AUTHOR=Auzmendi-Iriarte Jaione , Matheu Ander 

TITLE=Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 12 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.630743

DOI=10.3389/fnagi.2020.630743

ISSN=1663-4365

ABSTRACT=Brain aging is characterized by a time-dependent decline of tissue integrity and function, and it is a major risk for neurodegenerative diseases and brain cancer. Chaperone mediated autophagy (CMA) is a selective form of autophagy specialized in protein degradation, which is based on the individual translocation of a cargo protein through the lysosomal membrane. Regulation of processes such as proteostasis, cellular energetics or immune system activity has been associated to CMA, indicating its pivotal role on tissue homeostasis. Since first studies associating Parkinson’s disease to CMA dysfunction, increasing evidence point out that CMA is altered in both physiological and pathological brain aging. In this review we summarize the current knowledge regarding the impact of CMA during aging in brain physiopathology, highlighting the role of CMA in neurodegenerative diseases and glioblastoma, the most common and aggressive brain tumor in adults.