AUTHOR=Zhong Lingling , Ju KeJu , Chen Ainian , Cao Hua 

TITLE=Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 13 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.684289

DOI=10.3389/fnagi.2021.684289

ISSN=1663-4365

ABSTRACT=Parkinson's disease (PD) is a chronic and progressive degenerative disease of the central nervous system. Degenerative neuropathy can occur in patients with PD even before typical clinical symptoms appear in the preclinical stage. Therefore, if the early diagnosis of degenerative diseases can be timely and the correlation with the disease progression can be explored, the disease progression will be slowed down and the quality of life of patients will be improved. In this study, the circRNA microarray was employed to screen the dysregulated circRNA in plasma samples of PD. Four circRNAs (circ_0085869, circ_0004381, circ_0017204 and circ_0090668) were obtained with increased level in PD patients by cross comparison and preliminary verification in PD comparing with healthy controls. Further validation found the circRNA panel was consistent with training set. The ROC curve also revealed a high diagnostic ability of circ_0004381 and circ_0017204 in predicted the early stage of PD from healthy controls. Besides, circ_0085869, circ_0004381, circ_0017204 and circ_0090668 also presented a high ability for distinguish the late stage of PD from early stage. In conclusion, circulating circRNA panel might be the potential fingerprint for predicting the early diagnosis of PD and may acting as biomarker for disease progression.