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Front. Vet. Sci. | doi: 10.3389/fvets.2019.00294

Acute and subacute toxicity assessment of oxyclozanide in Wistar rats

Weiwei Wang1,  Zhen Dong1,  Jili Zhang1, Xuzheng Zhou1, Fusheng Cheng1, Xiaojuan Wei1, Bing Li1 and  Jiyu Zhang1*
  • 1Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CAAS), China

Oxyclozanide is an effective anthelmintic and has shown good properties in other ways including anti-adenovirus, anti-biofilm, antifungal and antibacterial activity. This study aimed to investigate the acute and subacute 28-day repeated dose oral toxicity of an oxyclozanide suspension in Wistar rats. A high oral lethal dose (LD50) of 3707 mg/kg was observed in the acute toxicity test. During the 28-day time period, no obvious adverse effects or death were detected. Histopathological changes were observed in the heart, liver, kidney of animals treated with high-dose of oxyclozanide. Based on the haematological parameters, there were no statistical differences between oxyclozanide treated group and control group. For biochemistry assays, ALP, AST, GLU, TBIL, GLO, TG, BUN, UA, LDH, CK were statistically changed in the treatment groups. These data suggested that the LD50 of oxyclozanide was approximately 3707 mg/kg. body weight (BW), and the lowest observed adverse effect level (LOAEL) of oxyclozanide was at a dose of 74 mg/kg in rats.

Keywords: Oxyclozanide, acute, subacute, Toxicity, Rats

Received: 02 Jul 2019; Accepted: 16 Aug 2019.

Copyright: © 2019 Wang, Dong, Zhang, Zhou, Cheng, Wei, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Jiyu Zhang, Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CAAS), Lanzhou, Gansu Province, China, zhangjiyu1967@163.com