TY - JOUR AU - Thomas, Ashleigh AU - Bates, Kathleen AU - Elchesen, Alex AU - Hartsock, Iryna AU - Lu, Hang AU - Bubenik, Peter PY - 2021 M3 - Original Research TI - Topological Data Analysis of C. elegans Locomotion and Behavior JO - Frontiers in Artificial Intelligence UR - https://www.frontiersin.org/articles/10.3389/frai.2021.668395 VL - 4 SN - 2624-8212 N2 - We apply topological data analysis to the behavior of C. elegans, a widely studied model organism in biology. In particular, we use topology to produce a quantitative summary of complex behavior which may be applied to high-throughput data. Our methods allow us to distinguish and classify videos from various environmental conditions and we analyze the trade-off between accuracy and interpretability. Furthermore, we present a novel technique for visualizing the outputs of our analysis in terms of the input. Specifically, we use representative cycles of persistent homology to produce synthetic videos of stereotypical behaviors. ER -