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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
<issn pub-type="epub">2296-2565</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpubh.2023.1036877</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Public Health</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Evidence of internal structure of the transactional eHealth literacy among Vietnamese youth: An instrument validation study</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Nguyen</surname> <given-names>Thao Phuong Thi</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1182045/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Do</surname> <given-names>Anh Linh</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Do</surname> <given-names>Ha Ngoc</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/685421/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Vu</surname> <given-names>Thuc Minh Thi</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>van Kessel</surname> <given-names>Robin</given-names></name>
<xref ref-type="aff" rid="aff5"><sup>5</sup></xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1326035/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Wong</surname> <given-names>Brian Li Han</given-names></name>
<xref ref-type="aff" rid="aff6"><sup>6</sup></xref>
<xref ref-type="aff" rid="aff7"><sup>7</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1263106/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Boyer</surname> <given-names>Laurent</given-names></name>
<xref ref-type="aff" rid="aff8"><sup>8</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/65625/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Fond</surname> <given-names>Guillaume</given-names></name>
<xref ref-type="aff" rid="aff8"><sup>8</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/76634/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Auquier</surname> <given-names>Pascal</given-names></name>
<xref ref-type="aff" rid="aff8"><sup>8</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Nguyen</surname> <given-names>Tham Thi</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1672012/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Latkin</surname> <given-names>Carl A.</given-names></name>
<xref ref-type="aff" rid="aff9"><sup>9</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1052412/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Ho</surname> <given-names>Cyrus S. H.</given-names></name>
<xref ref-type="aff" rid="aff10"><sup>10</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/333075/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Ho</surname> <given-names>Roger C. M.</given-names></name>
<xref ref-type="aff" rid="aff10"><sup>10</sup></xref>
<xref ref-type="aff" rid="aff11"><sup>11</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/471523/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Institute for Global Health Innovations, Duy Tan University</institution>, <addr-line>Da Nang</addr-line>, <country>Vietnam</country></aff>
<aff id="aff2"><sup>2</sup><institution>Faculty of Nursing, Duy Tan University</institution>, <addr-line>Da Nang</addr-line>, <country>Vietnam</country></aff>
<aff id="aff3"><sup>3</sup><institution>Institute of Health Economics and Technology</institution>, <addr-line>Hanoi</addr-line>, <country>Vietnam</country></aff>
<aff id="aff4"><sup>4</sup><institution>Youth Research Institute, Ho Chi Minh Communist Youth Union</institution>, <addr-line>Hanoi</addr-line>, <country>Vietnam</country></aff>
<aff id="aff5"><sup>5</sup><institution>Department of International Health, Care and Public Health Research Institute (CAPHRI), Maastricht University</institution>, <addr-line>Maastricht</addr-line>, <country>Netherlands</country></aff>
<aff id="aff6"><sup>6</sup><institution>Research Committee, Global Health Workforce Network (GHWN) Youth Hub, World Health Organization</institution>, <addr-line>Geneva</addr-line>, <country>Switzerland</country></aff>
<aff id="aff7"><sup>7</sup><institution>Medical Research Council Unit for Lifelong Health and Ageing at UCL, Department of Population Science and Experimental Medicine, UCL Institute of Cardiovascular Science, University College London</institution>, <addr-line>London</addr-line>, <country>United Kingdom</country></aff>
<aff id="aff8"><sup>8</sup><institution>EA 3279, CEReSS, Research Centre on Health Services and Quality of Life, Aix Marseille University</institution>, <addr-line>Marseille</addr-line>, <country>France</country></aff>
<aff id="aff9"><sup>9</sup><institution>Bloomberg School of Public Health, Johns Hopkins University</institution>, <addr-line>Baltimore, MD</addr-line>, <country>United States</country></aff>
<aff id="aff10"><sup>10</sup><institution>Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore</institution>, <addr-line>Singapore</addr-line>, <country>Singapore</country></aff>
<aff id="aff11"><sup>11</sup><institution>Institute for Health Innovation and Technology (iHealthtech), National University of Singapore</institution>, <addr-line>Singapore</addr-line>, <country>Singapore</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Anna Christina Singleton, The University of Sydney, Australia</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Saeedeh Valizadeh, Shahid Beheshti University of Medical Sciences, Iran; Jatinderkumar R. Saini, Symbiosis Institute of Computer Studies and Research (SICSR), India</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Thao Phuong Thi Nguyen <email>nguyentphuongthao73&#x00040;duytan.edu.vn</email></corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Digital Public Health, a section of the journal Frontiers in Public Health</p></fn></author-notes>
<pub-date pub-type="epub">
<day>24</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>11</volume>
<elocation-id>1036877</elocation-id>
<history>
<date date-type="received">
<day>05</day>
<month>09</month>
<year>2022</year>
</date>
<date date-type="accepted">
<day>06</day>
<month>03</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2023 Nguyen, Do, Do, Vu, van Kessel, Wong, Boyer, Fond, Auquier, Nguyen, Latkin, Ho and Ho.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Nguyen, Do, Do, Vu, van Kessel, Wong, Boyer, Fond, Auquier, Nguyen, Latkin, Ho and Ho</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>The progression into the Digital Age has brought an array of novel skill requirements. Unlike traditional literacy, there are currently few measures that can reliably measure eHealth literacy. The Transactional Model of eHealth Literacy and subsequent Transactional eHealth Literacy Instrument may provide a feasible option for measuring eHealth literacy.</p>
</sec>
<sec>
<title>Objective</title>
<p>This instrument has yet to be validated, which is the aim of this study. In particular, this article was conducted to validate the TeHLI to see which components of the tool (how many and which components included) would be the best fit statistically and whether the tool applies to groups of different characteristics.</p>
</sec>
<sec>
<title>Methods</title>
<p>We conducted an online cross-sectional study among 236 Vietnamese young people. A exploratory factor analysis was used to identify the best fit model of the Transactional eHealth Literacy Instrument. A confirmatory factor analysis tested measurement invariance at four levels: configural, metric, scalar, and strict invariance. Only metric invariance was partially invariant, while the rest tested fully invariant. Even with partial metric invariance, there is reason to assume that functional, communicative, critical, and translational eHealth literacy (the four levels according to the transactional model) are consistently measured when deploying the Transactional eHealth Literacy Instrument across groups.</p>
</sec>
<sec>
<title>Results</title>
