administration, where they spent more than 2 months attending Tana preparatory and secondary high schools. A systematic random sample was carried out using COVID-19 methods in each participant&#x2019;s eighth intervals for a total of 2,120 participants. The study included 257 street youths, and it evaluated both their lifetime and current substance use. Among individuals who were deemed to be current users, the prevalence of problematic substance use and its associated factors were determined.</p>
</sec>
<sec id="S2.SS5">
<title>Data collection instruments, personnel, and quality assurance</title>
<p>The questionnaire included sociodemographic information, problematic substance use, personal factors, environmental factors, individual-level factors, family factors (parental monitoring, substance use in the family, and family conflict), adverse childhood experiences (ACEs) (physical, psychological, or sexual abuse; violent or threatening mother), and perceived stress. The questionnaire was modified after a pretest was conducted. The questionnaire used to collect data was translated into local languages. The data were collected by four health extension workers who were supervised and assisted by one who qualified the Bachelor of Science degree in psychiatry nurse. A face-to-face interview was used to collect the data. Training was conducted on the data collection procedure and data collection tools for data collectors and supervisors.</p>
</sec>
<sec id="S2.SS6">
<title>Measurements</title>
<sec id="S2.SS6.SSS1">
<title>Street youth</title>
<p>Based on this study, homeless youths are defined as individuals aged between 12 and 24 years who are without stable housing and who identify with the culture and economy of living on the street (<xref ref-type="bibr" rid="B25">25</xref>, <xref ref-type="bibr" rid="B27">27</xref>, <xref ref-type="bibr" rid="B28">28</xref>).</p>
<p>Cut down, annoyed, guilty feeling, and eye opening-adapted to include drug (CAGE-AID) has been developed to identify problematic substance use in the community and has four items. A score of two or greater positive answers from the four-question screening tool was considered problematic. The sensitivity and specificity of this instrument were 0.7 and 0.85, respectively. The CAGE-AID in this study also had good internal consistency with a Cronbach&#x2019;s alpha of 0.81. This tool has also been widely used in Ethiopia to assess problematic substance use (<xref ref-type="bibr" rid="B24">24</xref>, <xref ref-type="bibr" rid="B29">29</xref>).</p>
<p>Usage of any psychoactive substance throughout one&#x2019;s life is considered &#x201C;lifetime use of a substance.&#x201D; Current substance use is defined as the use of psychoactive drugs for non-medical purposes (alcohol, cigarettes, inhalants, cannabis, and khat) in the previous 3 months (<xref ref-type="bibr" rid="B30">30</xref>).</p>
</sec>
<sec id="S2.SS6.SSS2">
<title>Alcohol, Smoking, Substance Involvement Scale</title>
<p>The first two items were used to assess the lifetime and current use of substances. Alcohol, Smoking, Substance Involvement Scale (ASSIST) was originally developed by the WHO in 2001 as a tool for substance and alcohol use screening in primary care settings. Current substance use was assessed by asking respondents whether or not they had used any substances in the previous 3 months. The response was dichotomized as 0 = no and 1 = yes. If they respond &#x201C;yes,&#x201D; a scale which ranges from (2) once or twice, (3) monthly, (4) weekly, and (5) daily or almost daily was assessed (<xref ref-type="bibr" rid="B30">30</xref>).</p>
</sec>
<sec id="S2.SS6.SSS3">
<title>Environmental variables</title>
<p>The availability of alcohol or drugs in one&#x2019;s community was assessed by asking youth, &#x201C;in terms of obtaining any type of alcohol or drug in your community,&#x201D; &#x201C;would you say it is (0) very difficult or somewhat difficult to obtain alcohol or drugs, and (1) somewhat easy or very easy to obtain alcohol or drugs.&#x201D; Peer pressure was assessed by dummy variables whether they had used substances due to peer influence or not, with a response of (0 = no and 1 = yes) (<xref ref-type="bibr" rid="B25">25</xref>).</p>
</sec>
<sec id="S2.SS6.SSS4">
<title>Individual-level factors</title>
<p>It consists of six components that were taken from a study that was conducted in Zambia. Participants were asked whether they used alcohol or drugs for the following purposes: (1) &#x201C;to enhance sexual encounters,&#x201D; (2) &#x201C;to cope with stress,&#x201D; (3) &#x201C;to forget their issues,&#x201D; (4) &#x201C;dueling hunger or cold weather,&#x201D; (5) &#x201C;out of curiosity,&#x201D; and (6) &#x201C;for pleasure,&#x201D; with a response of 0 = no; 1 = yes (<xref ref-type="bibr" rid="B25">25</xref>).</p>
</sec>
<sec id="S2.SS6.SSS5">
<title>Parental monitoring</title>
<p>The scale was assessed by using a 7-item Family, Friends, and Self-Assessment Scale (FFS). Each item was rated on a 4-scale range of (0) never, (1) rarely, (2) sometimes, (3) often, and (4) almost always. Those who scored above the mean score were considered to have high parental monitoring (<xref ref-type="bibr" rid="B31">31</xref>). From this study, this instrument had good internal consistency, which was 0.7.</p>
</sec>
<sec id="S2.SS6.SSS6">
<title>Family conflict</title>
<p>Four items from the FFS were used in the assessment. A four-point scale with the options (0) never, (1) seldom, (2) sometimes, (3) often, and (4) almost always was used to rate each item. High family conflict is defined as having a score above the mean (<xref ref-type="bibr" rid="B31">31</xref>). This tool&#x2019;s internal consistency in this study was good, with a Cronbach&#x2019;s alpha of 93.3%.</p>
<p>The ACE scale was used to determine whether a person had ever experienced psychological abuse (2 questions), physical abuse (2 questions), or sexual abuse (2 questions). There are four types of childhood exposure to dysfunctional households, namely, substance abuse (2 questions), mental illness (2 questions), physical abuse of a mother or stepmother (3 questions), and criminal activity (1 question). Every item has a code, 0 for no and 1 for yes (<xref ref-type="bibr" rid="B32">32</xref>).</p>
<p>The current stress was assessed using the perceived stress scale. Four items ask participants how often they found life situations stressful, unpredictable, and uncontrollable over the previous month using a 5-point Likert scale rated from 0 = never to 4 = very often. A score above the mean was considered to have a higher level of perceived stress (<xref ref-type="bibr" rid="B33">33</xref>). In Houston, Texas, these tools have been used for homeless youth and young adults (<xref ref-type="bibr" rid="B17">17</xref>). In this study, this tool had good internal consistency with a Cronbach&#x2019;s alpha of 89.3%.</p>
</sec>
</sec>
<sec id="S2.SS7">
<title>Data processing and analysis</title>
<p>The accuracy and consistency of the data used in this study were first verified. The data were then encoded and cleaned using EpiData version 4.6.2. The data were subsequently analyzed using SPSS version 25. To describe the study variables to the study participants, descriptive statistics (frequency distributions, percentages, and cross-tabulations) were utilized. Bivariate and multivariable logistic regressions were conducted. To determine the relationship between covariates and the dependent variable, variables with a bivariate logistic regression <italic>p</italic>-value of 0.25 were included in a multivariate logistic regression. The 95% confidence intervals and odds ratios were applied. Statistics were considered significant for <italic>p</italic>-values under 0.05.</p>
