AUTHOR=Zhou Wei , Shen Bo , Shen Wei-qiang , Chen Hao , Zheng Yi-feng , Fei Jing-jing 

TITLE=Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 12 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.559603

DOI=10.3389/fnagi.2020.559603

ISSN=1663-4365

ABSTRACT=Objective: The study aims to detect the potential relationship between iron deposition and the function of glymphatic system in normal ageing brain.
Methods: We recruited 213 health participates. We evaluated the function of glymphatic system by the index for diffusivity along the perivascular space (ALPS-index), assessed iron deposition on quantitative susceptibility mapping (QSM), and analyzed their relationship.
Results: The mean age was 60.1 ± 7.3, and 107 (50.2%) were female. The mean ALPS-index was 1.4 ± 0.2. The QSM values of caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra and dentate nucleus were all related to ALPS-index (all P < 0.001).
Conclusions: The main finding of the current study is that the regional brain iron deposition was related to the function of the glymphatic system.