<p>The study findings substantiate that the most optimal composition of the TeHLI consists of four factors: functional, communicative, critical, and translational eHealth literacy, with RMSEA = 0.116; CFI = 0.907, and the highest internal consistency (Cronbach&#x00027;s &#x003B1; = 0.91, 0.92, 0.88, and 0.92 for each factor respectively). After using measurement invariance, that gender, education, marital status, age, location, and household economy do not influence the way participants to respond to the TeHLI to the point that would introduce measurement bias. In other word, using TeHLI across population groups should not produce error margins that substantially differ from each other.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>This study suggests the instrument can be used for comparisons across groups and has the potential to generate high-quality data usable for informing change agents as to whether a particular population is proficient enough to adopt novel eHealth innovations.</p>
</sec></abstract>
<kwd-group>
<kwd>eHealth</kwd>
<kwd>eHealth literacy</kwd>
<kwd>transactional model of eHealth literacy</kwd>
<kwd>digital health</kwd>
<kwd>validation</kwd>
</kwd-group>
<counts>
<fig-count count="1"/>
<table-count count="5"/>
<equation-count count="0"/>
<ref-count count="29"/>
<page-count count="9"/>
<word-count count="5858"/>
</counts>
</article-meta>
</front>
<body>
<sec id="s1">
<title>1. Introduction</title>
<p>eHealth literacy is a skill set that is becoming increasingly relevant as the Digital Age progresses (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>). When healthcare and public health services slowly moved to the digital sphere (<xref ref-type="bibr" rid="B3">3</xref>), the skills required to search for, identify, and access these services started changing incrementally (<xref ref-type="bibr" rid="B4">4</xref>). However, much like most of the world, these services transitioned to digital environments at the beginning of the COVID-19 pandemic (<xref ref-type="bibr" rid="B5">5</xref>). While innovations are typically taken up gradually by a population (<xref ref-type="bibr" rid="B6">6</xref>), society adapted acutely to the pandemic&#x02014;resulting in digital and technological advances neither equally nor equitably permeating all layers of society across the globe and potentially widening existing inequalities (<xref ref-type="bibr" rid="B7">7</xref>&#x02013;<xref ref-type="bibr" rid="B9">9</xref>). In fact, there are some indications that the migration to the digital environment was used as a short-term solution and that&#x02014;when traditional health services reemerged&#x02014;these were again preferred by those seeking healthcare (<xref ref-type="bibr" rid="B10">10</xref>).</p>
<p>eHealth literacy is a specific branch in the field of digital literacy (<xref ref-type="bibr" rid="B4">4</xref>). Given the transition toward digitalization globally, there have been attempts to define eHealth literacy. For instance, UNESCO frames digital literacy as a set of foundational skills needed to work in the digital world and is considered a catalyst for individuals to achieve health and social outcomes (<xref ref-type="bibr" rid="B11">11</xref>). Current training programs tend to focus heavily on technical skills required to use digital technologies, while cognitive and ethical considerations are disregarded entirely (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B13">13</xref>). It takes &#x0007E;5 years for the average individual to become sufficiently proficient in using digital technologies (<xref ref-type="bibr" rid="B12">12</xref>). However, this 5-year gap is not equal across all societal domains. For example, the medical sector has been slower to adapt to the digital world (<xref ref-type="bibr" rid="B14">14</xref>).</p>
<p>Recent work by Paige and colleagues created a tool with which to measure eHealth literacy (<xref ref-type="bibr" rid="B15">15</xref>). The Transactional eHealth Literacy Instrument (TeHLI) is a multi-dimensional instrument to measure increasing levels of eHealth literacy, based on the Transactional Model of eHealth Literacy (TMeHL) (<xref ref-type="bibr" rid="B16">16</xref>): functional (the ability to successfully read and write about health using technological devices), communicative (the ability to control, adapt, and collaborate communication about health with others in online social environments), critical (the ability to evaluate the relevance, trustworthiness, and risks of sharing and receiving health-related information on the Internet), and translational eHealth literacy (the ability to apply health-related information from the Internet in different contexts). However, given the novelty of this assessment tool, its application has only been focused on the general and middle age populations. However, as the driver population of eHealth utilization is the teenager and working population, more research is needed to test TeHLI on younger adults (<xref ref-type="bibr" rid="B15">15</xref>). This article aims to validate the TeHLI to see which components of the tool (how many components and which components included) would be the best fit statistically and whether the tool can be applied to groups of different characteristics (i.e., whether the different characteristics in terms of gender, education level, age group and other sociodemographic factors impact the effectiveness of the tool in any way) through exploratory and confirmatory factor analyses of survey data from Vietnamese young adults.</p>
</sec>
<sec id="s2">
<title>2. Materials and methods</title>
<sec>
<title>2.1. Participants and study procedures</title>
<p>An online cross-sectional study was conducted among Vietnamese young people from April to June 2020 in Vietnam. The eligibility criteria for participating in this survey were: (1) ages between 16 and 35 years; (2) currently living in Vietnam; and (3) agreed to join this study by providing online informed consent.</p>
<p>In this study, the snowball sampling technique was used to recruit participants from all provinces of Vietnam. First, we developed a core group of participants with 20 people (including leaders of the Youth Union in different public institutions, companies, and organizations) and invited them to complete the survey. After completing the survey, these participants were requested to invite their peers in their respective networks to complete the online survey. At the end of the data collection period, 236 youths aged 16&#x02013;35 living in Vietnam agreed to participate and completed the survey. This study was approved by the institutional review board of the Youth Research Institute, Vietnam.</p>
</sec>
<sec>
<title>2.2. Measurement and instrument</title>
<p>In this study, we built an online survey on the Survey Monkey platform. This approach is low cost, consumes little time, is user-friendly for youth, and is highly accessible to reach the samples nationwide. To complete this survey, each participant spent about 5&#x02013;10 min. A structured questionnaire was used to collect information, consisting of two components: (1) sociodemographic characteristics, and (2) the TeHLI. The survey was first piloted on five youths to ensure the cross-cultural validity of translated instruments in Vietnamese. After that, the revised questionnaire was uploaded into the online survey portal. The data collection began once the online survey system was tested to assure accurate question contents and no technical issues.</p>
<sec>
<title>2.2.1. Sociodemographic and health status characteristics</title>
<p>Participants were asked to report their sociodemographic information, including age, sex (male/female), educational attainment (below high school and high school/college/tertiary and higher), marital status (single/other), and living areas (urban/town/rural or mountain area).</p>
</sec>
<sec>
<title>2.2.2. Transactional eHealth literacy instrument</title>
