AUTHOR=Vogler Christian , Spalek Klara , Aerni Amanda , Demougin Philippe , Müller Ariane , Huynh Kim-Dung , Papassotiropoul Andreas , De Quervain Dominique J.

TITLE=CPEB3 is associated with human episodic memory

JOURNAL=Frontiers in Behavioral Neuroscience

VOLUME=Volume 3 - 2009

YEAR=2009

URL=https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/neuro.08.004.2009

DOI=10.3389/neuro.08.004.2009

ISSN=1662-5153

ABSTRACT=Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism which influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data support a role for human CPEB3 in human episodic memory.