</sec>
</sec>
<sec id="S3" sec-type="results">
<title>Results</title>
<sec id="S3.SS1">
<title>Sociodemographic factors</title>
<p>A total of 252 respondents participated in the study, with a response rate of 98%. Of the total participants, 99.5% were men. The median age of the participants was 17 years, with an interquartile range of 7. All of the study participants were from the Amhara Region. The majority of the study subjects (227, 90.1%) were orthodox Christians, and 33.8% were able to read and write. The median duration in the street was 7.5 months, with an interquartile range of 10 (<xref ref-type="table" rid="T1">Table 1</xref>).</p>
<table-wrap position="float" id="T1">
<label>TABLE 1</label>
<caption><p>Sociodemographic characteristics of street youth in Bahir Dar, Northwest Ethiopia, in 2020.</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left">Socio-demographic characteristics</td>
<td valign="top" align="center">Number</td>
<td valign="top" align="center">Percentage (%)</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" colspan="3"><bold>Age</bold></td>
</tr>
<tr>
<td valign="top" align="left">12&#x2013;17</td>
<td valign="top" align="center">129</td>
<td valign="top" align="center">51.2</td>
</tr>
<tr>
<td valign="top" align="left">18&#x2013;24</td>
<td valign="top" align="center">123</td>
<td valign="top" align="center">48.8</td>
</tr>
<tr>
<td valign="top" align="left" colspan="3"><bold>Religion</bold></td>
</tr>
<tr>
<td valign="top" align="left">Orthodox</td>
<td valign="top" align="center">227</td>
<td valign="top" align="center">90.1</td>
</tr>
<tr>
<td valign="top" align="left">Muslim</td>
<td valign="top" align="center">20</td>
<td valign="top" align="center">7.9</td>
</tr>
<tr>
<td valign="top" align="left">Others</td>
<td valign="top" align="center">5</td>
<td valign="top" align="center">2</td>
</tr>
<tr>
<td valign="top" align="left" colspan="3"><bold>Educational status</bold></td>
</tr>
<tr>
<td valign="top" align="left">Unable to read or write</td>
<td valign="top" align="center">70</td>
<td valign="top" align="center">27.8</td>
</tr>
<tr>
<td valign="top" align="left">Able to read and write</td>
<td valign="top" align="center">84</td>
<td valign="top" align="center">33.3</td>
</tr>
<tr>
<td valign="top" align="left">Elementary school</td>
<td valign="top" align="center">76</td>
<td valign="top" align="center">30.2</td>
</tr>
<tr>
<td valign="top" align="left">High school</td>
<td valign="top" align="center">22</td>
<td valign="top" align="center">8.7</td>
</tr>
<tr>
<td valign="top" align="left" colspan="3"><bold>Parental characteristics</bold></td>
</tr>
<tr>
<td valign="top" align="left">Both are alive</td>
<td valign="top" align="center">29</td>
<td valign="top" align="center">11.5</td>
</tr>
<tr>
<td valign="top" align="left">Divorced</td>
<td valign="top" align="center">75</td>
<td valign="top" align="center">29.8</td>
</tr>
<tr>
<td valign="top" align="left">Death of both parents</td>
<td valign="top" align="center">59</td>
<td valign="top" align="center">23.4</td>
</tr>
<tr>
<td valign="top" align="left">Death of only the father</td>
<td valign="top" align="center">57</td>
<td valign="top" align="center">22.6</td>
</tr>
<tr>
<td valign="top" align="left">Death of only the mother</td>
<td valign="top" align="center">32</td>
<td valign="top" align="center">12.7</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="S3.SS2">
<title>Lifetime and current substance use</title>
<p>The majority of street youths (85.7%) in the sample of respondents as a whole reported using at least one drug at some point in their lives.</p>
<p>There were 208 people who used the substance recently (i.e., within the last 3 months) (82.5%). Most respondents who said they currently used drugs or alcohol did so for cigarettes (62.3%) and alcohol (61.1%) (<xref ref-type="table" rid="T2">Table 2</xref>).</p>
<table-wrap position="float" id="T2">
<label>TABLE 2</label>
<caption><p>Substance use history and current use among street youths in Bahir Dar, Northwest Ethiopia, in 2020.</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left">Substances</td>
<td valign="top" align="center" colspan="3">Lifetime use<hr/></td>
<td valign="top" align="center" colspan="3">Current use<hr/></td>
</tr>
<tr>
<td/>
<td valign="top" align="center" colspan="2">Frequency</td>
<td valign="top" align="center">Percent (%)</td>
<td valign="top" align="center" colspan="2">Frequency</td>
<td valign="top" align="center">Percent (%)</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Cigarette</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">159</td>
<td valign="top" align="center">63.1</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">157</td>
<td valign="top" align="center">62.3</td>
</tr>
<tr>
<td/>
<td valign="top" align="center">No</td>
<td valign="top" align="center">93</td>
<td valign="top" align="center">36.9</td>
<td valign="top" align="center">No</td>
<td valign="top" align="center">95</td>
<td valign="top" align="center">37.7</td>
</tr>
<tr>
<td valign="top" align="left">Alcohol</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">155</td>
<td valign="top" align="center">61.5</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">154</td>
<td valign="top" align="center">61.1</td>
</tr>
<tr>
<td/>
<td valign="top" align="center">No</td>
<td valign="top" align="center">97</td>
<td valign="top" align="center">38.5</td>
<td valign="top" align="center">No</td>
<td valign="top" align="center">98</td>
<td valign="top" align="center">38.9</td>
</tr>
<tr>
<td valign="top" align="left">Cannabis</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">37</td>
<td valign="top" align="center">14.7</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">23</td>
<td valign="top" align="center">9.1</td>
</tr>
<tr>
<td/>
<td valign="top" align="center">No</td>
<td valign="top" align="center">215</td>
<td valign="top" align="center">85.3</td>
<td valign="top" align="center">No</td>
<td valign="top" align="center">229</td>
<td valign="top" align="center">90.9</td>
</tr>
<tr>
<td valign="top" align="left">Amphetamines</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">51</td>
<td valign="top" align="center">20.2</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">33</td>
<td valign="top" align="center">13.1</td>
</tr>
<tr>
<td/>
<td valign="top" align="center">No</td>
<td valign="top" align="center">201</td>
<td valign="top" align="center">79.8</td>
<td valign="top" align="center">No</td>
<td valign="top" align="center">219</td>
<td valign="top" align="center">86.9</td>
</tr>
<tr>
<td valign="top" align="left">Inhalants</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">98</td>
<td valign="top" align="center">38.9</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">73</td>
<td valign="top" align="center">29</td>
</tr>
<tr>
<td/>
<td valign="top" align="center">No</td>
<td valign="top" align="center">154</td>
<td valign="top" align="center">61.1</td>
<td valign="top" align="center">No</td>
<td valign="top" align="center">179</td>
<td valign="top" align="center">71</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>The prevalence of problematic substance use among current substance users was found to be 116 (55.8%), with a 95% CI (49&#x2013;63%).</p>
</sec>
<sec id="S3.SS3">
<title>The reason for psychoactive substances&#x2019; use among street youth</title>
<p>Among the current substance users, 145 (69.7%) of the respondents use it to forget their problems, and out of curiosity, 126 (60.6%). Approximately 113 (54.3%) use it to cope with stress (<xref ref-type="table" rid="T3">Table 3</xref>).</p>