<p><italic>The Transactional eHealth Literacy Instrument (TeHLI)</italic> was developed to reflect the theoretical assumptions of the TMeHL by Paige et al. (<xref ref-type="bibr" rid="B15">15</xref>). This scale consisted 18 items to reflect four aspects of the TMeHL such as functional (4 items), communicative (5 items), critical (5 items), and translational (4 items). A 5-point Likert scale from 1 (strongly disagree) to 5 (strongly agree) was used for each item. The total score of all items in each domain was calculated, with 4&#x02013;16 points for both functional and translational domains and 5&#x02013;25 points for both communicative and critical domains. The higher score of each domain indicated a higher level of eHealth skills. In this study, the Cronbach&#x00027;s &#x003B1; of four domains of TeHLI were 0.91; 0.92; 0.88; 0.92, respectively. Furthermore, by reviewing previous studies, the characteristics, as well as other versions of TeHLI were present in <xref ref-type="table" rid="T1">Table 1</xref>.</p>
<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption><p>The characteristics of transactional ehealth literacy instrument (TeHLI).</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="left"><bold>Authors/year of publication</bold></th>
<th valign="top" align="left"><bold>Country</bold></th>
<th valign="top" align="left"><bold>Aimed</bold></th>
<th valign="top" align="center"><bold>No. of dimensions</bold></th>
<th valign="top" align="left"><bold>Name of dimensions/number of items/dimensions</bold></th>
<th valign="top" align="center"><bold>No. of items of instrument</bold></th>
<th valign="top" align="left"><bold>Score range</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Paige et al. (<xref ref-type="bibr" rid="B15">15</xref>)</td>
<td valign="top" align="left">USA</td>
<td valign="top" align="left">Development and psychometric testing of a multi-dimensional Transactional eHealth Literacy instrument based on Transactional Model of eHealth Literacy (TMeHL)</td>
<td valign="top" align="center">4</td>
<td valign="top" align="left">(1) Functional (4 items)<break/>(2) Communicative (5 items)<break/>(3) Critical (5 items)<break/>(4) Translational (4 items)</td>
<td valign="top" align="center">18</td>
<td valign="top" align="left">5-point Likert-type scale:<break/>1: Strongly disagree<break/>2: Disagree<break/>3: Undecided<break/>4: Agree<break/>5: Strongly agree</td>
</tr> <tr>
<td valign="top" align="left" rowspan="2">Taylor et al. (<xref ref-type="bibr" rid="B17">17</xref>)</td>
<td valign="top" align="left" rowspan="2">USA</td>
<td valign="top" align="left">(1) Validate the TeHLI within a sample of caregivers of patients living with a blood cancer</td>
<td valign="top" align="center">4</td>
<td valign="top" align="left">(1) Functional (4 items)<break/>(2) Communicative (5 items)<break/>(3) Critical (5 items)<break/>(4) Translational (4 items)</td>
<td valign="top" align="center">18</td>
<td valign="top" align="left">5-point Likert-type scale:<break/>1: Strongly disagree<break/>2: Disagree<break/>3: Undecided<break/>4: Agree<break/>5: Strongly agree</td>
</tr>
 <tr>
<td valign="top" align="left">(2) Validate the TeHLI after adding a 5th dimension within a sample of caregivers of patients living with a blood cancer</td>
<td valign="top" align="center">5</td>
<td valign="top" align="left">(1) Functional (4 items)<break/>(2) Communicative (5 items)<break/>(3) Critical (5 items)<break/>(4) Translational (4 items)<break/>(5) Clinical (5 items)</td>
<td valign="top" align="center">23</td>
<td valign="top" align="left">5-point Likert-type scale:<break/>1: Strongly disagree<break/>2: Disagree<break/>3: Undecided<break/>4: Agree<break/>5: Strongly agree</td>
</tr></tbody>
</table>
</table-wrap>
</sec>
</sec>
<sec>
<title>2.3. Statistical analysis</title>
<p>Statistical analysis was performed using STATA version 16 and R. Standard descriptive statistical analysis was conducted with mean and standard deviation (SD) for quantitative variables and frequency and percentage for qualitative variables. The value of Skewness and Kurtosis coefficients were reported. Floor and ceiling effects were identified if the percentage of participants answering the lowest or highest response option was above 15% (<xref ref-type="bibr" rid="B18">18</xref>). A <italic>p</italic>-value (<italic>p</italic>) &#x0003C; 0.05 was considered statistically significant. The Exploratory Factor Analysis (EFA) was performed to indicate the items belonging to the four models of the TMeHL: Model 1 (18 items divided into one factor); Model 2 (18 items into two factors); Model 3 (18 items into three factors); Model 3 (18 items into four factors). For the estimation of the number of questions of each component and properties of each item in each model, an orthogonal varimax rotation with Kaiser normalization was utilized. Furthermore, after using EFA, to determine the factor structure, we conducted a Confirmatory Factor Analysis (CFA) to test the original model (4 factors), then the new models of TeHLI. Multiple model fit indicators with respective cutoffs assessed the model fit of observed data (with Satorra-Bentler correction for non-normality data) (<xref ref-type="bibr" rid="B19">19</xref>), including:</p>
<list list-type="simple">
<list-item><p>- Relative Chi-square (&#x003C7;<sup>2</sup>/<italic>df</italic>): a value &#x02264;3.0 for good fit;</p></list-item>
<list-item><p>- Root Mean Square Error of Approximation (RMSEA): a value of &#x02264;0.08 for good fit;</p></list-item>
<list-item><p>- Comparative Fit Index (CFI): a value of &#x02265;0.9 for acceptable fit;</p></list-item>
<list-item><p>- Standardized Root Mean Square Residual (SRMR): a value of &#x02264;0.08 for good fit.</p></list-item>
</list>
<sec>
<title>2.3.1. Measurement invariance</title>
<p>Measurement invariance of 4-factor model of the TeHLI regarding gender, age group, education, marital status, location, and household economy was tested by using four models as recommended. four models with different levels of measurement invariance: (1) configural invariance; (2) metric invariance; (3) strong (scalar) invariance; and (4) strict invariance.</p>
<p>Firstly, we evaluated <italic>configural</italic> invariance to assess what model is least stringent. This step aimed to test whether the constructs have the same pattern of free and fixed loadings across groups. Secondly, when configural invariance was supported, we evaluated <italic>metric</italic> invariance (also called pattern or weak invariance) or equivalence of the item loadings on the factors. Metric invariance was established by constraining factor loadings to be equivalent across groups. Thirdly, we investigated <italic>scalar</italic> invariance by constraining equal intercepts and factor loadings across groups. This step assures that participants in different groups, on average, rate items similarly. Finally, we analyzed <italic>strict</italic> invariance, which is supported when equal error variances are constrained in addition to equal intercepts and factor loadings. Testing residual error establishes that the same amount of error, or variance not accounted by the factor, is consistent for each item across groups. Measurement invariance is tested by some goodness of fit indexes, such as &#x00394;CFI, &#x00394;RMSEA, &#x00394;&#x003C7;<sup>2</sup>. When we used &#x00394;&#x003C7;<sup>2</sup> as a sole measure of exact fit, the results showed that it was associated with lower levels of scalar invariance. By contrast, using the &#x00394;CFI (with or without other criteria like &#x00394;RMSEA) was associated with higher levels metrics, scalar, and strict model. Therefore, in this study, change in the CFI (&#x00394;CFI) was used as the primary criterion for comparing models, and &#x00394;CFI &#x0003C; 0.01 between successively more restricted models provides evidence for measurement invariance (<xref ref-type="bibr" rid="B20">20</xref>&#x02013;<xref ref-type="bibr" rid="B22">22</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s3">
<title>3. Results</title>
