Targeted drug discovery in ectopic calcification: Mechanism, prospect, and clinical application

Kang Xu, Charareh Pourzand, Jing Xie, Anna Malashicheva

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: Ectopic calcifications,­Osteogenic differentiation,­therapeutic drug screening,­Pharmacological studies,­translational medicine,­preclinical application and reports

Model-informed decision making in the preclinical stages of pharmaceutical research and development

Rui Li, Donald E. Mager, Alison Betts, Tristan Scott Maurer, Morgan Craig, David Z. D’Argenio

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: Drug Discovery,­Modeling and Simulation,­decision-making,­preclinical-to-clinical translation

Sepsis: Basic, Clinical and Therapeutic Approaches

Hong Zhou, Yan Kang, Lefu Lan, Daolin Tang

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: Sepsis,­Pathogenesis,­signal transduction pathway,­Treatment,­therapeutic strategies

Ocular Pharmacology: Recent Breakthroughs and Unmet Needs

Claudio Bucolo, Chiara M. Eandi, Mario Damiano Toro

Frontiers Media SA

The research on ocular pharmacology has increased significantly, over the past decade. More...

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: Ocular pharmacology,­Retinal Diseases,­Corneal Diseases,­Pharmacological Targets,­Ocular drug delivery systems,­Dry eye syndrome,­Glaucoma

Recent advances of minor saponins in panax species

Weicheng Hu, Guangbo Fu, Yunyao Jiang, Bing Chun Yan, Jae Youl Cho

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: Panax species,­Minor saponins,­Drug Discovery,­Pharmacological effects

Adenylyl cyclase isoforms as potential drug targets

Tarsis Brust, Rennolds S. Ostrom, Val J. Watts

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: adenylyl cyclase,­cAMP,­Adenylate Cyclase,­G protein

Novel modalities in cancer diagnostics and therapeutics

Dong-Hua Yang, Haichang Li

Frontiers Media SA

Science Pharmacology Cardiovascular and Smooth Muscle Pharmacology

Keywords: New technologies,­biomarkers,­molecular targets,­therapeutic targets,­Cancer,­drug screening

Exploring the Potential of Nanopharmaceuticals: Extending our Focus Beyond Conventional Drugs

Saeed Ahmad Khan, Amirali Popat, Alam Zeb, Hussain Ali, Faisal Raza

Frontiers Media SA

Health

Keywords: Drug Delivery Systems,­nanonization of drugs,­Nanotechnology,­NanoCrystal technology,­Nanomedicine

Computational Intelligence in Personalized Medicine

Khin Wee Lai, Khairunnisa Hasikin, Yuanpeng Zhang, Yan Chai Hum

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery