Drug metabolism and transport: The frontier of personalized medicine

Junmin Zhang, Rong Wang, Sofia Azeredo Pereira

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: drug metabolism,­Drug Transport,­pharmacokinetics,­drug-drug interactions,­Metabolic enzymes,­drug transporters,­external factors,­Gut Microbiota

Drug-drug interactions in pharmacology

Francesco Paolo Busardò, Simona Pichini, Oscar Garcia-Algar

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: Drug-interaction,­Medicine,­Pharmacotoxicology,­Cardiology,­oncology

Pharmacokinetic differences of drugs and their regulatory mechanisms under dual status including normal and diseased organism

Zipeng Gong, Ling Ye, Guo Ma, Kaustubh Kulkarni, Yan-Fang Xian

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: Dual status,­Pharmacokinetic differences,­drug metabolizing enzymes,­transporters,­Nuclear Receptors,­Gut Microbiota,­Pharmacokinetic-pharmacodynamic link model

Methods and Application in Drug Metabolism and Transport: 2021

Ren-ai Xu, Jiao Zheng, Sabina Passamonti

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: drug metabolism,­Pharmacology,­antitumor,­Blood deficiency syndrome,­Pharmacokinetic models

Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance

Jurgen Brockmoller, Mladen Vassilev Tzvetkov, Shuiying Hu

Frontiers Media SA

Around one third of all biologically relevant small molecules are organic cations. These include...

Science Pharmacology Drug Metabolism and Transport

Keywords: OCT1,­drug membrane transporter,­polymorphism,­pharmacokinetics,­structure and function

Pharmacokinetic Evaluation and Modeling of Clinically Significant Drug Metabolites

Constantin Mircioiu, Momir Mikov, Victor A. Voicu, Adrian Nicolescu, Valentina Anuta

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: IVIVC,­Metabolites,­biorelevant dissolution testing,­First pass metabolism,­pharmacokinetics

EUFEMED 2017

Kerstin Breithaupt-Grögler, Ingrid Klingmann, Hildegard Sourgens, Michael Hammond, Ulrike Lorch, Jorg Taubel, Jan de Hoon, Luc Van Bortel, Henri Caplain, Yves Donazzolo, Tim Hardman, Steffan Stringer

Frontiers Media SA

EUFEMED CONFERENCE, London, UK 17 - 19 May 2017

EUFEMED 2017 is the 1st conference of...

Science Pharmacology Analytical and Experimental Pharmacology

Keywords: human pharmacology,­early phase drug development,­Risk Management,­over-volunteering,­patient recruitment,­Exploratory clinical trials

The Importance of Iron in Pathophysiologic Conditions

Raffaella Gozzelino, Paolo Arosio

Frontiers Media SA

The iron element (Fe) is strictly required for the survival of most forms of life, including...

Science Pharmacology Drug Metabolism and Transport

Keywords: Iron,­iron metabolism,­Heme,­iron and genetic disorder,­Iron deficiency and anemia,­iron and inflammation,­iron and cardiotoxicity,­iron and neurodegeneration.

The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity and cytoprotection

Jaime Kapitulnik, Mahin D. Maines

Frontiers Media SA

Degradation of heme involves its conversion to biliverdin by heme oxygenase followed by reduction...

Science Pharmacology Drug Metabolism and Transport