<p><xref ref-type="table" rid="T2">Table 2</xref> shows the sociodemographic of the 236 participants in this study. The mean age of respondents was 21.3 &#x000B1; 4.8 years, with the most common age group about above 24 years old (78.8%). The majority of those were female (71.2%) and 56.8% of participants had the education tertiary and upper.</p>
<table-wrap position="float" id="T2">
<label>Table 2</label>
<caption><p>Demographic characteristics of participants.</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="left"><bold>Characteristics</bold></th>
<th valign="top" align="center"><bold><italic>n</italic></bold></th>
<th valign="top" align="center"><bold>%</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left"><bold>Total</bold></td>
<td valign="top" align="center">236</td>
<td valign="top" align="center">100.0</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="3"><bold>Gender</bold></td>
</tr> <tr>
<td valign="top" align="left">Male</td>
<td valign="top" align="center">68</td>
<td valign="top" align="center">28.8</td>
</tr> <tr>
<td valign="top" align="left">Female</td>
<td valign="top" align="center">168</td>
<td valign="top" align="center">71.2</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="3"><bold>Age group</bold></td>
</tr> <tr>
<td valign="top" align="left">Below 24-year</td>
<td valign="top" align="center">186</td>
<td valign="top" align="center">78.8</td>
</tr> <tr>
<td valign="top" align="left">Above 24-year</td>
<td valign="top" align="center">50</td>
<td valign="top" align="center">21.2</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="3"><bold>Education</bold></td>
</tr> <tr>
<td valign="top" align="left">Below and high school</td>
<td valign="top" align="center">59</td>
<td valign="top" align="center">25.0</td>
</tr> <tr>
<td valign="top" align="left">College</td>
<td valign="top" align="center">43</td>
<td valign="top" align="center">18.2</td>
</tr> <tr>
<td valign="top" align="left">Tertiary and higher</td>
<td valign="top" align="center">134</td>
<td valign="top" align="center">56.8</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="3"><bold>Location</bold></td>
</tr> <tr>
<td valign="top" align="left">Urban</td>
<td valign="top" align="center">110</td>
<td valign="top" align="center">46.6</td>
</tr> <tr>
<td valign="top" align="left">Suburban</td>
<td valign="top" align="center">41</td>
<td valign="top" align="center">17.4</td>
</tr> <tr>
<td valign="top" align="left">Rural/mountain area</td>
<td valign="top" align="center">85</td>
<td valign="top" align="center">36.0</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="3"><bold>Household economy</bold></td>
</tr> <tr>
<td valign="top" align="left">Poor</td>
<td valign="top" align="center">136</td>
<td valign="top" align="center">57.6</td>
</tr> <tr>
<td valign="top" align="left">Medium and above</td>
<td valign="top" align="center">100</td>
<td valign="top" align="center">42.4</td>
</tr> <tr style="background-color:#dee1e1">
<td/>
<td valign="top" align="center"><bold>Mean</bold></td>
<td valign="top" align="center"><bold>SD</bold></td>
</tr> <tr>
<td valign="top" align="left">Age</td>
<td valign="top" align="center">21.3</td>
<td valign="top" align="center">4.8</td>
</tr></tbody>
</table>
</table-wrap>
<p><xref ref-type="table" rid="T3">Table 3</xref> presents the results of the descriptive analysis for 18 items of the TeHLI. All the 18 items had a range of scores from 1 to 5. Out of 18 items, the maximum and mimimum scores was recored at 3.3 (0.9), and 3.3 (0.9), respectively. Skewness and Kurtosis coefficients were reported with ranging from &#x02212;1.0 to &#x02212;0.2 and 2.8 to 4.3, respectively. <xref ref-type="table" rid="T3">Table 3</xref> also presented the reliability of the modified TeHLI. Correlation coefficients with other items in respective factors ranged between 0.7 and 0.8. Cronbach&#x00027;s alpha value of factor 1 &#x0201C;Functional,&#x0201D; factor 2 &#x0201C;Communicative,&#x0201D; factor 3 &#x0201C;Critical,&#x0201D; and factor 4 &#x0201C;Translational&#x0201D; were good at 0.82, 0.92, 0.92, and 0.90, respectively.</p>
<table-wrap position="float" id="T3">
<label>Table 3</label>
<caption><p>Basic descriptions and reliability of transactional eHealth literacy.</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="left" rowspan="2"><bold>Items</bold></th>
<th valign="top" align="center" colspan="5"><bold>Responses (%)</bold></th>
<th valign="top" align="center" rowspan="2"><bold>Mean (SD)</bold></th>
<th valign="top" align="center" rowspan="2"><bold>Skewness</bold></th>
<th valign="top" align="center" rowspan="2"><bold>Kurtosis</bold></th>
<th valign="top" align="center" rowspan="2"><bold>Floor (%)</bold></th>
<th valign="top" align="center" rowspan="2"><bold>Ceiling (%)</bold></th>
<th valign="top" align="center" rowspan="2"><bold>Item-total correlation</bold></th>
<th valign="top" align="center" rowspan="2"><bold>Cronbach&#x00027;s alpha if item deleted</bold></th>
</tr>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="center"><bold>1</bold></th>
<th valign="top" align="center"><bold>2</bold></th>
<th valign="top" align="center"><bold>3</bold></th>
<th valign="top" align="center"><bold>4</bold></th>
<th valign="top" align="center"><bold>5</bold></th>
</tr>
</thead>
<tbody>
<tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="13"><bold>Factor 1: Functional</bold></td>
</tr> <tr>
<td valign="top" align="left">Q1. Summarize basic health information</td>
<td valign="top" align="center">4.2</td>
<td valign="top" align="center">12.3</td>
<td valign="top" align="center">36.0</td>
<td valign="top" align="center">39.0</td>
<td valign="top" align="center">8.5</td>
<td valign="top" align="center">3.4 (0.9)</td>
<td valign="top" align="center">&#x02212;0.5</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">4.2</td>
<td valign="top" align="center">8.5</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q2. Know how to access basic health information</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">6.8</td>
<td valign="top" align="center">22.5</td>
<td valign="top" align="center">58.1</td>
<td valign="top" align="center">9.8</td>
<td valign="top" align="center">3.6 (0.9)</td>
<td valign="top" align="center">&#x02212;1.0</td>
<td valign="top" align="center">4.3</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">9.8</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q3. Create messages that describe health</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">9.3</td>
<td valign="top" align="center">34.8</td>
<td valign="top" align="center">45.8</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">3.4 (0.9)</td>
<td valign="top" align="center">&#x02212;0.6</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q4. Tell someone how to find basic health information</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">8.5</td>
<td valign="top" align="center">29.7</td>
<td valign="top" align="center">49.2</td>
<td valign="top" align="center">9.8</td>
<td valign="top" align="center">3.5 (0.9)</td>
<td valign="top" align="center">&#x02212;0.7</td>
<td valign="top" align="center">3.5</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">9.8</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="13"><bold>Factor 2: Communicative</bold></td>
</tr> <tr>
<td valign="top" align="left">Q5. Information goals and help others have it</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">9.8</td>
<td valign="top" align="center">33.1</td>
<td valign="top" align="center">44.1</td>
<td valign="top" align="center">9.8</td>
<td valign="top" align="center">3.5 (0.9)</td>
<td valign="top" align="center">&#x02212;0.6</td>
<td valign="top" align="center">3.2</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">9.8</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q6. Talk about health topics with users</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">11.9</td>
<td valign="top" align="center">41.5</td>
<td valign="top" align="center">35.2</td>
<td valign="top" align="center">8.1</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.3</td>
