Reducing Animal Use in Carcinogenicity Testing

Joseph Manuppello, Jan Willem Van Der Laan, Federica Madia

Frontiers Media SA

Carcinogenicity to rats and mice is evaluated for substances to which humans are exposed, including...

Science Toxicology Regulatory Toxicology

Keywords: Animal Testing Alternatives,­replacement,­refinement,­Reduction,­biomarkers,­tumor,­Carcinogenicity Tests,­Investigational New Drug Application,­Neoplasms,­Rodent bioassay,­Chronic toxicity tests,­Weight of evidence,­WoE

European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment

Terje Svingen, Tamara Vanhaecke, Louise Ramhøj

Frontiers Media SA

The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in...

Science Toxicology Developmental and Reproductive Toxicology

Keywords: developmental neurotoxicity,­Immunotoxicity,­Non-genotoxic carcinogens,­Thyroid hormone disruptors,­Metabolic disruption,­Endocrine Disruptors,­New approach methodologies

The impact of clinical and environmental toxicological exposures and eye health

Anat Galor

Frontiers Media SA

The eye is often times referred to as the ”window to the soul”. This is relevant to the practice of...

Science Toxicology Clinical Toxicology

Keywords: Toxicology,­Eye Diseases,­Ocular findings,­dry eye,­retinopathy,­Corneal disease,­drugs,­Environmental exposures

Emerging talents in toxicology

Ana Luiza Ziulkoski, Samson Amos, Yuseok Moon, Alessandro Venosa, Iseult Lynch, Neus Feliu, Francesca Larese Filon, Salik Hussain, Lena Smirnova, Monica Renee Langley, Onyenmechi Afonne, Tara McMorrow, Luigi Margiotta-Casaluci, Alexa C. Alexander, Juliana Perobelli, Marina Trevizan Guerra, Dilek Battal, Vera Marisa Costa, Takamitsu A. Kato, Xiaohui Fan

Frontiers Media SA

Science Toxicology Clinical Toxicology

Keywords: in vitro,­methods,­Prediction Toxicology,­Mechanistic investigation,­3Rs,­Toxicology,­emerging talents

10 Years of frontiers in genetics: Past discoveries, current challenges and future perspectives

William C. Cho, Jordi Pérez-Tur, Rosalba Giugno, Mehdi Pirooznia, Kathleen Boris-Lawrie, Dov Greenbaum, Blanka Rogina, Mojgan Rastegar, Rui Henrique, Peng Xu, Joao Batista Teixeira da Rocha

Frontiers Media SA

Science Genetics Livestock Genomics

Keywords: Genetics,­Genomics,­Frontiers in genetics,­Human physiology,­genomics data analysis

Methods and protocols in nanotoxicology

Bengt Fadeel, Maria Dusinska

Frontiers Media SA

Science Toxicology Nanotoxicology

Keywords: nanotoxicology,­in vitro,­in vivo,­standardization,­standard operating procedures,­Validation

Chemical Testing Using New Approach Methodologies (NAMs)

Amy J. Clippinger, Tala Henry, Carole Hirn, Todd Stedeford, Andreas Stucki, Claire Terry

Frontiers Media SA

Science Toxicology Computational Toxicology and Informatics

Keywords: New approach methodologies (NAM),­in vitro,­in silico,­chemical toxicity,­human-relevant testing

Characteristics and Composition of Aerosol Generated by Electronic Cigarettes: What is the Impact on Human Health?

Dominic L. Palazzolo

Frontiers Media SA

Science Toxicology Immunotoxicology

Keywords: ECIG,­E-liquid,­aerosol,­flavors,­Oxidative Stress,­Inflammation,­health effects,­Particle dynamics