AUTHOR=Zheng Wei , Zhang Xin-Yang , Xu Rui , Huang Xiong , Zheng Ying-Jun , Huang Xing-Bing , Li Ze-Zhi , Chen Huo-Di 

TITLE=Adjunctive accelerated repetitive transcranial magnetic stimulation for older patients with depression: A systematic review

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1036676

DOI=10.3389/fnagi.2022.1036676

ISSN=1663-4365

ABSTRACT=Objective: We performed this systemic review to investigate the therapeutic potential and safety of adjunctive accelerated repetitive transcranial magnetic stimulation (aTMS) for older patients with depression.
Methods: We included published randomized clinical trials (RCTs) and observational studies targeting adjunctive aTMS for older patients with depression.
Results: Two open-label self-controlled studies (n=29) fulfilled the criteria for inclusion. The included studies reported significant improvements in depressive symptoms from baseline to post-aTMS (all Ps<0.05). One study reported a dropout rate of 10.5% (2/19). Mild headache was the most common adverse reaction. 
Conclusion: The currently available evidence from two open-label self-controlled studies indicates that adjunctive aTMS is a safe and effective therapy for older patients with depression.