<table-wrap position="float" id="T3">
<label>TABLE 3</label>
<caption><p>Individual-level factors associated with problematic substance use among street youth in Bahir Dar, Northwest Ethiopia, in 2020.</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left">Variables</td>
<td valign="top" align="center">Category</td>
<td valign="top" align="center">Frequencies</td>
<td valign="top" align="center">Percent (%)</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">To enhance sexual activity</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">37</td>
<td valign="top" align="center">17.8</td>
</tr>
<tr>
<td valign="top" align="left"/><td valign="top" align="center">No</td>
<td valign="top" align="center">171</td>
<td valign="top" align="center">82.2</td>
</tr>
<tr>
<td valign="top" align="left">To cope with stress</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">113</td>
<td valign="top" align="center">54.3</td>
</tr>
<tr>
<td valign="top" align="left"/><td valign="top" align="center">No</td>
<td valign="top" align="center">95</td>
<td valign="top" align="center">45.7</td>
</tr>
<tr>
<td valign="top" align="left">To forget your problems</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">145</td>
<td valign="top" align="center">69.7</td>
</tr>
<tr>
<td valign="top" align="left"/><td valign="top" align="center">No</td>
<td valign="top" align="center">63</td>
<td valign="top" align="center">30.3</td>
</tr>
<tr>
<td valign="top" align="left">For dueling hunger or cold weather</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">86</td>
<td valign="top" align="center">41.3</td>
</tr>
<tr>
<td valign="top" align="left"/><td valign="top" align="center">No</td>
<td valign="top" align="center">122</td>
<td valign="top" align="center">58.7</td>
</tr>
<tr>
<td valign="top" align="left">Out of curiosity</td>
<td valign="top" align="center">Yes</td>
<td valign="top" align="center">126</td>
<td valign="top" align="center">60.6</td>
</tr>
<tr>
<td valign="top" align="left"/><td valign="top" align="center">No</td>
<td valign="top" align="center">82</td>
<td valign="top" align="center">39.4</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="S3.SS4">
<title>Factors associated with problematic substance use</title>
<p>In a multivariable analysis, problematic substance use was found to be significantly associated (<italic>p</italic> &#x003C; 0.05) with peer pressure (adjusted odds ratio [AOR] = 3.01, 95% CI: 1.38, 6.59), family conflict (AOR = 5.05, 95% CI: 1.67, 15.25), physical abuse (AOR = 2.56, 95% CI: 1.11, 5.84), and substance use in the family (AOR = 2.85, 95% CI: 1.29, 6.27) (<xref ref-type="table" rid="T4">Table 4</xref>).</p>
<table-wrap position="float" id="T4">
<label>TABLE 4</label>
<caption><p>Bivariate and multivariable analysis of problematic substance use among street youth in Bahir Dar, Northwest Ethiopia, in 2020.</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left">Independent variable</td>
<td valign="top" align="center" colspan="2">Problematic substance use<hr/></td>
<td valign="top" align="center">COR 95% CI</td>
<td valign="top" align="center">AOR 95% CI</td>
<td valign="top" align="center"><italic>P</italic>-value</td>
</tr>
<tr>
<td/>
<td valign="top" align="center">Yes = 116</td>
<td valign="top" align="center">No = 92</td>
<td/>
<td/>
<td/>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" colspan="6"><bold>Age</bold></td>
</tr>
<tr>
<td valign="top" align="left">18&#x2013;24</td>
<td valign="top" align="center">42</td>
<td valign="top" align="center">61</td>
<td valign="top" align="center">0.29 (0.16, 0.51)</td>
<td valign="top" align="center">1.12 (0.49, 2.56)</td>
<td valign="top" align="center">0.782</td>
</tr>
<tr>
<td valign="top" align="left">12&#x2013;17</td>
<td valign="top" align="center">74</td>
<td valign="top" align="center">31</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Parental characteristics</bold></td>
</tr>
<tr>
<td valign="top" align="left">Death of mother</td>
<td valign="top" align="center">13</td>
<td valign="top" align="center">13</td>
<td valign="top" align="center">1.45 (0.49, 4.31)</td>
<td valign="top" align="center">1.57 (0.44, 5.66)</td>
<td valign="top" align="center">0.489</td>
</tr>
<tr>
<td valign="top" align="left">Death of father</td>
<td valign="top" align="center">13</td>
<td valign="top" align="center">27</td>
<td valign="top" align="center">0.7 (0.25, 1.93)</td>
<td valign="top" align="center">1.2 (0.35, 4.1)</td>
<td valign="top" align="center">0.767</td>
</tr>
<tr>
<td valign="top" align="left">Death of both parent</td>
<td valign="top" align="center">24</td>
<td valign="top" align="center">20</td>
<td valign="top" align="center">1.75 (0.67, 4.61)</td>
<td valign="top" align="center">2.72 (0.802, 9.25)</td>
<td valign="top" align="center">0.108</td>
</tr>
<tr>
<td valign="top" align="left">Divorced</td>
<td valign="top" align="center">55</td>
<td valign="top" align="center">16</td>
<td valign="top" align="center">5 (1.94, 12.91)</td>
<td valign="top" align="center">3.62 (0.99, 13.19)</td>
<td valign="top" align="center">0.051</td>
</tr>
<tr>
<td valign="top" align="left">Both are alive</td>
<td valign="top" align="center">11</td>
<td valign="top" align="center">16</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Peer pressure</bold></td>
</tr>
<tr>
<td valign="top" align="left">Yes</td>
<td valign="top" align="center">92</td>
<td valign="top" align="center">30</td>
<td valign="top" align="center">7.92 (4.24, 14.82)</td>
<td valign="top" align="center">3.01 (1.38, 6.59)</td>
<td valign="top" align="center"><bold>0.006&#x002A;&#x002A;</bold></td>
</tr>
<tr>
<td valign="top" align="left">No</td>
<td valign="top" align="center">24</td>
<td valign="top" align="center">62</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Parental monitoring</bold></td>
</tr>
<tr>
<td valign="top" align="left">High</td>
<td valign="top" align="center">52</td>
<td valign="top" align="center">58</td>
<td valign="top" align="center">0.48 (0.27, 0.83)</td>
<td valign="top" align="center">0.62 (0.31, 1.33)</td>
<td valign="top" align="center">0.229</td>
</tr>
<tr>
<td valign="top" align="left">Low</td>
<td valign="top" align="center">64</td>
<td valign="top" align="center">34</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Family conflict</bold></td>
</tr>
<tr>
<td valign="top" align="left">High</td>
<td valign="top" align="center">52</td>
<td valign="top" align="center">7</td>
<td valign="top" align="center">9.87 (4.2, 23.16)</td>
<td valign="top" align="center">5.05 (1.67, 15.25)</td>
<td valign="top" align="center"><bold>0.004&#x002A;&#x002A;</bold></td>
</tr>
<tr>
<td valign="top" align="left">Low</td>
<td valign="top" align="center">64</td>
<td valign="top" align="center">85</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Psychological abuse</bold></td>
</tr>
<tr>
<td valign="top" align="left">Yes</td>
<td valign="top" align="center">67</td>
<td valign="top" align="center">28</td>
<td valign="top" align="center">3.13 (1.76, 5.57)</td>
<td valign="top" align="center">1.04 (0.46, 2.35)</td>
<td valign="top" align="center">0.932</td>
</tr>
<tr>
<td valign="top" align="left">No</td>
<td valign="top" align="center">49</td>
<td valign="top" align="center">64</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Physical abuse</bold></td>
</tr>
<tr>
<td valign="top" align="left">Yes</td>
<td valign="top" align="center">66</td>
<td valign="top" align="center">30</td>
<td valign="top" align="center">2.73 (1.54, 4.82)</td>
