Community Series in Engineered Immune Cells in Cancer Immunotherapy (EICCI), volume II

Cristina Maccalli, Francisco Martin, Axel Schambach

Frontiers Media SA

This Research Topic is the third volume of the “Engineered Immune Cells in Cancer Immunotherapy...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: adoptive cell therapy,­Chimeric Antigen Receptor,­cytokine release syndrome,­engineered T lymphocytes,­CAR-T cell therapy

The Role of Neutrophil Extra Cellular Traps (NETs) Formation in Tumor Microenvironment- from Basic Research to Clinical Applications

Ronit Elhasid, Xue-Yan He, Rachel Shukrun, Alexey Stepanov

Frontiers Media SA

Neutrophil extracellular traps (NETs) are intricate structures released by neutrophils to ensnare...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Neutrophil Extracellular Traps (NETs) formation,­Cancer,­NETs biomarkers,­anti-NETs therapies,­combination treatments,­clinical NETs research,­NETs drug development

Mechanisms and Therapeutic Opportunities of T-Cell Impairment in Cancer Immunity and Immunotherapy

Guillaume Beyrend, Wantao Wu, Raquel Alarcon Rodriguez, Rosalinda Sorrentino

Frontiers Media SA

T lymphocytes are pivotal constituents of the adaptive immune repertoire, endowed with the...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: cancer immunotherapy,­Immune response assessment,­Tumor microenvironment analysis,­predictive biomarkers,­Personalized immunotherapy optimization,­Immune checkpoint blockade

Deciphering Macrophage Polarization/Transition in Human Inflammatory Disease and Cancer

Yu-Chan Chang, Nai-Jung Chiang, Peter Mu-Hsin Chang, Stefania Fiorcari

Frontiers Media SA

Macrophages, as integral components of the immune system, exhibit diverse roles due to their...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: macrophage,­polarization,­Inflammation,­Cancer,­applications

Exploring key pathways in the progression of gastrointestinal diseases based on metabolic reprogramming and developing drugs targeting metabolism

Jia Jinlin, Sujit Nair, Bing Yang, Zimo Jia

Frontiers Media SA

Digestive tract tumors are malignant diseases characterized by high aggressiveness, heterogeneity...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: metabolic reprogramming,­Immune imbalance,­Gastrointestinal tumors,­precision medicine

Immuno-metabolic Approaches for the Treatment of Hepatobiliary and Pancreatic Tumors

Ran Wei, Luyu Yang, Jianwei Xu

Frontiers Media SA

Hepatobiliary and pancreatic tumors represent a critical area of oncological research due to their...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: combination therapy,­Hepatobiliary tumors,­Immuno-metabolic approach,­Pancreatic Cancer,­Tumor microenvironment (TME)

Crosstalk in Tumor Microenvironments: Shaping Early Drug and Immunotherapy Strategies

Yusuke Oji, Alessandro Arcucci, Emanuele Sasso, Guendalina Froechlich

Frontiers Media SA

Cancers are complex tissues not only comprised of malignant cells but also of a dynamic Tumor...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Rare cancers,­Tumor Microenvironment,­Cancer associated fibroblast,­tumor associated macrophages,­tumor infiltrating lymphocytes,­cancer gene therapy,­cancer immunology,­local to systemic immune response

Metabolism in the Tumour Microenvironment: Implications for Pathogenesis and Therapeutics

Fabrizio Fontana, Adil Rasheed

Frontiers Media SA

The study of metabolism within the tumour microenvironment (TME) is a rapidly evolving field that...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Cancer-associated fibroblast,­immune cell,­T cell,­macrophage endothelial cell,­stromal cell,­tumour,­oncology,­Metabolism,­Kreb/TCA cycle,­oxidative phosophorylation

Precision Oncology in Checkpoint Immunotherapy: Leveraging Predictive Biomarkers for Personalized Treatment

Zodwa Dlamini, Abdullah Kahraman, Aristotle A. Chatziioannou

Frontiers Media SA

This Research Topic is apart of the series "The Future of Checkpoint Immunotherapy: New Roads...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: precision oncology,­Checkpoint immunotherapy,­COLD TUMOR,­Immune Reponse Prediction,­predictive biomarkers,­Tumor mutational burden (TMB),­microsatellite instability (MSI),­Immune cell profiling,­biomarker stratification,­machine learning algorithms,­Computational modelling,­Multi-omics data,­Data-driven interpretation