HOW DOES SPACE EXPLORATION AFFECT THE HEART AND BLOOD VESSELS?

During missions in space, men and women are exposed to many factors that can alter the cardiovascular system, which consists of the heart and blood vessels. Both onboard the International Space Station and in space crafts in deeper space, people experience very little (micro) gravity. Because the human cardiovascular system is used to working against the gravity we have on Earth, living in microgravity can lead to unwanted changes. Moreover, exposure to space radiation, the diet onboard space missions


FROM THE INTERNATIONAL SPACE STATION TO MISSIONS IN DEEP SPACE
The International Space Station (ISS), the largest object in space ever

INTERNATIONAL SPACE STATION (ISS)
A station built by several space agencies that circles about km above Earth.It is a laboratory for space research and can hold space explorers for weeks to months.
built by people, is a collaboration between the space agencies of many countries.The area within the ISS where people live is about cubic meters in size-about the same size as a family home in the United States or Canada, or .-homes in Europe.More than men and women have lived aboard the ISS for various lengths of time, mostly between months and a year per mission.Exciting plans have been made for manned missions that go much further than the ISS, deeper into our solar system.In the near future we may see multi-year missions to the Moon, other near-Earth objects such as asteroids, and even the planet Mars.During those deep-space missions, explorers will be exposed to an environment that is very di erent from that on Earth.

THE HEART AND BLOOD VESSELS OF SPACE EXPLORERS
The human cardiovascular system is made up of the heart and all the

CARDIOVASCULAR SYSTEM
The body system made up of the heart and blood vessels, which bring oxygen and other nutrients to all organs and tissues and remove carbon dioxide and other waste products.blood vessels, including the tiny ones that reach into all the organs and tissues.It is important to have a healthy cardiovascular system, and we know that there are things people can choose to do on Earth that can reduce cardiovascular health, such as smoking or eating an unhealthy diet.The environment that deep-space explorers will be in also has several factors that could influence the health of the heart and blood vessels.This article focuses on four of the main factors: microgravity, psychological stress, space radiation, and diet (Figure ).

MICROGRAVITY
The experience of very little gravity, so that people and objects appear to be weightless.
We will describe what we know and what we do not know about these factors of space, and we will tell you about some of the research that  Nemec-Bakk and Boerma is being done to increase our understanding and find ways to make space travel safer for crew members.

MICROGRAVITY AND THE CARDIOVASCULAR SYSTEM
Because humans have evolved on Earth, the cardiovascular system is built to function in Earth's gravity.However, far from Earth, deep-space explorers will be living in a state of very little gravity, called microgravity.Even missions to other space objects will involve altered gravity, as gravity on the surface of the Moon is only about one sixth of that on Earth, and gravity on Mars is about one third.The ISS is close enough to the Earth that gravity still exists, keeping the station circling around our planet.However, people inside the ISS experience no forces on their bodies, so to them it feels the same as being in microgravity.
When people live in microgravity, more blood and fluids will be in the tissues of the chest and head compared to the lower parts of the body, because the pull from Earth's gravity is not there to draw those fluids downwards.That is why the faces of people traveling in space can look slightly pu y compared to when they are on Earth (Figure ).When space travelers return to Earth, their appearances go back to normal.Nemec-Bakk and Boerma In addition to the appearance of the face, several studies on people aboard the ISS have shown changes in the shape and rhythm of the heart.However, we do not yet understand the consequences of living in these conditions for many years.

RADIATION IN DEEP SPACE
Several types of radiation travel through our solar system at almost the speed of light.The types of radiation that are particularly harmful to the human body are composed of very small particles that have a positive charge and very high energy.These particles come from elements of the periodic table, from helium all the way up to iron, which is the largest charged particle in space.When these particles, also called galactic cosmic rays (GCR), pass through the human

GALACTIC COSMIC RAYS (GCR)
High-energy, positively charged particles that move through space at almost the speed of light.They originate outside the Solar System in our own galaxy and from distant galaxies.body, they damage the body's cells.This could negatively a ect many organ systems, including the heart and blood vessels.Earth's magnetic fields reflect a large portion of GCR, which is why Earth dwellers are protected from this type of radiation.The levels of GCR are also not very high aboard the ISS, because the ISS is close enough to the Earth that it has some protection from Earth's magnetic fields.However, exposures to GCR will be higher on deep-space missions, where there is no protection.
For many years, we have known that radiation exposure on Earth, such as from nuclear accidents or from certain types of work, increase cardiovascular diseases.Therefore, there is concern that the cardiovascular system may be impacted by radiation in deep space-although we must keep in mind that GCR is di erent from the types of radiation on Earth.

