Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies

Ciria Hernandez, Luis Eduardo Diaz Gimenez, Jean-Marc Taymans, Tim Strassmaier, Marc Rogers

Frontiers Media SA

Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell...

Science Molecular Neuroscience Molecular Signalling and Pathways

Keywords: High throughput screening,­Drug Development,­Ion Channels

2021 WHO Classification of Pediatric Brain Tumors: A Final Wedding Between Morphology and Molecular Biology?

Angela Mastronuzzi, Andrea Carai, Lucia Quaglietta, Elisabetta Schiavello

Frontiers Media SA

Tumors of the central nervous system (CNS) are a dramatic health problem due to their high...

Science Molecular Neuroscience Brain Disease Mechanisms

Keywords: target therapy,­rare tumors,­high-grade glioma,­Medulloblastoma

Translational advances in Alzheimer’s, Parkinson’s, and other dementia: Molecular mechanisms, biomarkers, diagnosis, and therapies, volume III

Chih-Yu Hsu, Woon-Man Kung, Kenneth S. Hettie, Kuangyu Shi, Jiehui Jiang

Frontiers Media SA

Science Neuroscience Neurodegeneration

Keywords: Alzheimer's disease,­Parkinson's disease,­Dementia,­Neurodegenerative disorders,­big data mining,­Imaging Methods,­bioinformatic applications

Focus on Chronic Pain: Neuropathological Mechanism, Clinical Diagnosis and Treatment

Ma Ke, Boris Krylov, Yan Lu, Tao Song, Dong Huang

Frontiers Media SA

Pain is an unpleasant sensory and emotional experience and the most frequent causes for patients to...

Science Molecular Neuroscience Pain Mechanisms and Modulators

Keywords: Chronic Disease,­Neuropathology,­Drug Therapy,­ Combination,­Diagnosis,­ Differential,­Pain Management

Advances in brain disorders: From mechanisms to therapeutic targets

Arianna Bellucci, Federica Bono, Sara Anna Bonini, Maria Jose Sisalli, Giulia Abate

Frontiers Media SA

Science Molecular Neuroscience Brain Disease Mechanisms

Keywords: neurological disorders,­Mental Disorders,­neuodevelopmental disorders,­Mood Disorders,­acute brain injury disorders. molecular mechanisms of disease,­Novel therapeutic targets,­Disease biomarkers

Alternative Splicing in Brain Function

Kif Liakath-Ali, Matthias Soller

Frontiers Media SA

Functional and structural intricacies of biological systems emerge from the complex nature of the...

Science Molecular Neuroscience Molecular Signalling and Pathways

Keywords: Splice isoforms,­spliceosome,­tran

Astrocytic Synaptic Plasticity in Epilepsy: From Synapses to Circuits

Sandra Henriques Vaz, Vincenzo Crunelli, Giuseppe Di Giovanni, Ana Maria Sebastiao

Frontiers Media SA

Science Molecular Neuroscience Brain Disease Mechanisms

Keywords: astrocyte,­synaptic plasticity,­Epilepsy,­brain network,­Astrocyte-Based Cell Therapy

Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, volume II

Estela Maris Muñoz, Veronica Martinez Cerdeño

Frontiers Media SA

A finely tuned regulation of gene expression is essential for shaping the nervous system and for...

Science Aging Neuroscience

Keywords: Transcription Factors,­Transcription,­ Genetic,­Central Nervous System,­Deveopment,­Homeostatis

Neuroimaging of Brain Structure-Function Coupling Mechanism in Neuropsychiatric Disorders

Junghun Cho, Han Lv, Lingfei Guo, Hongwei Wen, Jing Li

Frontiers Media SA

Science Neuroscience Brain Imaging Methods

Keywords: neuropsychiatric disorders,­Structure-function coupling,­Brain,­Neuroimaging,­Cerebral oxygen metabolism