AUTHOR=Foo Heidi , Thalamuthu Anbupalam , Jiang Jiyang , Koch Forrest , Mather Karen A. , Wen Wei , Sachdev Perminder S. 

TITLE=Age- and Sex-Related Topological Organization of Human Brain Functional Networks and Their Relationship to Cognition

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 13 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.758817

DOI=10.3389/fnagi.2021.758817

ISSN=1663-4365

ABSTRACT=Age and sex associated with changes in functional brain network topology and cognition in large population of older adults have been poorly understood. We explored this question further by examining differences in 11 resting-state graph theory measures with respect to age, sex, and their relationships with cognitive performance in 17,127 UK Biobank participants (mean=62.837.41 years). Age was associated with an overall decrease in the effectiveness of network communication (i.e. integration) and loss of functional specialisation (i.e. segregation) of specific brain regions. Sex differences were also observed, with women showing more efficient networks which were less segregated than in men (FDR adjusted p<.05). Age-related changes were also more apparent in men than women, which suggests that men may be more vulnerable to cognitive decline with age. Interestingly, while network segregation and strength of limbic network were only nominally associated with cognitive performance, the network measures collectively were significantly associated with cognition (FDR adjusted p≤.002). This may imply that individual measures may be inadequate to capture much of the variance in neural activity or its output and need further refinement.  The complexity of the functional brain organisation may be shaped by an individual’s age and sex, which ultimately may influence cognitive performance of older adults. Age and sex stratification may be used to inform clinical neuroscience research to identify older adults at risk of cognitive dysfunction.