<td valign="top" align="center">3.1</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">8.1</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q7. Identify the emotional tone of a health conversation</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">11.4</td>
<td valign="top" align="center">43.2</td>
<td valign="top" align="center">35.6</td>
<td valign="top" align="center">6.4</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.4</td>
<td valign="top" align="center">3.2</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">6.4</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q8. Contribute to health conversations</td>
<td valign="top" align="center">2.5</td>
<td valign="top" align="center">14.0</td>
<td valign="top" align="center">43.2</td>
<td valign="top" align="center">32.6</td>
<td valign="top" align="center">7.6</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.2</td>
<td valign="top" align="center">2.9</td>
<td valign="top" align="center">2.5</td>
<td valign="top" align="center">7.6</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q9. Connections with others to share information</td>
<td valign="top" align="center">2.5</td>
<td valign="top" align="center">8.9</td>
<td valign="top" align="center">40.7</td>
<td valign="top" align="center">40.7</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">3.4 (0.8)</td>
<td valign="top" align="center">&#x02212;0.4</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">2.5</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="13"><bold>Factor 3: Critical</bold></td>
</tr> <tr>
<td valign="top" align="left">Q10. Identify a credible source of health information</td>
<td valign="top" align="center">2.5</td>
<td valign="top" align="center">15.3</td>
<td valign="top" align="center">39.8</td>
<td valign="top" align="center">35.2</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.2</td>
<td valign="top" align="center">2.8</td>
<td valign="top" align="center">2.5</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q11. Identify health information is fake</td>
<td valign="top" align="center">3.8</td>
<td valign="top" align="center">10.6</td>
<td valign="top" align="center">41.5</td>
<td valign="top" align="center">36.9</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.4</td>
<td valign="top" align="center">3.2</td>
<td valign="top" align="center">3.8</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q12. Identify website is safe for sharing personal health</td>
<td valign="top" align="center">4.2</td>
<td valign="top" align="center">10.6</td>
<td valign="top" align="center">39.8</td>
<td valign="top" align="center">38.6</td>
<td valign="top" align="center">6.8</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.5</td>
<td valign="top" align="center">3.2</td>
<td valign="top" align="center">4.2</td>
<td valign="top" align="center">6.8</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q13. Identify information is relevant to health needs</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">6.4</td>
<td valign="top" align="center">38.6</td>
<td valign="top" align="center">45.3</td>
<td valign="top" align="center">6.8</td>
<td valign="top" align="center">3.5 (0.8)</td>
<td valign="top" align="center">&#x02212;0.6</td>
<td valign="top" align="center">3.8</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">6.8</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q14. Know how to evaluate the credibility of others</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">11.4</td>
<td valign="top" align="center">39.8</td>
<td valign="top" align="center">39.4</td>
<td valign="top" align="center">5.9</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.5</td>
<td valign="top" align="center">3.2</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">5.9</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="13"><bold>Factor 4: Translational</bold></td>
</tr> <tr>
<td valign="top" align="left">Q15. Learn to manage health in a positive way</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">8.9</td>
<td valign="top" align="center">36.0</td>
<td valign="top" align="center">44.1</td>
<td valign="top" align="center">7.6</td>
<td valign="top" align="center">3.4 (0.9)</td>
<td valign="top" align="center">&#x02212;0.6</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">7.6</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q16. Use the Internet as a tool to improve health</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">13.6</td>
<td valign="top" align="center">36.0</td>
<td valign="top" align="center">39.4</td>
<td valign="top" align="center">7.6</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.4</td>
<td valign="top" align="center">2.9</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">7.6</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q17. Use the information to make a decision</td>
<td valign="top" align="center">3.8</td>
<td valign="top" align="center">13.1</td>
<td valign="top" align="center">40.7</td>
<td valign="top" align="center">35.2</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">3.3 (0.9)</td>
<td valign="top" align="center">&#x02212;0.3</td>
<td valign="top" align="center">3.0</td>
<td valign="top" align="center">3.8</td>
<td valign="top" align="center">7.2</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.96</td>
</tr> <tr>
<td valign="top" align="left">Q18. Learn about topics had relevant to me</td>
<td valign="top" align="center">3.8</td>
<td valign="top" align="center">8.1</td>
<td valign="top" align="center">30.9</td>
<td valign="top" align="center">46.6</td>
<td valign="top" align="center">10.6</td>
<td valign="top" align="center">3.5 (0.9)</td>
<td valign="top" align="center">&#x02212;0.7</td>
<td valign="top" align="center">3.5</td>
<td valign="top" align="center">3.8</td>
<td valign="top" align="center">10.6</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.96</td>
</tr> <tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="13"><bold>Factor score</bold></td>
</tr> <tr>
<td valign="top" align="left"><bold>Factor 1: Functional</bold></td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td valign="top" align="center">3.5 (0.8)</td>
<td valign="top" align="center">&#x02212;0.8</td>
<td valign="top" align="center">4.1</td>
<td/>
<td/>
<td/>
<td valign="top" align="center">0.88</td>
</tr> <tr>
<td valign="top" align="left"><bold>Factor 2: Communicative</bold></td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td valign="top" align="center">3.4 (0.8)</td>
<td valign="top" align="center">&#x02212;0.3</td>
<td valign="top" align="center">3.7</td>
<td/>
<td/>
<td/>
<td valign="top" align="center">0.92</td>
</tr> <tr>
<td valign="top" align="left"><bold>Factor 3: Critical</bold></td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td valign="top" align="center">3.4 (0.8)</td>
<td valign="top" align="center">&#x02212;0.4</td>
<td valign="top" align="center">3.4</td>
<td/>
<td/>
<td/>
<td valign="top" align="center">0.92</td>
</tr> <tr>
<td valign="top" align="left"><bold>Factor 4: Translational</bold></td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td valign="top" align="center">3.4 (0.8)</td>
<td valign="top" align="center">&#x02212;0.5</td>
<td valign="top" align="center">3.4</td>
<td/>
<td/>
<td/>
<td valign="top" align="center">0.90</td>
</tr> <tr>
<td valign="top" align="left"><bold>All</bold></td>
<td/>
<td/>
<td/>
<td/>
<td/>
<td valign="top" align="center">3.4 (0.7)</td>
<td valign="top" align="center">&#x02212;0.4</td>
<td valign="top" align="center">4.0</td>
<td/>
<td/>
<td/>
<td valign="top" align="center">0.96</td>
</tr></tbody>
</table>
</table-wrap>
<p><xref ref-type="table" rid="T4">Table 4</xref> further shows the results of Confirmatory Factor Analysis on four different models. The model with 1 factor of the TeHLI showed an RMSEA and CFI score of 0.157 and 0.806. In contrast, the model with four factors showed an RMSEA and CFI score of 0.116 and 0.907, respectively. As such, this model was used to conduct measurement invariance.</p>
