AUTHOR=Zhou Xiangyue , Li Youwei , Lenahan Cameron , Ou Yibo , Wang Minghuan , He Yue 

TITLE=Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 13 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.698036

DOI=10.3389/fnagi.2021.698036

ISSN=1663-4365

ABSTRACT=Stroke is the destruction of brain function and structure, and is caused by either cerebrovascular obstruction or ruptured hemorrhage. It is a disease associated with high mortality and disability worldwide. Brain edema after stroke is an important link affecting nerve function recovery. The formation and recovery of brain edema after stroke are closely related to the glymphatic system. In this review, we will introduce the physiology of the glymphatic system, as well as related mechanisms and therapeutic targets involved in the formation of cerebral edema after stroke, which could provide a new research direction for treating cerebral edema after stroke.