AUTHOR=Trejo-Castro Alejandro I. , Carrion-Alvarez Diego , Martinez-Torteya Antonio , Rangel-Escareño Claudia 

TITLE=A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.804177

DOI=10.3389/fnagi.2022.804177

ISSN=1663-4365

ABSTRACT=Research on microbiome has drawn an increasing amount of attention over the past decade. Even more so on its association to disease. Neurodegenerative diseases such as Alzheimer’s (AD) have been a subject of study for a long time with slow success improving diagnostic accuracy or a possibility for treatment. In this work, we analyze past and current research on microbiome and its positive impact on  AD treatment and diagnosis. We present a bibliometric analysis from 2012-2021 with data retrieved on September 2, 2021, from the Scopus database. Query includes “Gut AND (Microbiota OR Microbiome) AND Alzheimer*” within article title, abstract and keywords for all kind of documents in the database. Compared to 2016, the number of publications on the subject doubled by 2017. Moreover, we observe an exponential growth through 2020 and with the data presented it is almost certain that it will continue this trend and grow even further in the upcoming years. We identify key journals interested in the subject and discuss the articles with most citations analyzing trends and topics for future research, like the ability to diagnose the disease and complement the cognitive test with other clinical biomarkers. According to the test, Mild Cognitive Impairment is normally considered an initial stage for AD. This test, combined with the role of gut microbiome in early stages of the disease may improve the diagnostic accuracy. Based on our finding there is emerging evidence that microbiota – perhaps more specifically gut microbiota is a key player in the pathogenesis of diseases such as AD.