<table-wrap position="float" id="T4">
<label>Table 4</label>
<caption><p>Exploratory factor analysis and confirmatory factor analysis models and fit indices evaluating factor structure of the transactional eHealth literacy scale.</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th/>
<th valign="top" align="left"><bold>Model 1</bold></th>
<th valign="top" align="left"><bold>Model 2</bold></th>
<th valign="top" align="left"><bold>Model 3</bold></th>
<th valign="top" align="left"><bold>Model 4</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Q1. Summaries basic health information</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Functional</td>
<td valign="top" align="left">Functional</td>
</tr> <tr>
<td valign="top" align="left">Q2. Know how to access basic health information</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Functional</td>
<td valign="top" align="left">Functional</td>
</tr> <tr>
<td valign="top" align="left">Q3. Create messages that describe health</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Functional</td>
<td valign="top" align="left">Functional</td>
</tr> <tr>
<td valign="top" align="left">Q4. Tell someone how to find basic health information</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Functional</td>
<td valign="top" align="left">Functional</td>
</tr> <tr>
<td valign="top" align="left">Q5. Information goals and help others have it</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Communicative</td>
<td valign="top" align="left">Communicative</td>
</tr> <tr>
<td valign="top" align="left">Q6. Talk about health topics with users</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Communicative</td>
<td valign="top" align="left">Communicative</td>
</tr> <tr>
<td valign="top" align="left">Q7. Identify the emotional tone of a health-related conversation</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Communicative</td>
<td valign="top" align="left">Communicative</td>
</tr> <tr>
<td valign="top" align="left">Q8. Contribute to health conversations</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Communicative</td>
<td valign="top" align="left">Communicative</td>
</tr> <tr>
<td valign="top" align="left">Q9. Connections with others to share information</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Functional/communicative</td>
<td valign="top" align="left">Communicative</td>
<td valign="top" align="left">Communicative</td>
</tr> <tr>
<td valign="top" align="left">Q10. Identify a credible source of health information</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical</td>
</tr> <tr>
<td valign="top" align="left">Q11. Identify health information is fake</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical</td>
</tr> <tr>
<td valign="top" align="left">Q12. Identify a website that is safe for sharing personal health</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical</td>
</tr> <tr>
<td valign="top" align="left">Q13. Identify information is relevant to health needs</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical</td>
</tr> <tr>
<td valign="top" align="left">Q14. Know how to evaluate the credibility of others</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical</td>
</tr> <tr>
<td valign="top" align="left">Q15. Learn to manage health in a positive way</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Translational</td>
</tr> <tr>
<td valign="top" align="left">Q16. Use the Internet as a tool to improve health</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Translational</td>
</tr> <tr>
<td valign="top" align="left">Q17. Use the information to make a decision</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Translational</td>
</tr> <tr>
<td valign="top" align="left">Q18. Learn about topics had relevant to me</td>
<td valign="top" align="left">eHealth literacy</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Critical/translational</td>
<td valign="top" align="left">Translational</td>
</tr> <tr>
<td valign="top" align="left">Chi-square</td>
<td valign="top" align="left">912.388</td>
<td valign="top" align="left">765.282</td>
<td valign="top" align="left">674.437</td>
<td valign="top" align="left">488.49</td>
</tr> <tr>
<td valign="top" align="left">Degrees of freedom</td>
<td valign="top" align="left">135</td>
<td valign="top" align="left">134</td>
<td valign="top" align="left">132</td>
<td valign="top" align="left">117</td>
</tr> <tr>
<td valign="top" align="left"><italic>p</italic>-value</td>
<td valign="top" align="left">&#x0003C;0.01</td>
<td valign="top" align="left">&#x0003C;0.01</td>
<td valign="top" align="left">&#x0003C;0.01</td>
<td valign="top" align="left">&#x0003C;0.01</td>
</tr> <tr>
<td valign="top" align="left">RMSEA (90% CI)</td>
<td valign="top" align="left">0.157 (0.147; 0.166)</td>
<td valign="top" align="left">0.142 (0.132; 0.151)</td>
<td valign="top" align="left">0.132 (0.122; 0.142)</td>
<td valign="top" align="left">0.116 (0.106; 0.127)</td>
</tr> <tr>
<td valign="top" align="left">TLI</td>
<td valign="top" align="left">0.780</td>
<td valign="top" align="left">0.82</td>
<td valign="top" align="left">0.843</td>
<td valign="top" align="left">0.897</td>
</tr> <tr>
<td valign="top" align="left">CFI</td>
<td valign="top" align="left">0.806</td>
<td valign="top" align="left">0.842</td>
<td valign="top" align="left">0.865</td>
<td valign="top" align="left">0.907</td>
</tr></tbody>
</table>
<table-wrap-foot>
<p>RMSEA, root mean square error of approximation; TLI, Tucker-Lewis index; CFI, comparative fit index.</p>
</table-wrap-foot>
</table-wrap>
<p>The results obtained from the Confirmatory Factor Analysis for the TeHLI are estimated in <xref ref-type="fig" rid="F1">Figure 1</xref>. The standardized coefficients range from 0.87 to 1.1. The highest coefficient was found in 4 items (Q4, Q11, Q13, and Q17), while the lowest was Q8.</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption><p>CFA models through structural equation modeling for the transactional eHealth literacy instrument (RMSEA = 0.116; CFI: 0.907; SRMR: 0.047).</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpubh-11-1036877-g0001.tif"/>
</fig>
<p>The values of &#x00394;CFI were &#x0003C;0.01 when all models, with progressive restrictions, are compared across age groups, education, household economic (<xref ref-type="table" rid="T5">Table 5</xref>). These groups reported strict invariance. Besides, the configural model of gender, marital status, and location had fit statistics of RMSEA &#x0003C; 0.08, CFI &#x0003E; 0.9. However, in the metric model, the value of &#x00394;CFI was higher than 0.01 at all three variables (gender, marital status, and location). Metric invariance was therefore not supported by the data.</p>
<table-wrap position="float" id="T5">
<label>Table 5</label>
<caption><p>Measurement invariance in the transactional eHealth literacy questionnaire for the different groups.</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:&#x00023;919498;color:&#x00023;ffffff">
<th valign="top" align="left"><bold>Group</bold></th>
<th valign="top" align="left"><bold>Invariance</bold></th>
<th valign="top" align="center"><bold><italic>x</italic><sup>2</sup> (df)</bold></th>
<th valign="top" align="center"><bold><italic>x</italic><sup>2</sup>/<italic>df</italic></bold></th>
<th valign="top" align="center"><bold>CFI</bold></th>
<th valign="top" align="center"><bold>RMSEA (90%CI)</bold></th>
<th valign="top" align="center"><bold>&#x00394; <italic>x</italic><sup>2</sup>(&#x00394; df)</bold></th>
<th valign="top" align="center"><bold>&#x00394;CFI</bold></th>
<th valign="top" align="center"><bold>&#x00394; RMSEA</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Gender</td>
<td valign="top" align="left">Configural</td>
<td valign="top" align="center">288.467 (258)</td>
<td valign="top" align="center">1.118</td>
<td valign="top" align="center">0.966</td>
<td valign="top" align="center">0.032 (0.000; 0.050)</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Metric</td>