DIET OF EXPLORERS ON SPACE MISSIONS
Deep-space explorers will likely have to bring most of their food with them on the mission.So, their diets will be limited by the weight and volume that can be carried onboard.We know how important a healthy diet is for the cardiovascular system.Therefore, we must make sure that the most optimal food products will be brought aboard, and/or that space explorers will have the technology to grow their own crops during long missions.

PSYCHOLOGICAL STRESS OF DEEP-SPACE TRAVEL
Another concern of deep-space missions is the psychological stress that explorers will have to face, for instance from being far from family and friends, being confined in a small space, and the absence of days and nights as we have on Earth.Stress can become worse if crew members do not get enough sleep.Research on Earth is showing a connection between psychological stress and reduced cardiovascular Nemec-Bakk and Boerma health.Therefore, on deep-space missions, psychological stress may be one more risk factor that we should try to manage as much as we can.

WHAT RESEARCH CAN TEACH US
While we know all these factors can have negative e ects on the cardiovascular system, we do not know the exact risks for cardiovascular disease in deep-space explorers.We do not always know exactly how each of these factors alters the heart and blood vessels.And we must still do more research to find ways to reduce the risks and make deep-space missions safer, such as through dietary changes or medications.To answer some of the questions we have described, research is being done on people aboard the ISS.Some scientists can also send living cells or small animals to the ISS for research purposes.
Since only a few people have traveled to the moon, we must rely on research performed here on Earth to determine the health risks of space travel.For instance, to simulate the e ects of microgravity, research volunteers are asked to remain in bed for several days to weeks, with their heads slightly tilted down.These studies are safe and respectful of human rights and allow us to examine what happens when fluids shift to the head and chest, similar to microgravity.
Because the doses of GCR aboard the ISS are lower than what deep-space explorers will encounter, we must simulate GCR-like radiation on Earth to test its e ects.Luckily, the technologies for such research are now available [ ], and studies are being done in which small animals are exposed to simulated GCR while under the constant care of scientists and veterinary doctors.These studies have shown only small changes in the structure and function of the heart and the main arteries [ , ].However, we must keep in mind that the human body functions di erently from the body of a small animal.Therefore, we must be careful when we make predictions about human health based on the results of animal studies.
Lastly, there is an exciting new development called human organs-on-chip, which uses human cells to grow mini-organs that

ORGAN-ON-CHIP
Various cell types grown on a device with simulated blood flow, so that tiny organs develop and can be tested in the lab.are kept alive in the laboratory for research.The use of human organs-on-chip allows researchers to study the e ects of the ISS environment as well the e ects of simulated GCR on human organs on Earth-without using humans or research animals.

METHODS FOR INTERVENTION
Research is being done to find ways that we might reduce the negative e ects of space travel on the human body.For instance, crew members of the ISS are asked to exercise every day, because exercise is known to increase the health of the cardiovascular system, the muscles, and the bones [ ]. Exercise reduces stress, too.In addition, researchers are testing dietary supplements and medications to protect the heart and other organs from the e ects of space radiation.One strategy proposed to reduce psychological stress involves inviting artists to put their artwork on the ISS.Viewing or making art is thought to make people feel better and reduce stress.
In conclusion, we have exciting times ahead for deep-space travel.
There is a lot of exciting research happening to make space travel safe for humans, but there are still many questions to be answered and discoveries to be made.

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Figure

Figure
Figure During missions in deep space, factors such as microgravity, psychological stress, space radiation, and diet may all e ect the hearts and blood vessels of space explorers (Figure created with BioRender).

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Figure

Figure
Figure Faces of people in space often look a little pu y because microgravity inhibits body fluids from moving to the lower parts of the body.(A) NASA astronaut and Expedition Flight Engineer Nicole Mann on Earth, and (B) working on a physics experiment aboard the ISS.(C) NASA astronaut and Expedition flight engineer Woody Hoburg in training on Earth, and (D) while preparing a spacesuit inside the ISS for an upcoming spacewalk (Photo source: NASA Image and Video Library).