<td valign="top" align="center">2.56 (1.11, 5.84)</td>
<td valign="top" align="center"><bold>0.027<xref ref-type="table-fn" rid="t4fns1">&#x002A;</xref></bold></td>
</tr>
<tr>
<td valign="top" align="left">No</td>
<td valign="top" align="center">50</td>
<td valign="top" align="center">62</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Violent mother</bold></td>
</tr>
<tr>
<td valign="top" align="left">Yes</td>
<td valign="top" align="center">78</td>
<td valign="top" align="center">49</td>
<td valign="top" align="center">1.8 (1.03, 3.17)</td>
<td valign="top" align="center">0.86 (0.39, 1.88)</td>
<td valign="top" align="center">0.711</td>
</tr>
<tr>
<td valign="top" align="left">No</td>
<td valign="top" align="center">38</td>
<td valign="top" align="center">43</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
<tr>
<td valign="top" align="left" colspan="6"><bold>Substance use in the family</bold></td>
</tr>
<tr>
<td valign="top" align="left">Yes</td>
<td valign="top" align="center">90</td>
<td valign="top" align="center">45</td>
<td valign="top" align="center">3.62 (1.99, 6.57)</td>
<td valign="top" align="center">2.85 (1.29, 6.27)</td>
<td valign="top" align="center"><bold>0.01<xref ref-type="table-fn" rid="t4fns1">&#x002A;</xref></bold></td>
</tr>
<tr>
<td valign="top" align="left">No</td>
<td valign="top" align="center">26</td>
<td valign="top" align="center">47</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.00</td>
<td/>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t4fns1"><p>&#x002A;Significance &#x002A;&#x002A;highly significance at 0.05 (p-value) and 1.00 (reference). The bold values shows that factors that were significantly associated with problematic substance use.</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec id="S4" sec-type="discussion">
<title>Discussion</title>
<p>The prevalence of problematic substance use among street youth was found to be 55.8%, with a 95% CI (49&#x2013;63%). It was also found that peer pressure, family conflict, substance use in the family, and physical abuse were the factors associated with problematic substance use.</p>
<p>In this study, the prevalence of problematic substance use among street youth was found to be 55.8%. This result is almost similar to a longitudinal study that was done in Vancouver, Canada, which was 55% (<xref ref-type="bibr" rid="B19">19</xref>). In contrast, this study was high as compared to a community study that was conducted in Bahir Dar town, which was 37% (<xref ref-type="bibr" rid="B29">29</xref>). The possible reason might be that this study was conducted on homeless youths, and they are a highly vulnerable group to different psychoactive substances (<xref ref-type="bibr" rid="B15">15</xref>). The other possible explanation for the high prevalence of problematic substance use would be the involvement in the culture of the street, which provides opportunities to experiment with various substances (<xref ref-type="bibr" rid="B15">15</xref>). In addition, the stress resulting from sleeping outdoors and in public places may be alleviated or eased by using drugs and alcohol to keep warm and suppress hunger (<xref ref-type="bibr" rid="B4">4</xref>). Some drugs are also used to help these young people stay awake for extended periods, especially at night when the chances of victimization increase (<xref ref-type="bibr" rid="B7">7</xref>).</p>
<p>The lifetime prevalence of substance use in this study was 85.7%. This is higher than a study that was conducted in a resource-constrained setting by systematic review and meta-analysis. The overall pooled prevalence was 60% (<xref ref-type="bibr" rid="B21">21</xref>). This difference might be due to the study design and setting they used as well as the pooled prevalence used by including fifty studies (<xref ref-type="bibr" rid="B21">21</xref>).</p>
<p>The ever use of a cigarette for this study was 63.5%. This is lower than a study that was done in the United States city of Los Angeles, which showed that nearly 90% of the street youths smoke regular cigarettes (<xref ref-type="bibr" rid="B18">18</xref>). This difference might be due to cultural variation, and it is also affected by the economic status and living conditions of the youth living in developed countries, which are different from those in developing countries, so that they can afford it easily and they may use it regularly. The other difference might be the study design and the sample size they used (<italic>N</italic> = 469). It might also be the instruments that they have used (<xref ref-type="bibr" rid="B18">18</xref>).</p>
<p>The prevalence of alcohol ever used and current use from this study was found to be 61.5 and 61.1%, respectively. This finding is relatively in line with a study that was done in Houston, Texas, whose lifetime use of alcohol was 66% (<xref ref-type="bibr" rid="B17">17</xref>). It is also consistent with a study done in Kenya; the current use of alcohol was 57% (<xref ref-type="bibr" rid="B26">26</xref>). However, the lifetime prevalence of marijuana in this study was 14.7%, which is extremely lower than a study that was done in Houston, Texas, i.e., 66%, and a study that was done in Lusaka, Zambia, which was 35% (<xref ref-type="bibr" rid="B25">25</xref>). This difference might be due to the cultural difference and the availability of the substance (<xref ref-type="bibr" rid="B13">13</xref>).</p>
<p>The lifetime and current use of inhalants from this study were 38.9 and 29%, respectively. This is lower than a study that was done in Kenya, where the current prevalence of glue-sniffing was 48% (<xref ref-type="bibr" rid="B26">26</xref>). This difference might be the street youth&#x2019;s preference to use glue in this setting, which is lower. The other possible reasons might be due to the cost. They may use other substances that are easily affordable, like homemade alcohol (araqi) and cigarettes.</p>
<p>In this study, the current use of a psychoactive substance was found to be 82.5%. This is almost similar to a study that was done in Kenya among street boys which found 78% (<xref ref-type="bibr" rid="B26">26</xref>).</p>
<p>The current use of khat in this study was found to be 13.1%. This is somehow lower than a study that was done in Kenya, where the current prevalence of khat use was 22% (<xref ref-type="bibr" rid="B26">26</xref>). This difference might be due to the study setting and cultural variations. It might also be affected by the number of participants included in their study (<italic>N</italic> = 300) (<xref ref-type="bibr" rid="B26">26</xref>). The other possible reasons might be that chewing chat in the street is not suitable for them, since most of the time chewing khat needs a comfortable place like home (khat bet).</p>
<p>Street youths who had peer pressure had the odds ratio of having problematic substance use and were about 3 times more likely to be problematic as compared with participants who had no peer pressure (AOR = 3.01, 95% CI: 1.38, 6.59). This is consistent with a systematic review that was conducted in a resource-constrained setting (<xref ref-type="bibr" rid="B21">21</xref>). The reason might be that on the street, these youths are exposed to an abundance of peers who are already heavily involved in the street lifestyle and substance use (<xref ref-type="bibr" rid="B34">34</xref>). Peers also provide the opportunity and reinforcement required for participation in street life (<xref ref-type="bibr" rid="B35">35</xref>).</p>