<td valign="top" align="center">289.257 (272)</td>
<td valign="top" align="center">1.063</td>
<td valign="top" align="center">0.981</td>
<td valign="top" align="center">0.023 (0.000; 0.044)</td>
<td valign="top" align="center">0.790 (14)</td>
<td valign="top" align="center">0.015</td>
<td valign="top" align="center">0.009</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strong</td>
<td valign="top" align="center">307.891 (286)</td>
<td valign="top" align="center">1.077</td>
<td valign="top" align="center">0.976</td>
<td valign="top" align="center">0.026 (0.000; 0.045)</td>
<td valign="top" align="center">18.634 (14)</td>
<td valign="top" align="center">0.005</td>
<td valign="top" align="center">0.003</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strict</td>
<td valign="top" align="center">326.862 (304)</td>
<td valign="top" align="center">1.075</td>
<td valign="top" align="center">0.975</td>
<td valign="top" align="center">0.025 (0.000; 0.045)</td>
<td valign="top" align="center">18.971 (18)</td>
<td valign="top" align="center">0.001</td>
<td valign="top" align="center">0.001</td>
</tr> <tr>
<td valign="top" align="left">Education</td>
<td valign="top" align="left">Configural</td>
<td valign="top" align="center">406.792 (387)</td>
<td valign="top" align="center">1.051</td>
<td valign="top" align="center">0.978</td>
<td valign="top" align="center">0.026 (0.000; 0.049)</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Metric</td>
<td valign="top" align="center">436.604 (415)</td>
<td valign="top" align="center">1.052</td>
<td valign="top" align="center">0.976</td>
<td valign="top" align="center">0.026 (0.000; 0.048)</td>
<td valign="top" align="center">29.812 (28)</td>
<td valign="top" align="center">0.002</td>
<td valign="top" align="center">0.000</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strong</td>
<td valign="top" align="center">466.686 (443)</td>
<td valign="top" align="center">1.053</td>
<td valign="top" align="center">0.974</td>
<td valign="top" align="center">0.026 (0.000; 0.048)</td>
<td valign="top" align="center">30.082 (28)</td>
<td valign="top" align="center">0.002</td>
<td valign="top" align="center">0.000</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strict</td>
<td valign="top" align="center">501.197 (479)</td>
<td valign="top" align="center">1.046</td>
<td valign="top" align="center">0.975</td>
<td valign="top" align="center">0.024 (0.000; 0.046)</td>
<td valign="top" align="center">34.511 (36)</td>
<td valign="top" align="center">0.001</td>
<td valign="top" align="center">0.002</td>
</tr> <tr>
<td valign="top" align="left">Marital status</td>
<td valign="top" align="left">Configural</td>
<td valign="top" align="center">286.936 (258)</td>
<td valign="top" align="center">1.112</td>
<td valign="top" align="center">0.964</td>
<td valign="top" align="center">0.031 (0.000; 0.050)</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Metric</td>
<td valign="top" align="center">288.11 (272)</td>
<td valign="top" align="center">1.059</td>
<td valign="top" align="center">0.98</td>
<td valign="top" align="center">0.022 (0.000; 0.044)</td>
<td valign="top" align="center">1.174 (14)</td>
<td valign="top" align="center">0.016</td>
<td valign="top" align="center">0.008</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strong</td>
<td valign="top" align="center">300.773 (286)</td>
<td valign="top" align="center">1.052</td>
<td valign="top" align="center">0.982</td>
<td valign="top" align="center">0.021 (0.000; 0.042)</td>
<td valign="top" align="center">12.663 (14)</td>
<td valign="top" align="center">0.002</td>
<td valign="top" align="center">0.001</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strict</td>
<td valign="top" align="center">316.362 (304)</td>
<td valign="top" align="center">1.041</td>
<td valign="top" align="center">0.985</td>
<td valign="top" align="center">0.019 (0.000; 0.041)</td>
<td valign="top" align="center">15.589 (18)</td>
<td valign="top" align="center">0.003</td>
<td valign="top" align="center">0.002</td>
</tr> <tr>
<td valign="top" align="left">Age group</td>
<td valign="top" align="left">Configural</td>
<td valign="top" align="center">278.739 (258)</td>
<td valign="top" align="center">1.080</td>
<td valign="top" align="center">0.977</td>
<td valign="top" align="center">0.026 (0.000; 0.046)</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Metric</td>
<td valign="top" align="center">282.998 (272)</td>
<td valign="top" align="center">1.040</td>
<td valign="top" align="center">0.988</td>
<td valign="top" align="center">0.019 (0.000; 0.042)</td>
<td valign="top" align="center">4.259 (14)</td>
<td valign="top" align="center">0.010</td>
<td valign="top" align="center">0.008</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strong</td>
<td valign="top" align="center">297.374 (286)</td>
<td valign="top" align="center">1.040</td>
<td valign="top" align="center">0.987</td>
<td valign="top" align="center">0.018 (0.000; 0.041)</td>
<td valign="top" align="center">14.376 (14)</td>
<td valign="top" align="center">0.001</td>
<td valign="top" align="center">0.001</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strict</td>
<td valign="top" align="center">314.93 (304)</td>
<td valign="top" align="center">1.036</td>
<td valign="top" align="center">0.988</td>
<td valign="top" align="center">0.018 (0.000; 0.040)</td>
<td valign="top" align="center">17.556 (18)</td>
<td valign="top" align="center">0.001</td>
<td valign="top" align="center">0.000</td>
</tr> <tr>
<td valign="top" align="left">Location</td>
<td valign="top" align="left">Configural</td>
<td valign="top" align="center">415.767 (387)</td>
<td valign="top" align="center">1.074</td>
<td valign="top" align="center">0.967</td>
<td valign="top" align="center">0.031 (0.000; 0.052)</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Metric</td>
<td valign="top" align="center">419.695 (415)</td>
<td valign="top" align="center">1.011</td>
<td valign="top" align="center">0.995</td>
<td valign="top" align="center">0.012 (0.000; 0.042)</td>
<td valign="top" align="center">3.928 (28)</td>
<td valign="top" align="center">0.028</td>
<td valign="top" align="center">0.019</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strong</td>
<td valign="top" align="center">450.521 (443)</td>
<td valign="top" align="center">1.017</td>
<td valign="top" align="center">0.991</td>
<td valign="top" align="center">0.015 (0.000; 0.042)</td>
<td valign="top" align="center">30.826 (28)</td>
<td valign="top" align="center">0.003</td>
<td valign="top" align="center">0.003</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strict</td>
<td valign="top" align="center">484.828 (479)</td>
<td valign="top" align="center">1.012</td>
<td valign="top" align="center">0.993</td>
<td valign="top" align="center">0.013 (0.000; 0.041)</td>
<td valign="top" align="center">34.307 (36)</td>
<td valign="top" align="center">0.002</td>
<td valign="top" align="center">0.002</td>
</tr> <tr>
<td valign="top" align="left">Household economy</td>
<td valign="top" align="left">Configural</td>
<td valign="top" align="center">285.653 (258)</td>
<td valign="top" align="center">1.107</td>
<td valign="top" align="center">0.969</td>
<td valign="top" align="center">0.030 (0.000; 0.049)</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
<td valign="top" align="center">&#x02013;</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Metric</td>
<td valign="top" align="center">303.942 (272)</td>
<td valign="top" align="center">1.117</td>
<td valign="top" align="center">0.964</td>
<td valign="top" align="center">0.032 (0.000; 0.050)</td>
<td valign="top" align="center">18.289 (14)</td>
<td valign="top" align="center">0.005</td>
<td valign="top" align="center">0.002</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strong</td>
<td valign="top" align="center">317.675 (286)</td>
<td valign="top" align="center">1.111</td>
<td valign="top" align="center">0.964</td>
