TY - JOUR AU - Wu, Mengjia AU - Zhang, Yi AU - Grosser, Mark AU - Tipper, Steven AU - Venter, Deon AU - Lin, Hua AU - Lu, Jie PY - 2021 M3 - Original Research TI - Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics JO - Frontiers in Research Metrics and Analytics UR - https://www.frontiersin.org/articles/10.3389/frma.2021.683212 VL - 6 SN - 2504-0537 N2 - The COVID-19 pandemic constitutes an ongoing worldwide threat to human society and has caused massive impacts on global public health, the economy and the political landscape. The key to gaining control of the disease lies in understanding the genetics of SARS-CoV-2 and the disease spectrum that follows infection. This study leverages traditional and intelligent bibliometric methods to conduct a multi-dimensional analysis on 5,632 COVID-19 genetic research papers, revealing that 1) the key players include research institutions from the United States, China, Britain and Canada; 2) research topics predominantly focus on virus infection mechanisms, virus testing, gene expression related to the immune reactions and patient clinical manifestation; 3) studies originated from the comparison of SARS-CoV-2 to previous human coronaviruses, following which research directions diverge into the analysis of virus molecular structure and genetics, the human immune response, vaccine development and gene expression related to immune responses; and 4) genes that are frequently highlighted include ACE2, IL6, TMPRSS2, and TNF. Emerging genes to the COVID-19 consist of FURIN, CXCL10, OAS1, OAS2, OAS3, and ISG15. This study demonstrates that our suite of novel bibliometric tools could help biomedical researchers follow this rapidly growing field and provide substantial evidence for policymakers’ decision-making on science policy and public health administration. ER -