<p>In this study, for those who had a high family conflict, the odds ratios of having problematic substance use were about 5.05 times more likely to be problematic as compared to those who had a low family conflict (AOR = 5.05, 95% CI: 1.67, 15.25). The possible reason might be the parent&#x2019;s difficulty in setting boundaries and communicating in the family nucleus, which leads the youth to be problematic substance users (<xref ref-type="bibr" rid="B36">36</xref>). This study is consistent with a study that was done in Egypt (<xref ref-type="bibr" rid="B37">37</xref>). An important role of professionals involved with this population is, therefore, to understand and intervene with the family&#x2019;s social network to prevent migration to the streets due to family conflict.</p>
<p>When compared to street youth who didn&#x2019;t have a substance user in the family, they were 2.85 times more likely to be problematic substance users (2.85, 95% CI: 1.29, 6.27). This is consistent with a study done in Tehran, Iran, (<xref ref-type="bibr" rid="B38">38</xref>) and the Midwestern United States (<xref ref-type="bibr" rid="B39">39</xref>). It is also supported by a study that was done in Northern Ireland (<xref ref-type="bibr" rid="B40">40</xref>). The reason might be that youths who witnessed their parents or siblings regularly intoxicated were at much greater risk of being heavy drinkers or drug users. It appears that parental substance use conveys information and rules regarding a youth&#x2019;s own use (<xref ref-type="bibr" rid="B12">12</xref>).</p>
<p>For those who had been physically abused, the odds ratios of being problematic substance users were about 2.56 times higher as compared with street youths who had not been physically abused (AOR = 2.56, 95% CI: 1.11, 5.84). This is also consistent with a study that was done in Egypt (<xref ref-type="bibr" rid="B39">39</xref>) and Zambia (<xref ref-type="bibr" rid="B25">25</xref>). The possible reason might be that users self-medicate themselves for a range of problems and emotional pain due to being physically abused (<xref ref-type="bibr" rid="B34">34</xref>).</p>
<sec id="S4.SS1">
<title>Strength and limitations of the study</title>
<p>This study serves as a baseline for future studies and interventional plans. Social desirability may be a concern for this study, since participants were interviewed face to face and may have answered questions in a manner they perceived as most desirable to the interviewer.</p>
</sec>
</sec>
<sec id="S5" sec-type="conclusion">
<title>Conclusion</title>
<p>Among street youths, problematic substance use was shown to be very common. The causes of problematic substance use include peer pressure, family conflict, family substance misuse, and physical abuse. Therefore, peer-to-peer counseling and family involvement should be prioritized in street youth programs that are effective in addressing these vulnerable populations. Reducing family conflicts and substance use within the family is crucial to fostering positive family dynamics and improving family bonding. In addition, longitudinal investigations that pinpoint typical etiological components are advised to be conducted.</p>
</sec>
<sec id="S6" sec-type="data-availability">
<title>Data availability statement</title>
<p>The data elements used in this study are available from the corresponding author upon reasonable request.</p>
</sec>
<sec id="S7">
<title>Ethics statement</title>
<p>The studies involving human participants were reviewed and approved by the Bahir Dar University Institutional review board. Written informed consent to participate in this study was provided by the participants&#x2019; legal guardian/next of kin. Written informed consent was obtained from the individual(s), and minor(s)&#x2019; legal guardian/next of kin, for the publication of any potentially identifiable images or data included in this article.</p>
</sec>
<sec id="S8">
<title>Author contributions</title>
<p>MSh and WF designed the research work, led the study in doing the analysis of the research, and prepared the manuscript. MSh, WF, MB, MM, MSe, SY, KY, MN, SM, and TA reviewed the final manuscript and approved it. All authors contributed to the article and approved the submitted version.</p>
</sec>
</body>
<back>
<ack><p>We thank the study participants for their participation.</p>
</ack>
<sec id="S19" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="S20" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<glossary>
<title>Abbreviations</title>
<def-list id="DL1">
<def-item><term>ACE</term><def><p>adverse childhood experience</p></def></def-item>
<def-item><term>AOR</term><def><p>adjusted odds ratio</p></def></def-item>
<def-item><term>CAGE- AID, cut down</term><def><p>annoyed, guilty and eye-opener-adapted to include drugs</p></def></def-item>
<def-item><term>CI</term><def><p>confidence interval</p></def></def-item>
<def-item><term>IRB</term><def><p>Institutional Review Board.</p></def></def-item>
</def-list>
</glossary>
<ref-list>
<title>References</title>
<ref id="B1"><label>1.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Association</surname> <given-names>AP.</given-names></name></person-group> <source><italic>Diagnostic and Statistical Manual of Mental Disorders (DSM-5<sup>&#x00AE;</sup>).</italic></source> <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>American Psychiatric Pub</publisher-name> (<year>2013</year>).</citation></ref>
<ref id="B2"><label>2.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kidan</surname> <given-names>A.</given-names></name></person-group> <source><italic>Psycho Active Substance Abuse and Intention to stop Among Students of Mekelle University. Ethiopia. Unpublished Master&#x2019;s Thesis.</italic></source> <publisher-loc>Addis Ababa</publisher-loc>: <publisher-name>Addis Ababa University</publisher-name> (<year>2011</year>).</citation></ref>
<ref id="B3"><label>3.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jalilian</surname> <given-names>F</given-names></name> <name><surname>Karami Matin</surname> <given-names>B</given-names></name> <name><surname>Mirzaei Alavijeh</surname> <given-names>M</given-names></name> <name><surname>Ataee</surname> <given-names>M</given-names></name> <name><surname>Mahboubi</surname> <given-names>M</given-names></name> <name><surname>Motlagh</surname> <given-names>F</given-names></name><etal/></person-group> <article-title>Prevalence and factor related to ritalin abuse among Iranian medical college student: an application of theory of planned behavior.</article-title> <source><italic>Ter Arkh.</italic></source> (<year>2013</year>) <volume>85</volume>:<fpage>22</fpage>&#x2013;<lpage>7</lpage>.</citation></ref>
<ref id="B4"><label>4.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Panter-Brick</surname> <given-names>C.</given-names></name></person-group> <article-title>Street children, human rights, and public health: a critique and future directions.</article-title> <source><italic>Annu Rev Anthropol.</italic></source> (<year>2002</year>) <volume>31</volume>:<fpage>147</fpage>&#x2013;<lpage>71</lpage>.</citation></ref>
<ref id="B5"><label>5.</label><citation citation-type="journal"><collab>Un Office on Drugs and Crime.</collab> <source><italic>World Drug Report.</italic></source> (<volume>Vol. 2</volume>). <publisher-loc>New York, NY</publisher-loc>: <publisher-name>United Nations Publications</publisher-name> (<year>2005</year>).</citation></ref>
