Mechanisms and Complexities Underlying the Cancer Cell Immune Evasion and its Therapeutic Implications

Akhileshwar Namani, Zhexu Chi, Tapas Patra

Frontiers Media SA

Cancer continues to be one of the most challenging diseases to treat worldwide. The three main...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Immunotherapy,­Immune Evasion,­Tumor Microenvironment,­therapeutic targets,­biomarkers

Interplay of Epigenetic Regulation and Cellular Metabolism in Cancer Microenvironments

Qihui Zhou, Maria Virumbrales Munoz, Lei Zhang

Frontiers Media SA

In recent years, the complex ecosystem surrounding cancer cells, known as the tumor...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Epigenetic regulation,­Tumor Microenvironment,­Protein post-translational modifications,­non-coding RNAs,­Metabolism

Community Series in Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics, volume II

Subhash Kumar Tripathi, Saravanan Rajendrasozhan, Mohd Wajid Ali Khan, Mohammad Azhar Aziz, Shariq Qayyum

Frontiers Media SA

Cancer is a multifactorial chronic disease, with its pathogenesis and progression influenced by...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Immunotherapy,­cancer therapeutics,­immune cells,­APCs,­immune checkpoints,­small molecules,­Novel technologies,­pre-clinical studies,­clinical trials

Achilles Heel of CAR T-Cell Therapy

Maurizio Chiriva-Internati, Fabio Grizzi

Frontiers Media SA

Chimeric Antigen Receptor (CAR) T-cell therapy represents a groundbreaking advancement in cancer...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: CAR-T therapy,­biomarker,­ag,­ab,­target,­Allogeneic,­autologous,­cell therapy,­virus,­innate and adoptive cell therapy

Community Series in The Immunosuppressive Tumor Microenvironment and Strategies to Revert its Immune Regulatory Milieu for Cancer Immunotherapy, volume II

Jayakumar Nair, Mazdak Ganjalikhani Hakemi

Frontiers Media SA

This Research Topic is the second volume of the “The Immunosuppressive Tumor Microenvironment and...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Tumor Microenvironment,­Tumor immunotherapy,­immunosurveillance,­Immunometabolism,­Immunosuppressive cells,­Tumor spheroids,­tumor organoids,­Multiorgan-on-chip,­organ-on-chip,­Microfluidic chips

New Avenues for the Development of Advanced Immunotherapies: Capitalizing on Studies of the B and T Cell Receptor Repertoire

Massimiliano Mazza, Fabio Nicolini, Maria Del Mar Naranjo Gomez, Mireia Pelegrin

Frontiers Media SA

Immunotherapy has emerged as a transformative domain within oncology and a variety of other medical...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Antibody identification and engineering,­Immunotherapy,­bi-specific antibodies,­CAR-T cells,­TCR/ BCR repertoire study

Response/Resistance to PD-1 Axis Inhibitors: Focus on the Tumor Microenvironment

Thazin N. Aung, Ioannis Vathiotis, Arutha Kulasinghe

Frontiers Media SA

PD-1 axis inhibitors are a group of immune checkpoint inhibitors (ICIs) that block the PD-1/PD-L1...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: PD-1 inhibitor,­Tumor Microenvironment,­Immunotherapy response,­resistance to PD-1 inhibitor,­PD-1/PD-L1 blockade,­cancer immunotherapy,­T cells,­NK cells,­Immunotherapy resistance

Community Series in Immune Responses Against Tumors - From the Bench to the Bedside, volume II

Tiezheng Hou, Xiaoxiao Liu, Chunjing Wang, Shisan Bao

Frontiers Media SA

This Research Topic is the second volume of the “Immune Responses Against Tumors - From the Bench...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: amino acid metabolism,­machine learning,­Clonal neoantigen,­adoptive cell therapy,­Targeted nanoparticle

The crosstalk between emerging cell death and immune microenvironment remodeling in cancer progression and treatment

Bufu Tang, Xuanzhang Huang, Weiliang Hou, Ling Wang, Jifeng Wang

Frontiers Media SA

The field of cancer research has increasingly focused on the intricate interplay between regulated...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Emerging cell death,­immune microenvironment remodeling,­RCD,­Regulated cell death,­Curroptosis,­ferroptosis,­Pan-apoptosis