AUTHOR=He Fan , Zhou Yu-ming , Qi Yan-jie , Huang Huan-huan , Guan Lin , Luo Jie , Cheng Yu-hang , Zheng Yi 

TITLE=Exploration of Mutated Genes and Prediction of Potential Biomarkers for Childhood-Onset Schizophrenia Using an Integrated Bioinformatic Analysis

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=Volume 14 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.829217

DOI=10.3389/fnagi.2022.829217

ISSN=1663-4365

ABSTRACT=Childhood-onset schizophrenia (COS) is an unusual severe neurodevelopmental disorder of unknown etiology. With this study, we aimed to survey the missense variants in new cases of COS and also identify possible pathology biomarkers for COS. We found one list of mutated genes such as TTN, MUC12, and MUC2 which are candidates to be involved in the etiology of COS. Next, we used WGSNA to predict COS disease-related genes and identified differential DNA methylation between COS Disease groups, COS Dangerous groups, and Normal groups, and found 8 methylation sites that can be used as diagnostic biomarkers. Six key genes are obtained through the intersection analysis between WGCNA Mode, methylation-related genes, and differentially expressed genes (DGenes). These genes may play important roles in the progression of COS and serve as potential biomarkers for future diagnosis. Our results might help design the molecule or gene targeted drugs for COS.