AUTHOR=Chen Daji , Wan Linlin , Chen Zhao , Yuan Xinrong , Liu Mingjie , Tang Zhichao , Fu You , Zhu Sudan , Zhang Xuewei , Qiu Rong , Tang Beisha , Jiang Hong 

TITLE=Serum vitamin levels in multiple system atrophy: A case-control study

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1105019

DOI=10.3389/fnagi.2022.1105019

ISSN=1663-4365

ABSTRACT=There is increasing evidence suggesting that vitamins may play important roles in the pathogenesis of multiple system atrophy (MSA). In this study, we investigated whether serum vitamin levels, including vitamin A, B1, B2, B9 (folate), B12, C, D, and E, were discriminative among MSA patients (N=244), Parkinson’s disease (PD) patients (N=200) and healthy controls (N=244). Compared with the healthy controls, decreased serum vitamin B9 levels and increased serum vitamin A and C levels were detected in MSA patients. No difference was detected between MSA and PD patients. In MSA patients, significant correlation was found between serum vitamin levels and relevant clinical parameters. In addition, ROC analysis showed potential diagnostic value of the combination of vitamin A, B9, and C in distinguishing MSA patients from healthy controls. The significant changes in the blood vitamin spectrums of MSA patients suggested that dysregulation of vitamins homeostasis might play an important role in the pathogenesis of MSA.