<ref id="B6"><label>6.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Roy</surname> <given-names>&#x00C9;</given-names></name> <name><surname>Haley</surname> <given-names>N</given-names></name> <name><surname>Leclerc</surname> <given-names>P</given-names></name> <name><surname>Sochanski</surname> <given-names>B</given-names></name> <name><surname>Boudreau</surname> <given-names>JF</given-names></name> <name><surname>Boivin</surname> <given-names>JF.</given-names></name></person-group> <article-title>Mortality in a cohort of street youth in montreal.</article-title> <source><italic>JAMA.</italic></source> (<year>2004</year>) <volume>292</volume>:<fpage>569</fpage>&#x2013;<lpage>74</lpage>. <pub-id pub-id-type="pmid">15292082</pub-id></citation></ref>
<ref id="B7"><label>7.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>McVicar</surname> <given-names>D</given-names></name> <name><surname>Moschion</surname> <given-names>J</given-names></name> <name><surname>van Ours</surname> <given-names>JC.</given-names></name></person-group> <article-title>From substance use to homelessness or vice versa?</article-title> <source><italic>Soc Sci Med.</italic></source> (<year>2015</year>) <volume>136</volume>:<fpage>89</fpage>&#x2013;<lpage>98</lpage>. <pub-id pub-id-type="doi">10.1016/j.socscimed.2015.05.005</pub-id></citation></ref>
<ref id="B8"><label>8.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mayock</surname> <given-names>P</given-names></name> <name><surname>Corr</surname> <given-names>ML</given-names></name> <name><surname>O&#x2019;Sullivan</surname> <given-names>E.</given-names></name></person-group> <article-title>Homeless young people, families and change: family support as a facilitator to exiting homelessness.</article-title> <source><italic>Child Fam Soc Work.</italic></source> (<year>2011</year>) <volume>16</volume>:<fpage>391</fpage>&#x2013;<lpage>401</lpage>. <pub-id pub-id-type="doi">10.1111/j.1365-2206.2010.00753.x</pub-id> <pub-id pub-id-type="pmid">30923776</pub-id></citation></ref>
<ref id="B9"><label>9.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Morewitz</surname> <given-names>SJ.</given-names></name></person-group> <source><italic>Runaway and Homeless Youth: New Research and Clinical Perspectives.</italic></source> <publisher-loc>New York, NY</publisher-loc>: <publisher-name>Springer</publisher-name> (<year>2016</year>). <pub-id pub-id-type="doi">10.1007/978-3-319-30863-0</pub-id></citation></ref>
<ref id="B10"><label>10.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tyler</surname> <given-names>KA.</given-names></name></person-group> <article-title>A qualitative study of early family histories and transitions of homeless youth.</article-title> <source><italic>J Interpers Violence.</italic></source> (<year>2006</year>) <volume>21</volume>:<fpage>1385</fpage>&#x2013;<lpage>93</lpage>. <pub-id pub-id-type="doi">10.1177/0886260506291650</pub-id></citation></ref>
<ref id="B11"><label>11.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Schmitz</surname> <given-names>RM</given-names></name> <name><surname>Tyler</surname> <given-names>KA.</given-names></name></person-group> <article-title>Growing up before their time: the early adultification experiences of homeless young people.</article-title> <source><italic>Child Youth Serv Rev.</italic></source> (<year>2016</year>) <volume>64</volume>:<fpage>15</fpage>&#x2013;<lpage>22</lpage>. <pub-id pub-id-type="doi">10.1016/j.childyouth.2016.02.026</pub-id> <pub-id pub-id-type="pmid">27003952</pub-id></citation></ref>
<ref id="B12"><label>12.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tyler</surname> <given-names>KA</given-names></name> <name><surname>Johnson</surname> <given-names>KA.</given-names></name></person-group> <article-title>Pathways in and out of substance use among homeless-emerging adults.</article-title> <source><italic>J Adolesc Res.</italic></source> (<year>2006</year>) <volume>21</volume>:<fpage>133</fpage>&#x2013;<lpage>57</lpage>. <pub-id pub-id-type="doi">10.1177/0743558405285494</pub-id></citation></ref>
<ref id="B13"><label>13.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tsering</surname> <given-names>D</given-names></name> <name><surname>Pal</surname> <given-names>R.</given-names></name></person-group> <article-title>Role of family and peers in initiation and continuation of substance use.</article-title> <source><italic>Indian J Psychol Med.</italic></source> (<year>2009</year>) <volume>31</volume>:<fpage>30</fpage>. <pub-id pub-id-type="doi">10.4103/0253-7176.53312</pub-id></citation></ref>
<ref id="B14"><label>14.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Velleman</surname> <given-names>RD</given-names></name> <name><surname>Templeton</surname> <given-names>LJ</given-names></name> <name><surname>Copello</surname> <given-names>AG.</given-names></name></person-group> <article-title>The role of the family in preventing and intervening with substance use and misuse: a comprehensive review of family interventions, with a focus on young people.</article-title> <source><italic>Drug Alcoh Rev.</italic></source> (<year>2005</year>) <volume>24</volume>:<fpage>93</fpage>&#x2013;<lpage>109</lpage>. <pub-id pub-id-type="doi">10.1080/09595230500167478</pub-id> <pub-id pub-id-type="pmid">16076580</pub-id></citation></ref>
<ref id="B15"><label>15.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Islam</surname> <given-names>F</given-names></name> <name><surname>Kar</surname> <given-names>S</given-names></name> <name><surname>Debroy</surname> <given-names>A</given-names></name> <name><surname>Sarma</surname> <given-names>R.</given-names></name></person-group> <article-title>Substance abuse amongst the street children in Guwahati city, Assam.</article-title> <source><italic>Ann Med Health Sci Res.</italic></source> (<year>2014</year>) <volume>4</volume>:<fpage>233</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.4103/2141-9248.141965</pub-id> <pub-id pub-id-type="pmid">25364595</pub-id></citation></ref>
<ref id="B16"><label>16.</label><citation citation-type="journal"><collab>World Health Organization.</collab> <source><italic>Neuroscience of Psychoactive Substance use and Dependence.</italic></source> <publisher-loc>Geneva</publisher-loc>: <publisher-name>World Health Organization</publisher-name> (<year>2004</year>).</citation></ref>
<ref id="B17"><label>17.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Santa Maria</surname> <given-names>DM</given-names></name> <name><surname>Narendorf</surname> <given-names>SC</given-names></name> <name><surname>Cross</surname> <given-names>MB.</given-names></name></person-group> <article-title>Prevalence and correlates of substance use in homeless youth and young adults.</article-title> <source><italic>J Addict Nurs.</italic></source> (<year>2018</year>) <volume>29</volume>:<fpage>23</fpage>&#x2013;<lpage>31</lpage>. <pub-id pub-id-type="doi">10.1097/JAN.0000000000000206</pub-id></citation></ref>
<ref id="B18"><label>18.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tucker</surname> <given-names>JS</given-names></name> <name><surname>Shadel</surname> <given-names>WG</given-names></name> <name><surname>Golinelli</surname> <given-names>D</given-names></name> <name><surname>Seelam</surname> <given-names>R</given-names></name> <name><surname>Siconolfi</surname> <given-names>D.</given-names></name></person-group> <article-title>Correlates of cigarette and alternative tobacco product use among young tobacco users experiencing homelessness.</article-title> <source><italic>Addict Behav.</italic></source> (<year>2019</year>) <volume>95</volume>:<fpage>145</fpage>&#x2013;<lpage>51</lpage>. <pub-id pub-id-type="doi">10.1016/j.addbeh.2019.03.012</pub-id> <pub-id pub-id-type="pmid">30921625</pub-id></citation></ref>
