Pharmacoinformatics: New developments and challenges in drug design

David Ramirez, Rafael Pelaez, Carlos F. Lagos, Jose L. Medina-Franco

Frontiers Media SA

Pharmacoinformatics combines bio- and chemoinformatics approaches as well as artificial...

Science Pharmacology Translational Pharmacology

Keywords: bioinformatics,­chemoinformatics,­drug design,­Multitarget drug design,­System Pharmacology Network Pharmacology,­machine learning,­artificial intelligence,­QSAR/QSRP modeling Ligand-based drug design,­structure-based drug design,­molecular docking,­molecular dynamics simulations,­Virtual Screening,­ADME/Tox prediction

Recent advances in the treatment of epilepsy

Khojasteh Malekmohammad, Mahmoud Rafieian-Kopaei, Antonella Riva

Frontiers Media SA

Epilepsy is one of the most common neurological chronic disorders characterized by unpredictable...

Science Pharmacology Analytical and Experimental Pharmacology

Keywords: Epilepsy,­Drug Development,­pharmacokinetics,­Pharmacodynamics,­Drug Discovery,­Pharmacological Targets

Innovative Pharmacometric Approaches to Inform Drug Development and Clinical Use

Victor Mangas Sanjuan, Zinnia P. Parra-Guillen, Maria Garcia-Cremades, Hugo Geerts

Frontiers Media SA

Pharmacometrics represents a strategy to optimize and rationalize decision-making process...

Science Pharmacology Translational Pharmacology

Keywords: pharmacometrics,­population analysis,­physiologically based pharmacokinetic modeling,­PBPK,­Quantitative Systems Pharmacology,­QSP,­Pharmacokinetic-pharmacodynamic model

Sepsis: Basic, Clinical and Therapeutic Approaches

Hong Zhou, Yan Kang, Lefu Lan, Daolin Tang

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: Sepsis,­Pathogenesis,­signal transduction pathway,­Treatment,­therapeutic strategies

Protection and healing in the digestive system and other tissues: Novel factors, mechanisms, and pharmaceutical targets

Predrag Sikiric, Thomas Brzozowski, Duan Chen, Ki Baik Hahm, Sven Seiwerth

Frontiers Media SA

Science Pharmacology Gastrointestinal and Hepatic Pharmacology

Keywords: gastrointestinal intergrity,­Ulcer healing,­Mucosal defense,­organ healing,­GI-tract

Model-informed drug development and evidence-based translational pharmacology

Yu-Wei Lin, S. Y. Amy Cheung, Songwen Tan, Weiguo Li, Chuanpin Chen, Amal Kaddoumi, Xiu-Li Guo

Frontiers Media SA

Science Pharmacology Translational Pharmacology

Keywords: pharmacometrics,­Drug Development,­Clinical observations,­Advanced analysis tools,­Cellular and molecular mechanics

Advance in Translational Research of Preterm Birth and Related Pregnancy

Nanbert Zhong, Thomas McElrath, Hao Ying

Frontiers Media SA

Science Pharmacology Obstetric and Pediatric Pharmacology

Keywords: Adverse outcome of pregnancy,­Pathological pregnancy,­biomarker,­Advanced technology,­Pathogenesis,­Therapeutic target,­Molecular pathway,­Placenta,­omics

Recent Advances in Radiation Medical Countermeasures

Ales Tichy, Diane Riccobono, Lynnette H. Cary, Christophe Badie

Frontiers Media SA

Science Pharmacology Translational Pharmacology

Keywords: radioprotection,­ionising radiation,­Acute Radiation Syndrome,­Radiocontamination

Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis, Volume II

Cecilia Battistelli, Marc Diederich, Timothy Joseph Keane, Pilar Sandoval, Sergio Valente, Raffaele Strippoli

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: EMT,­Fibrosis,­epigenetics,­therapeutic targets,­Biomaterials