<td valign="top" align="center">0.031 (0.000; 0.049)</td>
<td valign="top" align="center">13.733 (14)</td>
<td valign="top" align="center">0.000</td>
<td valign="top" align="center">0.001</td>
</tr> <tr>
<td/>
<td valign="top" align="left">Strict</td>
<td valign="top" align="center">334.803 (304)</td>
<td valign="top" align="center">1.101</td>
<td valign="top" align="center">0.965</td>
<td valign="top" align="center">0.029 (0.000; 0.047)</td>
<td valign="top" align="center">17.128 (18)</td>
<td valign="top" align="center">0.001</td>
<td valign="top" align="center">0.002</td>
</tr></tbody>
</table>
</table-wrap>
</sec>
<sec id="s4">
<title>4. Discussion</title>
<p>This article aimed to validate the TeHLI to see which components of the tool (how many and which components included) would be the best fit statistically and whether the tool applies to groups of different characteristics. Overall, we found that a TeHLI divided into four factors (functional, communicative, critical, and translational) had the best statistical fit (RMSEA = 0.116; CFI = 0.907) and the highest level of internal consistency (Cronbach&#x00027;s &#x003B1; = 0.96). The individual items in the TeHLI have medium-to-high levels of correlation with other items in respective factors (<italic>r</italic> &#x0003E; 0.6). Upon further analysis, we found partial invariance of the TeHLI&#x02014;only lacking support for metric invariance.</p>
<p>The study findings substantiate that the most optimal composition of the TeHLI consists of four factors: functional, communicative, critical, and translational eHealth literacy. In this model, Q1&#x02013;Q4 measure functional eHealth literacy, Q5&#x02013;Q9 measure communicative eHealth literacy, Q10&#x02013;Q14 measure critical eHealth literacy, and Q15&#x02013;Q18 measure transactional eHealth literacy. This tool composition is in line with the original dimensions of the TMeHL (<xref ref-type="bibr" rid="B16">16</xref>). The initial measurements of high internal consistency of the four domains by Paige and colleagues (Cronbach&#x00027;s &#x003B1; = 0.91, 0.92, 0.88, and 0.92 respectively) was also supported by our findings (Cronbach&#x00027;s &#x003B1; = 0.88, 0.92, 0.92, and 0.90 respectively) (<xref ref-type="bibr" rid="B15">15</xref>).</p>
<p>In terms of measurement invariance, the support for configural invariance indicates that the same construct is measured in different population groups. In the context of this study, functional, communicative, critical, and translational eHealth literacy are consistently measured when the TeHLI is deployed in different population groups. The support for scalar invariance indicates the ability to justify the comparison of means across population groups. It indicates that gender, education, marital status, age, location, and household economy do not influence the way participants to respond to the TeHLI to the point that would introduce measurement bias. The support for strict invariance indicates that the residual errors are equivalent across participants. In other words, using the TeHLI across population groups should not produce error margins that substantially differ from each other. However, metric invariance was only found in two groups (education [&#x00394;CFI = 0.002] and household economy [&#x00394;CFI = 0.005]; age group being precisely on the threshold [&#x00394;CFI = 0.010]) and, therefore, only partial metric invariance is supported by this data (<xref ref-type="bibr" rid="B23">23</xref>), which suggests that the constructs measured have different meanings across some of the participant groups.</p>
<p>Finding partial support for metric invariance is reported to have minimal effects on the mean differences of a latent factor (<xref ref-type="bibr" rid="B24">24</xref>). Since two factor loadings reported metric invariance, there are grounds to assume the TeHLI can be used for comparisons across groups (<xref ref-type="bibr" rid="B25">25</xref>, <xref ref-type="bibr" rid="B26">26</xref>). Simultaneously, there is also the question of whether partial invariance is sufficient as significant bias can still be introduced into study findings if the partial invariance is ignored (<xref ref-type="bibr" rid="B27">27</xref>, <xref ref-type="bibr" rid="B28">28</xref>). As such, deploying a partially (including invariant items only) and a fully invariant model (including invariant and non-invariant items) and compare the results of interest arises as a viable solution to use the TeHLI across different population groups (<xref ref-type="bibr" rid="B29">29</xref>). The risk of this solution is that&#x02014;if the results differ substantially&#x02014;there is no clear path forward.</p>
<p>Some limitations apply to this study. The survey findings had a mild-to-moderate negative skewness. However, as extrapolation to the population is impossible given the lack of participants, this limitation does not significantly affect the study findings. The survey was also distributed only among the Vietnamese population. Therefore, the influence of culture could not be determined and needs to be examined in a future study that includes multiple countries or regions. Lastly, the current study sample did not reflect a balanced distribution of some socio-demographic characteristics and could lead to limit representativeness with respect to the Vietnamese youth population. Hence, further studies are required to explore the effect of the data imbalance on measurement invariances of the scales.</p>
</sec>
<sec id="s5">
<title>5. Conclusions</title>
<p>Ultimately, the TeHLI can be considered a valuable tool to measure different competency levels of eHealth literacy. As such, the TeHLI has the potential (if deployed correctly) to generate high-quality data that can be used to inform governments and change agents whether the general or a target population is capable of understanding, appraising, distinguishing, and acting appropriately on high- and low-quality health information on the Internet. As a result, it can make vital contributions in informing and guiding policy and practice sustainably into the Digital Age.</p>
</sec>
<sec sec-type="data-availability" id="s6">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec sec-type="ethics-statement" id="s7">
<title>Ethics statement</title>
<p>The protocol of this study was approved by the Institutional Review Board of Youth Research Institute, Vietnam (No 404Q&#x000D0;&#x0002A;/TW&#x000D0;&#x0002A;TN-VCNTN) on 08/01/2020. The patients/participants provided their written informed consent to participate in this study.</p>
</sec>
<sec sec-type="author-contributions" id="s8">
<title>Author contributions</title>
<p>TPTN: conceptualization, data collection, project management, and writing&#x02014;review and editing. AD and HD: conceptualization, data collection, and project management. TV and RK: formal analysis, validation, writing&#x02014;original draft, and writing&#x02014;review and editing. BLHW, LB, GF, and PA: formal analysis, writing&#x02014;original draft, and writing&#x02014;review and editing. TTN: formal analysis, data collection, data analysis, and writing&#x02014;original draft. CL and CH: conceptualization and writing&#x02014;review and editing. RH: conceptualization, validation, and writing&#x02014;review and editing. All authors contributed to the article and approved the submitted version.</p>
</sec>
</body>
<back>
<sec sec-type="funding-information" id="s9">
<title>Funding</title>
<p>The article process charge of this paper is supported by the NUS Department of Psychological Medicine (R-177-000-100-001/R-177-000-003-001); and NUS iHeathtech Other Operating Expenses (R-722-000-004-731).</p>
</sec>
<ack><p>The authors would like to acknowledge supports by all respondents who participated in the study.</p>
</ack>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s10">
<title>Publisher&#x00027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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