AUTHOR=Hernandez-Rapp Julia , Martin-Lannerée Séverine , Hirsch Théo Z., Launay Jean-Marie , Mouillet-Richard Sophie TITLE=Hijacking PrPc-dependent signal transduction: when prions impair Aβ clearance JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 6 - 2014 YEAR=2014 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2014.00025 DOI=10.3389/fnagi.2014.00025 ISSN=1663-4365 ABSTRACT=The cellular prion protein PrPC is the normal counterpart of the scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. The recent discovery that PrPC can serve as a receptor for the amyloid Αβ peptide and relay its neurotoxicity is sparking renewed interest on this protein and its involvement in signal transduction processes. Disease-associated PrPSc shares with Αβ the ability to hijack PrPC-dependent signalling cascades, and thereby instigate pathogenic events. Among these is an impairment of Αβ clearance, uncovered in prion-infected neuronal cells. These findings add another facet to the intricate interplay between PrPC and Αβ. Here, we summarize the connection between PrP-mediated signalling and Αβ clearance and discuss its pathological implications.