AUTHOR=Zhang Xiaowen , Hou Xuejia , Te Liu , Zhongsheng Zhou , Jiang Jinlan , Wu Xiaodong 

TITLE=Mesenchymal stem cells and exosomes improve cognitive function in the aging brain by promoting neurogenesis

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1010562

DOI=10.3389/fnagi.2022.1010562

ISSN=1663-4365

ABSTRACT=Normal aging is characterized by the progressive loss of various physiological functions in all body organ systems. Brain aging is one of the most critical biological processes that affect the physiological balance between health and disease. Age-related brain dysfunction is a severe health problem that contributes to the current aging society, and so far, there is no good way to slow down aging. Mesenchymal stem cells have inflammation-inhibiting and proliferation-promoting functions. At the same time, their secreted exosomes inherit the regulatory and therapeutic procedures of MSCs with small diameters, allowing high-dose injections and improved therapeutic efficiency. This paper describes how MSCs and their derived exosomes promote brain neurogenesis and thereby delay aging by improving brain inflammation.