<ref id="B19"><label>19.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fairbairn</surname> <given-names>N</given-names></name> <name><surname>Wood</surname> <given-names>E</given-names></name> <name><surname>Dong</surname> <given-names>H</given-names></name> <name><surname>Kerr</surname> <given-names>T</given-names></name> <name><surname>DeBeck</surname> <given-names>K.</given-names></name></person-group> <article-title>Unsafe sexual behaviour associated with hazardous alcohol use among street-involved youth.</article-title> <source><italic>AIDS Care.</italic></source> (<year>2017</year>) <volume>29</volume>:<fpage>481</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1080/09540121.2016.1220480</pub-id> <pub-id pub-id-type="pmid">27539676</pub-id></citation></ref>
<ref id="B20"><label>20.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ayenew</surname> <given-names>M</given-names></name> <name><surname>Kabeta</surname> <given-names>T</given-names></name> <name><surname>Woldemichael</surname> <given-names>K.</given-names></name></person-group> <article-title>Prevalence and factors associated with substance use among street children in Jimma town, Oromiya national regional state, Ethiopia: a community based cross-sectional study.</article-title> <source><italic>Subst Abuse Treat Prev Policy.</italic></source> (<year>2020</year>) <volume>15</volume>:<fpage>1</fpage>&#x2013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1186/s13011-020-00304-3</pub-id> <pub-id pub-id-type="pmid">32819391</pub-id></citation></ref>
<ref id="B21"><label>21.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Embleton</surname> <given-names>L</given-names></name> <name><surname>Mwangi</surname> <given-names>A</given-names></name> <name><surname>Vreeman</surname> <given-names>R</given-names></name> <name><surname>Ayuku</surname> <given-names>D</given-names></name> <name><surname>Braitstein</surname> <given-names>P.</given-names></name></person-group> <article-title>The epidemiology of substance use among street children in resource-constrained settings: a systematic review and meta-analysis.</article-title> <source><italic>Addiction.</italic></source> (<year>2013</year>) <volume>108</volume>:<fpage>1722</fpage>&#x2013;<lpage>33</lpage>. <pub-id pub-id-type="doi">10.1111/add.12252</pub-id> <pub-id pub-id-type="pmid">23844822</pub-id></citation></ref>
<ref id="B22"><label>22.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Walls</surname> <given-names>NE</given-names></name> <name><surname>Bell</surname> <given-names>S.</given-names></name></person-group> <article-title>Correlates of engaging in survival sex among homeless youth and young adults.</article-title> <source><italic>J Sex Res.</italic></source> (<year>2011</year>) <volume>48</volume>:<fpage>423</fpage>&#x2013;<lpage>36</lpage>. <pub-id pub-id-type="doi">10.1080/00224499.2010.501916</pub-id> <pub-id pub-id-type="pmid">20799134</pub-id></citation></ref>
<ref id="B23"><label>23.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Martino</surname> <given-names>SC</given-names></name> <name><surname>Tucker</surname> <given-names>JS</given-names></name> <name><surname>Ryan</surname> <given-names>G</given-names></name> <name><surname>Wenzel</surname> <given-names>SL</given-names></name> <name><surname>Golinelli</surname> <given-names>D</given-names></name> <name><surname>Munjas</surname> <given-names>B.</given-names></name></person-group> <article-title>Increased substance use and risky sexual behavior among migratory homeless youth: exploring the role of social network composition.</article-title> <source><italic>J Youth Adolesc.</italic></source> (<year>2011</year>) <volume>40</volume>:<fpage>1634</fpage>&#x2013;<lpage>48</lpage>. <pub-id pub-id-type="doi">10.1007/s10964-011-9646-6</pub-id> <pub-id pub-id-type="pmid">21400037</pub-id></citation></ref>
<ref id="B24"><label>24.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Aklog</surname> <given-names>T</given-names></name> <name><surname>Tiruneh</surname> <given-names>G</given-names></name> <name><surname>Tsegay</surname> <given-names>G.</given-names></name></person-group> <source>Assessment of Substance Abuse and Associated Factors Among Students of debre Markos poly Technique College in debre Markos town, East Gojjam Zone, Amhara Regional State, Ethiopia</source>. <publisher-name>Debre Markos: Global journal of medical research</publisher-name> (<year>2013</year>).</citation></ref>
<ref id="B25"><label>25.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tyler</surname> <given-names>KA</given-names></name> <name><surname>Handema</surname> <given-names>R</given-names></name> <name><surname>Schmitz</surname> <given-names>RM</given-names></name> <name><surname>Phiri</surname> <given-names>F</given-names></name> <name><surname>Comm</surname> <given-names>H</given-names></name> <name><surname>Kuyper</surname> <given-names>KS</given-names></name><etal/></person-group> <article-title>Multi-level risk and protective factors for substance use among Zambian Street Youth.</article-title> <source><italic>Subst Use Misuse.</italic></source> (<year>2016</year>) <volume>51</volume>:<fpage>922</fpage>&#x2013;<lpage>31</lpage>. <pub-id pub-id-type="doi">10.3109/10826084.2016.1156702</pub-id> <pub-id pub-id-type="pmid">27144671</pub-id></citation></ref>
<ref id="B26"><label>26.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Auerswald</surname> <given-names>CC</given-names></name> <name><surname>Sara</surname> <given-names>GA</given-names></name> <name><surname>Zachary</surname> <given-names>KA.</given-names></name></person-group> <article-title>110. Prevalence and risk factors for inhalant and other substance use among street boys in Kisumu, Kenya.</article-title> <source><italic>J Adolesc Health.</italic></source> (<year>2013</year>) <volume>52</volume>:<fpage>S74</fpage>. <pub-id pub-id-type="doi">10.1016/j.jadohealth.2012.10.173</pub-id></citation></ref>
<ref id="B27"><label>27.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gomez</surname> <given-names>R</given-names></name> <name><surname>Thompson</surname> <given-names>SJ</given-names></name> <name><surname>Barczyk</surname> <given-names>AN.</given-names></name></person-group> <article-title>Factors associated with substance use among homeless young adults.</article-title> <source><italic>Subst Abuse.</italic></source> (<year>2010</year>) <volume>31</volume>:<fpage>24</fpage>&#x2013;<lpage>34</lpage>. <pub-id pub-id-type="doi">10.1080/08897070903442566</pub-id></citation></ref>
<ref id="B28"><label>28.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bender</surname> <given-names>K</given-names></name> <name><surname>Sanna</surname> <given-names>T</given-names></name> <name><surname>Holly</surname> <given-names>M</given-names></name> <name><surname>Janet</surname> <given-names>L</given-names></name> <name><surname>Patrick</surname> <given-names>F.</given-names></name></person-group> <article-title>Capacity for survival: exploring strengths of homeless street youth.</article-title> <source><italic>Child Youth Care Forum.</italic></source> (<year>2007</year>) <volume>36</volume>:<fpage>25</fpage>&#x2013;<lpage>42</lpage>. <pub-id pub-id-type="doi">10.1007/s10566-006-9029-4</pub-id> <pub-id pub-id-type="pmid">19915687</pub-id></citation></ref>
<ref id="B29"><label>29.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Belete</surname> <given-names>H</given-names></name> <name><surname>Mekonen</surname> <given-names>T</given-names></name> <name><surname>Fekadu</surname> <given-names>W</given-names></name> <name><surname>Legas</surname> <given-names>G</given-names></name> <name><surname>Getnet</surname> <given-names>A.</given-names></name></person-group> <article-title>Help-seeking behavior for problematic substance uses in Bahir Dar town, North-West Ethiopia.</article-title> <source><italic>BioRxiv</italic></source> [<comment>Preprint</comment>] (<year>2018</year>):<fpage>363705</fpage>. <pub-id pub-id-type="doi">10.1101/363705</pub-id></citation></ref>
