AUTHOR=Baig Mohammad H. , Ahmad Khurshid , Rabbani Gulam , Choi Inho 

TITLE=Use of Peptides for the Management of Alzheimer’s Disease: Diagnosis and Inhibition

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 10 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00021

DOI=10.3389/fnagi.2018.00021

ISSN=1663-4365

ABSTRACT=Alzheimer’s disease (AD) is a form of dementia and the most common progressive neurodegenerative disease. The targeting of amyloid-β (Aβ) aggregation is one of the most widely used strategies to manage AD. Efforts are being made globally to develop peptide-based compounds for early diagnosis and treatment of AD. Here, we briefly discuss the use of peptide-based compounds for the early diagnosis and treatment of AD and the use of peptide-based inhibitors at various Aβ aggregation checkpoints. Furthermore, we have briefly discussed the recent application of peptide based inhibitors against various AD targets including amyloid beta, BACE1, GAPDH, tyrosine phosphatase and potassium channel KV1.3.