AUTHOR=Jia Yuxi , Yan Shoumeng , Sun Mengzi , Yang Yixue , Wang Ling , Wu Caihong , Li Ping 

TITLE=Association between dietary inflammatory index and cognitive impairment: A meta-analysis

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1007629

DOI=10.3389/fnagi.2022.1007629

ISSN=1663-4365

ABSTRACT=Aims: Cognitive impairment is an increasingly pressing public health problem worldwide. Dietary Inflammatory Index (DII) is a literature-derived score that links diet to inflammation. The relationship between DII and cognitive impairment remains controversial. Therefore, our study aimed to evaluate the role of DII on the risk of cognitive impairment by meta-analysis.
Methods: PubMed, Cochrane Library, MEDLINE, Web of Science and EMBASE databases were searched up to July 2022. Newcastle–Ottawa scale (NOS) and Joanna Briggs Institute (JBI) Checklist were used to estimate the quality of studies. 
Results: Nine observational studies with 19379 subjects were included. Our study found that higher DII could increase the risk of cognitive impairment (OR =1.46, 95%CI=1.26, 1.69). Meanwhile, the OR of cognitive impairment was 1.49 (95%CI=1.21, 1.83) for cross-sectional studies and 1.42 (95%CI=1.12, 1.79) for cohort studies, respectively.
Conclusions: Our meta-analysis indicated that higher DII (representing a more pro-inflammatory diet) is associated with increased risk of cognitive impairment.