<ref id="B30"><label>30.</label><citation citation-type="journal"><collab>World Health Organization.</collab> <source><italic>WHO-Assist v3.0.</italic></source> <publisher-loc>Geneva</publisher-loc>: <publisher-name>World Health Organization</publisher-name> (<year>2016</year>).</citation></ref>
<ref id="B31"><label>31.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Simpson</surname> <given-names>DD</given-names></name> <name><surname>McBride</surname> <given-names>AA.</given-names></name></person-group> <article-title>Family, friends, and self (FFS) assessment scales for Mexican American youth.</article-title> <source><italic>Hisp J Behav Sci.</italic></source> (<year>1992</year>) <volume>14</volume>:<fpage>327</fpage>&#x2013;<lpage>40</lpage>. <pub-id pub-id-type="doi">10.1177/07399863920143003</pub-id></citation></ref>
<ref id="B32"><label>32.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Felitti</surname> <given-names>VJ</given-names></name> <name><surname>Anda</surname> <given-names>RF</given-names></name> <name><surname>Nordenberg</surname> <given-names>D</given-names></name> <name><surname>Williamson</surname> <given-names>DF</given-names></name> <name><surname>Spitz</surname> <given-names>AM</given-names></name> <name><surname>Edwards</surname> <given-names>V</given-names></name><etal/></person-group> <article-title>Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study.</article-title> <source><italic>Am J Prev Med.</italic></source> (<year>2019</year>) <volume>56</volume>:<fpage>774</fpage>&#x2013;<lpage>86</lpage>. <pub-id pub-id-type="doi">10.1016/j.amepre.2019.04.001</pub-id></citation></ref>
<ref id="B33"><label>33.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cohen</surname> <given-names>S.</given-names></name></person-group> <article-title>Perceived stress in a probability sample of the United States.</article-title> In: <person-group person-group-type="editor"><name><surname>Spacapan</surname> <given-names>S</given-names></name> <name><surname>Oskamp</surname> <given-names>S</given-names></name></person-group> <role>editors</role>. <source><italic>The Claremont Symposium on Applied Social Psychology. The Social Psychology of Health.</italic></source> <publisher-loc>Thousand Oaks, CA</publisher-loc>: <publisher-name>Sage Publications, Inc</publisher-name> (<year>1988</year>). <fpage>p. 31</fpage>&#x2013;<lpage>67</lpage>.</citation></ref>
<ref id="B34"><label>34.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Baron</surname> <given-names>SW.</given-names></name></person-group> <article-title>Street youths and substance use: the role of background, street lifestyle, and economic factors.</article-title> <source><italic>Youth Soc.</italic></source> (<year>1999</year>) <volume>31</volume>:<fpage>3</fpage>&#x2013;<lpage>26</lpage>. <pub-id pub-id-type="doi">10.1177/0044118X99031001001</pub-id></citation></ref>
<ref id="B35"><label>35.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Nyamathi</surname> <given-names>A</given-names></name> <name><surname>Hudson</surname> <given-names>A</given-names></name> <name><surname>Greengold</surname> <given-names>B</given-names></name> <name><surname>Slagle</surname> <given-names>A</given-names></name> <name><surname>Marfisee</surname> <given-names>M</given-names></name> <name><surname>Khalilifard</surname> <given-names>F</given-names></name><etal/></person-group> <article-title>Correlates of substance use severity among homeless youth.</article-title> <source><italic>J Child Adolesc Psychiatr Nurs.</italic></source> (<year>2010</year>) <volume>23</volume>:<fpage>214</fpage>&#x2013;<lpage>22</lpage>. <pub-id pub-id-type="doi">10.1111/j.1744-6171.2010.00247.x</pub-id></citation></ref>
<ref id="B36"><label>36.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Trujillo</surname> <given-names>&#x00C1;</given-names></name> <name><surname>Obando</surname> <given-names>D</given-names></name> <name><surname>Trujillo</surname> <given-names>CA.</given-names></name></person-group> <article-title>Family dynamics and alcohol and marijuana use among adolescents: the mediating role of negative emotional symptoms and sensation seeking.</article-title> <source><italic>Addict Behav.</italic></source> (<year>2016</year>) <volume>62</volume>:<fpage>99</fpage>&#x2013;<lpage>107</lpage>. <pub-id pub-id-type="doi">10.1016/j.addbeh.2016.06.020</pub-id> <pub-id pub-id-type="pmid">27344116</pub-id></citation></ref>
<ref id="B37"><label>37.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Amr</surname> <given-names>S</given-names></name> <name><surname>Garas</surname> <given-names>M</given-names></name> <name><surname>Boulos</surname> <given-names>DNK</given-names></name> <name><surname>Saleh</surname> <given-names>DA</given-names></name> <name><surname>Jillson</surname> <given-names>IA</given-names></name> <name><surname>Loffredo</surname> <given-names>CA.</given-names></name></person-group> <article-title>Circumstances of substance use by street youth in egypt support the case for intervening to prevent adverse childhood experiences.</article-title> <source><italic>J Subst Use.</italic></source> (<year>2019</year>) <volume>24</volume>:<fpage>341</fpage>&#x2013;<lpage>5</lpage>. <pub-id pub-id-type="doi">10.1080/14659891.2019.1572804</pub-id> <pub-id pub-id-type="pmid">31798339</pub-id></citation></ref>
<ref id="B38"><label>38.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Dejman</surname> <given-names>M</given-names></name> <name><surname>Vameghi</surname> <given-names>M</given-names></name> <name><surname>Roshanfekr</surname> <given-names>P</given-names></name> <name><surname>Dejman</surname> <given-names>F</given-names></name> <name><surname>Rafiey</surname> <given-names>H</given-names></name> <name><surname>Forouzan</surname> <given-names>AS.</given-names></name></person-group> <article-title>Drug use among street children in Tehran, iran: a qualitative study.</article-title> <source><italic>Front Public Health.</italic></source> (<year>2015</year>) <volume>3</volume>:<fpage>279</fpage>. <pub-id pub-id-type="doi">10.3389/fpubh.2015.00279</pub-id></citation></ref>
<ref id="B39"><label>39.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tyler</surname> <given-names>KA</given-names></name> <name><surname>Ray</surname> <given-names>CM.</given-names></name></person-group> <article-title>Risk and protective factors for substance use among youth experiencing homelessness.</article-title> <source><italic>Child Youth Serv Rev.</italic></source> (<year>2019</year>) <volume>107</volume>:<fpage>104548</fpage>. <pub-id pub-id-type="doi">10.1016/j.childyouth.2019.104548</pub-id></citation></ref>
<ref id="B40"><label>40.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>McLaughlin</surname> <given-names>A</given-names></name> <name><surname>Campbell</surname> <given-names>A</given-names></name> <name><surname>McColgan</surname> <given-names>M.</given-names></name></person-group> <article-title>Adolescent substance use in the context of the family: a qualitative study of young people&#x2019;s views on parent-child attachments, parenting style and parental substance use.</article-title> <source><italic>Subst Use Misuse.</italic></source> (<year>2016</year>) <volume>51</volume>:<fpage>1846</fpage>&#x2013;<lpage>55</lpage>. <pub-id pub-id-type="doi">10.1080/10826084.2016.1197941</pub-id> <pub-id pub-id-type="pmid">27606719</pub-id></citation></ref>
</ref-list>
</back>
</article>
