The Cerebellum Inside-Out

The cerebellum is a complex brain structure that subserves sensori-motor control functions but also probably plays a key role in cognition. The interest of this initiative is to reconnect different levels of current knowledge and promote cross-fertilization among research fields. On the one hand, the cerebellar microcircuit is amongst the most investigated ever and has inspired fundamental neurophysiological theories. On the other hand cerebellar dysfunction is at the base of a complex set of motor and non-motor pathologies that are only recently coming to light. In this course, we will move from cellular and molecular biophysics of the cerebellar neurons and circuits up to integrative aspects of cerebellar functioning. A set of selected abstracts covers this range of experimental approaches allowing to integrate cerebellar mechanisms of functions on the micro-, meso and macro-scale of brain organization and to pilot future experimentation and modeling. Thus fundamental knowledge on cerebellar functioning can be applied to the analysis of the brain pathologies in animal models and humans, ranging from hereditary ataxias to multiple slerosis, neurodegenerative diseases and autism. The abstracts derive from the 2016 Course of the School of Brain Cells and Circuits that has been held in the wonderful context of Erice by the " Ettore Majorana Foundation and Centre for Scientific Culture". - See more at: http://www.frontiersin.org/events/The_Cerebellum_inside_out_cells_circuits_and_functions_/4220#sthash.8rKDFvLY.dpuf