Challenges Associated with Identifying Preclinical Animal Models for the Development of Immune-based Therapies

Rajan P. Adhikari, Rajat Varma, Silke Paust, An Coosemans

Frontiers Media SA

There hasn’t been a better time to be a drug developer for immune-based therapies than the past...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Animal Models,­Cancer,­Immune based therapies

Transcriptome and Single-Cell Sequencing Analyses to Classify Immune Subtypes, Uncover Novel Biomarkers, and Assess Immunotherapeutic Responses in Cancer

Hongda Liu, Jie Shen, Zheng Gong, Xianzhou Song, Peixin Dong

Frontiers Media SA

According to the most recent projections of the International Agency for Research on Cancer (IARC),...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: single-cell sequencing,­immune subtype,­Novel biomarker,­mmunotherapeutic Response,­cancer immunotherapy,­Transcriptome

Reactive Oxygen Species (ROS): Key Components in Cancer Immunotherapy

Anwen Shao, Xiang Xue, Dongmei Zhang, Yu-Hang Zhang, Yang Wang

Frontiers Media SA

The class of highly bioactive chemicals known as reactive oxygen species (ROS) has been extensively...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: reactive oxygen species (ROS),­Tumor microenvironment (TME),­Immune checkpoint blockades,­Immunotherapy,­Oxidative Stress

Mathematical Modeling and Computational Predictions in Oncoimmunology

Vladimir A. Kuznetsov, Heiko Enderling, Mark Chaplain

Frontiers Media SA

Cancer is a complex adaptive dynamic system that causes both local and systemic failures in the...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Oncoimmunology,­mathematical modeling,­Data-driven,­Computational predictions,­Immunotherapy optimization,­Treatment outcomes

Novel Immune Markers and Predictive Models for Immunotherapy and Prognosis in Breast and Gynecological Cancers

Chao Liu, Feifei Teng, Alberto Traverso, Shicheng Guo

Frontiers Media SA

Precision medicine is an emerging practice by which clinicians aim to deliver a personalized...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: immune marker,­predictive model,­Immunotherapy×,­Rognosis,­breast cancer,­gynecological cancer

Understanding convergent evasion mechanisms in cancer and chronic infection: Implications for immunotherapy

Hakim Echchannaoui, Matthieu Perreau, Matthias Theobald, Hansjörg Schild

Frontiers Media SA

The complex interactions between the innate and adaptive immune systems function to recognize and...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Tumor Microenvironment,­Immunotherapy,­chimeric antigen receptor (CAR),­T-cell receptor (TCR),­vaccines (mRNA),­signaling,­Metabolism,­tumor evasion,­Chronic infection,­T cell dysfunction,­immune checkpoint therapy,­Combinational therapy

Targeting Key Cellular Signaling Network for Cancer Chemotherapy and Immunotherapy

Bo Zhai, Zhendong Jin, Chen Yang, Gang Tian

Frontiers Media SA

The cellular signaling network refers to the complex system formed by the interactions between...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: cellular signaling network,­Cancer,­chemotherapy,­Immunotherapy

Immunologic Tumor Microenvironment Modulators for Turning "Cold" Tumors to "Hot" Tumors

Xin He, Gulderen Yanikkaya Demirel, Chengwu Zeng, Mazdak Ganjalikhani Hakemi

Frontiers Media SA

Cancer immunotherapy is based on using the immune system components to fight tumors, without...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: COLD TUMOR,­Small peptide,­small molecule,­Bioactive peptide,­cancer vaccine,­immune check-point inhibitor

Improving Responses to Immunotherapy in Glioblastoma Multiforme

Stephanie E. B. McArdle, Divya Nagarajan, Michael Barish

Frontiers Media SA

Glioblastoma multiforme (GBM) is a uniformly fatal primary brain tumour. Whilst many therapeutic...

Health Immunology Cancer Immunity and Immunotherapy