AUTHOR=Persson Ninni , Lavebratt Catharina , Sundström Anna , Fischer Håkan 

TITLE=Pulse Pressure Magnifies the Effect of COMT Val158Met on 15 Years Episodic Memory Trajectories

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 8 - 2016

YEAR=2016

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00034

DOI=10.3389/fnagi.2016.00034

ISSN=1663-4365

ABSTRACT=We investigated whether a physiological marker of cardiovascular health, pulse pres­sure (PP), and age magnified the effect of the functional COMT Val158Met (rs4680) pol­ymor­phism on 15-year cognitive trajectories (episodic memory [EM], visuospatial ability, and se­man­tic memory) using data from 1585 non-demented adults from the Betula study. A mul­tiple-group growth model was specified to gauge individual differences in change. The allelic variants showed negligible differences across the cognitive markers in average trends. The older portion of the sample selectively age-magnified the effects of Val158Met on EM changes, resulting in greater decline in Val compared to homozygote Met carriers. This effect was attenuated by sta­tistical control for PP. Further, PP mod­erated the effects of COMT on 15-year EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (dia­betes, stroke, and hypertension), and chronological age, controlled for practice gains. The effect was still present after excluding individuals with a history of cardiovascular diseases. The effects of cognitive change were not moderated by any other covariates. This report underscores the importance of addressing synergistic effects in nor­mal cognitive aging, as the addition thereof may even place healthy individuals at greater risk for memory decline.