AUTHOR=Krzosek Patrycja , Madetko Natalia , Migda Anna , Migda Bartosz , Jaguś Dominika , Alster Piotr 

TITLE=Differential Diagnosis of Rare Subtypes of Progressive Supranuclear Palsy and PSP-Like Syndromes—Infrequent Manifestations of the Most Common Form of Atypical Parkinsonism

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.804385

DOI=10.3389/fnagi.2022.804385

ISSN=1663-4365

ABSTRACT=Growing interest is associated with recently more widely described variants of PSP other than PSP-RS and PSP-P. The exact diagnosis of these variants is extremely complex, as it is generally based on clinical manifestation. The accurate examination remains a major challenge for clinicians. Individual phenotypes often show high similarity not only to other neurodegenerative diseases but also to genetic, autoimmune or infectious disorders manifesting as PSP-mimicking syndromes. The limited data on rare PSP subtypes makes it impossible to isolate a specific technique that would give a chance for a confident ante-mortem diagnosis of each of the variants discussed. The aim of this review is to discuss recent developments concerning the assessment of the rare phenotypes of PSP and PSP-like syndromes.