AUTHOR=Wu Luobing , Wang Caihong , Liu Jingchun , Guo Jun , Wei Ying , Wang Kaiyu , Miao Peifang , Wang Yingying , Cheng Jingliang 

TITLE=Voxel-Mirrored Homotopic Connectivity Associated With Change of Cognitive Function in Chronic Pontine Stroke

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 13 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.621767

DOI=10.3389/fnagi.2021.621767

ISSN=1663-4365

ABSTRACT=Cognitive function impairment after infarction is a commonly accepted reality. In addition, the research on cognitive function has attracted much attention nowadays. There is still a large space for cognitive opinions, and no one seems to have explored the influence of inter-hemispheric homotopic information exchange on cognitive function. This study attempts to explore this blank space. Fifty-six patients with onset chronic pontine stroke (28 left-sided stroke (LP) and 28 right-sided stroke (RP)) and 35 matched healthy controls (HC) underwent functional magnetic resonance imaging and behavioral assessments of cognitive function. One-way ANOVA analysis was performed for the three groups（the HC, the LP and the RP）with voxel-mirrored homotopic connectivity (VMHC). Results showed that there were significant decreases in bilateral lingual gurus (Lingual_L and Lingual_R) and left precuneus (Precuneus_L). Post hoc multiple comparisons showed a significant difference between the RP and the HC. Moreover, we explored the relationship between z-values of the significantly different clusters in VMHC and the behavior-task scores by using Pearson correlation, and found that both scores of short-term memory and long-term memory in Rey Auditory Verbal Learning Test were positively correlated with z-values of Lingual_L, Lingual_R and Precuneus_L in VMHC. Besides that, z-values of Precuneus_L in VMHC was also found negatively correlated with reaction time for correct responses of Flanker task, of digital_1_back task and spatial_1_back task. In conclusion, first, that right hemisphere offered more contribution in rusults this study; Second, lingual gurus showed a important pole in semantic processing and then affected verbal memory; Third, the precuneus influenced the working memory no matter in auditory vebal or visual term. This study provides a perspective for us to recognize the cognitive impairment after stroke.