Multi-omics Reveals Goose Fatty Liver Formation from Metabolic Reprogramming
Rongxue Wei1
Yongqiang Teng1
Chunchun Han1*
Shouhai Wei1
Liang Li1
Hehe Liu1
Shenqiang Hu1
Bo Kang1
Hengyong Xu1
- 1Sichuan Agricultural University, China
To comprehensively provide insight into goose fatty liver formation, we performed integrative analysis of liver transcriptome, lipidome and amino acids metabolome, as well as peripheral adipose tissues transcriptome analysis using samples collected from the overfed geese and normally-fed geese. Transcriptome analysis showed that liver metabolism pathways were mainly enriched in glucolipid metabolism, amino acid metabolism, inflammation response and cell cycle; peripheral adipose tissue and the liver cooperatively regulated liver lipid accumulation during overfeeding. Liver lipidome patterns obviously changed after overfeeding, and 157 different lipids were yielded. In liver amino acid metabolome, the level of Lys increased after overfeeding. In summary, this is the first study describing the goose fatty liver formation from an integrative analysis of transcriptome, lipidome and amino acids metabolome, which will provide a whole new dimension to understand the mechanism of goose fatty liver formation.
Keywords: Goose fatty liver, Transcriptome, Lipidome, amino acids metabolome, peripheral adipose tissue
Received: 14 Dec 2022;
Accepted: 08 Jan 2024.
Copyright: © 2024 Wei, Teng, Han, Wei, Li, Liu, Hu, Kang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Chunchun Han, Sichuan Agricultural University, Ya'an, Sichuan Province, China