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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Vet. Sci. | doi: 10.3389/fvets.2019.00284

Diagnostic criteria for obesity disease in cats

 Toshiro Arai1*,  Yuki Okada2, Hiromichi Ueno2,  TAKAYUKI MIZOROGI2, Kenji Ohara2 and  Koh Kawasumi2
  • 1Department of Basic Veterinary Medicine, Nippon Veterinary and Life Science University, Japan
  • 2Nippon Veterinary and Life Science University, Japan

Accumulated visceral and subcutaneous fat masses were measured with computed tomography (CT) in cats with various body condition scores (BCS) from 5/9 to 9/9. BCS does not always reflect visceral fat accumulation which induces pro-inflammatory reactions. Obese cats with accumulated visceral fat showed low plasma adiponectin and high serum amyloid A (SAA) concentrations, an inflammatory marker. Based on the above results, new diagnostic criteria for obesity disease were established as follows. For overweight cats with high BCS of >7/9, showing 2 or more of the following 3 symptoms, low adiponectin concentrations, hyperlipidemia and high SAA concentrations, categorizes them as having obesity disease. Cats with BCS 6/9 to 9/9, without inflammatory reactions, were classified as simple obesity, which is similar to metabolically healthy obesity (MHO) defined in human medicine. Simple obesity group showed significantly higher adiponectin concentrations than those in control group. The obesity disease group showed significantly higher plasma triglyceride (TG) and SAA concentrations and lower concentrations of adiponectin than the control group. Moreover, plasma glucose and malondialdehyde (MDA) concentrations in the obesity disease group were higher than those in healthy control group, although the differences were not statistically significant. Establishing criteria for obesity disease based on visceral fat accumulation and inflammation markers levels contributes to early and correct diagnosis of obesity in cats.

Keywords: cat, Adiponectin, Obesity, visceral fat, serum amyloid A

Received: 10 May 2019; Accepted: 09 Aug 2019.

Copyright: © 2019 Arai, Okada, Ueno, MIZOROGI, Ohara and Kawasumi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Toshiro Arai, Nippon Veterinary and Life Science University, Department of Basic Veterinary Medicine, Musashino, 180-8602, Japan, tarai@nvlu.ac.jp