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Resolution of inflammation: leukocytes and molecular pathways as potential therapeutic targets

Edited by: Janos G. Filep

Publisher: Frontiers Media SA

ISBN: 978-2-88919-227-4

Product Name: Frontiers Research Topic Ebook

Inflammation is the principal defense mechanism against invading pathogens and host injury. Neutralization of the offending insult ideally prompts resolution of inflammation and restoration of tissue homeostasis. Excessive or dysregulated inflammatory response results in nonresolving inflammation and persisting tissue damage. Ground-breaking work during the past decade has led to the recognition that resolution of inflammation is a tightly-controlled active process that involves generation of a new class of lipid mediators, proteins and autacoids.

This Research Topic focuses on articles that discuss the molecular mechanisms governing resolution circuits and the function and fate of leukocytes in inflammation underlying asthma, insulin resistance, metabolic dysfunction, myocardial ischemia/reperfusion, diabetic nephropathy arthritis, multiple sclerosis and sepsis. These articles also identify potential targets for development of innovative therapeutic approaches for the treatment of inflammatory pathologies based on either mimicking or activating endogenous pro-resolution mechanisms.

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