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ORIGINAL RESEARCH article

Front. Microbiomes
Sec. Nutrition, Metabolism and the Microbiome
Volume 3 - 2024 | doi: 10.3389/frmbi.2024.1381423
This article is part of the Research Topic

Gut Microbiota Modulation to Mitigate Stress-Induced Functional Changes

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Stress-induced obesity in mice causes cognitive decline associated with inhibition of hippocampal neurogenesis and dysfunctional gut microbiota Provisionally Accepted

Jinqiang Zhang1* Yu-E Liu1 Zhihuang Zhao1 Haili He1 Liangyuan Li1 Chenghong Xiao1 Tao Zhou1* Zili You2*
  • 1Guizhou University of Traditional Chinese Medicine, China
  • 2University of Electronic Science and Technology of China, China

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1. Chronic stress can induce diet-independent obesity in mice.2. Stress-induced obesity involves alterations in the gut microbiome and hyperactivation of the hypothalamic-pituitary-adrenal axis.In brief: Liu et al. provide evidence from a mouse model that chronic stress can induce dietindependent obesity and cognitive deficits involving hyperactive hypothalamic-pituitary-adrenal signaling, hyperactive microglia, impaired neurogenesis, systemic inflammation, and alterations in the gut microbiome. Mitigating one or more of these processes may ameliorate the stress-induced 2 cognitive deficits and obesity.

Keywords: stress, Obesity, Depression, Cognitive Function, gut microbiome, Adult hippocampus neurogenesis, Microglia Abbreviations ACTH, adrenocorticotropin, CRH, corticotropin-releasing hormone

Received: 03 Feb 2024; Accepted: 10 May 2024.

Copyright: © 2024 Zhang, Liu, Zhao, He, Li, Xiao, Zhou and You. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Jinqiang Zhang, Guizhou University of Traditional Chinese Medicine, Guiyang, China
Prof. Tao Zhou, Guizhou University of Traditional Chinese Medicine, Guiyang, China
Prof. Zili You, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China