AUTHOR=Santiago Jose A. , Bottero Virginie , Potashkin Judith A. TITLE=Evaluation of RNA Blood Biomarkers in the Parkinson’s Disease Biomarkers Program JOURNAL=Frontiers in Aging Neuroscience VOLUME=Volume 10 - 2018 YEAR=2018 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00157 DOI=10.3389/fnagi.2018.00157 ISSN=1663-4365 ABSTRACT=
There is a high misdiagnosis rate between Parkinson’s disease (PD) and atypical parkinsonian disorders (APD), such as progressive supranuclear palsy (PSP), the second most common parkinsonian syndrome. In our earlier studies, we identified and replicated RNA blood biomarkers in several independent cohorts, however, replication in a cohort that includes PSP patients has not yet been performed. To this end, we evaluated the diagnostic potential of nine previously identified RNA biomarkers using quantitative PCR assays in 138 blood samples at baseline from PD, PSP and healthy controls (HCs) nested in the PD Biomarkers Program. Linear discriminant analysis showed that