AUTHOR=Touchard Cyril , Cartailler Jérôme , Levé Charlotte , Serrano José , Sabbagh David , Manquat Elsa , Joachim Jona , Mateo Joaquim , Gayat Etienne , Engemann Denis , Vallée Fabrice 

TITLE=Propofol Requirement and EEG Alpha Band Power During General Anesthesia Provide Complementary Views on Preoperative Cognitive Decline

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 12 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.593320

DOI=10.3389/fnagi.2020.593320

ISSN=1663-4365

ABSTRACT=Background: Although cognitive decline (CD) is associated with increased post-operative morbidity and mortality, routinely screening patients remains difficult. The main objective of this prospective study is to use the EEG response to a Propofol-based gen-eral anesthesia (GA) to reveal CD. 
Methods: 42 patients with collected EEG and Propofol target concentration infusion (TCI) during GA had a preoperative cognitive assessment using MoCA. We evaluated the per-formance of three variables to detect CD (MoCA < 25 points): age, Propofol requirement to induce unconsciousness (TCI at SEF95: 8-13 Hz) and the frontal alpha band power (AP at SEF95: 8-13 Hz). 
Results: The 17 patients (40%) with CD were significantly older (p < 0.001), had lower TCI (p < 0.001) and AP (p < 0.001). We found using logistic models that TCI and AP were the best set of variables associated with CD (AUC: 0.89) and performed better than age (p < 0.05). Propofol TCI had a greater impact on CD probability compared to AP, alt-hough both were complementary in detecting CD. 
Conclusion: TCI and AP contribute additively to reveal patient with preoperative cogni-tive decline. Further research on post-operative cognitive trajectory are necessary to con-firm the interest of intra operative variables in complement to cognitive evaluation or when it could not to be done.