AUTHOR=Bai Yutong , Diao Yu , Gan Lu , Zhuo Zhizheng , Yin Zixiao , Hu Tianqi , Cheng Dan , Xie Hutao , Wu Delong , Fan Houyou , Zhang Quan , Duan Yunyun , Meng Fangang , Liu Yaou , Jiang Yin , Zhang Jianguo 

TITLE=Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.794987

DOI=10.3389/fnagi.2022.794987

ISSN=1663-4365

ABSTRACT=Background: Deep brain stimulation (DBS) improves motor and non-motor symptoms in Parkinson’s disease (PD) patients. Research mainly investigated the motor networks to reveal DBS mechanisms, with few studies extending to other networks. This study aimed to investigate multi-network modulation patterns using DBS in PD patients.
Methods: Twenty-four PD patients underwent 1.5 T functional magnetic resonance imaging scans in both DBS-on and DBS-off states, with twenty-seven age-matched healthy controls (HCs). Default mode, sensorimotor, salience, and left and right frontoparietal networks were identified by using independent component analysis. Power spectra and functional connectivity of these networks were calculated. In addition, multi-regional connectivity were established from 15 selected regions extracted from the above networks. Comparisons were made among groups. Finally, correlation analyses were performed between the connectivity changes and symptom improvements.
Results: Compared with HCs, PD-off showed abnormal power spectra and functional connectivity both within and among these networks. Some of the above-mentioned abnormal could be corrected by DBS, including increasing the power spectra in the sensorimotor network, modulating parts of the ipsilateral functional connectivity in different regions centered in the frontoparietal network. Moreover, The DBS-induced functional connectivity changes were correlated with motor and depression improvements in PD patients.
Conclusions: DBS modulated abnormalities in multi-networks. The functional connectivity alterations were associated with motor and psychiatric improvements in PD. This study lays the foundation for large-scale brain network research on multi-network DBS modulation.