Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies

Ciria Hernandez, Luis Eduardo Diaz Gimenez, Jean-Marc Taymans, Tim Strassmaier, Marc Rogers

Frontiers Media SA

Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell...

Science Molecular Neuroscience Molecular Signalling and Pathways

Keywords: High throughput screening,­Drug Development,­Ion Channels

Alternative Splicing in Brain Function

Kif Liakath-Ali, Matthias Soller

Frontiers Media SA

Functional and structural intricacies of biological systems emerge from the complex nature of the...

Science Molecular Neuroscience Molecular Signalling and Pathways

Keywords: Splice isoforms,­spliceosome,­tran

Astrocytic Synaptic Plasticity in Epilepsy: From Synapses to Circuits

Sandra Henriques Vaz, Vincenzo Crunelli, Giuseppe Di Giovanni, Ana Maria Sebastiao

Frontiers Media SA

Science Molecular Neuroscience Brain Disease Mechanisms

Keywords: astrocyte,­synaptic plasticity,­Epilepsy,­brain network,­Astrocyte-Based Cell Therapy

From Oxidative Stress to Cognitive Decline - Towards Novel Therapeutic Approaches

Touqeer Ahmed, Nady Braidy

Frontiers Media SA

Oxidative stress plays multiple roles in the pathobiology of several neurodegenerative disorders...

Science Molecular Neuroscience Molecular Signalling and Pathways

Keywords: Oxidative Stress,­Protective mechanism,­learning and memory,­Cellular pathways,­neurodegeneration

Molecular mechanisms and pathways in cerebellar function

Catarina Osorio, Lilian Kisiswa, Alanna J. Watt

Frontiers Media SA

Science Molecular Neuroscience Brain Disease Mechanisms

Keywords: neurodevelopment,­signalling pathways,­plasticity,­Aging,­cerebellar disorders

Molecular advances and applications of machine learning in understanding autism and comorbid psychiatric disorders

Salam Salloum-Asfar, Javier Corral, Jesualdo Tomás Fernández-Breis, Nasser H. Zawia

Frontiers Media SA

Science Molecular Neuroscience Brain Disease Mechanisms

Keywords: ASD,­Molecular mechanisms,­Neurodevelopmental disorders,­machine learning,­psychiatric disorders

The biochemistry of amyloids in neurodegenerative diseases, volume II

Cláudio M. Gomes, Jinghui Luo, Wolfgang Hoyer

Frontiers Media SA

Science Neuroscience Neurodegeneration

Keywords: Alzheimer's disease,­Parkinson's disease,­protein aggregation,­Amyloid,­tau,­synuclein,­chaperones

Endogenous opioids in systems neuroscience

Hugo Tejeda, Gregory Corder, Nicolas Massaly, Catherine Cahill

Frontiers Media SA

Science Neuroscience Systems Neuroscience

Keywords: enkephalin,­mu-opioid receptor,­Delta-opioid receptor,­kappa-opioid receptor,­dynorphin,­Endorphin,­Pain,­Reward,­Aversion,­Cognition,­Social Behavior,­Addiction,­compulsive,­Stress Affect,­Emotions,­learning and memory,­limbic circuits

RNA at a breaking point? cytoplasmic cleavage and other post-transcriptional RNA processing in neurodevelopment and disease

Catia Andreassi, Monika Piwecka, Raphaëlle Luisier

Frontiers Media SA

Science Cellular Neuroscience Cellular Neurophysiology

Keywords: non-coding RNA,­Non-coding RNA biogenesis,­RNA processing,­Bi-functional RNA,­Intron retention,­Alternative Splicing,­RNA modification,­RNA metabolism,­mRNA stability,­translational regulation,­mRNA localization,­UTRs,­Neuron,­glia,­Brain Development