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Front. Vet. Sci. | doi: 10.3389/fvets.2019.00283

Cytological Grading of Breast Tumours - The Human and Canine Perspective

 Krithiga Kuppusamy1, Arathi Rajan1, Arathy V. Warrier1, Revathy Nadhan1, Dipyaman Patra1 and  Priya Srinivas1*
  • 1Rajiv Gandhi Centre for Biotechnology, India

Human breast cancers (HBCs) are one of the leading causes of global cancer death among women. Domesticated canines are the most affected domestic species with a prevalence rate more than three times in women. While the human cancer patients receive substantial diagnostic and treatment facilities, inadequacy in canine cancer care, calls for greater attention. Fine Needle Aspiration Cytology (FNAC) is comparatively simple, quick and easily reproducible technique, which aids in pre-surgical diagnosis. In humans, FNAC has a standard protocol, the Robinson’s grading system, which has greater correlation with the established histological grading system of Scarff Bloom- Richardson. However, Canine Mammary Tumours (CMTs), which are known to be similar to HBCs in biological behaviour and gene expressions, still bank on the histopathological methods for diagnostic purposes. This review sheds light on various factors that could be considered for developing a standard FNAC technique for CMT grading and analyzes its future perspectives.

Keywords: Breast, canine, cytology, Grading, human, tumour

Received: 16 May 2019; Accepted: 08 Aug 2019.

Copyright: © 2019 Kuppusamy, Rajan, Warrier, Nadhan, Patra and Srinivas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Priya Srinivas, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India, priyasrinivas@rgcb.res.in