Challenges Associated with Identifying Preclinical Animal Models for the Development of Immune-based Therapies

Rajan P. Adhikari, Rajat Varma, Silke Paust, An Coosemans

Frontiers Media SA

There hasn’t been a better time to be a drug developer for immune-based therapies than the past...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Animal Models,­Cancer,­Immune based therapies

Community Series in Translational Insights into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma, volume III

Christoph Thiemermann, Bettina Jungwirth, Valentin A. Pavlov, Pietro Ghezzi, Madhav Bhatia, Borna Relja, Sina M. Coldewey

Frontiers Media SA

Life-threatening organ dysfunction/failure in critically ill patients suffering from sepsis or...

Health Immunology Inflammation

Keywords: Trauma,­Sepsis,­Inflammation,­Organ injury,­DAMPs,­PAMPS,­Glycocalyx

Transcriptome and Single-Cell Sequencing Analyses to Classify Immune Subtypes, Uncover Novel Biomarkers, and Assess Immunotherapeutic Responses in Cancer

Hongda Liu, Jie Shen, Zheng Gong, Xianzhou Song, Peixin Dong

Frontiers Media SA

According to the most recent projections of the International Agency for Research on Cancer (IARC),...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: single-cell sequencing,­immune subtype,­Novel biomarker,­mmunotherapeutic Response,­cancer immunotherapy,­Transcriptome

Deciphering the T Cell Response in SARS-CoV-2 Infection

Alessio Mazzoni, Sara De Biasi, Pia Kvistborg, Laura Maggi

Frontiers Media SA

COVID-19 is a recently emerged infectious disease caused by the novel coronavirus SARS-CoV-2. The...

Health Immunology T Cell Biology

Keywords: SARS-CoV-2,­COVID-19,­CD4+ T cells,­CD8+ T cells,­Vaccines,­Adaptive Immunity,­Cytokines

Negative Regulators of Innate Immunity and their Role in Host Responses to Injury and Infection, 2nd edition

Maciej Lech, Shrikant R. Mulay

Frontiers Media SA

Every organism must recognize damage-associated and pathogen-associated molecular patterns (DAMPs...

Health Immunology Immunological Regulation

Research Advances of Tuberculosis Vaccine and its Implication on COVID-19

Wenping Gong, Ashok Aspatwar, Jianping Xie, Hao Li

Frontiers Media SA

Tuberculosis (TB) is a global infectious disease caused by the Mycobacterium tuberculosis complex....

Health Immunology Vaccines and Molecular Therapeutics

Keywords: Tuberculosis,­Immune mechanism,­progress,­Vaccine,­BCG,­COVID-19

Single-cell analysis on the pathophysiology of autoimmune diseases

Shiang-Jong Tzeng, InKyeom Kim, Kuang-Hui Sun

Frontiers Media SA

Despite increasing research to facilitate the understanding of the pathophysiology of autoimmune...

Health Immunology Autoimmune and Autoinflammatory Disorders

Keywords: autoimmune disease,­single-cell RNA sequencing (scRNA-seq),­single cell,­spatial,­tran

Biology of C-reactive Protein

Alok Agrawal, Yi Wu

Frontiers Media SA

C-reactive protein (CRP) is a component of the innate immune system. CRP is synthesized by the...

Health Immunology Molecular Innate Immunity

Keywords: C-Reactive Protein,­Inflammation,­innate immunity,­pentraxin,­Pattern-recognition molecule,­complement,­Infection

Community Series in Recent Advances in Drosophila Cellular and Humoral Innate Immunity, volume II

Susanna Valanne, Laura Vesala, Dan Hultmark

Frontiers Media SA

This Research Topic is the second volume of the “Recent Advances in Drosophila Cellular and...

Health Immunology Comparative Immunology

Keywords: Drosophila,­innate immunity,­signaling,­Hemocytes,­antimicrobial peptides